DE602006007976D1 - Benzimidazolderivate und deren verwendung zur modulation des gabaa-rezeptorkomplexes - Google Patents

Benzimidazolderivate und deren verwendung zur modulation des gabaa-rezeptorkomplexes

Info

Publication number
DE602006007976D1
DE602006007976D1 DE602006007976T DE602006007976T DE602006007976D1 DE 602006007976 D1 DE602006007976 D1 DE 602006007976D1 DE 602006007976 T DE602006007976 T DE 602006007976T DE 602006007976 T DE602006007976 T DE 602006007976T DE 602006007976 D1 DE602006007976 D1 DE 602006007976D1
Authority
DE
Germany
Prior art keywords
modulation
receptor complex
benzimidazole derivatives
gabaa receptor
gabaa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006007976T
Other languages
English (en)
Inventor
Janus S Larsen
Lene Teuber
Philip K Ahring
Elsebet Oestergaard Nielsen
Naheed Mirza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch AS filed Critical Neurosearch AS
Publication of DE602006007976D1 publication Critical patent/DE602006007976D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
DE602006007976T 2005-04-13 2006-04-07 Benzimidazolderivate und deren verwendung zur modulation des gabaa-rezeptorkomplexes Active DE602006007976D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67064705P 2005-04-13 2005-04-13
DKPA200500530 2005-04-13
PCT/EP2006/061417 WO2006108800A1 (en) 2005-04-13 2006-04-07 Benzimidazole derivatives and their use for modulating the gabaa receptor complex

Publications (1)

Publication Number Publication Date
DE602006007976D1 true DE602006007976D1 (de) 2009-09-03

Family

ID=36658703

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006007976T Active DE602006007976D1 (de) 2005-04-13 2006-04-07 Benzimidazolderivate und deren verwendung zur modulation des gabaa-rezeptorkomplexes

Country Status (19)

Country Link
US (1) US7851490B2 (de)
EP (1) EP1877052B1 (de)
JP (1) JP2008535891A (de)
KR (1) KR20070119691A (de)
AU (1) AU2006233894A1 (de)
CA (1) CA2604516A1 (de)
CO (1) CO6241194A2 (de)
DE (1) DE602006007976D1 (de)
DK (1) DK1877052T3 (de)
ES (1) ES2330468T3 (de)
HR (1) HRP20090453T1 (de)
IL (1) IL185371A0 (de)
MX (1) MX2007012624A (de)
NO (1) NO20075793L (de)
NZ (1) NZ560939A (de)
PL (1) PL1877052T3 (de)
PT (1) PT1877052E (de)
RU (1) RU2405779C2 (de)
WO (1) WO2006108800A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602006010602D1 (de) 2005-12-05 2009-12-31 Neurosearch As Benzimidazolderivate und ihre verwendung zur modulierung des gabaa-rezeptorkomplexes
TWI391381B (zh) 2006-03-24 2013-04-01 Neurosearch As 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途
WO2010055126A1 (en) * 2008-11-14 2010-05-20 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
WO2010055124A1 (en) * 2008-11-14 2010-05-20 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
WO2010055125A1 (en) * 2008-11-14 2010-05-20 Neurosearch A/S Benzimidazole derivatives and their use for modulating the gabaa receptor complex
RU2452486C1 (ru) * 2011-04-13 2012-06-10 Общество с ограниченной ответственностью "Лечебно-реабилитационный научный центр "Феникс" Способ фармакотерапии панического расстройства

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK40192D0 (da) 1992-03-26 1992-03-26 Neurosearch As Imidazolforbindelser, deres fremstilling og anvendelse
CZ287545B6 (en) 1995-04-21 2000-12-13 Neurosearch As Benzimidazole derivatives, pharmaceutical preparation in which they are comprised and their use
JP2001502675A (ja) * 1996-10-21 2001-02-27 ニューロサーチ・アクティーゼルスカブ １―フエニル―ベンズイミダゾール化合物及びこれをｂａｇａ▲下ａ▼―レセプターモデュレーターとして使用する方法
WO1999019323A1 (en) * 1997-10-10 1999-04-22 Neurosearch A/S Benzimidazole compounds, pharmaceutical compositions containing the compounds and their use
WO2000078728A1 (en) 1999-06-22 2000-12-28 Neurosearch A/S Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds
WO2002050057A1 (en) 2000-12-20 2002-06-27 Neurosearch A/S Novel benzimidazole derivatives for the treatment of gaba-alpha mediated disorders
EP1613618A2 (de) * 2003-04-03 2006-01-11 Neurosearch A/S Benzimidazol derivate und ihre verwendung als modulatoren des gaba-a rezeptoren komplexes
US7335777B2 (en) 2003-04-03 2008-02-26 Neurosearch A/S Benzimidazole derivatives and their use for modulating the GABAA receptor complex
AP2006003549A0 (en) * 2003-08-21 2006-04-30 Osi Pharm Inc N-substituted benzimidazolyl C-kit inhibitors.
JP2007509108A (ja) 2003-10-23 2007-04-12 アクゾ ノベル ナムローゼ フェンノートシャップ １，５，７−三置換ベンズイミダゾール誘導体及びｇａｂａａ受容体複合体を調節するためのその使用
BRPI0518794A2 (pt) * 2004-12-01 2008-12-09 Osi Pharm Inc composto, composiÇço, mÉtodo de tratamento de distérbio hiperproliferativo, e, biblioteca combinatorial
TWI391381B (zh) 2006-03-24 2013-04-01 Neurosearch As 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途

