|
GB0110029D0
(en)
*
|
2001-04-24 |
2001-06-13 |
Grosveld Frank |
Transgenic animal
|
|
ES2440990T5
(es)
*
|
2004-07-22 |
2022-10-25 |
Univ Erasmus Med Ct Rotterdam |
Moléculas de unión
|
|
JP5184374B2
(ja)
*
|
2006-01-25 |
2013-04-17 |
エラスムス・ユニヴァーシティ・メディカル・センター・ロッテルダム |
対立遺伝子排除
|
|
SI2602323T1
(en)
|
2007-06-01 |
2018-05-31 |
Open Monoclonal Technology, Inc. |
Compositions and procedures for inhibiting endogenous immunoglobin gene and the formation of transgenic human idiopathic antibodies
|
|
WO2009013620A2
(en)
*
|
2007-06-11 |
2009-01-29 |
Erasmus University Medical Center Rotterdam |
Homologous recombination
|
|
EP2288623B1
(en)
|
2008-05-23 |
2013-07-10 |
Ablexis, LLC |
Method of generating single vl domain antibodies in transgenic animals
|
|
US20100122358A1
(en)
*
|
2008-06-06 |
2010-05-13 |
Crescendo Biologics Limited |
H-Chain-only antibodies
|
|
RU2011129459A
(ru)
|
2008-12-18 |
2013-01-27 |
Эрасмус Юниверсити Медикал Сентр Роттердам |
Трансгенные животные (не человек), экспрессирующие гуманизированные антитела, и их применение
|
|
GB0905023D0
(en)
|
2009-03-24 |
2009-05-06 |
Univ Erasmus Medical Ct |
Binding molecules
|
|
US9445581B2
(en)
|
2012-03-28 |
2016-09-20 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
EP2517556B2
(en)
*
|
2009-07-08 |
2023-03-22 |
Kymab Limited |
Site-Specific Recombination Method, Rodents & Rodent Cells capable of Expressing Chimaeric Antibodies or Chains
|
|
DK2509409T3
(en)
*
|
2009-12-10 |
2016-11-14 |
Regeneron Pharma |
MICE, WHICH PRODUCES HEAVY CHAIN ANTIBODIES
|
|
US20130045492A1
(en)
|
2010-02-08 |
2013-02-21 |
Regeneron Pharmaceuticals, Inc. |
Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain
|
|
US9796788B2
(en)
|
2010-02-08 |
2017-10-24 |
Regeneron Pharmaceuticals, Inc. |
Mice expressing a limited immunoglobulin light chain repertoire
|
|
WO2011097603A1
(en)
|
2010-02-08 |
2011-08-11 |
Regeneron Pharmaceuticals, Inc. |
Common light chain mouse
|
|
RS55495B1
(sr)
|
2010-08-02 |
2017-04-28 |
Regeneron Pharma |
Miševi koji stvaraju vezujuće proteine koji sadrže vl domene
|
|
SI3865581T1
(sl)
|
2011-08-05 |
2024-12-31 |
Regeneron Pharmaceuticals, Inc. |
Miši s humanizirano univerzalno lahko verigo
|
|
CA2846319A1
(en)
|
2011-09-19 |
2013-03-28 |
Kymab Limited |
Antibodies, variable domains & chains tailored for human use
|
|
EP2761008A1
(en)
|
2011-09-26 |
2014-08-06 |
Kymab Limited |
Chimaeric surrogate light chains (slc) comprising human vpreb
|
|
SG10202010120XA
(en)
|
2011-10-17 |
2020-11-27 |
Regeneron Pharma |
Restricted immunoglobulin heavy chain mice
|
|
US9253965B2
(en)
|
2012-03-28 |
2016-02-09 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
PL2793567T3
(pl)
|
2011-12-20 |
2019-09-30 |
Regeneron Pharmaceuticals, Inc. |
Myszy z humanizowanym łańcuchem lekkim
|
|
US10251377B2
(en)
|
2012-03-28 |
2019-04-09 |
Kymab Limited |
Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies
|
|
GB2502127A
(en)
*
|
2012-05-17 |
2013-11-20 |
Kymab Ltd |
Multivalent antibodies and in vivo methods for their production
|
|
CN104540383B
(zh)
|
2012-06-12 |
2017-08-29 |
瑞泽恩制药公司 |
