JP2009528983A5 - - Google Patents
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- Publication number
- JP2009528983A5 JP2009528983A5 JP2008552472A JP2008552472A JP2009528983A5 JP 2009528983 A5 JP2009528983 A5 JP 2009528983A5 JP 2008552472 A JP2008552472 A JP 2008552472A JP 2008552472 A JP2008552472 A JP 2008552472A JP 2009528983 A5 JP2009528983 A5 JP 2009528983A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- methyl
- biphenyl
- oxazol
- difluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76216806P | 2006-01-25 | 2006-01-25 | |
| US76216906P | 2006-01-25 | 2006-01-25 | |
| US60/762,168 | 2006-01-25 | ||
| US60/762,169 | 2006-01-25 | ||
| PCT/US2007/002305 WO2007087441A2 (en) | 2006-01-25 | 2007-01-25 | Substituted aromatic compounds for inflammation and immune-related uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009528983A JP2009528983A (ja) | 2009-08-13 |
| JP2009528983A5 true JP2009528983A5 (enExample) | 2010-03-11 |
| JP5430943B2 JP5430943B2 (ja) | 2014-03-05 |
Family
ID=38309875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552472A Expired - Fee Related JP5430943B2 (ja) | 2006-01-25 | 2007-01-25 | 炎症及び免疫関連用途のための置換芳香族化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8741960B2 (enExample) |
| EP (1) | EP1983971A4 (enExample) |
| JP (1) | JP5430943B2 (enExample) |
| AU (1) | AU2007208239B2 (enExample) |
| CA (1) | CA2640090A1 (enExample) |
| TW (1) | TW200806641A (enExample) |
| WO (1) | WO2007087441A2 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2866886B1 (fr) * | 2004-02-26 | 2007-08-31 | Sanofi Synthelabo | Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique |
| MX2007000016A (es) * | 2004-07-01 | 2007-03-27 | Daiichi Seiyaku Co | Derivados de pirazol. |
| RS51470B (sr) | 2005-09-16 | 2011-04-30 | Arrow Therapeutics Limited | Derivati bifenila i njihova upotreba za lečenje hepatitisa c |
| AU2007208240B2 (en) * | 2006-01-25 | 2013-04-11 | Synta Pharmaceuticals Corp. | Substituted biaryl compounds for inflammation and immune-related uses |
| WO2007087443A2 (en) * | 2006-01-25 | 2007-08-02 | Synta Pharmaceuticals Corp. | Vinyl-phenyl derivatives for inflammation and immune-related uses |
| US8455658B2 (en) * | 2006-01-25 | 2013-06-04 | Synta Pharmaceuticals Corp. | Thiazole and thiadiazole compounds for inflammation and immune-related uses |
| TWI417096B (zh) * | 2006-01-25 | 2013-12-01 | Synta Pharmaceuticals Corp | 用於發炎及免疫相關用途之苯基及吡啶基化合物 |
| WO2007089904A2 (en) * | 2006-01-31 | 2007-08-09 | Synta Pharmaceuticals Corp. | Pyridylphenyl compounds for inflammation and immune-related uses |
| TW200812587A (en) * | 2006-03-20 | 2008-03-16 | Synta Pharmaceuticals Corp | Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses |
| CN102516115B (zh) | 2006-08-09 | 2016-05-11 | 史密丝克莱恩比彻姆公司 | 作为阿片样物质受体的拮抗剂或反向激动剂的新型化合物 |
| US8779154B2 (en) * | 2006-09-26 | 2014-07-15 | Qinglin Che | Fused ring compounds for inflammation and immune-related uses |
| WO2009009041A2 (en) * | 2007-07-06 | 2009-01-15 | Kinex Pharmaceuticals, Llc | Compositions and methods for modulating a kinase cascade |