Also Published As

Publication number Publication date
CA2604516A1 (en) 2006-10-19
RU2007137096A (ru) 2009-05-20
PL1877052T3 (pl) 2010-01-29
HRP20090453T1 (hr) 2009-10-31
US7851490B2 (en) 2010-12-14
NO20075793L (no) 2008-01-14
EP1877052B1 (de) 2009-07-22
CO6241194A2 (es) 2011-01-20
IL185371A0 (en) 2008-02-09
AU2006233894A1 (en) 2006-10-19
DK1877052T3 (da) 2009-10-12
US20090036493A1 (en) 2009-02-05
MX2007012624A (es) 2008-01-11
EP1877052A1 (de) 2008-01-16
NZ560939A (en) 2010-07-30
WO2006108800A1 (en) 2006-10-19
PT1877052E (pt) 2009-08-25
ES2330468T3 (es) 2009-12-10
RU2405779C2 (ru) 2010-12-10
KR20070119691A (ko) 2007-12-20
JP2008535891A (ja) 2008-09-04

Similar Documents

Publication Publication Date Title
ATE486856T1 (de) Benzimidazol-derivate und ihre verwendung zur modulierung des gabaa-rezeptor-komplexes
NL301192I2 (nl) Finerenon en zijn zouten, solvaten en solvaten van de zouten daarvan
DE112008002275A5 (de) Scheinwerferlampe und deren Verwendung
DE602007012308D1 (de) Bicyclische pyrimidinone und deren verwendung
ATE531712T1 (de) Substituierte aryloxazole und ihre verwendung
ATE543808T1 (de) 5,6-ring-annelierte indolderivate und ihre verwendung
BRPI0810524A2 (pt) Derivado de (aza)indol e uso do mesmo para propósitos médicos
DE602005023639D1 (de) Chinuclidinderivate und deren verwendung als muscarin-m3-rezeptor-antagonisten
DE602005022115D1 (de) Heteroaromatische chinolinverbindungen und deren verwendung als pde10-inhibitoren
DE602007008052D1 (de) 2-(polysubstituiertes aryl)-6-amino-5-halogen-4-pyrimidincarbonsäuren und deren verwendung als herbizide
ATE548355T1 (de) 4- (4-cyano-2-thioaryl) -dihydropyrimidinone und ihre verwendung
ATE489389T1 (de) 2 -heteroaryl- pyrrolo ä3, 4-cüpyrrol- derivate und deren verwendung als scd inhibitoren
DE602008001120D1 (de) Rauchdetektor und Probeluftversorgungsverfahren für den Rauchdetektor
DE112009000115A5 (de) Polyolefinfolie und Verwendung derselben
ATE511507T1 (de) Piperidinylcarbonylpyrrolidine und deren verwendung als melanocortinagonisten
DE502007001209D1 (de) Wachszusammensetzung und deren Verwendung
DE602006002916D1 (de) Interferometer und Kalibrierverfahren dafür
DE602006018166D1 (de) Polyrotaxanhaltige lösung und verwendung davon
ATE454377T1 (de) 2-phenyl-6-aminocarbonylpyrimidinderivate und ihre verwendung als antagonisten am p2y12- rezeptor
ATE544752T1 (de) Aryloxyacetamidderivate und ihre verwendung als fungizide
DE602006007976D1 (de) Benzimidazolderivate und deren verwendung zur modulation des gabaa-rezeptorkomplexes
DE602006008025D1 (de) Amidverbindungen und deren verwendung
ATE513817T1 (de) Pyrimidinderivate und ihre verwendung als pestizide
DE602007006540D1 (de) Cyclopropancarboxylate und deren verwendung als pestizide
DE602005007866D1 (de) 1-phenyl- und 1-pyridylpyrazolderivate und deren verwendung als pestizide

Legal Events

Date Code Title Description
8364 No opposition during term of opposition