BRPI0706781A2 - 7h-pirido[3,4-d]pirimidin-8-onas, sua fabricação e uso como inibidores da proteìna quinase - Google Patents
7h-pirido[3,4-d]pirimidin-8-onas, sua fabricação e uso como inibidores da proteìna quinase Download PDFInfo
- Publication number
- BRPI0706781A2 BRPI0706781A2 BRPI0706781-0A BRPI0706781A BRPI0706781A2 BR PI0706781 A2 BRPI0706781 A2 BR PI0706781A2 BR PI0706781 A BRPI0706781 A BR PI0706781A BR PI0706781 A2 BRPI0706781 A2 BR PI0706781A2
- Authority
- BR
- Brazil
- Prior art keywords
- pyrido
- alkyl
- pyrimidin
- phenyl
- phenylamino
- Prior art date
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- ORFSSYGWXNGVFB-UHFFFAOYSA-N sodium 4-amino-6-[[4-[4-[(8-amino-1-hydroxy-5,7-disulfonaphthalen-2-yl)diazenyl]-3-methoxyphenyl]-2-methoxyphenyl]diazenyl]-5-hydroxynaphthalene-1,3-disulfonic acid Chemical compound COC1=C(C=CC(=C1)C2=CC(=C(C=C2)N=NC3=C(C4=C(C=C3)C(=CC(=C4N)S(=O)(=O)O)S(=O)(=O)O)O)OC)N=NC5=C(C6=C(C=C5)C(=CC(=C6N)S(=O)(=O)O)S(=O)(=O)O)O.[Na+] ORFSSYGWXNGVFB-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Immunology (AREA)
- Neurosurgery (AREA)
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- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
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- Urology & Nephrology (AREA)
- Obesity (AREA)
- Psychology (AREA)
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- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06001915.5 | 2006-01-31 | ||
| EP06001915 | 2006-01-31 | ||
| PCT/EP2007/000725 WO2007088014A1 (en) | 2006-01-31 | 2007-01-29 | 7h-pyrido[3,4-d]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0706781A2 true BRPI0706781A2 (pt) | 2011-04-05 |
Family
ID=36609592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0706781-0A BRPI0706781A2 (pt) | 2006-01-31 | 2007-01-29 | 7h-pirido[3,4-d]pirimidin-8-onas, sua fabricação e uso como inibidores da proteìna quinase |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8058283B2 (enExample) |
| EP (1) | EP1981886B1 (enExample) |
| JP (1) | JP2009525292A (enExample) |
| KR (1) | KR20080083046A (enExample) |
| CN (1) | CN101374840B (enExample) |
| AT (1) | ATE439361T1 (enExample) |
| AU (1) | AU2007211684A1 (enExample) |
| BR (1) | BRPI0706781A2 (enExample) |
| CA (1) | CA2636981A1 (enExample) |
| DE (1) | DE602007001952D1 (enExample) |
| ES (1) | ES2329419T3 (enExample) |
| IL (1) | IL191748A0 (enExample) |
| WO (1) | WO2007088014A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1981886B1 (en) | 2006-01-31 | 2009-08-12 | F.Hoffmann-La Roche Ag | 7h-pyrido[3,4-d]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors |
| SA111320200B1 (ar) * | 2010-02-17 | 2014-02-16 | ديبيوفارم اس ايه | مركبات ثنائية الحلقة واستخداماتها كمثبطات c-src/jak مزدوجة |
| MX2014010176A (es) * | 2012-02-23 | 2014-11-10 | Abbvie Inc | Inhibidores de cinasas de piridopirimidinona. |
| EP2872161B1 (en) | 2012-06-26 | 2020-12-16 | Del Mar Pharmaceuticals | Dianhydrogalactitol for use in treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations |
| CN105130986B (zh) * | 2015-09-30 | 2017-07-18 | 广州科擎新药开发有限公司 | 嘧啶或吡啶并吡啶酮类化合物及其应用 |
| CN110016026B (zh) * | 2018-01-08 | 2022-11-25 | 上海凌济生物科技有限公司 | 一类具有抗肿瘤活性的嘧啶并吡啶酮类化合物、制备方法和用途 |
| KR102747104B1 (ko) * | 2019-02-18 | 2024-12-27 | 한국과학기술연구원 | 단백질 키나아제 저해 활성을 갖는 신규한 피리도[3,4-d]피리미딘-8-온 유도체 및 이를 포함하는 암의 예방, 개선 또는 치료용 약학 조성물 |
| KR102329720B1 (ko) * | 2019-08-30 | 2021-11-23 | 한국과학기술연구원 | 단백질 키나아제 저해 활성을 갖는 신규한 피리미도[4,5-d]피리미딘-2-온 유도체 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TJ342B (en) | 1994-11-14 | 2002-10-06 | Warner Lambert Co | Derivatives of 6-aryl pyrido Ä2,3-dÜ pyrimidines and naphthyridines pharmaceutical composition possess inhibiting effect of cellular proliferation pr ovoking protein tyrosine kinase and method of inhibiting cellular proliferation |
| IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| GB9800569D0 (en) * | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
| SK17532000A3 (sk) | 1998-05-26 | 2002-08-06 | Warner-Lambert Company | Prípadne substituované 3,4-dihydrogenované pyrimidíny, ich použitie a farmaceutické formulácie na ich báze |
| CZ20011394A3 (cs) | 1998-10-23 | 2001-12-12 | F. Hoffmann-La Roche Ag | Derivát bicyklických, dusík obsahujících heterocyklických sloučenin, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje |
| BR0014973A (pt) | 1999-10-21 | 2002-07-16 | Hoffmann La Roche Ag G | Heterociclos de nitrogênio bicìclico de alquilamino substituìdo como inibidores de proteìna quinase p38 |
| CZ20021744A3 (cs) | 1999-10-21 | 2002-08-14 | F. Hoffmann-La Roche Ag | Bicyklické dusíkové heterocykly substituované heteroalkylaminoskupinou jako inhibitory P38 proteinkinázy |
| EP1315726A1 (en) | 2000-08-31 | 2003-06-04 | F. Hoffmann-La Roche Ag | 7- oxo pyridopyrimidines as inhibitors of cellular proliferation |
| EP1315727B1 (en) | 2000-08-31 | 2005-06-29 | F. Hoffmann-La Roche Ag | 7-oxo pyridopyrimidines |
| US7196090B2 (en) | 2002-07-25 | 2007-03-27 | Warner-Lambert Company | Kinase inhibitors |
| TW200413381A (en) | 2002-11-04 | 2004-08-01 | Hoffmann La Roche | Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents |
| US7112676B2 (en) | 2002-11-04 | 2006-09-26 | Hoffmann-La Roche Inc. | Pyrimido compounds having antiproliferative activity |
| CL2004000366A1 (es) | 2003-02-26 | 2005-01-07 | Pharmacia Corp Sa Organizada B | USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA. |
| KR100864393B1 (ko) | 2003-04-10 | 2008-10-20 | 에프. 호프만-라 로슈 아게 | 피리미도 화합물 |
| AU2004260689B8 (en) | 2003-07-29 | 2008-05-15 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| MXPA06003996A (es) | 2003-10-08 | 2006-07-05 | Irm Llc | Compuestos y composiciones como inhibidores de la proteina cinasa. |
| WO2006012577A2 (en) * | 2004-07-22 | 2006-02-02 | Bayer Pharmaceuticals Corporation | Quinazolinone derivatives useful for the regulation of glucose homeostasis and food intake |
| EP1981886B1 (en) | 2006-01-31 | 2009-08-12 | F.Hoffmann-La Roche Ag | 7h-pyrido[3,4-d]pyrimidin-8-ones, their manufacture and use as protein kinase inhibitors |
-
2007
- 2007-01-29 EP EP07703091A patent/EP1981886B1/en not_active Not-in-force
- 2007-01-29 ES ES07703091T patent/ES2329419T3/es active Active
- 2007-01-29 KR KR1020087018893A patent/KR20080083046A/ko not_active Ceased
- 2007-01-29 US US12/087,420 patent/US8058283B2/en not_active Expired - Fee Related
- 2007-01-29 CN CN2007800035988A patent/CN101374840B/zh not_active Expired - Fee Related
- 2007-01-29 DE DE602007001952T patent/DE602007001952D1/de active Active
- 2007-01-29 BR BRPI0706781-0A patent/BRPI0706781A2/pt not_active IP Right Cessation
- 2007-01-29 AU AU2007211684A patent/AU2007211684A1/en not_active Abandoned
- 2007-01-29 JP JP2008552729A patent/JP2009525292A/ja not_active Ceased
- 2007-01-29 WO PCT/EP2007/000725 patent/WO2007088014A1/en not_active Ceased
- 2007-01-29 CA CA002636981A patent/CA2636981A1/en not_active Abandoned
- 2007-01-29 AT AT07703091T patent/ATE439361T1/de not_active IP Right Cessation
-
2008
- 2008-05-27 IL IL191748A patent/IL191748A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101374840A (zh) | 2009-02-25 |
| WO2007088014A1 (en) | 2007-08-09 |
| CA2636981A1 (en) | 2007-08-09 |
| JP2009525292A (ja) | 2009-07-09 |
| US20090030020A1 (en) | 2009-01-29 |
| EP1981886B1 (en) | 2009-08-12 |
| KR20080083046A (ko) | 2008-09-12 |
| US8058283B2 (en) | 2011-11-15 |
| AU2007211684A1 (en) | 2007-08-09 |
| IL191748A0 (en) | 2008-12-29 |
| ATE439361T1 (de) | 2009-08-15 |
| ES2329419T3 (es) | 2009-11-25 |
| EP1981886A1 (en) | 2008-10-22 |
| DE602007001952D1 (de) | 2009-09-24 |
| CN101374840B (zh) | 2011-09-28 |
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