JP2009525999A5 - - Google Patents
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- Publication number
- JP2009525999A5 JP2009525999A5 JP2008553660A JP2008553660A JP2009525999A5 JP 2009525999 A5 JP2009525999 A5 JP 2009525999A5 JP 2008553660 A JP2008553660 A JP 2008553660A JP 2008553660 A JP2008553660 A JP 2008553660A JP 2009525999 A5 JP2009525999 A5 JP 2009525999A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroxy
- group
- alkyl
- formula
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 monofluoromethoxy, difluoromethoxy Chemical group 0.000 claims description 27
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 17
- 125000001424 substituent group Chemical group 0.000 claims description 15
- 150000001875 compounds Chemical class 0.000 claims description 14
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 14
- 229910052736 halogen Inorganic materials 0.000 claims description 14
- 150000002367 halogens Chemical class 0.000 claims description 14
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 11
- 239000001257 hydrogen Substances 0.000 claims description 11
- 229910052739 hydrogen Inorganic materials 0.000 claims description 11
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 11
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- 150000003839 salts Chemical class 0.000 claims description 10
- 239000012453 solvate Substances 0.000 claims description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 9
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 9
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims description 7
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 6
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims description 5
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 5
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 4
- 229910052801 chlorine Inorganic materials 0.000 claims description 4
- 239000000460 chlorine Substances 0.000 claims description 4
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 5
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 4
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 4
- 208000036142 Viral infection Diseases 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 230000009385 viral infection Effects 0.000 claims 4
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- 241000701024 Human betaherpesvirus 5 Species 0.000 claims 2
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 2
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 241000700586 Herpesviridae Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 125000004185 ester group Chemical group 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006005861.5 | 2006-02-09 | ||
| DE102006005861A DE102006005861A1 (de) | 2006-02-09 | 2006-02-09 | Substituierte Chinolone III |
| PCT/EP2007/000923 WO2007090579A2 (de) | 2006-02-09 | 2007-02-02 | Substituierte chinolone iii |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009525999A JP2009525999A (ja) | 2009-07-16 |
| JP2009525999A5 true JP2009525999A5 (https=) | 2010-04-02 |
| JP5198291B2 JP5198291B2 (ja) | 2013-05-15 |
Family
ID=38283107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008553660A Expired - Fee Related JP5198291B2 (ja) | 2006-02-09 | 2007-02-02 | 置換キノロン類ｉｉｉ |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7977349B2 (https=) |
| EP (1) | EP1994020B1 (https=) |
| JP (1) | JP5198291B2 (https=) |
| KR (1) | KR101400568B1 (https=) |
| CN (1) | CN101379055B (https=) |
| AR (1) | AR059417A1 (https=) |
| AT (1) | ATE513826T1 (https=) |
| AU (1) | AU2007214006B2 (https=) |
| BR (1) | BRPI0706988A2 (https=) |
| CA (1) | CA2637204C (https=) |
| CY (1) | CY1111805T1 (https=) |
| DE (1) | DE102006005861A1 (https=) |
| DK (1) | DK1994020T3 (https=) |
| DO (1) | DOP2007000027A (https=) |
| ES (1) | ES2366970T3 (https=) |
| IL (1) | IL192662A (https=) |
| MY (1) | MY151590A (https=) |
| PE (1) | PE20080113A1 (https=) |
| PL (1) | PL1994020T3 (https=) |
| PT (1) | PT1994020E (https=) |
| RU (1) | RU2433125C2 (https=) |
| SI (1) | SI1994020T1 (https=) |
| TW (1) | TWI382980B (https=) |
| UA (1) | UA94934C2 (https=) |
| UY (1) | UY30135A1 (https=) |
| WO (1) | WO2007090579A2 (https=) |
| ZA (1) | ZA200806355B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR059339A1 (es) * | 2006-02-09 | 2008-03-26 | Chugai Pharmaceutical Co Ltd | Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene |
| TW200811153A (en) | 2006-06-23 | 2008-03-01 | Japan Tobacco Inc | 6-(heterocyclyl-substituted benzyl)-4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
| DE102011101446A1 (de) | 2011-05-10 | 2012-11-15 | Aicuris Gmbh & Co. Kg | Herstellung von "Dense Bodies" (DB) |
| EP3558992A4 (en) | 2016-12-15 | 2020-12-02 | ONO Pharmaceutical Co., Ltd. | TREK CHANNEL ACTIVATOR (K + CHANNELS ASSOCIATED WITH TWIK) |
| JP7403472B2 (ja) | 2018-05-09 | 2023-12-22 | バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 新規キノリン誘導体 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB932487A (en) | 1960-07-25 | 1963-07-31 | D G Searle & Co | Piperidine derivatives |
