KR101400568B1 - 치환된 퀴놀론 ⅲ - Google Patents

치환된 퀴놀론 ⅲ Download PDF

Info

Publication number
KR101400568B1
KR101400568B1 KR1020087021888A KR20087021888A KR101400568B1 KR 101400568 B1 KR101400568 B1 KR 101400568B1 KR 1020087021888 A KR1020087021888 A KR 1020087021888A KR 20087021888 A KR20087021888 A KR 20087021888A KR 101400568 B1 KR101400568 B1 KR 101400568B1
Authority
KR
South Korea
Prior art keywords
alkyl
mmol
group
formula
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020087021888A
Other languages
English (en)
Korean (ko)
Other versions
KR20080100248A (ko
Inventor
칸탈 푸에르스트너
카이 테드
홀거 짐메르만
다비드 브루엑크너
케르스틴 헨닝거
디터 랑
루돌프 쇼헤-루프
Original Assignee
아이쿠리스 게엠베하 운트 코. 카게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아이쿠리스 게엠베하 운트 코. 카게 filed Critical 아이쿠리스 게엠베하 운트 코. 카게
Publication of KR20080100248A publication Critical patent/KR20080100248A/ko
Application granted granted Critical
Publication of KR101400568B1 publication Critical patent/KR101400568B1/ko
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020087021888A 2006-02-09 2007-02-02 치환된 퀴놀론 ⅲ Expired - Fee Related KR101400568B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102006005861.5 2006-02-09
DE102006005861A DE102006005861A1 (de) 2006-02-09 2006-02-09 Substituierte Chinolone III
PCT/EP2007/000923 WO2007090579A2 (de) 2006-02-09 2007-02-02 Substituierte chinolone iii

Publications (2)

Publication Number Publication Date
KR20080100248A KR20080100248A (ko) 2008-11-14
KR101400568B1 true KR101400568B1 (ko) 2014-05-26

Family

ID=38283107

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087021888A Expired - Fee Related KR101400568B1 (ko) 2006-02-09 2007-02-02 치환된 퀴놀론 ⅲ

Country Status (27)

Country Link
US (1) US7977349B2 (https=)
EP (1) EP1994020B1 (https=)
JP (1) JP5198291B2 (https=)
KR (1) KR101400568B1 (https=)
CN (1) CN101379055B (https=)
AR (1) AR059417A1 (https=)
AT (1) ATE513826T1 (https=)
AU (1) AU2007214006B2 (https=)
BR (1) BRPI0706988A2 (https=)
CA (1) CA2637204C (https=)
CY (1) CY1111805T1 (https=)
DE (1) DE102006005861A1 (https=)
DK (1) DK1994020T3 (https=)
DO (1) DOP2007000027A (https=)
ES (1) ES2366970T3 (https=)
IL (1) IL192662A (https=)
MY (1) MY151590A (https=)
PE (1) PE20080113A1 (https=)
PL (1) PL1994020T3 (https=)
PT (1) PT1994020E (https=)
RU (1) RU2433125C2 (https=)
SI (1) SI1994020T1 (https=)
TW (1) TWI382980B (https=)
UA (1) UA94934C2 (https=)
UY (1) UY30135A1 (https=)
WO (1) WO2007090579A2 (https=)
ZA (1) ZA200806355B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR059339A1 (es) * 2006-02-09 2008-03-26 Chugai Pharmaceutical Co Ltd Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene
TW200811153A (en) 2006-06-23 2008-03-01 Japan Tobacco Inc 6-(heterocyclyl-substituted benzyl)-4-oxoquinoline compound and use thereof as HIV integrase inhibitor
DE102011101446A1 (de) 2011-05-10 2012-11-15 Aicuris Gmbh & Co. Kg Herstellung von "Dense Bodies" (DB)
EP3558992A4 (en) 2016-12-15 2020-12-02 ONO Pharmaceutical Co., Ltd. TREK CHANNEL ACTIVATOR (K + CHANNELS ASSOCIATED WITH TWIK)
JP7403472B2 (ja) 2018-05-09 2023-12-22 バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 新規キノリン誘導体

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000040561A1 (en) 1999-01-08 2000-07-13 Pharmacia & Upjohn Company Quinolinecarboxamides as antiviral agents
WO2002085886A2 (en) 2001-04-25 2002-10-31 Wockhardt Limited Chiral, broad-spectrum antibacterial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation and compositions

