JP2009525292A5 - - Google Patents
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- Publication number
- JP2009525292A5 JP2009525292A5 JP2008552729A JP2008552729A JP2009525292A5 JP 2009525292 A5 JP2009525292 A5 JP 2009525292A5 JP 2008552729 A JP2008552729 A JP 2008552729A JP 2008552729 A JP2008552729 A JP 2008552729A JP 2009525292 A5 JP2009525292 A5 JP 2009525292A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrido
- pyrimidin
- alkyl
- phenylamino
- tolyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06001915 | 2006-01-31 | ||
| PCT/EP2007/000725 WO2007088014A1 (en) | 2006-01-31 | 2007-01-29 | 7h-pyrido[3,4-d]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009525292A JP2009525292A (ja) | 2009-07-09 |
| JP2009525292A5 true JP2009525292A5 (enExample) | 2012-01-26 |
Family
ID=36609592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552729A Ceased JP2009525292A (ja) | 2006-01-31 | 2007-01-29 | ７ｈ−ピリド［３，４−ｄ］ピリミジン−８−オン、それらの製造及びプロテインキナーゼ阻害剤としての使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8058283B2 (enExample) |
| EP (1) | EP1981886B1 (enExample) |
| JP (1) | JP2009525292A (enExample) |
| KR (1) | KR20080083046A (enExample) |
| CN (1) | CN101374840B (enExample) |
| AT (1) | ATE439361T1 (enExample) |
| AU (1) | AU2007211684A1 (enExample) |
| BR (1) | BRPI0706781A2 (enExample) |
| CA (1) | CA2636981A1 (enExample) |
| DE (1) | DE602007001952D1 (enExample) |
| ES (1) | ES2329419T3 (enExample) |
| IL (1) | IL191748A0 (enExample) |
| WO (1) | WO2007088014A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602007001952D1 (de) | 2006-01-31 | 2009-09-24 | Hoffmann La Roche | 7h-pyridoä3,4-düpyrimidin-8-one, ihre herstellung und ihre verwendung als proteinkinaseinhibitoren |
| SA111320200B1 (ar) * | 2010-02-17 | 2014-02-16 | ديبيوفارم اس ايه | مركبات ثنائية الحلقة واستخداماتها كمثبطات c-src/jak مزدوجة |
| MX2014010176A (es) | 2012-02-23 | 2014-11-10 | Abbvie Inc | Inhibidores de cinasas de piridopirimidinona. |
| JP6280546B2 (ja) | 2012-06-26 | 2018-02-14 | デル マー ファーマシューティカルズ | ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はａｈｉ１の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法 |
| CN105130986B (zh) | 2015-09-30 | 2017-07-18 | 广州科擎新药开发有限公司 | 嘧啶或吡啶并吡啶酮类化合物及其应用 |
| CN110016026B (zh) * | 2018-01-08 | 2022-11-25 | 上海凌济生物科技有限公司 | 一类具有抗肿瘤活性的嘧啶并吡啶酮类化合物、制备方法和用途 |
| KR102747104B1 (ko) * | 2019-02-18 | 2024-12-27 | 한국과학기술연구원 | 단백질 키나아제 저해 활성을 갖는 신규한 피리도[3,4-d]피리미딘-8-온 유도체 및 이를 포함하는 암의 예방, 개선 또는 치료용 약학 조성물 |
| KR102329720B1 (ko) * | 2019-08-30 | 2021-11-23 | 한국과학기술연구원 | 단백질 키나아제 저해 활성을 갖는 신규한 피리미도[4,5-d]피리미딘-2-온 유도체 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2146782T3 (es) | 1994-11-14 | 2000-08-16 | Warner Lambert Co | 6-aril-pirido(2,3-d)pirimidinas y naftiridinas para la inhibicion de la proliferacion celular inducida por la proteina tirosina quinasa. |
| IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| GB9800569D0 (en) * | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| CN1138778C (zh) | 1998-05-26 | 2004-02-18 | 沃尼尔·朗伯公司 | 用作细胞增殖抑制剂的二环嘧啶及二环3,4-二氢嘧啶化合物及用途 |
| HRP20010274A2 (en) | 1998-10-23 | 2002-06-30 | Hoffmann La Roche | Bicyclic nitrogen heterocycles |
| HUP0203477A3 (en) | 1999-10-21 | 2004-12-28 | Hoffmann La Roche | Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase, pharmaceutical compositions containing them and their preparations |
| ATE353329T1 (de) | 1999-10-21 | 2007-02-15 | Hoffmann La Roche | Heteroalkylamino-substituierte bicyclische stickstoffheterocyclen |
| CA2420122A1 (en) | 2000-08-31 | 2002-03-07 | F. Hoffmann-La Roche Ag | 7-oxo pyridopyrimidines |
| JP4141830B2 (ja) | 2000-08-31 | 2008-08-27 | エフ．ホフマン−ラ ロシュ アーゲー | 細胞増殖の阻害剤としての７−オキソ−ピリドピリミジン類 |
| PA8577501A1 (es) | 2002-07-25 | 2004-02-07 | Warner Lambert Co | Inhibidores de quinasas |
| US7129351B2 (en) | 2002-11-04 | 2006-10-31 | Hoffmann-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| TW200413381A (en) | 2002-11-04 | 2004-08-01 | Hoffmann La Roche | Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents |
| CL2004000366A1 (es) | 2003-02-26 | 2005-01-07 | Pharmacia Corp Sa Organizada B | USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA. |
| KR100864393B1 (ko) | 2003-04-10 | 2008-10-20 | 에프. 호프만-라 로슈 아게 | 피리미도 화합물 |
| MXPA06001098A (es) | 2003-07-29 | 2006-04-24 | Irm Llc | Compuestos y composiciones utiles como inhibidores de proteina cinasa. |
| CA2542105C (en) * | 2003-10-08 | 2011-08-02 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| WO2006012577A2 (en) * | 2004-07-22 | 2006-02-02 | Bayer Pharmaceuticals Corporation | Quinazolinone derivatives useful for the regulation of glucose homeostasis and food intake |
| DE602007001952D1 (de) | 2006-01-31 | 2009-09-24 | Hoffmann La Roche | 7h-pyridoä3,4-düpyrimidin-8-one, ihre herstellung und ihre verwendung als proteinkinaseinhibitoren |
-
2007
- 2007-01-29 DE DE602007001952T patent/DE602007001952D1/de active Active
- 2007-01-29 CN CN2007800035988A patent/CN101374840B/zh not_active Expired - Fee Related
- 2007-01-29 CA CA002636981A patent/CA2636981A1/en not_active Abandoned
- 2007-01-29 US US12/087,420 patent/US8058283B2/en not_active Expired - Fee Related
- 2007-01-29 BR BRPI0706781-0A patent/BRPI0706781A2/pt not_active IP Right Cessation
- 2007-01-29 AU AU2007211684A patent/AU2007211684A1/en not_active Abandoned
- 2007-01-29 KR KR1020087018893A patent/KR20080083046A/ko not_active Ceased
- 2007-01-29 EP EP07703091A patent/EP1981886B1/en not_active Not-in-force
- 2007-01-29 AT AT07703091T patent/ATE439361T1/de not_active IP Right Cessation
- 2007-01-29 WO PCT/EP2007/000725 patent/WO2007088014A1/en not_active Ceased
- 2007-01-29 ES ES07703091T patent/ES2329419T3/es active Active
- 2007-01-29 JP JP2008552729A patent/JP2009525292A/ja not_active Ceased
-
2008
- 2008-05-27 IL IL191748A patent/IL191748A0/en unknown
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