JP2009529658A5 - - Google Patents

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JP2009529658A5
JP2009529658A5 JP2008556383A JP2008556383A JP2009529658A5 JP 2009529658 A5 JP2009529658 A5 JP 2009529658A5 JP 2008556383 A JP2008556383 A JP 2008556383A JP 2008556383 A JP2008556383 A JP 2008556383A JP 2009529658 A5 JP2009529658 A5 JP 2009529658A5
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JP2009529658A (ja
JP4790026B2 (ja
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JP2008556383A 2006-02-21 2007-02-20 標的分析物検出および溶液中の標的分析物濃度の決定のための方法およびアレイ Active JP4790026B2 (ja)

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Application Number Priority Date Filing Date Title
US77569206P 2006-02-21 2006-02-21
US60/775,692 2006-02-21
US79273606P 2006-04-17 2006-04-17
US60/792,736 2006-04-17
PCT/US2007/004349 WO2007098148A2 (en) 2006-02-21 2007-02-20 Mthods and arrays for target analyte detection and determination of target analyte concentration in solution

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JP2011034007A Division JP5410464B2 (ja) 2006-02-21 2011-02-18 標的分析物検出および溶液中の標的分析物濃度の決定のための方法およびアレイ

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JP2009529658A JP2009529658A (ja) 2009-08-20
JP2009529658A5 true JP2009529658A5 (enExample) 2011-04-21
JP4790026B2 JP4790026B2 (ja) 2011-10-12

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JP2011034007A Active JP5410464B2 (ja) 2006-02-21 2011-02-18 標的分析物検出および溶液中の標的分析物濃度の決定のための方法およびアレイ

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US (8) US8460879B2 (enExample)
EP (2) EP2538220B1 (enExample)
JP (2) JP4790026B2 (enExample)
AU (1) AU2007217819B2 (enExample)
CA (1) CA2643993C (enExample)
ES (2) ES2613083T3 (enExample)
WO (1) WO2007098148A2 (enExample)

Families Citing this family (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006047038A1 (en) * 2004-09-28 2006-05-04 Trustees Of Tufts College Apparatus and method for cell migration assays
US7709197B2 (en) 2005-06-15 2010-05-04 Callida Genomics, Inc. Nucleic acid analysis by random mixtures of non-overlapping fragments
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
EP2201374B1 (en) 2007-08-30 2015-10-07 Trustees Of Tufts College Methods for determining the concentration of an analyte in solution.
US8214646B2 (en) * 2008-05-06 2012-07-03 Research In Motion Limited Bundle verification
US20100075439A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of molecules by capture-and-release using reducing agents followed by quantification
WO2010039179A1 (en) * 2008-09-23 2010-04-08 Quanterix Corporation Ultra-sensitive detection of molecules or enzymes
US20100075862A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
WO2010088547A1 (en) * 2009-01-29 2010-08-05 Bayer Healthcare Llc Assays for detecting pegylated blood coagulation factors
US9063156B2 (en) 2009-06-12 2015-06-23 Pacific Biosciences Of California, Inc. Real-time analytical methods and systems
GB0912231D0 (en) * 2009-07-14 2009-08-26 Imp Innovations Ltd Method and apparatus for determining an analyte parameter
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
CN103026232B (zh) * 2010-03-01 2015-02-04 匡特里克斯公司 扩大用于检测分子或颗粒的测定法中的动态范围的方法和系统
US8236574B2 (en) * 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US20120040843A1 (en) 2010-08-12 2012-02-16 Dublin City University Centrifugal capture system
FR2968314B1 (fr) * 2010-12-01 2016-03-18 Commissariat Energie Atomique Procede de detection et de quantification de microorganismes
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
EP2683484A2 (en) 2011-03-09 2014-01-15 Seng Enterprises Ltd. Arresting objects
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
WO2013130674A1 (en) 2012-02-27 2013-09-06 Cellular Research, Inc. Compositions and kits for molecular counting
JP6200948B2 (ja) 2012-05-25 2017-09-20 ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル マイクロ流体デバイス
US9657290B2 (en) * 2012-07-03 2017-05-23 The Board Of Trustees Of The Leland Stanford Junior University Scalable bio-element analysis
EP4148118A1 (en) 2012-08-24 2023-03-15 Yale University System, device and method for high-throughput multi-plexed detection
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
WO2014165061A1 (en) 2013-03-13 2014-10-09 Meso Scale Technologies, Llc. Improved assay methods
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
BR112015023775B1 (pt) 2013-03-15 2022-08-16 Lubrizol Advanced Materials, Inc Composições de cpvc isentas de metal pesado
ES2711168T3 (es) 2013-08-28 2019-04-30 Becton Dickinson Co Análisis masivo en paralelo de células individuales
JP6076500B2 (ja) * 2014-03-31 2017-02-08 日本碍子株式会社 標的物質の検出方法
CN112239774B (zh) 2014-05-15 2024-12-03 中尺度技术有限责任公司 改进的测定方法
CN112782140A (zh) 2014-12-03 2021-05-11 伊索普莱西斯公司 细胞分泌特征的分析和筛选
US11434264B2 (en) 2015-02-13 2022-09-06 Quanterix Corporation Immunoassays for differential detection of clostridium difficile
US11353448B2 (en) 2015-02-13 2022-06-07 California Institute Of Technology Methods and compositions for quantifying metabolites and proteins from single cells
JP6920997B2 (ja) 2015-02-22 2021-08-18 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー マイクロスクリーニング装置、プロセス、及び生成物
EP3262192B1 (en) 2015-02-27 2020-09-16 Becton, Dickinson and Company Spatially addressable molecular barcoding
CN107406888A (zh) 2015-03-30 2017-11-28 赛卢拉研究公司 用于组合条形编码的方法和组合物
US11390914B2 (en) 2015-04-23 2022-07-19 Becton, Dickinson And Company Methods and compositions for whole transcriptome amplification
WO2017044574A1 (en) 2015-09-11 2017-03-16 Cellular Research, Inc. Methods and compositions for nucleic acid library normalization