具有受限制的免疫球蛋白重链基因座的人源化非人动物
|
|
ES2963516T3
(es)
|
2012-12-14 |
2024-03-27 |
Omniab Inc |
Polinucleótidos que codifican anticuerpos de roedores con idiotipos humanos y animales que los contienen
|
|
WO2014130690A1
(en)
|
2013-02-20 |
2014-08-28 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals with modified immunoglobulin heavy chain sequences
|
|
US9980470B2
(en)
|
2013-03-14 |
2018-05-29 |
Erasmus University Medical Center |
Antibody production
|
|
US10993420B2
(en)
|
2013-03-15 |
2021-05-04 |
Erasmus University Medical Center |
Production of heavy chain only antibodies in transgenic mammals
|
|
US9788534B2
(en)
|
2013-03-18 |
2017-10-17 |
Kymab Limited |
Animal models and therapeutic molecules
|
|
US9783618B2
(en)
|
2013-05-01 |
2017-10-10 |
Kymab Limited |
Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics
|
|
US9783593B2
(en)
|
2013-05-02 |
2017-10-10 |
Kymab Limited |
Antibodies, variable domains and chains tailored for human use
|
|
US11707056B2
(en)
|
2013-05-02 |
2023-07-25 |
Kymab Limited |
Animals, repertoires and methods
|
|
ES2993142T3
(en)
|
2013-10-01 |
2024-12-23 |
Kymab Ltd |
Animal models and therapeutic molecules
|
|
WO2015143406A2
(en)
|
2014-03-21 |
2015-09-24 |
Regeneron Pharmaceuticals, Inc. |
Vl antigen binding proteins exhibiting distinct binding characteristics
|
|
ES2872475T3
(es)
|
2014-03-21 |
2021-11-02 |
Regeneron Pharma |
Animales no humanos que producen proteínas de unión de dominio único
|
|
JP2018508224A
(ja)
|
2015-03-19 |
2018-03-29 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. |
抗原を結合する軽鎖可変領域を選択する非ヒト動物
|
|
HUE051165T2
(hu)
|
2015-07-29 |
2021-03-01 |
Allergan Inc |
ANG-2 elleni, csak nehézláncot tartalmazó antitestek
|
|
CN105384825B
(zh)
|
2015-08-11 |
2018-06-01 |
南京传奇生物科技有限公司 |
一种基于单域抗体的双特异性嵌合抗原受体及其应用
|
|
JP2018523673A
(ja)
|
2015-08-14 |
2018-08-23 |
アラーガン、インコーポレイテッドAllergan,Incorporated |
Pdgfに対する重鎖のみ抗体
|
|
WO2017058944A1
(en)
|
2015-09-29 |
2017-04-06 |
Amgen Inc. |
Asgr inhibitors
|
|
WO2018014260A1
(en)
|
2016-07-20 |
2018-01-25 |
Nanjing Legend Biotech Co., Ltd. |
Multispecific antigen binding proteins and methods of use thereof
|
|
WO2018068201A1
(en)
|
2016-10-11 |
2018-04-19 |
Nanjing Legend Biotech Co., Ltd. |
Single-domain antibodies and variants thereof against ctla-4
|
|
EP3332637A1
(en)
*
|
2016-12-09 |
2018-06-13 |
Universitätsklinikum Hamburg-Eppendorf |
Vhh-containing heavy chain antibody and production thereof
|
|
CN110662421B
(zh)
|
2017-01-19 |
2023-03-24 |
欧莫诺艾比公司 |
来自具有多个重链免疫球蛋白基因座的转基因啮齿类动物的人抗体
|
|
WO2019000223A1
(en)
|
2017-06-27 |
2019-01-03 |
Nanjing Legend Biotech Co., Ltd. |
ENABLERS OF IMMUNE EFFECTOR CELLS OF CHIMERIC ANTIBODIES AND METHODS OF USE THEREOF
|
|
AU2018396964C1
(en)
|
2017-12-28 |
2024-10-03 |
Nanjing Legend Biotech Co., Ltd. |
Antibodies and variants thereof against PD-L1
|
|
AU2018396970B2
(en)
|
2017-12-28 |
2025-09-25 |
Nanjing Legend Biotech Co., Ltd. |
Single-domain antibodies and variants thereof against TIGIT
|
|
CN111699200B
(zh)
|
2018-01-15 |
2023-05-26 |
南京传奇生物科技有限公司 |
针对pd-1的单域抗体和其变体
|
|
WO2019175250A1
(en)
|
2018-03-13 |
