CN101379055B - 取代的喹诺酮类ⅲ - Google Patents
取代的喹诺酮类ⅲ Download PDFInfo
- Publication number
- CN101379055B CN101379055B CN2007800049872A CN200780004987A CN101379055B CN 101379055 B CN101379055 B CN 101379055B CN 2007800049872 A CN2007800049872 A CN 2007800049872A CN 200780004987 A CN200780004987 A CN 200780004987A CN 101379055 B CN101379055 B CN 101379055B
- Authority
- CN
- China
- Prior art keywords
- group
- alkyl
- compound
- trifluoromethoxy
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC(*)(CCN(C)C1)CC(C)(*)CC1(C)S Chemical compound CC(*)(CCN(C)C1)CC(C)(*)CC1(C)S 0.000 description 3
- BYJRKZUGWIEHPS-UHFFFAOYSA-N CCOC(C(CC1)CCN1c(c(F)cc1c2N(CC(F)(F)F)C=C(C(NCc(ccc(Cl)c3)c3Cl)=O)C1=O)c2OC)=O Chemical compound CCOC(C(CC1)CCN1c(c(F)cc1c2N(CC(F)(F)F)C=C(C(NCc(ccc(Cl)c3)c3Cl)=O)C1=O)c2OC)=O BYJRKZUGWIEHPS-UHFFFAOYSA-N 0.000 description 1
- BQFJGHDFTPAXEN-UHFFFAOYSA-N CCOC(C(CC1)CCN1c(c(OC)c(c1c2)N(CCF)C=C(C(NCc(c(C)c3)ccc3OC(F)(F)F)=O)C1=O)c2F)=O Chemical compound CCOC(C(CC1)CCN1c(c(OC)c(c1c2)N(CCF)C=C(C(NCc(c(C)c3)ccc3OC(F)(F)F)=O)C1=O)c2F)=O BQFJGHDFTPAXEN-UHFFFAOYSA-N 0.000 description 1
- IMCGNXBJTWWKMH-UHFFFAOYSA-N CN(CC1)CCC1(CO1)NC1=O Chemical compound CN(CC1)CCC1(CO1)NC1=O IMCGNXBJTWWKMH-UHFFFAOYSA-N 0.000 description 1
- MMQRRQFEBDAKME-UHFFFAOYSA-N COc(c(N(C1CC1)C=C1C(O)=O)c(cc2F)C1=O)c2N1CCC(C2)(CNC2=O)CC1 Chemical compound COc(c(N(C1CC1)C=C1C(O)=O)c(cc2F)C1=O)c2N1CCC(C2)(CNC2=O)CC1 MMQRRQFEBDAKME-UHFFFAOYSA-N 0.000 description 1
- BNTXGGNFBSCEFE-UHFFFAOYSA-N COc(c(N(CC(F)(F)F)C=C1C(NCc(c(Cl)c2)ccc2Cl)=O)c(cc2F)C1=O)c2N(CC1)CCC1C(O)=O Chemical compound COc(c(N(CC(F)(F)F)C=C1C(NCc(c(Cl)c2)ccc2Cl)=O)c(cc2F)C1=O)c2N(CC1)CCC1C(O)=O BNTXGGNFBSCEFE-UHFFFAOYSA-N 0.000 description 1
- FAUSWDKADZYCCX-UHFFFAOYSA-N COc(c(N(CC(F)(F)F)C=C1C(O)=O)c(cc2F)C1=O)c2N1CCC(C2)(CNC2=O)CC1 Chemical compound COc(c(N(CC(F)(F)F)C=C1C(O)=O)c(cc2F)C1=O)c2N1CCC(C2)(CNC2=O)CC1 FAUSWDKADZYCCX-UHFFFAOYSA-N 0.000 description 1
- RQMGPGBTFYGTAU-UKLHQJQCSA-N C[C@H](CN(C[C@@H]1C)c(c(OC)c(c2c3)N(CC(F)(F)F)C=C(C(O)=[U])C2=[U])c3F)[C@H]1O Chemical compound C[C@H](CN(C[C@@H]1C)c(c(OC)c(c2c3)N(CC(F)(F)F)C=C(C(O)=[U])C2=[U])c3F)[C@H]1O RQMGPGBTFYGTAU-UKLHQJQCSA-N 0.000 description 1
- XWMNKXXLTZKPQA-KVSKUHBBSA-N C[C@H](CNC[C@@H]1C)[C@H]1O Chemical compound C[C@H](CNC[C@@H]1C)[C@H]1O XWMNKXXLTZKPQA-KVSKUHBBSA-N 0.000 description 1
- HEFDAMYVQYIFOH-UHFFFAOYSA-N O=C1OCC2(CCNCC2)N1 Chemical compound O=C1OCC2(CCNCC2)N1 HEFDAMYVQYIFOH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006005861.5 | 2006-02-09 | ||
| DE102006005861A DE102006005861A1 (de) | 2006-02-09 | 2006-02-09 | Substituierte Chinolone III |
| PCT/EP2007/000923 WO2007090579A2 (de) | 2006-02-09 | 2007-02-02 | Substituierte chinolone iii |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101379055A CN101379055A (zh) | 2009-03-04 |
| CN101379055B true CN101379055B (zh) | 2012-12-05 |
Family
ID=38283107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007800049872A Expired - Fee Related CN101379055B (zh) | 2006-02-09 | 2007-02-02 | 取代的喹诺酮类ⅲ |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7977349B2 (https=) |
| EP (1) | EP1994020B1 (https=) |
| JP (1) | JP5198291B2 (https=) |
| KR (1) | KR101400568B1 (https=) |
| CN (1) | CN101379055B (https=) |
| AR (1) | AR059417A1 (https=) |
| AT (1) | ATE513826T1 (https=) |
| AU (1) | AU2007214006B2 (https=) |
| BR (1) | BRPI0706988A2 (https=) |