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB932487A (en) 1960-07-25 1963-07-31 D G Searle & Co Piperidine derivatives
DE3420743A1 (de) 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DK164287A (da) 1986-03-31 1987-10-01 Sankyo Co Quinolin-3-carboxylsyrederivater og fremgangsmaade til fremstilling deraf og deres anvendelse
DE3702393A1 (de) 1987-01-28 1988-08-11 Bayer Ag 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel
AU618823B2 (en) 1988-07-20 1992-01-09 Sankyo Company Limited 4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their use
US4959363A (en) 1989-06-23 1990-09-25 Sterling Drug Inc. Quinolonecarboxamide compounds, their preparation and use as antivirals.
DE4303657A1 (de) 1993-02-09 1994-08-11 Bayer Ag Neue Chinolon- und Naphthyridoncarbonsäurederivate
KR0169500B1 (ko) * 1993-08-13 1999-01-15 이우용 새로운 퀴놀론 카르복실산 유도체 및 그의 제조방법
FR2713116B1 (fr) 1993-11-30 1996-01-12 Techmetal Promotion Dispositif d'alimentation pour le dépôt par simple gravité d'un matériau granuleux sur la surface d'un métal liquide coulé en continu.
KR960004339A (ko) 1994-07-02 1996-02-23 임성기 신규한 퀴놀린계 화합물 및 그 의 제조방법
AU696390B2 (en) 1995-08-02 1998-09-10 Darwin Discovery Limited Quinolones and their therapeutic use
DE69631423T2 (de) 1995-08-02 2004-12-02 Darwin Discovery Ltd., Slough Chinolone und deren therapeutische verwendung
DE69840599D1 (de) * 1997-09-15 2009-04-09 Procter & Gamble Antimikrobielle chinolone, ihre zusammensetzungen und ihre verwendungen
DE19937024A1 (de) 1999-08-05 2001-02-08 Bayer Ag Verwendung von Acylsulfonamido substituierten Polymethin-Farbstoffen als Fluoreszenz-Farbstoffe und/oder Marker
US6525049B2 (en) * 2000-07-05 2003-02-25 Pharmacia & Upjohn Company Pyrroloquinolones as antiviral agents
AU2001280091A1 (en) 2000-08-01 2002-02-13 Wockhardt Limited Inhibitors of cellular efflux pumps of microbes
GB0023918D0 (en) 2000-09-29 2000-11-15 King S College London Antiparasitic compounds
AR037097A1 (es) 2001-10-05 2004-10-20 Novartis Ag Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento
AU2002361493A1 (en) 2001-12-13 2003-06-23 Wockhardt Limited New generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments
EP1610759A4 (en) 2003-04-07 2007-04-25 Cylene Pharmaceuticals Inc SUBSTITUTED CHINOBENZOXAZINE ANALOGUE
WO2005049602A1 (en) * 2003-11-18 2005-06-02 Warner-Lambert Company Llc Quinolone antibacterial agents
DE102004035203A1 (de) 2004-07-21 2006-02-16 Bayer Healthcare Ag Substituierte Chinolone
DE102005030524A1 (de) 2005-06-30 2007-01-18 Aicuris Gmbh & Co. Kg Substituierte Chinolone II

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000040561A1 (en) 1999-01-08 2000-07-13 Pharmacia & Upjohn Company Quinolinecarboxamides as antiviral agents
WO2002085886A2 (en) 2001-04-25 2002-10-31 Wockhardt Limited Chiral, broad-spectrum antibacterial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation and compositions

Also Published As

Publication number Publication date
EP1994020A2 (de) 2008-11-26
DK1994020T3 (da) 2011-09-19
WO2007090579A3 (de) 2007-11-15
PT1994020E (pt) 2011-09-02
RU2433125C2 (ru) 2011-11-10
EP1994020B1 (de) 2011-06-22
DE102006005861A1 (de) 2007-08-23
JP5198291B2 (ja) 2013-05-15
KR20080100248A (ko) 2008-11-14
PL1994020T3 (pl) 2011-10-31
HK1125372A1 (zh) 2009-08-07
RU2008136079A (ru) 2010-03-20
BRPI0706988A2 (pt) 2011-04-19
TWI382980B (zh) 2013-01-21
ATE513826T1 (de) 2011-07-15
AR059417A1 (es) 2008-04-09
ZA200806355B (en) 2010-02-24
JP2009525999A (ja) 2009-07-16
AU2007214006B2 (en) 2011-11-03
WO2007090579A2 (de) 2007-08-16
UY30135A1 (es) 2007-09-28
US20090181996A1 (en) 2009-07-16
SI1994020T1 (sl) 2011-10-28
IL192662A (en) 2013-04-30
MY151590A (en) 2014-06-13
CY1111805T1 (el) 2015-10-07
AU2007214006A1 (en) 2007-08-16
TW200808757A (en) 2008-02-16
CN101379055A (zh) 2009-03-04
CA2637204C (en) 2013-04-16
ES2366970T3 (es) 2011-10-27
DOP2007000027A (es) 2007-10-31
UA94934C2 (uk) 2011-06-25
IL192662A0 (en) 2009-08-03
CN101379055B (zh) 2012-12-05
PE20080113A1 (es) 2008-04-18
US7977349B2 (en) 2011-07-12
CA2637204A1 (en) 2007-08-16

Similar Documents

Publication Publication Date Title
US7867992B2 (en) Substituted quinolones
AU2011317855B2 (en) Substituted 6-amino-nicotinamides as KCNQ2/3 modulators
KR101447758B1 (ko) 항바이러스제로서의 치환된 아릴술폰아미드
WO2003000660A1 (fr) Derive de quinoleine et derive de quinoleine permettant d'inhiber l'auto-phosphorylation du recepteur des proliferateurs des hepatocytes, ainsi que des compositions medicinales contenant ce derive
AU2007264791A1 (en) Derivatives of ureas of piperidine or pyrrolidine, their preparation and their therapeutical use
KR101400568B1 (ko) 치환된 퀴놀론 ⅲ
EP1262477B1 (en) Anti-acid-fast bacterial agents containing pyridonecarboxylic acids as the active ingredient
EP2609085A1 (en) Substituted quinoline-3-carboxamides as kcnq2/3 modulators
AU2011295408B2 (en) Substituted 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides as KCNQ2/3 modulators
US7569563B2 (en) Substituted quinolones II
MX2008010198A (en) Substituted quinolones iii
AU2004240167B2 (en) Anti acid-fast bacterial agent containing pyridonecarboxylic acids as active ingredient
WO2010012138A1 (zh) 7-[4-(胺甲基)-4-氟-3-(烷氧亚氨基)吡咯烷-1-基]取代的喹啉羧酸衍生物及其制备方法

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

FPAY Annual fee payment

Payment date: 20170512

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

FPAY Annual fee payment

Payment date: 20180510

Year of fee payment: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20210522

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20210522