2019-09-19 |
Smivet B.V. |
Single domain antibodies binding to tetanus neurotoxin
|
|
CN108486125B
(zh)
*
|
2018-03-27 |
2024-01-05 |
重庆金迈博生物科技有限公司 |
一种核酸分子及其在制备人源单域抗体中的应用
|
|
US11958903B2
(en)
|
2018-03-30 |
2024-04-16 |
Nanjing Legend Biotech Co., Ltd. |
Single-domain antibodies against LAG-3 and uses thereof
|
|
WO2019227490A1
(en)
|
2018-06-01 |
2019-12-05 |
Tayu Huaxia Biotech Medical Group Co., Ltd. |
Compositions and methods for imaging
|
|
JP2021525806A
(ja)
|
2018-06-01 |
2021-09-27 |
タユー ファシャ バイオテック メディカル グループ カンパニー, リミテッド |
疾患または状態を処置するための組成物およびそれらの使用
|
|
US12275788B2
(en)
|
2018-09-10 |
2025-04-15 |
Legend Biotech Ireland Limited |
Single-domain antibodies against CD33 and constructs thereof
|
|
US12263234B2
(en)
|
2019-01-23 |
2025-04-01 |
Tayu Huaxia Biotech Medical Group Co., Ltd. |
Anti-PD-L1 diabodies and the use thereof
|
|
US20220275059A1
(en)
|
2019-02-20 |
2022-09-01 |
Harbour Antibodies Bv |
Antibodies
|
|
MA56120A
(fr)
|
2019-06-07 |
2022-04-13 |
Amgen Inc |
Constructions de liaison bispécifiques
|
|
CN110818795B
(zh)
|
2020-01-10 |
2020-04-24 |
上海复宏汉霖生物技术股份有限公司 |
抗tigit抗体和使用方法
|
|
EP4097144A4
(en)
*
|
2020-01-28 |
2024-02-28 |
University of Southern California |
Genome engineering the human immunoglobulin locus to express recombinant binding domain molecules
|
|
KR20220145859A
(ko)
|
2020-02-28 |
2022-10-31 |
상하이 헨리우스 바이오테크, 인크. |
항cd137 작제물, 다중 특이적 항체 및 그 용도
|
|
BR112022016491A2
(pt)
|
2020-02-28 |
2022-10-11 |
Shanghai Henlius Biotech Inc |
Construto anti-cd137 e usos do mesmo
|
|
GB202003632D0
(en)
|
2020-03-12 |
2020-04-29 |
Harbour Antibodies Bv |
SARS-Cov-2 (SARS2, COVID-19) antibodies
|
|
US20230235075A1
(en)
|
2020-06-02 |
2023-07-27 |
Dynamicure Biotechnology Llc |
Anti-cd93 constructs and uses thereof
|
|
CN116529260A
(zh)
|
2020-06-02 |
2023-08-01 |
当康生物技术有限责任公司 |
抗cd93构建体及其用途
|
|
US20230203198A1
(en)
|
2020-06-04 |
2023-06-29 |
Amgen Inc. |
Bispecific binding constructs
|
|
WO2021257679A1
(en)
|
2020-06-17 |
2021-12-23 |
Janssen Biotech, Inc. |
Materials and methods for the manufacture of pluripotent stem cells
|
|
WO2022002038A1
(zh)
|
2020-06-30 |
2022-01-06 |
和铂医药(上海)有限责任公司 |
免疫细胞衔接器多特异性结合蛋白及其制备和应用
|
|
KR20230015996A
(ko)
|
2020-06-30 |
2023-01-31 |
하버 바이오메드 (상하이) 컴퍼니 리미티드 |
H2l2 및 hcab 구조를 갖는 결합 단백질
|
|
WO2022011457A1
(en)
*
|
2020-07-13 |
2022-01-20 |
Kisoji Biotechnology Inc. |
Transgenic animals expressing heavy chain antibodies
|
|
AU2021315665A1
(en)
|
2020-07-29 |
2023-03-16 |
Dynamicure Biotechnology Llc |
Anti-CD93 constructs and uses thereof
|
|
KR20230062833A
(ko)
|
2020-08-10 |
2023-05-09 |
얀센 바이오테크 인코포레이티드 |
생물공학적 바이러스 특이적 림프구 생산을 위한 재료 및 방법
|
|
CN114134144A
(zh)
*
|
2020-09-04 |
2022-03-04 |
北京仁源欣生生物科技有限公司 |
一种非人哺乳动物或其子代的制备方法及其应用
|
|
CN118126189A
(zh)
|
2020-09-28 |
2024-06-04 |
安济盛生物医药有限公司 |
抗硬骨抑素构建体及其用途
|
|
AU2021370895A1
(en)
|
2020-10-29 |
2023-06-08 |
Industrial Polymers and Chemicals, Inc. |
Air filter with pathogen monitoring and inactivation
|
|
GB202017555D0
(en)
|
2020-11-06 |
2020-12-23 |
Harbour Antibodies Bv |
Antibody-conjugated nanoparticles
|
|
CA3203468A1
(en)
|
