JP2009523770A5 - - Google Patents
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- Publication number
- JP2009523770A5 JP2009523770A5 JP2008550785A JP2008550785A JP2009523770A5 JP 2009523770 A5 JP2009523770 A5 JP 2009523770A5 JP 2008550785 A JP2008550785 A JP 2008550785A JP 2008550785 A JP2008550785 A JP 2008550785A JP 2009523770 A5 JP2009523770 A5 JP 2009523770A5
- Authority
- JP
- Japan
- Prior art keywords
- taxane
- solid composition
- surfactant
- formulation
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229940123237 Taxane Drugs 0.000 claims 27
- 239000000203 mixture Substances 0.000 claims 26
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 26
- 239000008247 solid mixture Substances 0.000 claims 20
- 239000004094 surface-active agent Substances 0.000 claims 13
- 238000002360 preparation method Methods 0.000 claims 12
- 238000009472 formulation Methods 0.000 claims 10
- 239000003960 organic solvent Substances 0.000 claims 9
- 229920000642 polymer Polymers 0.000 claims 7
- 239000000243 solution Substances 0.000 claims 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 5
- 239000003921 oil Substances 0.000 claims 5
- 239000003755 preservative agent Substances 0.000 claims 5
- 239000008137 solubility enhancer Substances 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 claims 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 4
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 4
- 229960003668 docetaxel Drugs 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 241000282412 Homo Species 0.000 claims 3
- 229930012538 Paclitaxel Natural products 0.000 claims 3
- 150000004200 baccatin III derivatives Chemical class 0.000 claims 3
- 150000004677 hydrates Chemical class 0.000 claims 3
- 229960001592 paclitaxel Drugs 0.000 claims 3
- 230000002335 preservative effect Effects 0.000 claims 3
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 2
- 101000656751 Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) 30S ribosomal protein S24e Proteins 0.000 claims 2
- 238000004108 freeze drying Methods 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- JVKUCNQGESRUCL-UHFFFAOYSA-N 2-Hydroxyethyl 12-hydroxyoctadecanoate Chemical compound CCCCCCC(O)CCCCCCCCCCC(=O)OCCO JVKUCNQGESRUCL-UHFFFAOYSA-N 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- SHBUUTHKGIVMJT-UHFFFAOYSA-N Hydroxystearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OO SHBUUTHKGIVMJT-UHFFFAOYSA-N 0.000 claims 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 229920001304 Solutol HS 15 Polymers 0.000 claims 1
- 239000004359 castor oil Substances 0.000 claims 1
- 235000019438 castor oil Nutrition 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 230000008014 freezing Effects 0.000 claims 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 1
- 229940072106 hydroxystearate Drugs 0.000 claims 1
- -1 includes Solutol® Substances 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 239000003978 infusion fluid Substances 0.000 claims 1
- 239000007972 injectable composition Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 229960003511 macrogol Drugs 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- 230000010412 perfusion Effects 0.000 claims 1
- 229960000502 poloxamer Drugs 0.000 claims 1
- 229920001983 poloxamer Polymers 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AR20060100208A AR054215A1 (es) | 2006-01-20 | 2006-01-20 | Una formulacion farmaceutica de un taxano, una composicion solida de un taxano liofilizado a partir de una solucion de acido acetico, un procedimiento para la preparacion de dicha composicion solida de un taxano, una composicion solubilizante de un taxano liofilizado, y un conjunto de elementos (kit |