| DE3420743A1 (de) | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| DK164287A (da) | 1986-03-31 | 1987-10-01 | Sankyo Co | Quinolin-3-carboxylsyrederivater og fremgangsmaade til fremstilling deraf og deres anvendelse |
| DE3702393A1 (de) | 1987-01-28 | 1988-08-11 | Bayer Ag | 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel |
| AU618823B2 (en) | 1988-07-20 | 1992-01-09 | Sankyo Company Limited | 4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their use |
| US4959363A (en) | 1989-06-23 | 1990-09-25 | Sterling Drug Inc. | Quinolonecarboxamide compounds, their preparation and use as antivirals. |
| DE4303657A1 (de) | 1993-02-09 | 1994-08-11 | Bayer Ag | Neue Chinolon- und Naphthyridoncarbonsäurederivate |
| KR0169500B1 (ko) * | 1993-08-13 | 1999-01-15 | 이우용 | 새로운 퀴놀론 카르복실산 유도체 및 그의 제조방법 |
| FR2713116B1 (fr) | 1993-11-30 | 1996-01-12 | Techmetal Promotion | Dispositif d'alimentation pour le dépôt par simple gravité d'un matériau granuleux sur la surface d'un métal liquide coulé en continu. |
| KR960004339A (ko) | 1994-07-02 | 1996-02-23 | 임성기 | 신규한 퀴놀린계 화합물 및 그 의 제조방법 |
| AU696390B2 (en) | 1995-08-02 | 1998-09-10 | Darwin Discovery Limited | Quinolones and their therapeutic use |
| DE69631423T2 (de) | 1995-08-02 | 2004-12-02 | Darwin Discovery Ltd., Slough | Chinolone und deren therapeutische verwendung |
| DE69840599D1 (de) * | 1997-09-15 | 2009-04-09 | Procter & Gamble | Antimikrobielle chinolone, ihre zusammensetzungen und ihre verwendungen |
| US6248739B1 (en) * | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | Quinolinecarboxamides as antiviral agents |
| DE19937024A1 (de) | 1999-08-05 | 2001-02-08 | Bayer Ag | Verwendung von Acylsulfonamido substituierten Polymethin-Farbstoffen als Fluoreszenz-Farbstoffe und/oder Marker |
| US6525049B2 (en) * | 2000-07-05 | 2003-02-25 | Pharmacia & Upjohn Company | Pyrroloquinolones as antiviral agents |
| AU2001280091A1 (en) | 2000-08-01 | 2002-02-13 | Wockhardt Limited | Inhibitors of cellular efflux pumps of microbes |
| GB0023918D0 (en) | 2000-09-29 | 2000-11-15 | King S College London | Antiparasitic compounds |
| US6964966B2 (en) | 2001-04-25 | 2005-11-15 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
| AR037097A1 (es) | 2001-10-05 | 2004-10-20 | Novartis Ag | Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento |
| AU2002361493A1 (en) | 2001-12-13 | 2003-06-23 | Wockhardt Limited | New generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
| EP1610759A4 (en) | 2003-04-07 | 2007-04-25 | Cylene Pharmaceuticals Inc | SUBSTITUTED CHINOBENZOXAZINE ANALOGUE |
| WO2005049602A1 (en) * | 2003-11-18 | 2005-06-02 | Warner-Lambert Company Llc | Quinolone antibacterial agents |
| DE102004035203A1 (de) | 2004-07-21 | 2006-02-16 | Bayer Healthcare Ag | Substituierte Chinolone |
| DE102005030524A1 (de) | 2005-06-30 | 2007-01-18 | Aicuris Gmbh & Co. Kg | Substituierte Chinolone II |
-
2006
- 2006-02-09 DE DE102006005861A patent/DE102006005861A1/de not_active Ceased
-
2007
- 2007-01-23 MY MYPI20070105 patent/MY151590A/en unknown
- 2007-02-02 ZA ZA200806355A patent/ZA200806355B/xx unknown
- 2007-02-02 DK DK07711438.7T patent/DK1994020T3/da active
- 2007-02-02 PT PT07711438T patent/PT1994020E/pt unknown
- 2007-02-02 BR BRPI0706988-0A patent/BRPI0706988A2/pt active Search and Examination
- 2007-02-02 EP EP07711438A patent/EP1994020B1/de not_active Not-in-force
- 2007-02-02 WO PCT/EP2007/000923 patent/WO2007090579A2/de not_active Ceased
- 2007-02-02 RU RU2008136079/04A patent/RU2433125C2/ru not_active IP Right Cessation
- 2007-02-02 PL PL07711438T patent/PL1994020T3/pl unknown
- 2007-02-02 JP JP2008553660A patent/JP5198291B2/ja not_active Expired - Fee Related
- 2007-02-02 CA CA2637204A patent/CA2637204C/en not_active Expired - Fee Related
- 2007-02-02 UA UAA200810891A patent/UA94934C2/uk unknown
- 2007-02-02 KR KR1020087021888A patent/KR101400568B1/ko not_active Expired - Fee Related
- 2007-02-02 AU AU2007214006A patent/AU2007214006B2/en not_active Ceased
- 2007-02-02 AT AT07711438T patent/ATE513826T1/de active
- 2007-02-02 CN CN2007800049872A patent/CN101379055B/zh not_active Expired - Fee Related
- 2007-02-02 ES ES07711438T patent/ES2366970T3/es active Active
- 2007-02-02 SI SI200730702T patent/SI1994020T1/sl unknown
- 2007-02-06 DO DO2007000027A patent/DOP2007000027A/es unknown
- 2007-02-07 UY UY30135A patent/UY30135A1/es not_active Application Discontinuation
- 2007-02-08 TW TW096104540A patent/TWI382980B/zh not_active IP Right Cessation
- 2007-02-08 PE PE2007000136A patent/PE20080113A1/es active IP Right Grant
- 2007-02-09 AR ARP070100546A patent/AR059417A1/es unknown
-
2008
- 2008-07-07 IL IL192662A patent/IL192662A/en not_active IP Right Cessation
- 2008-08-08 US US12/188,940 patent/US7977349B2/en not_active Expired - Fee Related
-
2011
- 2011-08-31 CY CY20111100842T patent/CY1111805T1/el unknown