JP2009507851A5 - - Google Patents
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- Publication number
- JP2009507851A5 JP2009507851A5 JP2008530198A JP2008530198A JP2009507851A5 JP 2009507851 A5 JP2009507851 A5 JP 2009507851A5 JP 2008530198 A JP2008530198 A JP 2008530198A JP 2008530198 A JP2008530198 A JP 2008530198A JP 2009507851 A5 JP2009507851 A5 JP 2009507851A5
- Authority
- JP
- Japan
- Prior art keywords
- ring
- optionally substituted
- compound
- aliphatic
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- RLYUNPNLXMSXAX-UHFFFAOYSA-N Cc1cnc[s]1 Chemical compound Cc1cnc[s]1 RLYUNPNLXMSXAX-UHFFFAOYSA-N 0.000 description 1
- VZWOXDYRBDIHMA-UHFFFAOYSA-N Cc1ncc[s]1 Chemical compound Cc1ncc[s]1 VZWOXDYRBDIHMA-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71598005P | 2005-09-09 | 2005-09-09 | |
| PCT/US2006/034857 WO2007030618A2 (en) | 2005-09-09 | 2006-09-08 | Bicyclic derivatives as modulators of voltage gated ion channels |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009507851A JP2009507851A (ja) | 2009-02-26 |
| JP2009507851A5 true JP2009507851A5 (https=) | 2009-10-15 |
Family
ID=37686027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008530198A Pending JP2009507851A (ja) | 2005-09-09 | 2006-09-08 | 電位型イオンチャネルの調節因子としての二環式誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US7855220B2 (https=) |
| EP (1) | EP1928871A2 (https=) |
| JP (1) | JP2009507851A (https=) |
| KR (1) | KR20080044910A (https=) |
| CN (1) | CN101300253B (https=) |
| AU (1) | AU2006287480B2 (https=) |
| CA (1) | CA2622076A1 (https=) |
| IL (1) | IL190017A0 (https=) |
| MX (1) | MX2008003337A (https=) |
| NO (1) | NO20081725L (https=) |
| NZ (1) | NZ567132A (https=) |
| RU (1) | RU2008113836A (https=) |
| WO (1) | WO2007030618A2 (https=) |
| ZA (1) | ZA200802977B (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7491827B2 (en) * | 2002-12-23 | 2009-02-17 | Millennium Pharmaceuticals, Inc. | Aryl sulfonamides useful as inhibitors of chemokine receptor activity |
| US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| KR20080015102A (ko) * | 2005-05-10 | 2008-02-18 | 버텍스 파마슈티칼스 인코포레이티드 | 이온 채널 조절인자로서의 바이사이클릭 유도체 |
| ATE527251T1 (de) * | 2005-05-16 | 2011-10-15 | Vertex Pharma | Bicyclische derivate als modulatoren von ionenkanälen |
| MX2008003337A (es) * | 2005-09-09 | 2008-09-26 | Vertex Pharma | Derivados biciclicos como modulares de canales ionicos regulados por voltaje. |
| EP1948597A1 (en) * | 2005-10-21 | 2008-07-30 | Vertex Pharmaceuticals Incorporated | Derivatives for modulation of ion channels |
| NZ593074A (en) | 2005-12-21 | 2012-04-27 | Vertex Pharma | sulfonamide-pyrrolidone derivatives as Modulators of Ion Channels |
| AU2008256937A1 (en) | 2007-05-25 | 2008-12-04 | Vertex Pharmaceuticals Incorporated | Ion channel modulators and methods of use |
| US7994174B2 (en) * | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
| CN101910166A (zh) * | 2007-11-13 | 2010-12-08 | 沃泰克斯药物股份有限公司 | 用作钠离子通道调节剂的杂环衍生物 |
| EP2231655B1 (en) | 2007-11-13 | 2011-08-31 | Vertex Pharmaceuticals Incorporated | 4(-3-(-2-(phenyl)morpholino)-2-oxopyrrolidin-1-yl)-n-(thiazol-2-yl)benzenesulfonamide derivatives and related compounds as modulators of ion channels for the treatment of pain |
| WO2009133641A1 (ja) * | 2008-04-30 | 2009-11-05 | シャープ株式会社 | 照明装置、及び表示装置 |
| RU2011103451A (ru) * | 2008-07-01 | 2012-08-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Гетероциклические производные в качестве модуляторов ионных каналов |
| BRPI0913879A2 (pt) * | 2008-07-02 | 2019-09-24 | Hoffmann La Roche | fenilpirazinonas como inibidores de quinase |
| EP2323482A4 (en) * | 2008-08-06 | 2011-08-17 | Merck & Co Inc | SUBSTITUTED DIHYDROISOCHINOLINONE AND ISOCHINOLINDION DERIVATIVES AS CALCIUM CHANNEL BLOCKERS |
| KR102295748B1 (ko) | 2013-01-31 | 2021-09-01 | 버텍스 파마슈티칼스 인코포레이티드 | 나트륨 채널의 조절제로서의 피리돈 아미드 |
| AU2019302534B2 (en) | 2018-07-09 | 2024-10-03 | Lieber Institute, Inc. | Pyridazine compounds for inhibiting NaV1.8 |
| AU2019301628C1 (en) | 2018-07-09 | 2025-02-06 | Lieber Institute, Inc. | Pyridine carboxamide compounds for inhibiting NaV1.8 |
| CN114901642B (zh) * | 2019-12-30 | 2024-02-23 | 武汉朗来科技发展有限公司 | 一种稠环化合物及其应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5378715A (en) * | 1992-02-24 | 1995-01-03 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
| TWI234557B (en) | 1999-05-26 | 2005-06-21 | Telik Inc | Novel naphthalene ureas as glucose uptake enhancers |
| JP2003055209A (ja) * | 2001-07-31 | 2003-02-26 | Bayer Ag | フェニルナフチル尿素誘導体 |
| WO2003097586A1 (en) * | 2002-05-17 | 2003-11-27 | Janssen Pharmaceutica N.V. | Aminotetralin-derived urea modulators of vanilloid vr1 receptor |
| US7491827B2 (en) * | 2002-12-23 | 2009-02-17 | Millennium Pharmaceuticals, Inc. | Aryl sulfonamides useful as inhibitors of chemokine receptor activity |
| US7615563B2 (en) * | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| US8202861B2 (en) * | 2003-08-08 | 2012-06-19 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of voltage-gated sodium channels |
| KR20080015102A (ko) * | 2005-05-10 | 2008-02-18 | 버텍스 파마슈티칼스 인코포레이티드 | 이온 채널 조절인자로서의 바이사이클릭 유도체 |
| ATE527251T1 (de) * | 2005-05-16 | 2011-10-15 | Vertex Pharma | Bicyclische derivate als modulatoren von ionenkanälen |
| MX2007015726A (es) * | 2005-06-09 | 2008-03-04 | Vertex Pharma | Derivados de indano como moduladores de canales ionicos. |
| MX2008003337A (es) * | 2005-09-09 | 2008-09-26 | Vertex Pharma | Derivados biciclicos como modulares de canales ionicos regulados por voltaje. |
| RU2008118350A (ru) | 2005-10-12 | 2009-11-20 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Бифенильные производные в качестве модуляторов потенциалзависимых ионных каналов |
| EP1948597A1 (en) * | 2005-10-21 | 2008-07-30 | Vertex Pharmaceuticals Incorporated | Derivatives for modulation of ion channels |
| NZ593074A (en) * | 2005-12-21 | 2012-04-27 | Vertex Pharma | sulfonamide-pyrrolidone derivatives as Modulators of Ion Channels |
| US8293450B2 (en) * | 2006-11-28 | 2012-10-23 | Hewlett-Packard Development Company, L.P. | Laser imaging coating and methods for imaging |
| AU2008256937A1 (en) * | 2007-05-25 | 2008-12-04 | Vertex Pharmaceuticals Incorporated | Ion channel modulators and methods of use |
| US7994174B2 (en) * | 2007-09-19 | 2011-08-09 | Vertex Pharmaceuticals Incorporated | Pyridyl sulfonamides as modulators of ion channels |
| CN101910166A (zh) | 2007-11-13 | 2010-12-08 | 沃泰克斯药物股份有限公司 | 用作钠离子通道调节剂的杂环衍生物 |
| EP2231655B1 (en) * | 2007-11-13 | 2011-08-31 | Vertex Pharmaceuticals Incorporated | 4(-3-(-2-(phenyl)morpholino)-2-oxopyrrolidin-1-yl)-n-(thiazol-2-yl)benzenesulfonamide derivatives and related compounds as modulators of ion channels for the treatment of pain |
| RU2011103451A (ru) * | 2008-07-01 | 2012-08-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Гетероциклические производные в качестве модуляторов ионных каналов |
-
2006
- 2006-09-08 MX MX2008003337A patent/MX2008003337A/es not_active Application Discontinuation
- 2006-09-08 NZ NZ567132A patent/NZ567132A/en not_active IP Right Cessation
- 2006-09-08 JP JP2008530198A patent/JP2009507851A/ja active Pending
- 2006-09-08 WO PCT/US2006/034857 patent/WO2007030618A2/en not_active Ceased
- 2006-09-08 US US11/517,754 patent/US7855220B2/en active Active
- 2006-09-08 KR KR1020087008510A patent/KR20080044910A/ko not_active Withdrawn
- 2006-09-08 CN CN2006800406004A patent/CN101300253B/zh not_active Expired - Fee Related
- 2006-09-08 AU AU2006287480A patent/AU2006287480B2/en not_active Expired - Fee Related
- 2006-09-08 CA CA002622076A patent/CA2622076A1/en not_active Abandoned
- 2006-09-08 RU RU2008113836/04A patent/RU2008113836A/ru not_active Application Discontinuation
- 2006-09-08 EP EP06803117A patent/EP1928871A2/en not_active Withdrawn
- 2006-09-08 ZA ZA200802977A patent/ZA200802977B/xx unknown
-
2008
- 2008-03-09 IL IL190017A patent/IL190017A0/en unknown
- 2008-04-09 NO NO20081725A patent/NO20081725L/no not_active Application Discontinuation
-
2010
- 2010-11-03 US US12/938,556 patent/US8236829B2/en active Active
-
2012
- 2012-06-29 US US13/537,903 patent/US8357702B2/en active Active
-
2013
- 2013-01-21 US US13/745,919 patent/US8492403B2/en not_active Expired - Fee Related
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