| PCT/ES2007/070012 WO2007082978A1 (es) | 2006-01-20 | 2007-01-18 | Una formulación farmacéutica de taxano, una composición sólida de taxano, un procedimiento para la preparación de dicha composición sólida de taxano, una composición solubilizante de dicha composición sólida de taxano, y un conjunto de elementos (kit) par |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009523770A JP2009523770A (ja) | 2009-06-25 |
| JP2009523770A5 true JP2009523770A5 (https=) | 2010-02-25 |
Family
ID=38134453
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008550785A Pending JP2009523770A (ja) | 2006-01-20 | 2007-01-18 | タキサン医薬製剤、固形タキサン組成物、前記固形タキサン組成物の調製方法、前記固形タキサン組成物を可溶化するための組成物および注射可能なタキサン製剤のための構成要素のセット（キット） |
| JP2008550786A Abandoned JP2009523771A (ja) | 2006-01-20 | 2007-01-19 | 凍結乾燥した個体状タキサン類組成物、前記組成物を生成する方法、前記組成物の医薬調剤、前記組成物の調剤用キット。 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008550786A Abandoned JP2009523771A (ja) | 2006-01-20 | 2007-01-19 | 凍結乾燥した個体状タキサン類組成物、前記組成物を生成する方法、前記組成物の医薬調剤、前記組成物の調剤用キット。 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20090215883A1 (https=) |
| EP (2) | EP1994925A4 (https=) |
| JP (2) | JP2009523770A (https=) |
| AR (1) | AR054215A1 (https=) |
| AU (1) | AU2007206877A1 (https=) |
| BR (2) | BRPI0706931A2 (https=) |
| CA (2) | CA2637893A1 (https=) |
| GT (2) | GT200800146A (https=) |
| MX (2) | MX2008009358A (https=) |
| NZ (2) | NZ569783A (https=) |
| PE (2) | PE20071243A1 (https=) |
| RU (1) | RU2429837C2 (https=) |
| UY (2) | UY30099A1 (https=) |
| WO (2) | WO2007082978A1 (https=) |
| ZA (2) | ZA200805704B (https=) |
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-
2006
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-
2007
- 2007-01-18 RU RU2008133761/15A patent/RU2429837C2/ru not_active IP Right Cessation
- 2007-01-18 US US12/161,625 patent/US20090215883A1/en not_active Abandoned
- 2007-01-18 WO PCT/ES2007/070012 patent/WO2007082978A1/es not_active Ceased
- 2007-01-18 EP EP07712569A patent/EP1994925A4/en not_active Withdrawn
- 2007-01-18 CA CA002637893A patent/CA2637893A1/en not_active Abandoned
- 2007-01-18 NZ NZ569783A patent/NZ569783A/en not_active IP Right Cessation
- 2007-01-18 BR BRPI0706931-6A patent/BRPI0706931A2/pt not_active IP Right Cessation
- 2007-01-18 MX MX2008009358A patent/MX2008009358A/es unknown
- 2007-01-18 JP JP2008550785A patent/JP2009523770A/ja active Pending
- 2007-01-19 EP EP07712570A patent/EP1982699A1/en not_active Withdrawn
- 2007-01-19 US US12/161,609 patent/US20090215882A1/en not_active Abandoned
- 2007-01-19 PE PE2007000063A patent/PE20071243A1/es not_active Application Discontinuation
- 2007-01-19 NZ NZ569968A patent/NZ569968A/en not_active IP Right Cessation
- 2007-01-19 UY UY30099A patent/UY30099A1/es not_active Application Discontinuation
- 2007-01-19 PE PE2007000062A patent/PE20070945A1/es not_active Application Discontinuation
- 2007-01-19 AU AU2007206877A patent/AU2007206877A1/en not_active Abandoned
- 2007-01-19 MX MX2008009357A patent/MX2008009357A/es not_active Application Discontinuation
- 2007-01-19 JP JP2008550786A patent/JP2009523771A/ja not_active Abandoned
- 2007-01-19 WO PCT/ES2007/070013 patent/WO2007082979A1/es not_active Ceased
- 2007-01-19 CA CA002638034A patent/CA2638034A1/en not_active Abandoned
- 2007-01-19 UY UY30100A patent/UY30100A1/es not_active Application Discontinuation
- 2007-01-19 BR BRPI0706932-4A patent/BRPI0706932A2/pt not_active IP Right Cessation
- 2007-01-19 ZA ZA200805704A patent/ZA200805704B/xx unknown
-
2008
- 2008-07-09 ZA ZA200805989A patent/ZA200805989B/xx unknown
- 2008-07-18 GT GT200800146A patent/GT200800146A/es unknown
- 2008-07-18 GT GT200800145A patent/GT200800145A/es unknown
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