US10301677B2 (en) 2016-05-25 2019-05-28 Cellular Research, Inc. Normalization of nucleic acid libraries
US10202641B2 (en) 2016-05-31 2019-02-12 Cellular Research, Inc. Error correction in amplification of samples
US10640763B2 (en) 2016-05-31 2020-05-05 Cellular Research, Inc. Molecular indexing of internal sequences
CN109964126B (zh) 2016-09-12 2022-12-27 伊索普莱克西斯公司 用于细胞治疗法和其他免疫治疗法的多重分析的系统和方法
IL265478B2 (en) 2016-09-26 2024-10-01 Becton Dickinson Co Measurement of protein expression using reagents with barcoded oligonucleotide sequences
US11493508B2 (en) 2016-11-11 2022-11-08 IsoPlexis Corporation Compositions and methods for the simultaneous genomic, transcriptomic and proteomic analysis of single cells
JP7086092B2 (ja) 2016-11-14 2022-06-17 オルカ バイオシステムズ インコーポレイテッド 標的粒子を選別する方法および装置
CN110226084A (zh) 2016-11-22 2019-09-10 伊索普莱克西斯公司 用于细胞捕获的系统、装置和方法,以及其制造方法
WO2018102759A1 (en) 2016-12-01 2018-06-07 Ignite Biosciences, Inc. Methods of assaying proteins
CN110268108B (zh) 2016-12-12 2022-09-06 埃克切拉生物科学公司 用于使用微毛细管阵列进行筛选的方法和系统
US11085039B2 (en) 2016-12-12 2021-08-10 xCella Biosciences, Inc. Methods and systems for screening using microcapillary arrays
US10324041B2 (en) 2016-12-21 2019-06-18 Abbott Japan Co., Ltd. Optical imaging system using lateral illumination for digital assays
EP3562796B1 (en) 2016-12-30 2023-04-19 Xcella Biosciences, Inc. Multi-stage sample recovery system
WO2018144240A1 (en) 2017-02-01 2018-08-09 Cellular Research, Inc. Selective amplification using blocking oligonucleotides
US11047854B2 (en) 2017-02-06 2021-06-29 Abbott Japan Llc Methods for reducing noise in signal-generating digital assays
JP7141405B2 (ja) * 2017-02-09 2022-09-22 プロメガ コーポレイション 検体検出イムノアッセイ
CN110719959B (zh) 2017-06-05 2021-08-06 贝克顿迪金森公司 针对单细胞的样品索引
WO2019060607A1 (en) 2017-09-20 2019-03-28 Quanterix Corporation METHODS AND SYSTEMS FOR DETECTING MOLECULES OF ANALYTES
JP7458678B2 (ja) 2017-12-29 2024-04-01 ノーティラス・サブシディアリー・インコーポレイテッド タンパク質同定のためのデコーディングアプローチ方法
CN108169480B (zh) * 2018-02-07 2024-03-08 上海澜澈生物科技有限公司 一种生物标志物的分子数量的检测方法及系统、芯片
US11365409B2 (en) 2018-05-03 2022-06-21 Becton, Dickinson And Company Molecular barcoding on opposite transcript ends
WO2019213294A1 (en) 2018-05-03 2019-11-07 Becton, Dickinson And Company High throughput multiomics sample analysis
WO2020068174A2 (en) 2018-05-18 2020-04-02 The University Of North Carolina At Chapel Hill Compositions, devices, and methods for improving a surface property of a substrate
WO2020036906A1 (en) * 2018-08-17 2020-02-20 President And Fellows Of Harvard College Methods and compositions for detection and quantification of small molecules and other analytes
EP4471156A3 (en) 2018-10-01 2025-02-26 Becton, Dickinson and Company Determining 5' transcript sequences
CN112969789A (zh) 2018-11-08 2021-06-15 贝克顿迪金森公司 使用随机引发的单细胞全转录组分析
CA3117813A1 (en) 2018-12-06 2020-06-11 xCella Biosciences, Inc. Lateral loading of microcapillary arrays
WO2020123384A1 (en) 2018-12-13 2020-06-18 Cellular Research, Inc. Selective extension in single cell whole transcriptome analysis
EP4242322B1 (en) 2019-01-23 2024-08-21 Becton, Dickinson and Company Oligonucleotides associated with antibodies
WO2020167920A1 (en) 2019-02-14 2020-08-20 Cellular Research, Inc. Hybrid targeted and whole transcriptome amplification
EP3931201A1 (en) 2019-03-01 2022-01-05 Meso Scale Technologies, LLC Electrochemiluminescent labeled probes for use in immunoassay methods, methods using such and kits comprising same
US12281187B2 (en) 2019-07-02 2025-04-22 Asahi Kasei Kabushiki Kaisha Microwell film for bioassay, photosensitive resin composition for formation of the microwell film for bioassay, and method of manufacturing the microwell film for bioassay
WO2021016239A1 (en) 2019-07-22 2021-01-28 Becton, Dickinson And Company Single cell chromatin immunoprecipitation sequencing assay
JP7479051B2 (ja) * 2019-09-27 2024-05-08 国立大学法人広島大学 プラスチック粒子の検出方法およびプラスチック粒子の検出キット
US11773436B2 (en) 2019-11-08 2023-10-03 Becton, Dickinson And Company Using random priming to obtain full-length V(D)J information for immune repertoire sequencing
CN115244184A (zh) 2020-01-13 2022-10-25 贝克顿迪金森公司 用于定量蛋白和rna的方法和组合物
CN115335520A (zh) 2020-01-29 2022-11-11 贝克顿迪金森公司 用于通过测序对单细胞进行空间映射的条形码化的孔
WO2021173719A1 (en) 2020-02-25 2021-09-02 Becton, Dickinson And Company Bi-specific probes to enable the use of single-cell samples as single color compensation control
EP4135897A2 (en) 2020-04-15 2023-02-22 Quanterix Corporation Methods and systems related to highly sensitive, digital assays by improved delivery of capture objects
WO2021231779A1 (en) 2020-05-14 2021-11-18 Becton, Dickinson And Company Primers for immune repertoire profiling
US12290813B2 (en) 2020-05-26 2025-05-06 Bio-Rad Laboratories, Inc. Apparatus and method for fast digital detection
EP4407030B1 (en) 2020-06-02 2025-12-17 Becton, Dickinson and Company Oligonucleotides and beads for 5 prime gene expression assay
WO2021252800A1 (en) 2020-06-11 2021-12-16 Nautilus Biotechnology, Inc. Methods and systems for computational decoding of biological, chemical, and physical entities
US11932901B2 (en) 2020-07-13 2024-03-19 Becton, Dickinson And Company Target enrichment using nucleic acid probes for scRNAseq
EP4189112A1 (en) 2020-07-31 2023-06-07 Becton Dickinson and Company Single cell assay for transposase-accessible chromatin
US11739443B2 (en) 2020-11-20 2023-08-29 Becton, Dickinson And Company Profiling of highly expressed and lowly expressed proteins
EP4263859A1 (en) 2020-12-15 2023-10-25 Becton, Dickinson and Company Single cell secretome analysis
CA3203106A1 (en) 2021-01-20 2022-07-28 Parag Mallick Systems and methods for biomolecule quantitation
US20220227890A1 (en) 2021-01-21 2022-07-21 Nautilus Biotechnology, Inc. Systems and methods for biomolecule preparation
IL305336B2 (en) 2021-03-11 2025-09-01 Nautilus Subsidiary Inc Systems and methods for preserving biomolecules
US12529049B2 (en) 2021-09-09 2026-01-20 Nautilus Subsidiary, Inc. Characterization and localization of protein modifications
CA3227592A1 (en) 2021-09-22 2023-03-30 Gregory KAPP Methods and systems for determining polypeptide interactions
WO2023081728A1 (en) 2021-11-03 2023-05-11 Nautilus Biotechnology, Inc. Systems and methods for surface structuring
AU2023241893A1 (en) 2022-03-29 2024-09-26 Nautilus Subsidiary, Inc. Integrated arrays for single-analyte processes
US20230360732A1 (en) 2022-04-25 2023-11-09 Nautilus Subsidiary, Inc. Systems and methods for assessing and improving the quality of multiplex molecular assays
WO2023250364A1 (en) 2022-06-21 2023-12-28 Nautilus Subsidiary, Inc. Method for detecting analytes at sites of optically non-resolvable distances
US20240094215A1 (en) 2022-09-15 2024-03-21 Nautilus Subsidiary, Inc. Characterizing accessibility of macromolecule structures
WO2024073599A1 (en) 2022-09-29 2024-04-04 Nautilus Subsidiary, Inc. Preparation of array surfaces for single-analyte processes
WO2024107857A1 (en) 2022-11-15 2024-05-23 Nautilus Subsidiary, Inc. Standard polypeptides
US20240192202A1 (en) 2022-12-09 2024-06-13 Nautilus Subsidiary, Inc. Fluidic media for single-analtye arrays
EP4634285A1 (en) 2022-12-15 2025-10-22 Nautilus Subsidiary, Inc. Inhibition of photon phenomena on single molecule arrays
US20240241110A1 (en) 2023-01-12 2024-07-18 Nautilus Subsidiary, Inc. Characterization of glycans and glycoconjugates
EP4666071A2 (en) 2023-02-13 2025-12-24 Nautilus Subsidiary, Inc. Affinity reagents having artificial polymer scaffolds
US20240301469A1 (en) 2023-02-24 2024-09-12 Nautilus Subsidiary, Inc. Modifying, separating and detecting proteoforms
US20240344116A1 (en) 2023-03-24 2024-10-17 Nautilus Subsidiary, Inc. Transfer of nanoparticles to array surfaces
WO2024216233A1 (en) 2023-04-13 2024-10-17 Nautilus Subsidiary, Inc. Artificial proteins for displaying epitopes
WO2024243237A1 (en) 2023-05-24 2024-11-28 Nautilus Subsidiary, Inc. Systems and methods for machine vision
US20240426839A1 (en) 2023-06-21 2024-12-26 Nautilus Subsidiary, Inc. Compositions and methods for improving affinity reagent avidity
WO2025043159A1 (en) 2023-08-24 2025-02-27 Nautilus Subsidiary, Inc. Compositions and methods for detecting binding interactions under equilibrium or non-equilibrium conditions
WO2025128588A1 (en) 2023-12-11 2025-06-19 Nautilus Subsidiary, Inc. Methods and compositions of particle-based arrays
WO2025137166A1 (en) 2023-12-20 2025-06-26 Nautilus Subsidiary, Inc. Fluidic devices for single-analyte assays
WO2025199236A1 (en) 2024-03-22 2025-09-25 Nautilus Subsidiary, Inc. Plasmonic particle systems for single-analyte assays
WO2025212338A1 (en) 2024-04-01 2025-10-09 Nautilus Subsidiary, Inc. Nanostructures for modulation of analyte conformation

Family Cites Families (297)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US423119A (en) * 1890-03-11 Punching-machine
US3212986A (en) 1964-11-05 1965-10-19 Robert T Pennington Three tank separate superheat reactor
US3712986A (en) 1969-04-03 1973-01-23 Westinghouse Electric Corp Electron imaging device utilizing a fiber optic input window
SE427505B (sv) 1977-03-04 1983-04-11 Pharmacia Diagnostics Ab Reagens till anvendning vid immunkemiska bestemningsmetoder
US4200110A (en) * 1977-11-28 1980-04-29 United States Of America Fiber optic pH probe
JPS58219456A (ja) 1982-06-16 1983-12-20 Aloka Co Ltd 生化学分析装置
US4568737A (en) 1983-01-07 1986-02-04 The Dow Chemical Company Dense star polymers and dendrimers
US4737550A (en) 1983-01-07 1988-04-12 The Dow Chemical Company Bridged dense star polymers
US4631337A (en) 1983-01-07 1986-12-23 The Dow Chemical Company Hydrolytically-stable dense star polyamine
US4507466A (en) 1983-01-07 1985-03-26 The Dow Chemical Corporation Dense star polymers having core, core branches, terminal groups
US4558120A (en) 1983-01-07 1985-12-10 The Dow Chemical Company Dense star polymer
FR2565350B1 (fr) 1984-06-05 1986-10-10 Paris Nord Universite Moyens propres a permettre le support, le traitement, le stockage et l'analyse automatiques en continu d'echantillons biologiques
US4587329A (en) 1984-08-17 1986-05-06 The Dow Chemical Company Dense star polymers having two dimensional molecular diameter
US4631211A (en) 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US4871779A (en) 1985-12-23 1989-10-03 The Dow Chemical Company Ion exchange/chelation resins containing dense star polymers having ion exchange or chelate capabilities
US4694064A (en) 1986-02-28 1987-09-15 The Dow Chemical Company Rod-shaped dendrimer
US4780421A (en) 1986-04-03 1988-10-25 Sclavo Inc. Cleavable labels for use in binding assays
US4713975A (en) 1986-05-30 1987-12-22 The Dow Chemical Company Dense star polymers for calibrating/characterizing sub-micron apertures
US5252494A (en) * 1986-06-25 1993-10-12 Trustees Of Tufts College Fiber optic sensors, apparatus, and detection methods using controlled release polymers and reagent formulations held within a polymeric reaction matrix
US5338532A (en) 1986-08-18 1994-08-16 The Dow Chemical Company Starburst conjugates
US5527524A (en) 1986-08-18 1996-06-18 The Dow Chemical Company Dense star polymer conjugates
US5560929A (en) 1986-08-18 1996-10-01 The Dow Chemical Company Structured copolymers and their use as absorbents, gels and carriers of metal ions