| CA2699157A1 (en) | 2007-09-10 | 2009-03-19 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| HUE035130T2 (en) | 2007-09-10 | 2018-05-02 | Janssen Pharmaceutica Nv | A method for preparing compounds useful as SGLT inhibitors |
| WO2009076454A2 (en) * | 2007-12-12 | 2009-06-18 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| KR101724161B1 (ko) * | 2008-08-27 | 2017-04-06 | 칼시메디카, 인크 | 세포내 칼슘을 조절하는 화합물 |
| US8524763B2 (en) * | 2008-09-22 | 2013-09-03 | Calcimedica, Inc. | Inhibitors of store operated calcium release |
| US8143269B2 (en) * | 2008-10-03 | 2012-03-27 | Calcimedica, Inc. | Inhibitors of store operated calcium release |
| US9056850B2 (en) | 2008-10-17 | 2015-06-16 | Janssen Pharmaceutica N.V. | Process for the preparation of compounds useful as inhibitors of SGLT |
| US20110009347A1 (en) | 2009-07-08 | 2011-01-13 | Yin Liang | Combination therapy for the treatment of diabetes |
| DK2451797T3 (da) | 2009-07-10 | 2013-06-24 | Janssen Pharmaceutica Nv | Fremgangsmåde til krystallisation for 1-(b-D-GLUCOPYRANOSYL)-4-METHYL-3-[5-(4-fluorphenyl)-2- thienylmethyl]benzen |
| US8618307B2 (en) * | 2009-09-16 | 2013-12-31 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| US8377970B2 (en) | 2009-10-08 | 2013-02-19 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel |
| US8993612B2 (en) | 2009-10-08 | 2015-03-31 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer |
| EP2488515B1 (en) | 2009-10-14 | 2017-01-04 | Janssen Pharmaceutica NV | Process for the preparation of compounds useful as inhibitors of sglt2 |
| WO2011139489A2 (en) | 2010-04-27 | 2011-11-10 | Calcimedica Inc. | Compounds that modulate intracellular calcium |
| US10703722B2 (en) | 2010-04-27 | 2020-07-07 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| CA2797533A1 (en) | 2010-04-27 | 2011-11-10 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| TWI599360B (zh) | 2010-05-11 | 2017-09-21 | 健生藥品公司 | 醫藥調配物 |
| WO2012027710A2 (en) | 2010-08-27 | 2012-03-01 | Calcimedica Inc. | Compounds that modulate intracellular calcium |
| NZ609572A (en) | 2010-10-30 | 2015-05-29 | Lupin Ltd | Oxazoline and isoxazoline derivatives as crac modulators |
| KR101762724B1 (ko) * | 2011-01-25 | 2017-07-28 | 더 리젠츠 오브 더 유니버시티 오브 미시건 | Bcl-2/bcl-xl 억제제 및 이를 이용한 치료 방법 |
| RS55056B1 (sr) | 2011-04-13 | 2016-12-30 | Janssen Pharmaceutica Nv | Proces za pripremu jedinjenja koja su korisna kao inhibitori sglt2 |
| TWI542596B (zh) | 2011-05-09 | 2016-07-21 | 健生藥品公司 | （２ｓ,３ｒ,４ｒ,５ｓ,６ｒ）－２－（３－（（５－（４－氟苯基）噻吩－２－基）甲基）－４－甲基苯基）－６－（羥甲基）四氫－２ｈ－哌喃－３,４,５－三醇之ｌ－脯胺酸及檸檬酸共晶體 |
| WO2012170931A2 (en) | 2011-06-10 | 2012-12-13 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| WO2013059677A1 (en) | 2011-10-19 | 2013-04-25 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| US9409898B2 (en) | 2012-05-02 | 2016-08-09 | Lupin Limited | Substituted pyrazole compounds as CRAC modulators |
| EP2844655A1 (en) | 2012-05-02 | 2015-03-11 | Lupin Limited | Substituted pyridine compounds as crac modulators |