| CA (1) | CA2637204C (https=) |
| CY (1) | CY1111805T1 (https=) |
| DE (1) | DE102006005861A1 (https=) |
| DK (1) | DK1994020T3 (https=) |
| DO (1) | DOP2007000027A (https=) |
| ES (1) | ES2366970T3 (https=) |
| IL (1) | IL192662A (https=) |
| MY (1) | MY151590A (https=) |
| PE (1) | PE20080113A1 (https=) |
| PL (1) | PL1994020T3 (https=) |
| PT (1) | PT1994020E (https=) |
| RU (1) | RU2433125C2 (https=) |
| SI (1) | SI1994020T1 (https=) |
| TW (1) | TWI382980B (https=) |
| UA (1) | UA94934C2 (https=) |
| UY (1) | UY30135A1 (https=) |
| WO (1) | WO2007090579A2 (https=) |
| ZA (1) | ZA200806355B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR059339A1 (es) * | 2006-02-09 | 2008-03-26 | Chugai Pharmaceutical Co Ltd | Derivados de la cumarina para trastornos proliferativos de celulas, composicion farmaceutica y agente terapeutico que los contiene |
| TW200811153A (en) | 2006-06-23 | 2008-03-01 | Japan Tobacco Inc | 6-(heterocyclyl-substituted benzyl)-4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
| DE102011101446A1 (de) | 2011-05-10 | 2012-11-15 | Aicuris Gmbh & Co. Kg | Herstellung von "Dense Bodies" (DB) |
| EP3558992A4 (en) | 2016-12-15 | 2020-12-02 | ONO Pharmaceutical Co., Ltd. | TREK CHANNEL ACTIVATOR (K + CHANNELS ASSOCIATED WITH TWIK) |
| JP7403472B2 (ja) | 2018-05-09 | 2023-12-22 | バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 新規キノリン誘導体 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB932487A (en) | 1960-07-25 | 1963-07-31 | D G Searle & Co | Piperidine derivatives |
| DE3420743A1 (de) | 1984-06-04 | 1985-12-05 | Bayer Ag, 5090 Leverkusen | 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
| DK164287A (da) | 1986-03-31 | 1987-10-01 | Sankyo Co | Quinolin-3-carboxylsyrederivater og fremgangsmaade til fremstilling deraf og deres anvendelse |
| DE3702393A1 (de) | 1987-01-28 | 1988-08-11 | Bayer Ag | 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel |
| AU618823B2 (en) | 1988-07-20 | 1992-01-09 | Sankyo Company Limited | 4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their use |
| US4959363A (en) | 1989-06-23 | 1990-09-25 | Sterling Drug Inc. | Quinolonecarboxamide compounds, their preparation and use as antivirals. |
| DE4303657A1 (de) | 1993-02-09 | 1994-08-11 | Bayer Ag | Neue Chinolon- und Naphthyridoncarbonsäurederivate |
| KR0169500B1 (ko) * | 1993-08-13 | 1999-01-15 | 이우용 | 새로운 퀴놀론 카르복실산 유도체 및 그의 제조방법 |
| FR2713116B1 (fr) | 1993-11-30 | 1996-01-12 | Techmetal Promotion | Dispositif d'alimentation pour le dépôt par simple gravité d'un matériau granuleux sur la surface d'un métal liquide coulé en continu. |
| KR960004339A (ko) | 1994-07-02 | 1996-02-23 | 임성기 | 신규한 퀴놀린계 화합물 및 그 의 제조방법 |
| AU696390B2 (en) | 1995-08-02 | 1998-09-10 | Darwin Discovery Limited | Quinolones and their therapeutic use |
| DE69631423T2 (de) | 1995-08-02 | 2004-12-02 | Darwin Discovery Ltd., Slough | Chinolone und deren therapeutische verwendung |
| DE69840599D1 (de) * | 1997-09-15 | 2009-04-09 | Procter & Gamble | Antimikrobielle chinolone, ihre zusammensetzungen und ihre verwendungen |
| US6248739B1 (en) * | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | Quinolinecarboxamides as antiviral agents |
| DE19937024A1 (de) | 1999-08-05 | 2001-02-08 | Bayer Ag | Verwendung von Acylsulfonamido substituierten Polymethin-Farbstoffen als Fluoreszenz-Farbstoffe und/oder Marker |