WO1988005533A1 (en) 1987-01-16 1988-07-28 Kelsius, Inc. Amplification of signals from optical fibers
FR2613074B1 (fr) 1987-03-27 1990-06-08 Commissariat Energie Atomique Capteur chimique actif, a fibres optiques
US4962037A (en) 1987-10-07 1990-10-09 United States Of America Method for rapid base sequencing in DNA and RNA
US4857599A (en) 1988-02-08 1989-08-15 The Dow Chemical Company Modified dense star polymers
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5028535A (en) 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay
US4924870A (en) * 1989-01-13 1990-05-15 Fiberoptic Sensor Technologies, Inc. Fiber optic sensors
US5196306A (en) 1989-03-29 1993-03-23 E. I. Du Pont De Nemours And Company Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system
US5190857A (en) 1989-05-19 1993-03-02 Acrogen, Inc. Optical method for measuring an analyte using area-modulated luminescence
US5026159A (en) 1989-05-19 1991-06-25 Acrogen, Inc. Area-modulated luminescence (AML)
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5091300A (en) 1989-08-03 1992-02-25 Merck & Co., Inc. Radio-immuno assay for hepatitis b virus pres2 antibodies
US5152816A (en) * 1989-10-16 1992-10-06 Corning Incorporated Method of enlarging end of capillary tube bore
US5108961A (en) 1989-12-29 1992-04-28 Circon Corporation Etchable core glass compositions and method for manufacturing a high performance microchannel plate
US5770029A (en) 1996-07-30 1998-06-23 Soane Biosciences Integrated electrophoretic microdevices
US5532138A (en) 1990-04-26 1996-07-02 Behringwerke Ag Method and kits for determining peroxidatively active catalysts
US5496938A (en) 1990-06-11 1996-03-05 Nexstar Pharmaceuticals, Inc. Nucleic acid ligands to HIV-RT and HIV-1 rev
US5637459A (en) 1990-06-11 1997-06-10 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chimeric selex
US5705337A (en) 1990-06-11 1998-01-06 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: chemi-SELEX
US5683867A (en) 1990-06-11 1997-11-04 Nexstar Pharmaceuticals, Inc. Systematic evolution of ligands by exponential enrichment: blended SELEX
US5567588A (en) 1990-06-11 1996-10-22 University Research Corporation Systematic evolution of ligands by exponential enrichment: Solution SELEX
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US5475096A (en) 1990-06-11 1995-12-12 University Research Corporation Nucleic acid ligands
US5631329A (en) 1990-08-27 1997-05-20 Dendritech, Inc. Process for producing hyper-comb-branched polymers
US5773527A (en) 1990-08-27 1998-06-30 Dendritech, Inc. Non-crosslinked, polybranched polymers
US6582908B2 (en) 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
US5320814A (en) 1991-01-25 1994-06-14 Trustees Of Tufts College Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample
US5244813A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample
US5244636A (en) * 1991-01-25 1993-09-14 Trustees Of Tufts College Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample
US5250264A (en) * 1991-01-25 1993-10-05 Trustees Of Tufts College Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample
DK0604552T3 (da) 1991-09-18 1997-08-04 Affymax Tech Nv Fremgangsmåde til syntese af forskellige samlinger af oligomerer
US6943034B1 (en) 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US5315375A (en) 1992-02-11 1994-05-24 Acrogen, Inc. Sensitive light detection system
US6113946A (en) 1992-04-03 2000-09-05 The Regents Of The University Of California Self-assembling polynucleotide delivery system comprising dendrimer polycations
HU9201687D0 (en) 1992-05-21 1992-08-28 Arpad Furka Preparation of sets from peptid mixtures with polycomponents and their use for the identification of biologically active peptides
US6156270A (en) 1992-05-21 2000-12-05 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US5329461A (en) 1992-07-23 1994-07-12 Acrogen, Inc. Digital analyte detection system
US5298741A (en) 1993-01-13 1994-03-29 Trustees Of Tufts College Thin film fiber optic sensor array and apparatus for concurrent viewing and chemical sensing of a sample
US7241569B2 (en) 1993-01-18 2007-07-10 Olympus Corporation Method and a device for the evaluation of biopolymer fitness
US5387617A (en) 1993-01-22 1995-02-07 The Dow Chemical Company Small cell foams and blends and a process for their preparation
US5898005A (en) 1993-02-24 1999-04-27 Dade Behring Inc. Rapid detection of analytes with receptors immobilized on soluble submicron particles
EP0637385B1 (en) 1993-02-24 1999-04-07 Dade Behring Inc. Immobilization of specific binding assay reagents
JP3441763B2 (ja) 1993-06-30 2003-09-02 キリン−アムジエン・インコーポレーテツド モノクローナル抗体及び該モノクローナル抗体を用いたヒトg−csfの測定法
US6087186A (en) 1993-07-16 2000-07-11 Irori Methods and apparatus for synthesizing labeled combinatorial chemistry libraries
US5374395A (en) 1993-10-14 1994-12-20 Amoco Corporation Diagnostics instrument
US6015880A (en) 1994-03-16 2000-01-18 California Institute Of Technology Method and substrate for performing multiple sequential reactions on a matrix
EP0763202A4 (en) 1994-05-23 1998-12-09 Smithkline Beecham Corp ENCODED COMBINATORIAL LIBRARIES
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
WO1995035506A2 (en) 1994-06-17 1995-12-28 Kensington Laboratories, Inc. Scribe mark reader
US5512490A (en) 1994-08-11 1996-04-30 Trustees Of Tufts College Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns
US6001564A (en) 1994-09-12 1999-12-14 Infectio Diagnostic, Inc. Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US6013445A (en) * 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US20030104361A1 (en) 1997-09-29 2003-06-05 Susan Weininger Method of detection of nucleic acids with a specific sequence composition
US6884357B2 (en) 1995-02-21 2005-04-26 Iqbal Waheed Siddiqi Apparatus and method for processing magnetic particles
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US5532379A (en) * 1995-05-05 1996-07-02 Pierce Chemical Company Biotin containing heterobifunctional cleavable compounds
US5690894A (en) 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US5545531A (en) 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
IL115465A0 (en) 1995-09-29 1995-12-31 Yeda Res & Dev Assay for the diagnosis of dementia
US5981180A (en) 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
DE19540098C2 (de) 1995-10-27 2001-05-17 Inst Chemo Biosensorik Verfahren und Mehrkanalbiosensor zur Mehrkomponentenanalyse von Mischungen und/oder Gemischen
JP3974941B2 (ja) 1995-11-21 2007-09-12 イェール ユニバーシティ 単分子セグメントの増幅および検出
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US5633972A (en) * 1995-11-29 1997-05-27 Trustees Of Tufts College Superresolution imaging fiber for subwavelength light energy generation and near-field optical microscopy
US5641634A (en) 1995-11-30 1997-06-24 Mandecki; Wlodek Electronically-indexed solid-phase assay for biomolecules
US5814524A (en) * 1995-12-14 1998-09-29 Trustees Of Tufts College Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations
US5846839A (en) 1995-12-22 1998-12-08 Glaxo Group Limited Methods for hard-tagging an encoded synthetic library
US5837196A (en) 1996-01-26 1998-11-17 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor
US6387707B1 (en) 1996-04-25 2002-05-14 Bioarray Solutions Array Cytometry
US6586193B2 (en) 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US5824478A (en) 1996-04-30 1998-10-20 Vysis, Inc. Diagnostic methods and probes
US5885529A (en) 1996-06-28 1999-03-23 Dpc Cirrus, Inc. Automated immunoassay analyzer
US7169556B2 (en) 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6432630B1 (en) 1996-09-04 2002-08-13 Scandinanian Micro Biodevices A/S Micro-flow system for particle separation and analysis
US5900481A (en) 1996-11-06 1999-05-04 Sequenom, Inc. Bead linkers for immobilizing nucleic acids to solid supports
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
AU5794498A (en) 1996-12-10 1998-07-03 Genetrace Systems, Inc. Releasable nonvolatile mass-label molecules
SE9700384D0 (sv) 1997-02-04 1997-02-04 Biacore Ab Analytical method and apparatus
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US6023540A (en) 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US6143496A (en) 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US6406845B1 (en) 1997-05-05 2002-06-18 Trustees Of Tuft College Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
US6203983B1 (en) 1997-06-16 2001-03-20 Affymetrix, Inc. Method for detecting chemical interactions between naturally occurring bio-polymers which are non-identical binding partners
FR2764989B1 (fr) * 1997-06-20 1999-08-27 Pasteur Sanofi Diagnostics Procede de dosage du c-peptide
US6174695B1 (en) 1997-08-12 2001-01-16 The Regents Of The University Of California Epoxide hydrolase inhibitor methods
US6838051B2 (en) 1999-05-03 2005-01-04 Ljl Biosystems, Inc. Integrated sample-processing system
US5987180A (en) 1997-09-26 1999-11-16 Sarnoff Corporation Multiple component compression encoder motion search method and apparatus
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
US7348181B2 (en) 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US6878345B1 (en) 1997-12-08 2005-04-12 Thomas W. Astle Ultra high throughput bioassay screening system
SE9800360D0 (sv) 1998-02-06 1998-02-06 Goeteborg University Science I Method, apparatus and flow cell for high sensitivity detection of fluorescent molecules
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
DE69940970D1 (de) 1998-03-25 2009-07-23 Olink Ab Rolling circle replikation von padlock-sonden
US6713908B1 (en) * 1998-03-31 2004-03-30 California Institute Of Technology Using a micromachined magnetostatic relay in commutating a DC motor
EP1188059A2 (en) * 1998-05-13 2002-03-20 Accelr8 Technology Corporation Enumeration method of analyte detection
WO1999067641A2 (en) 1998-06-24 1999-12-29 Illumina, Inc. Decoding of array sensors with microspheres
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
JP2002525587A (ja) 1998-08-28 2002-08-13 フェビット フェラリウス バイオテクノロジー ゲゼルシャフト ミット ベシュレンクテル ハフツング 試料中の分析物を測定するための方法および装置
US5971180A (en) * 1998-09-02 1999-10-26 Wu; Mao Sheng Sealing plug cap for a sealing container
US6285807B1 (en) 1998-11-16 2001-09-04 Trustees Of Tufts College Fiber optic sensor for long-term analyte measurements in fluids
DE19854003A1 (de) 1998-11-18 2000-05-25 Jenoptik Jena Gmbh Simultanes Magnetpartikelhandling in zweidimensionaler Anordnung
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
JP2002536665A (ja) 1999-02-09 2002-10-29 イルミナ インコーポレイテッド ランダムに並んだアレイにおける自動情報処理
WO2000049382A2 (en) 1999-02-16 2000-08-24 The Perkin-Elmer Corporation Bead dispensing system
CA2373146A1 (en) 1999-05-07 2000-11-16 Quantum Dot Corporation A method of detecting an analyte using semiconductor nanocrystals
CA2374390A1 (en) * 1999-05-20 2000-12-14 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
ATE338273T1 (de) * 1999-05-20 2006-09-15 Illumina Inc Vorrichtung zur halterung und präsentation von mindestens einer mikrokugelmatrix zu lösungen und/oder zu optischen abbildungssystemen
US8080380B2 (en) 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6706519B1 (en) 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
WO2001006253A2 (en) 1999-07-16 2001-01-25 Board Of Regents, The University Of Texas System Detection system based on an analyte reactive particle
US6713309B1 (en) 1999-07-30 2004-03-30 Large Scale Proteomics Corporation Microarrays and their manufacture
CA2382436C (en) 1999-08-30 2011-05-17 Illumina, Inc. Methods for improving signal detection from an array
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7244559B2 (en) * 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
JP2001249079A (ja) 1999-12-28 2001-09-14 Fujirebio Inc 発光量調節剤を用いた化学発光測定方法及び酵素免疫測定方法
US6649403B1 (en) 2000-01-31 2003-11-18 Board Of Regents, The University Of Texas Systems Method of preparing a sensor array
DE10005301A1 (de) 2000-02-07 2001-08-09 Trutnau Hans Heinrich Multi-Schritt-Kinetik molekularer Interaktionen als analytisches Mess- und Auswerte-Verfahren
AU2001247417A1 (en) 2000-03-14 2001-09-24 Trustees Of Tufts College Cross-reactive sensors
JP2001269196A (ja) 2000-03-24 2001-10-02 Hamamatsu Photonics Kk 被検体核酸の定量方法、および被検体核酸の分子数の計数方法
US20020090650A1 (en) 2000-04-06 2002-07-11 Quantum Dot Corporation Two-dimensional spectral imaging system
US6759235B2 (en) 2000-04-06 2004-07-06 Quantum Dot Corporation Two-dimensional spectral imaging system
EP1287167A2 (en) 2000-04-11 2003-03-05 Mats Bo Johan Nilsson Nucleic acid detection medium
US7682837B2 (en) 2000-05-05 2010-03-23 Board Of Trustees Of Leland Stanford Junior University Devices and methods to form a randomly ordered array of magnetic beads and uses thereof
WO2001087458A1 (en) 2000-05-12 2001-11-22 University Of Cincinnati Magnetic bead-based arrays
US6471968B1 (en) 2000-05-12 2002-10-29 Regents Of The University Of Michigan Multifunctional nanodevice platform
WO2005000087A2 (en) * 2003-06-03 2005-01-06 Chiron Corporation Gene products differentially expressed in cancerous colon cells and their methods of use ii
US7601497B2 (en) 2000-06-15 2009-10-13 Qiagen Gaithersburg, Inc. Detection of nucleic acids by target-specific hybrid capture method
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
DK1180679T3 (da) 2000-08-14 2013-02-04 Evotec Ag Fremgangsmåde til detektion af fluorescerende prøver ved hjælp af momentanalyse
US20030096243A1 (en) 2000-09-28 2003-05-22 Busa William Brian Methods and reagents for live-cell gene expression quantification
US20060068409A1 (en) 2000-11-27 2006-03-30 Phan Brigitte C Use of restriction enzymes and other chemical methods to decrease non-specific binding in dual bead assays and related bio-discs, methods, and system apparatus for detecting medical targets
EP1336106B1 (en) 2001-02-15 2004-11-17 Unibio S.R.L. Diagnostic method for bacterial vaginosis based on detecting antibodies against gvh toxin of gardnerella vaginalis
US6573051B2 (en) 2001-03-09 2003-06-03 Molecular Staging, Inc. Open circle probes with intramolecular stem structures
US20030162236A1 (en) 2001-03-26 2003-08-28 Response Biomedical Corporation Compensation for variability in specific binding in quantitative assays
US20040091939A1 (en) 2001-03-28 2004-05-13 To Cheung Device and method for detection of multiple analytes
US7060441B2 (en) 2001-05-04 2006-06-13 Biomerieux Method for fragmenting and labeling DNA involving abasic sites and phosphate labeling
WO2002103058A2 (en) 2001-06-19 2002-12-27 Molecular Staging, Inc. Process for enhanced molecular target detection using layered rolling circle amplification
AU2002319613A1 (en) 2001-07-19 2003-03-03 Signet Laboratories, Inc. Human tissue specific drug screening procedure
WO2003008943A1 (en) * 2001-07-19 2003-01-30 Tufts University Optical array device and methods of use thereof for screening, analysis and manipulation of particles
GB2378245A (en) 2001-08-03 2003-02-05 Mats Nilsson Nucleic acid amplification method
US20030040129A1 (en) 2001-08-20 2003-02-27 Shah Haresh P. Binding assays using magnetically immobilized arrays
US6616554B2 (en) * 2001-08-22 2003-09-09 Grace Liao Training device for baseball hitting
EP2184346B1 (en) 2001-09-06 2017-03-08 Rapid Micro Biosystems, Inc. Rapid detection of replicating cells
US20030091475A1 (en) 2001-09-26 2003-05-15 Micralyne Inc. Bead trapping device
US7195913B2 (en) 2001-10-05 2007-03-27 Surmodics, Inc. Randomly ordered arrays and methods of making and using
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
GB2382137A (en) 2001-11-20 2003-05-21 Mats Gullberg Nucleic acid enrichment
US7632671B2 (en) 2001-11-29 2009-12-15 Sun-Wing Tong Molecular detection and assay by electrobiochip micro-array
AU2002353049A1 (en) 2001-12-14 2003-06-30 Corning Incorporated Two step etching process for an optical fiber preform
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US20030198573A1 (en) 2002-01-25 2003-10-23 Illumina, Inc. Sensor arrays for detecting analytes in fluids
US7553619B2 (en) 2002-02-08 2009-06-30 Qiagen Gmbh Detection method using dissociated rolling circle amplification
US7480433B2 (en) 2002-02-19 2009-01-20 Tufts University Electro-optical stimulation/measurement
US7232547B2 (en) 2002-03-22 2007-06-19 Marshfield Clinic Apparatus and method for testing and continuously reading low-volume samples
US7312085B2 (en) 2002-04-01 2007-12-25 Fluidigm Corporation Microfluidic particle-analysis systems
WO2003089901A2 (en) 2002-04-19 2003-10-30 Palsson Bernhard O Methods for preparing libraries of unique tags and related screening methods
PL374438A1 (en) 2002-05-10 2005-10-17 Pharmacia Corporation Peptide compounds and their use as protease substrates
EP1506283A1 (en) 2002-05-24 2005-02-16 F. Sperling ApS A method for testing the interaction between at least one liquid sample and a respective solid sample.
US7387889B2 (en) 2002-08-22 2008-06-17 Massachusetts Institute Of Technology Measurement of concentrations and binding energetics
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
US7597936B2 (en) 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
WO2004048936A2 (en) 2002-11-26 2004-06-10 University Of Utah Research Foundation Microporous materials, methods, and articles for localizing and quantifying analytes
WO2004057386A1 (en) 2002-12-18 2004-07-08 The Regents Of The University Of Michigan Enhancing fiber-optic sensing technique using a dual-core fiber
US7046888B2 (en) 2002-12-18 2006-05-16 The Regents Of The University Of Michigan Enhancing fiber-optic sensing technique using a dual-core fiber
WO2004083443A1 (en) 2002-12-20 2004-09-30 Caliper Life Sciences, Inc. Single molecule amplification and detection of dna
US20050221281A1 (en) 2003-01-08 2005-10-06 Ho Winston Z Self-contained microfluidic biochip and apparatus
CA2513985C (en) 2003-01-21 2012-05-29 Illumina Inc. Chemical reaction monitor
US20040185484A1 (en) 2003-01-29 2004-09-23 Costa Gina L. Method for preparing single-stranded DNA libraries
US7575865B2 (en) 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US10533998B2 (en) 2008-07-18 2020-01-14 Bio-Rad Laboratories, Inc. Enzyme quantification
US8043834B2 (en) 2003-03-31 2011-10-25 Qiagen Gmbh Universal reagents for rolling circle amplification and methods of use
JP2007524755A (ja) 2003-04-02 2007-08-30 ノースウエスタン ユニバーシティ ナノ粒子の成長制御方法
EP1615721B1 (en) 2003-04-03 2014-06-18 Fluidigm Corporation Microfluidic devices and methods of using same
US7148043B2 (en) 2003-05-08 2006-12-12 Bio-Rad Laboratories, Inc. Systems and methods for fluorescence detection with a movable detection module
WO2004107321A2 (en) * 2003-05-28 2004-12-09 Tufts University High density optical data storage
JP2004354164A (ja) 2003-05-28 2004-12-16 Olympus Corp 微粒子を用いた検体の検査方法及びその検査システム
US20040248103A1 (en) 2003-06-04 2004-12-09 Feaver William John Proximity-mediated rolling circle amplification
US7572581B2 (en) 2003-06-30 2009-08-11 Roche Molecular Systems, Inc. 2′-terminator nucleotide-related methods and systems
JP5183063B2 (ja) 2003-07-05 2013-04-17 ザ ジョンズ ホプキンス ユニバーシティ 遺伝的変異の検出および列挙のための方法ならびに組成物
US20090088982A1 (en) 2003-07-31 2009-04-02 Fukushima Noelle H Co-detection of single polypeptide and polynucleotide molecules
US8022013B2 (en) 2003-08-29 2011-09-20 Illumina, Inc. Method of forming and using solid-phase support
US20050226780A1 (en) 2003-09-19 2005-10-13 Donald Sandell Manual seal applicator
US20050112634A1 (en) 2003-09-19 2005-05-26 Woudenberg Timothy M. High density sequence detection methods and apparatus
SE0302525D0 (sv) 2003-09-24 2003-09-24 Biacore Ab Method and system for interaction analysis
JP2007533971A (ja) 2003-09-30 2007-11-22 シンギュレックス・インコーポレイテッド 粒子検出の分析精度を改善する方法
AU2004286253A1 (en) 2003-10-28 2005-05-12 Bioarray Solutions Ltd. Gel-shell beads with adsorbed or bound biomolecules
WO2005050224A2 (en) 2003-11-13 2005-06-02 Epitome Biosystems Inc. Small molecule and peptide arrays and uses thereof
WO2005054431A2 (en) 2003-12-01 2005-06-16 454 Corporation Method for isolation of independent, parallel chemical micro-reactions using a porous filter
AU2005218622A1 (en) 2004-03-03 2005-09-15 Living Microsystems Magnetic device for isolation of cells and biomolecules in a microfluidic environment
US8634072B2 (en) 2004-03-06 2014-01-21 Michael Trainer Methods and apparatus for determining characteristics of particles
WO2005095262A1 (en) 2004-04-01 2005-10-13 Nanyang Technological University Microchip and method for detecting molecules and molecular interactions
US8961900B2 (en) 2004-04-28 2015-02-24 Yokogawa Electric Corporation Chemical reaction cartridge, method of producing chemical reaction cartridge, and mechanism for driving chemical reaction cartridge
DE102004021780B4 (de) 2004-04-30 2008-10-02 Siemens Ag Verfahren und Anordnung zur DNA-Isolierung mit Trockenreagenzien
AU2005325273B2 (en) 2004-05-12 2009-07-02 Nanosphere, Inc. Bio-barcode based detection of target analytes
US6999647B2 (en) * 2004-05-25 2006-02-14 Honeywell International Inc. Fast pivot mechanism
CN101793826B (zh) 2004-06-07 2016-04-13 先锋生物科技股份有限公司 用于微流体器件的光学透镜系统和方法
CA2475240A1 (en) * 2004-07-20 2006-01-20 Biophys, Inc. Method and device to measure dynamic internal calibration true dose response curves
KR100806568B1 (ko) 2004-08-21 2008-02-28 주식회사 엘지생명과학 미세 유체 소자 및 이를 구비한 진단 및 분석 장치
CN1286987C (zh) 2004-09-23 2006-11-29 湖南大学 一维生物芯片及其在基因、蛋白表达分析中的应用
US7572640B2 (en) * 2004-09-28 2009-08-11 Singulex, Inc. Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
JP2008514955A (ja) 2004-09-28 2008-05-08 シンギュレックス・インコーポレイテッド サンプル分析システムおよび方法
US8685711B2 (en) 2004-09-28 2014-04-01 Singulex, Inc. Methods and compositions for highly sensitive detection of molecules
WO2006047038A1 (en) 2004-09-28 2006-05-04 Trustees Of Tufts College Apparatus and method for cell migration assays
US7602952B2 (en) * 2004-11-16 2009-10-13 Illumina, Inc. Scanner having spatial light modulator
WO2006055739A2 (en) 2004-11-17 2006-05-26 Robert Sack Stationary phase antibody arrays for trace protein analysis
AU2006208907A1 (en) 2005-01-26 2006-08-03 Enigma Diagnostics Ltd Method for carrying out a multi-step reaction, breakable container for storing reagents and method for transferring solid reagent using an electrostatically charged wand
WO2006102297A1 (en) 2005-03-22 2006-09-28 Applera Corporation Automated seal applicator
US7682816B2 (en) 2005-04-07 2010-03-23 454 Life Sciences Corporation Thin film coated microwell arrays and methods of using same
ATE483032T1 (de) 2005-04-12 2010-10-15 Olink Ab Verfahren zur herstellung von oligonukleotiden
WO2006108422A2 (en) 2005-04-12 2006-10-19 In Situ Rcp A/S Under Founding Methods for production of oligonucleotides
EP1721657A1 (en) 2005-05-13 2006-11-15 SONY DEUTSCHLAND GmbH A method of fabricating a polymeric membrane having at least one pore
EP2477029A1 (en) 2005-06-02 2012-07-18 Fluidigm Corporation Analysis using microfluidic partitioning devices
CA2614180A1 (en) 2005-07-06 2007-01-11 The Regents Of The University Of California Apparatuses, systems, and methods for isolating and separating biological materials
US7595473B2 (en) 2005-08-22 2009-09-29 Tufts University Method and system of array imaging