| CN105263907B (zh) | 2012-08-30 | 2018-11-20 | 阿西纳斯公司 | 作为蛋白质酪氨酸激酶调节剂的n-(3-氟苄基)-2-(5-(4-吗啉代苯基)吡啶-2-基)乙酰胺 |
| US9512116B2 (en) | 2012-10-12 | 2016-12-06 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| WO2014108337A1 (en) | 2013-01-10 | 2014-07-17 | Grünenthal GmbH | Pyrazolyl-based carboxamides i as crac channel inhibitors |
| WO2014108336A1 (en) | 2013-01-10 | 2014-07-17 | Grünenthal GmbH | Pyrazolyl-based carboxamides ii as crac channel inhibitors |
| CN103288684B (zh) * | 2013-05-03 | 2014-12-10 | 西安交通大学 | 一种具有抗肿瘤活性的联苯脲化合物及其制备方法 |
| WO2014203217A1 (en) | 2013-06-21 | 2014-12-24 | Lupin Limited | Substituted heterocyclic compounds as crac modulators |
| WO2014207648A1 (en) | 2013-06-24 | 2014-12-31 | Lupin Limited | Chromane and chromene derivatives and their use as crac modulators |
| WO2015197187A1 (en) | 2014-06-24 | 2015-12-30 | Grünenthal GmbH | Pyrazolyl-based carboxamides v |
| EP3261641B1 (en) | 2015-02-27 | 2023-07-12 | Calcimedica, Inc. | Pancreatitis treatment |
| CA2995094A1 (en) | 2015-08-07 | 2017-02-16 | Calcimedica, Inc. | Use of crac channel inhibitors for the treatment of stroke and traumatic brain injury |
| US20170071970A1 (en) | 2015-09-15 | 2017-03-16 | Janssen Pharmaceutica Nv | Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders |
| EP3849552A1 (en) | 2018-09-14 | 2021-07-21 | Rhizen Pharmaceuticals AG | Compositions comprising a crac inhibitor and a corticosteroid and methods of use thereof |
| SG11202105850YA (en) * | 2018-11-02 | 2021-07-29 | Shanghai Maxinovel Pharmaceuticals Co Ltd | Diphenyl-like compound, intermediate thereof, preparation method therefor, pharmaceutical composition thereof and uses thereof |
| MX2022008627A (es) | 2020-01-13 | 2022-11-08 | Verge Analytics Inc | Pirazolo-pirimidinas sustituidas y usos de las mismas. |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62196666A (ja) | 1986-02-25 | 1987-08-31 | Canon Inc | 電子写真感光体 |
| CA1322004C (en) | 1987-11-25 | 1993-09-07 | Merck Frosst Canada Incorporated | Pyridyl styrene dialkanoic acids |
| JPH01229003A (ja) | 1988-03-09 | 1989-09-12 | Fuji Photo Film Co Ltd | 光重合性組成物 |
| WO1993005014A1 (en) | 1991-09-05 | 1993-03-18 | Pharno-Wedropharm Gmbh | Aromatic sulfonamide derivatives, their use as enzyme inhibitors and pharmaceutical compositions containing them |
| EP0534005A1 (en) | 1991-09-24 | 1993-03-31 | Agfa-Gevaert N.V. | Electrophotographic recording material |
| US5451677A (en) | 1993-02-09 | 1995-09-19 | Merck & Co., Inc. | Substituted phenyl sulfonamides as selective β 3 agonists for the treatment of diabetes and obesity |
| JPH11503110A (ja) | 1995-02-17 | 1999-03-23 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ−８受容体拮抗剤 |
| PT938471E (pt) | 1996-10-16 | 2002-05-31 | American Cyanamid Co | A preparacao e uso de acidos ortosulfonamidoarilhidroxamicos como inibidores de metaloproteinases de matriz e "tace" |
| CA2283961A1 (en) | 1997-03-19 | 1998-09-24 | Basf Aktiengesellschaft | Pyrrolo[2,3d]pyrimidines and their use as tyrosine kinase inhibitors |
| EP1000932B9 (en) | 1997-06-27 | 2005-12-28 | Fujisawa Pharmaceutical Co., Ltd. | Aromatic ring derivatives |