| US6525049B2 (en) * | 2000-07-05 | 2003-02-25 | Pharmacia & Upjohn Company | Pyrroloquinolones as antiviral agents |
| AU2001280091A1 (en) | 2000-08-01 | 2002-02-13 | Wockhardt Limited | Inhibitors of cellular efflux pumps of microbes |
| GB0023918D0 (en) | 2000-09-29 | 2000-11-15 | King S College London | Antiparasitic compounds |
| US6964966B2 (en) | 2001-04-25 | 2005-11-15 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
| AR037097A1 (es) | 2001-10-05 | 2004-10-20 | Novartis Ag | Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento |
| AU2002361493A1 (en) | 2001-12-13 | 2003-06-23 | Wockhardt Limited | New generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
| EP1610759A4 (en) | 2003-04-07 | 2007-04-25 | Cylene Pharmaceuticals Inc | SUBSTITUTED CHINOBENZOXAZINE ANALOGUE |
| WO2005049602A1 (en) * | 2003-11-18 | 2005-06-02 | Warner-Lambert Company Llc | Quinolone antibacterial agents |
| DE102004035203A1 (de) | 2004-07-21 | 2006-02-16 | Bayer Healthcare Ag | Substituierte Chinolone |
| DE102005030524A1 (de) | 2005-06-30 | 2007-01-18 | Aicuris Gmbh & Co. Kg | Substituierte Chinolone II |
-
2006
- 2006-02-09 DE DE102006005861A patent/DE102006005861A1/de not_active Ceased
-
2007
- 2007-01-23 MY MYPI20070105 patent/MY151590A/en unknown
- 2007-02-02 ZA ZA200806355A patent/ZA200806355B/xx unknown
- 2007-02-02 DK DK07711438.7T patent/DK1994020T3/da active
- 2007-02-02 PT PT07711438T patent/PT1994020E/pt unknown
- 2007-02-02 BR BRPI0706988-0A patent/BRPI0706988A2/pt active Search and Examination
- 2007-02-02 EP EP07711438A patent/EP1994020B1/de not_active Not-in-force
- 2007-02-02 WO PCT/EP2007/000923 patent/WO2007090579A2/de not_active Ceased
- 2007-02-02 RU RU2008136079/04A patent/RU2433125C2/ru not_active IP Right Cessation
- 2007-02-02 PL PL07711438T patent/PL1994020T3/pl unknown
- 2007-02-02 JP JP2008553660A patent/JP5198291B2/ja not_active Expired - Fee Related
- 2007-02-02 CA CA2637204A patent/CA2637204C/en not_active Expired - Fee Related
- 2007-02-02 UA UAA200810891A patent/UA94934C2/uk unknown
- 2007-02-02 KR KR1020087021888A patent/KR101400568B1/ko not_active Expired - Fee Related
- 2007-02-02 AU AU2007214006A patent/AU2007214006B2/en not_active Ceased
- 2007-02-02 AT AT07711438T patent/ATE513826T1/de active
- 2007-02-02 CN CN2007800049872A patent/CN101379055B/zh not_active Expired - Fee Related
- 2007-02-02 ES ES07711438T patent/ES2366970T3/es active Active
- 2007-02-02 SI SI200730702T patent/SI1994020T1/sl unknown
- 2007-02-06 DO DO2007000027A patent/DOP2007000027A/es unknown
- 2007-02-07 UY UY30135A patent/UY30135A1/es not_active Application Discontinuation
- 2007-02-08 TW TW096104540A patent/TWI382980B/zh not_active IP Right Cessation
- 2007-02-08 PE PE2007000136A patent/PE20080113A1/es active IP Right Grant
- 2007-02-09 AR ARP070100546A patent/AR059417A1/es unknown
-
2008
- 2008-07-07 IL IL192662A patent/IL192662A/en not_active IP Right Cessation
- 2008-08-08 US US12/188,940 patent/US7977349B2/en not_active Expired - Fee Related
-
2011
- 2011-08-31 CY CY20111100842T patent/CY1111805T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190108 Address after: Germany Wuppertal Patentee after: AICURIS GMBH Address before: Germany Wuppertal Patentee before: Aicuris GmbH & Co. KG |
|
| TR01 | Transfer of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121205 Termination date: 20210202 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |