JP2009524591A5 - - Google Patents

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Publication number
JP2009524591A5
JP2009524591A5 JP2008547549A JP2008547549A JP2009524591A5 JP 2009524591 A5 JP2009524591 A5 JP 2009524591A5 JP 2008547549 A JP2008547549 A JP 2008547549A JP 2008547549 A JP2008547549 A JP 2008547549A JP 2009524591 A5 JP2009524591 A5 JP 2009524591A5
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JP
Japan
Prior art keywords
aliphatic
compound
halo
independently selected
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008547549A
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English (en)
Japanese (ja)
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JP2009524591A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/048802 external-priority patent/WO2007075895A2/en
Publication of JP2009524591A publication Critical patent/JP2009524591A/ja
Publication of JP2009524591A5 publication Critical patent/JP2009524591A5/ja
Pending legal-status Critical Current

Links

JP2008547549A 2005-12-21 2006-12-21 イオンチャネルのモジュレーターとしての複素環誘導体 Pending JP2009524591A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US75292605P 2005-12-21 2005-12-21
US79118106P 2006-04-11 2006-04-11
US79979706P 2006-05-12 2006-05-12
US83944406P 2006-08-23 2006-08-23
PCT/US2006/048802 WO2007075895A2 (en) 2005-12-21 2006-12-21 Heterocyclic derivatives as modulators of ion channels

Publications (2)

Publication Number Publication Date
JP2009524591A JP2009524591A (ja) 2009-07-02
JP2009524591A5 true JP2009524591A5 (https=) 2011-01-13

Family

ID=38050930

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008547549A Pending JP2009524591A (ja) 2005-12-21 2006-12-21 イオンチャネルのモジュレーターとしての複素環誘導体

Country Status (15)

Country Link
US (4) US7799822B2 (https=)
EP (3) EP2308872A1 (https=)
JP (1) JP2009524591A (https=)
KR (1) KR20080081178A (https=)
CN (1) CN101365686A (https=)
AU (1) AU2006331608B2 (https=)
CA (1) CA2633653A1 (https=)
IL (1) IL192184A0 (https=)
NO (1) NO20083220L (https=)
NZ (2) NZ593074A (https=)
RU (1) RU2008129821A (https=)
SG (1) SG181209A1 (https=)
TW (1) TW200740803A (https=)
WO (1) WO2007075895A2 (https=)
ZA (1) ZA200805338B (https=)