| US6492421B1 (en) | 1997-07-31 | 2002-12-10 | Athena Neurosciences, Inc. | Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4 |
| JPH1149762A (ja) | 1997-08-08 | 1999-02-23 | Japan Tobacco Inc | チアゾール化合物 |
| US6677488B2 (en) | 1997-11-17 | 2004-01-13 | G.D. Searle & Co. | Substituted biphenyl compounds for the treatment of inflammation |
| JPH11352640A (ja) * | 1998-06-10 | 1999-12-24 | Fuji Photo Film Co Ltd | 熱現像感光材料 |
| SK3852001A3 (en) | 1998-09-18 | 2003-03-04 | Basf Ag | 4-Aminopyrrolopyrimidines as kinase inhibitors |
| WO2001027094A1 (en) | 1999-10-12 | 2001-04-19 | Japan Tobacco Inc. | Hypertriglyceridemia remedies and antiobestics |
| ATE355269T1 (de) | 1999-11-18 | 2006-03-15 | Ajinomoto Kk | Phenylalaninderivate |
| DE10008329A1 (de) | 2000-02-23 | 2001-08-30 | Merck Patent Gmbh | Aminosulfonylbiphenylderivate |
| AU2002248432A1 (en) | 2001-02-14 | 2002-08-28 | Sankyo Company, Limited | Oxazole derivatives, their preparation and their use as cytokine inhibitors |
| TWI239942B (en) | 2001-06-11 | 2005-09-21 | Dainippon Pharmaceutical Co | N-arylphenylacetamide derivative and pharmaceutical composition containing the same |
| KR20040048407A (ko) | 2001-09-06 | 2004-06-09 | 시녹스, 인크. | 3-데옥시플라보노이드에 의한 ｔ-림프구 활성화의 억제 및그의 관련 치료법 |
| EP1461311A2 (en) | 2001-12-26 | 2004-09-29 | Bayer HealthCare AG | Urea derivatives as vr1-antagonists |
| JPWO2003064389A1 (ja) | 2002-01-31 | 2005-05-26 | 小野薬品工業株式会社 | 含窒素二環性化合物およびその化合物を有効成分として含有する薬剤 |
| GB0206876D0 (en) | 2002-03-22 | 2002-05-01 | Merck Sharp & Dohme | Therapeutic agents |
| US7148357B2 (en) | 2002-07-31 | 2006-12-12 | Schering Ag | VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines |
| TW200510311A (en) | 2002-12-23 | 2005-03-16 | Millennium Pharm Inc | CCr8 inhibitors |
| JP4194859B2 (ja) | 2003-02-24 | 2008-12-10 | リーダー電子株式会社 | 映像信号監視装置 |
| SE0301010D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| US20040242673A1 (en) | 2003-05-16 | 2004-12-02 | Ambit Biosciences Corporation | Heterocyclic compounds and uses thereof |
| US6919483B2 (en) | 2003-05-23 | 2005-07-19 | Mediquest Therapeutics, Inc. | Immunomodulation with novel pharmaceutical compositions |
| BRPI0412805A (pt) | 2003-07-23 | 2006-09-26 | Synta Pharmaceuticals Corp | método para modular canais de ìon de cálcio ativado por liberação de ìon de cálcio |
| EP1678147B1 (en) | 2003-09-15 | 2012-08-08 | Lead Discovery Center GmbH | Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases |
| KR20060017929A (ko) | 2004-08-04 | 2006-02-28 | 동화약품공업주식회사 | 티아졸 유도체가 치환된 신규한 벤즈아미딘 유도체, 그의제조방법 및 이를 유효성분으로 하는 약학 조성물 |
| KR20070057965A (ko) | 2004-09-21 | 2007-06-07 | 신타 파마슈티칼스 코프. | 염증 및 면역 관련 용도를 위한 화합물 |
| SE0402735D0 (sv) | 2004-11-09 | 2004-11-09 | Astrazeneca Ab | Novel compounds |
| KR20070107022A (ko) | 2005-01-07 | 2007-11-06 | 신타 파마슈티칼스 코프. | 염증 및 면역 관련 용도를 위한 화합물 |
| KR101436161B1 (ko) | 2005-01-25 | 2014-09-01 | 신타 파마슈티칼스 코프. | 염증 및 면역 관련 용도를 위한 화합물 |
| US8802721B2 (en) | 2005-01-25 | 2014-08-12 | Synta Pharmaceuticals Corp. | Thiophene compounds for inflammation and immune-related uses |
| NZ569327A (en) | 2005-12-28 | 2011-09-30 | Vertex Pharma | 1-(benzo [d] [1,3] dioxol-5-yl) -n- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-binding cassette transporters for the treatment of cystic fibrosis |
| WO2007087443A2 (en) | 2006-01-25 | 2007-08-02 | Synta Pharmaceuticals Corp. | Vinyl-phenyl derivatives for inflammation and immune-related uses |
| AU2007208240B2 (en) | 2006-01-25 | 2013-04-11 | Synta Pharmaceuticals Corp. | Substituted biaryl compounds for inflammation and immune-related uses |
| US8455658B2 (en) | 2006-01-25 | 2013-06-04 | Synta Pharmaceuticals Corp. | Thiazole and thiadiazole compounds for inflammation and immune-related uses |
| TWI417096B (zh) | 2006-01-25 | 2013-12-01 | Synta Pharmaceuticals Corp | 用於發炎及免疫相關用途之苯基及吡啶基化合物 |
| WO2007089904A2 (en) | 2006-01-31 | 2007-08-09 | Synta Pharmaceuticals Corp. | Pyridylphenyl compounds for inflammation and immune-related uses |
| TW200812587A (en) | 2006-03-20 | 2008-03-16 | Synta Pharmaceuticals Corp | Benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses |
| EP2004626A4 (en) | 2006-03-23 | 2010-10-27 | Synta Pharmaceuticals Corp | BENZIMIDAZOLYL-PYRIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS |
| US8779154B2 (en) | 2006-09-26 | 2014-07-15 | Qinglin Che | Fused ring compounds for inflammation and immune-related uses |
| EP2086326B1 (en) | 2006-11-13 | 2014-01-08 | Synta Pharmaceuticals Corp. | Cyclohexenyl-aryl compounds for inflammation and immune-related uses |
| TW200901961A (en) | 2007-02-16 | 2009-01-16 | Synta Pharmaceuticals Corp | Substituted fused-ring compounds for inflammation and immune-related uses |
| AU2008282737A1 (en) | 2007-08-01 | 2009-02-05 | Synta Pharmaceuticals Corp. | Vinyl-aryl derivatives for inflammation and immune-related uses |
| CA2695143A1 (en) | 2007-08-01 | 2009-02-05 | Synta Pharmaceuticals Corp. | Heterocycle-aryl compounds for inflammation and immune-related uses |
| TW200911800A (en) | 2007-08-01 | 2009-03-16 | Synta Pharmaceuticals Corp | Pyridine compounds for inflammation and immune-related uses |
| WO2009038775A1 (en) | 2007-09-20 | 2009-03-26 | Synta Pharmaceuticals Corp. | Substituted benzoimidazolyl-pyrazine compounds for inflammation and immune-related uses |
| JP2011509261A (ja) | 2008-01-07 | 2011-03-24 | シンタ ファーマシューティカルズ コーポレーション | 炎症および免疫関連用途向けの化合物 |
-
2007
- 2007-01-25 US US11/698,780 patent/US8741960B2/en not_active Expired - Fee Related
- 2007-01-25 AU AU2007208239A patent/AU2007208239B2/en not_active Ceased
- 2007-01-25 EP EP20070762448 patent/EP1983971A4/en not_active Withdrawn
- 2007-01-25 JP JP2008552472A patent/JP5430943B2/ja not_active Expired - Fee Related
- 2007-01-25 TW TW096102792A patent/TW200806641A/zh unknown
- 2007-01-25 CA CA002640090A patent/CA2640090A1/en not_active Abandoned
- 2007-01-25 WO PCT/US2007/002305 patent/WO2007087441A2/en not_active Ceased
-
2014
- 2014-05-08 US US14/272,727 patent/US20140242120A1/en not_active Abandoned
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