WO2007033385A2 (en) * 2005-09-13 2007-03-22 Fluidigm Corporation Microfluidic assay devices and methods
JP2009513948A (ja) 2005-09-16 2009-04-02 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 検体検出のための比色バイオバーコード増幅アッセイ
WO2007035633A2 (en) 2005-09-16 2007-03-29 President & Fellows Of Harvard College Screening assays and methods
WO2007044974A2 (en) 2005-10-12 2007-04-19 The Research Foundation Of State University Of New York Absolute pcr quantification
US20070116607A1 (en) * 2005-11-23 2007-05-24 Pharmacom Microlelectronics, Inc. Microsystems that integrate three-dimensional microarray and multi-layer microfluidics for combinatorial detection of bioagent at single molecule level
WO2007072290A2 (en) 2005-12-21 2007-06-28 Koninklijke Philips Electronics N.V. Method of performing a microarray assay
CN101379399A (zh) 2005-12-22 2009-03-04 罗姆股份有限公司 免疫测定装置和方法
AU2006335290A1 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
GB0600927D0 (en) 2006-01-17 2006-02-22 Glaxosmithkline Biolog Sa Assay and materials therefor
US8460879B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
JP5308328B2 (ja) 2006-04-04 2013-10-09 シングレックス,インコーポレイテッド トロポニンの分析のための高感度のシステムおよび方法
US8470606B2 (en) 2006-04-18 2013-06-25 Duke University Manipulation of beads in droplets and methods for splitting droplets
US7759062B2 (en) 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
WO2008016335A1 (en) 2006-08-03 2008-02-07 National University Of Singapore A microarray system and a process for producing microarrays
CN1928561A (zh) 2006-09-15 2007-03-14 东南大学 基于光子晶体微球的多元免疫检测方法
WO2008064336A2 (en) 2006-11-22 2008-05-29 Inivitrogen Corporation Autoimmune disease biomarkers
JP2010516455A (ja) 2007-01-26 2010-05-20 ハース−モンドミックス・ベスローテン・フェンノートシャップ 発泡物質を計量分配する装置と方法
EP3628729B1 (en) 2007-07-16 2025-07-09 California Institute of Technology Devices for detecting target molecules
US20090053719A1 (en) 2007-08-03 2009-02-26 The Chinese University Of Hong Kong Analysis of nucleic acids by digital pcr
WO2009029550A2 (en) 2007-08-24 2009-03-05 Singulex, Inc. Highly sensitive system and methods for analysis of prostate specific antigen (psa)
EP2201374B1 (en) 2007-08-30 2015-10-07 Trustees Of Tufts College Methods for determining the concentration of an analyte in solution.
US8093063B2 (en) * 2007-11-29 2012-01-10 Quest Diagnostics Investments Incorporated Assay for detecting genetic abnormalities in genomic nucleic acids
US20090254180A1 (en) 2008-01-14 2009-10-08 Walt Pazanowski Customizable vertebral replacement assembly system
US9487822B2 (en) 2008-03-19 2016-11-08 Fluidigm Corporation Method and apparatus for determining copy number variation using digital PCR
US20100189338A1 (en) * 2008-04-09 2010-07-29 Nexcelom Bioscience Systems and methods for counting cells and biomolecules
ITTO20080314A1 (it) 2008-04-23 2009-10-24 Milano Politecnico Biosensori spintronici con area attiva localizzata su una parete di dominio magnetico.
US8093064B2 (en) 2008-05-15 2012-01-10 The Regents Of The University Of California Method for using magnetic particles in droplet microfluidics
US20090307772A1 (en) 2008-05-21 2009-12-10 Honeywell International Inc. framework for scalable state estimation using multi network observations
US20090289834A1 (en) 2008-05-23 2009-11-26 Honeywell International Inc. High integrity radio altimeter
US8297355B2 (en) 2008-08-22 2012-10-30 Texaco Inc. Using heat from produced fluids of oil and gas operations to produce energy
US20100075862A1 (en) 2008-09-23 2010-03-25 Quanterix Corporation High sensitivity determination of the concentration of analyte molecules or particles in a fluid sample
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
US20100075355A1 (en) 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of enzymes by capture-and-release followed by quantification
US20100075439A1 (en) 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of molecules by capture-and-release using reducing agents followed by quantification
US20100204335A1 (en) 2008-12-01 2010-08-12 Allergan, Inc. Kit and composition for eyelash growth
TWI373617B (en) 2009-03-03 2012-10-01 Univ Nat Taiwan Compact disk based system for separating immunomagnetic bead labeled particulates and method thereof
CN103026232B (zh) 2010-03-01 2015-02-04 匡特里克斯公司 扩大用于检测分子或颗粒的测定法中的动态范围的方法和系统
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US20120214160A1 (en) 2011-01-14 2012-08-23 Life Technologies Corporation Methods, compositions, and kits for detecting rare cells
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
US20140094386A1 (en) 2011-04-12 2014-04-03 David Wilson Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury resulting from a hypoxic event
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
WO2012170776A2 (en) 2011-06-09 2012-12-13 Quanterix Corporation Methods of determining a patient's prognosis for recurrence of prostate cancer and/or determining a course of treatment for prostate cancer following a radical prostatectomy
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
US20160123969A1 (en) 2013-05-09 2016-05-05 Quanterix Corporation Methods, materials, and kits for covalently associating molecular species with a surface of an object
US9482622B2 (en) 2014-05-16 2016-11-01 Massachusetts Institute Of Technology Methods and apparatus for surface classification
WO2016115256A1 (en) 2015-01-13 2016-07-21 Quanterix Corporation Methods relating to improving accuracy of capture object-based assays
US11434264B2 (en) 2015-02-13 2022-09-06 Quanterix Corporation Immunoassays for differential detection of clostridium difficile
US9809163B2 (en) 2015-04-14 2017-11-07 Harman International Industries, Incorporation Techniques for transmitting an alert towards a target area
WO2018222585A2 (en) 2017-05-30 2018-12-06 Quanterix Corporation Single molecule detection and quantification of nucleic acids with single base specificity
WO2019060607A1 (en) 2017-09-20 2019-03-28 Quanterix Corporation METHODS AND SYSTEMS FOR DETECTING MOLECULES OF ANALYTES
US20200032326A1 (en) 2018-05-29 2020-01-30 Trustees Of Tufts College Ultrasensitive assays for detection of short nucleic acids
US20220205992A1 (en) 2020-12-28 2022-06-30 Quanterix Corporation Materials and kits relating to association of reporter species and targeting entities with beads

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