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ATE527251T1 (de) * 2005-05-16 2011-10-15 Vertex Pharma Bicyclische derivate als modulatoren von ionenkanälen
MX2008003337A (es) * 2005-09-09 2008-09-26 Vertex Pharma Derivados biciclicos como modulares de canales ionicos regulados por voltaje.
EP1948597A1 (en) * 2005-10-21 2008-07-30 Vertex Pharmaceuticals Incorporated Derivatives for modulation of ion channels
AU2008256937A1 (en) 2007-05-25 2008-12-04 Vertex Pharmaceuticals Incorporated Ion channel modulators and methods of use
SA08290520B1 (ar) 2007-08-22 2012-02-22 استرازينيكا ايه بي مشتقات سيكلو بروبيل أميد وتركيبات صيدلية تحتوي عليها لعلاج حالة مرضية سببها مستقبلات هيستامين h3
US7994174B2 (en) * 2007-09-19 2011-08-09 Vertex Pharmaceuticals Incorporated Pyridyl sulfonamides as modulators of ion channels
CN101910166A (zh) * 2007-11-13 2010-12-08 沃泰克斯药物股份有限公司 用作钠离子通道调节剂的杂环衍生物
EP2231655B1 (en) 2007-11-13 2011-08-31 Vertex Pharmaceuticals Incorporated 4(-3-(-2-(phenyl)morpholino)-2-oxopyrrolidin-1-yl)-n-(thiazol-2-yl)benzenesulfonamide derivatives and related compounds as modulators of ion channels for the treatment of pain
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UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
RU2011103451A (ru) 2008-07-01 2012-08-10 Вертекс Фармасьютикалз Инкорпорейтед (Us) Гетероциклические производные в качестве модуляторов ионных каналов
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RU2012139082A (ru) 2010-02-18 2014-03-27 Астразенека Аб Способы получения производных циклопропиламида и связанных с ними промежуточных соединений
JP2014532660A (ja) * 2011-10-28 2014-12-08 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． 電位作動型ナトリウムチャネルにおける選択活性を有するベンゾオキサゾリノン化合物
EP2911668A4 (en) * 2012-10-26 2016-07-20 Merck Sharp & Dohme BENZOXAZOLINONE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-CONTROLLED SODIUM CHANNELS
WO2015031036A1 (en) * 2013-08-26 2015-03-05 Purdue Pharma L.P. Azaspiro[4.5] decane derivatives and use thereof
WO2015077905A1 (en) 2013-11-29 2015-06-04 Merck Sharp & Dohme Corp. Bicycloamine-substituted-n-benzenesulfonamide compounds with selective activity in voltage-gated sodium channels
KR102412146B1 (ko) 2015-02-11 2022-06-22 주식회사 아이엔테라퓨틱스 소디움 채널 차단제
WO2016177340A1 (zh) * 2015-05-05 2016-11-10 上海海雁医药科技有限公司 双环取代的苯磺酰胺衍生物、其制法与医药上的用途
TW201718557A (zh) * 2015-10-08 2017-06-01 歌林達有限公司 經吡唑基取代之四氫吡喃基碸
PL3458449T3 (pl) 2016-05-20 2025-06-23 Xenon Pharmaceuticals Inc. Związki benzenosulfonamidowe i ich zastosowanie jako środki terapeutyczne
WO2018093694A1 (en) * 2016-11-17 2018-05-24 Merck Sharp & Dohme Corp. Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels
CN110325531B (zh) 2016-12-09 2022-05-27 泽农医药公司 苯磺酰胺及其作为治疗剂的用途
EP3649108A1 (en) * 2017-07-03 2020-05-13 GlaxoSmithKline Intellectual Property Development Limited 2-(4-chlorophenoxy)-n-((1 -(2-(4-chlorophenoxy)ethynazetidin-3-yl)methyl)acetamide derivatives and related compounds as atf4 inhibitors for treating cancer and other diseases
US10745392B2 (en) 2018-06-13 2020-08-18 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
GB201810092D0 (en) 2018-06-20 2018-08-08 Ctxt Pty Ltd Compounds
GB201810581D0 (en) 2018-06-28 2018-08-15 Ctxt Pty Ltd Compounds
KR20210054510A (ko) 2018-08-31 2021-05-13 제논 파마슈티칼스 인크. 헤테로아릴-치환된 술폰아미드 화합물 및 치료제로서의 그의 용도
MA53488A (fr) 2018-08-31 2021-12-08 Xenon Pharmaceuticals Inc Composés de sulfonamide substitués par hétéroaryle et leur utilisation en tant qu'inhibiteurs de canaux sodiques
WO2020113094A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
KR102823056B1 (ko) 2019-06-18 2025-06-23 화이자 인코포레이티드 벤즈이속사졸 설폰아마이드 유도체
EP4210825A1 (en) * 2020-09-14 2023-07-19 Genzyme Corporation Compounds as modulators of bis-phosphoglycerate mutase for the treatment of sickle cell disease
WO2022265993A1 (en) 2021-06-14 2022-12-22 Scorpion Therapeutics, Inc. Urea derivatives which can be used to treat cancer
WO2023028056A1 (en) * 2021-08-24 2023-03-02 Genentech, Inc. 3-amino piperidyl sodium channel inhibitors
IL314330A (en) 2022-01-18 2024-09-01 Maze Therapeutics Inc Apol1 inhibitors and methods of use
WO2024249254A2 (en) * 2023-05-26 2024-12-05 Maze Therapeutics, Inc. Methods of using apol1 inhibitors
CN117326903B (zh) * 2023-09-27 2025-05-02 常州大学 一种高立体选择性合成n-烷基化吲哚衍生物的方法
WO2025096637A1 (en) * 2023-10-31 2025-05-08 Xenon Pharmaceuticals Inc. Substituted aryl sulfonamides for use as sodium channel inhibitors
CN117384091B (zh) * 2023-12-08 2024-02-20 四川大学华西第二医院 一类酰胺衍生物、合成方法及用途
WO2025245351A1 (en) * 2024-05-22 2025-11-27 Xenon Pharmaceuticals Inc. Substituted aryl sulfonamides and compositions and uses thereof

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JP4473764B2 (ja) * 2005-03-31 2010-06-02 タカラベルモント株式会社 椅子昇降用油圧装置
KR20080015102A (ko) 2005-05-10 2008-02-18 버텍스 파마슈티칼스 인코포레이티드 이온 채널 조절인자로서의 바이사이클릭 유도체
ATE527251T1 (de) 2005-05-16 2011-10-15 Vertex Pharma Bicyclische derivate als modulatoren von ionenkanälen
MX2007015726A (es) 2005-06-09 2008-03-04 Vertex Pharma Derivados de indano como moduladores de canales ionicos.
MX2008003337A (es) 2005-09-09 2008-09-26 Vertex Pharma Derivados biciclicos como modulares de canales ionicos regulados por voltaje.
RU2008118350A (ru) 2005-10-12 2009-11-20 Вертекс Фармасьютикалз Инкорпорейтед (Us) Бифенильные производные в качестве модуляторов потенциалзависимых ионных каналов
EP1948597A1 (en) 2005-10-21 2008-07-30 Vertex Pharmaceuticals Incorporated Derivatives for modulation of ion channels
US7994174B2 (en) 2007-09-19 2011-08-09 Vertex Pharmaceuticals Incorporated Pyridyl sulfonamides as modulators of ion channels

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