2020-12-03 |
2022-06-09 |
Amgen Inc. |
Immunoglobuline constructs with multiple binding domains
|
|
US20240023526A1
(en)
*
|
2020-12-09 |
2024-01-25 |
Trianni, Inc. |
Heavy chain-only antibodies
|
|
KR102836733B1
(ko)
|
2021-02-19 |
2025-07-21 |
(주)샤페론 |
Pd-l1 및 cd47에 대한 이중특이적 단일 도메인 항체 및 이의 용도
|
|
WO2022177393A1
(ko)
|
2021-02-19 |
2022-08-25 |
(주)샤페론 |
Pd-l1에 대한 단일 도메인 항체 및 이의 용도
|
|
EP4296282A4
(en)
|
2021-02-19 |
2025-02-26 |
SHAPERON Inc. |
SINGLE DOMAIN ANTIBODIES AGAINST CD47 AND USE THEREOF
|
|
EP4301472A1
(en)
|
2021-03-05 |
2024-01-10 |
Dynamicure Biotechnology LLC |
Anti-vista constructs and uses thereof
|
|
JP2024511424A
(ja)
|
2021-03-25 |
2024-03-13 |
ダイナミキュア バイオテクノロジー エルエルシー |
抗igfbp7構築物およびその使用
|
|
EP4355785A1
(en)
|
2021-06-17 |
2024-04-24 |
Amberstone Biosciences, Inc. |
Anti-cd3 constructs and uses thereof
|
|
WO2022269473A1
(en)
|
2021-06-23 |
2022-12-29 |
Janssen Biotech, Inc. |
Materials and methods for hinge regions in functional exogenous receptors
|
|
GB202112935D0
(en)
|
2021-09-10 |
2021-10-27 |
Harbour Antibodies Bv |
Sars-cov-2 (sars2, covid-19) heavy chain only antibodies
|
|
WO2023036982A1
(en)
|
2021-09-10 |
2023-03-16 |
Harbour Antibodies Bv |
Anti-sars2-s antibodies
|
|
CN118488965A
(zh)
|
2021-12-17 |
2024-08-13 |
上海复宏汉霖生物技术股份有限公司 |
抗ox40抗体、多特异性抗体及其使用方法
|
|
CA3240565A1
(en)
|
2021-12-17 |
2023-06-22 |
Wenfeng Xu |
Anti-ox40 antibodies and methods of use
|
|
AU2023240941A1
(en)
|
2022-03-25 |
2024-09-19 |
Shanghai Henlius Biologics Co., Ltd. |
Anti-msln antibodies and methods of use
|
|
WO2024018426A1
(en)
|
2022-07-22 |
2024-01-25 |
Janssen Biotech, Inc. |
Enhanced transfer of genetic instructions to effector immune cells
|
|
EP4584296A1
(en)
|
2022-09-07 |
2025-07-16 |
Dynamicure Biotechnology LLC |
Anti-vista constructs and uses thereof
|
|
WO2025034806A1
(en)
|
2023-08-08 |
2025-02-13 |
Wisconsin Alumni Research Foundation |
Single-domain antibodies and variants thereof against fibroblast activation protein
|
|
EP4512243A1
(en)
*
|
2023-08-21 |
2025-02-26 |
Kymab Limited |
Binding molecules
|
|
WO2025045250A1
(en)
|
2023-09-03 |
2025-03-06 |
Kira Pharmaceuticals (Us) Llc |
Anti-human factor d antibody constructs and uses thereof
|
|
WO2025154058A1
(en)
*
|
2024-01-21 |
2025-07-24 |
Ibi-Ag Innovative Bio Insecticides Ltd. |
Anti-insect hsp70 nanobodies and uses thereof
|
|
WO2025178959A1
(en)
|
2024-02-20 |
2025-08-28 |
University Of Georgia Research Foundation, Inc. |
Single-domain antibodies and variants thereof against tab1
|
|
GB202406483D0
(en)
|
2024-05-09 |
2024-06-26 |
Harbour Antibodies Bv |
Crossing the blood brain barrier to treat diseases of the brain
|
|
US20250361309A1
(en)
|
2024-05-24 |
2025-11-27 |
Regeneron Pharmaceuticals, Inc. |
Tumor-targeted split il12 receptor agonists
|
|
WO2025255452A2
(en)
|
2024-06-07 |
2025-12-11 |
Regeneron Pharmaceuticals, Inc. |
Antigen-binding molecules that bind to aav particles and uses thereof
|
|
US20250376524A1
(en)
|
2024-06-07 |
2025-12-11 |
Regeneron Pharmaceuticals, Inc. |
Tetravalent multispecific binding molecules and methods of use thereof
|