PE20070945A1 - Una formulacion farmaceutica de taxano, una composicion solida de taxano, un procedimiento para la preparacion de dicha composicion solida de taxano, una composicion solubilizante de dicha composicion solida de taxano, y un conjunto de elementos (kit - Google Patents
Una formulacion farmaceutica de taxano, una composicion solida de taxano, un procedimiento para la preparacion de dicha composicion solida de taxano, una composicion solubilizante de dicha composicion solida de taxano, y un conjunto de elementos (kitInfo
- Publication number
- PE20070945A1 PE20070945A1 PE2007000062A PE2007000062A PE20070945A1 PE 20070945 A1 PE20070945 A1 PE 20070945A1 PE 2007000062 A PE2007000062 A PE 2007000062A PE 2007000062 A PE2007000062 A PE 2007000062A PE 20070945 A1 PE20070945 A1 PE 20070945A1
- Authority
- PE
- Peru
- Prior art keywords
- taxane
- composition
- solid composition
- lyofilized
- pharmaceutical formulation
- Prior art date
Links
- 229940123237 Taxane Drugs 0.000 title abstract 10
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title abstract 10
- 239000000203 mixture Substances 0.000 title abstract 8
- 239000008247 solid mixture Substances 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 230000003381 solubilizing effect Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 1
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 abstract 1
- 229960003668 docetaxel Drugs 0.000 abstract 1
- 230000008014 freezing Effects 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 229960003511 macrogol Drugs 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 239000002244 precipitate Substances 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AR20060100208A AR054215A1 (es) | 2006-01-20 | 2006-01-20 | Una formulacion farmaceutica de un taxano, una composicion solida de un taxano liofilizado a partir de una solucion de acido acetico, un procedimiento para la preparacion de dicha composicion solida de un taxano, una composicion solubilizante de un taxano liofilizado, y un conjunto de elementos (kit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20070945A1 true PE20070945A1 (es) | 2007-10-07 |
Family
ID=38134453
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000062A PE20070945A1 (es) | 2006-01-20 | 2007-01-19 | Una formulacion farmaceutica de taxano, una composicion solida de taxano, un procedimiento para la preparacion de dicha composicion solida de taxano, una composicion solubilizante de dicha composicion solida de taxano, y un conjunto de elementos (kit |
| PE2007000063A PE20071243A1 (es) | 2006-01-20 | 2007-01-19 | Una composicion solida de taxano liofilizada, un procedimiento para preparar dicha composicion solida, una formulacion farmaceutica y un conjunto (kit) para la preparacion de una formulacion inyectable de taxano |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000063A PE20071243A1 (es) | 2006-01-20 | 2007-01-19 | Una composicion solida de taxano liofilizada, un procedimiento para preparar dicha composicion solida, una formulacion farmaceutica y un conjunto (kit) para la preparacion de una formulacion inyectable de taxano |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20090215883A1 (https=) |
| EP (2) | EP1994925A4 (https=) |
| JP (2) | JP2009523770A (https=) |
| AR (1) | AR054215A1 (https=) |
| AU (1) | AU2007206877A1 (https=) |
| BR (2) | BRPI0706931A2 (https=) |
| CA (2) | CA2637893A1 (https=) |
| GT (2) | GT200800146A (https=) |
| MX (2) | MX2008009358A (https=) |
| NZ (2) | NZ569783A (https=) |
| PE (2) | PE20070945A1 (https=) |
| RU (1) | RU2429837C2 (https=) |
| UY (2) | UY30100A1 (https=) |
| WO (2) | WO2007082978A1 (https=) |
| ZA (2) | ZA200805704B (https=) |
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| KR100573289B1 (ko) | 2002-07-20 | 2006-04-24 | 대화제약 주식회사 | 방광내 투여를 통한 방광암치료용 파클리탁셀 조성물 및그의 제조 방법 |
| KR100508518B1 (ko) | 2002-11-13 | 2005-08-17 | 한미약품 주식회사 | 초임계유체 공정을 이용한 파클리탁셀 고체분산체의 제조방법 및 이 방법으로 제조된 파클리탁셀 고체분산체 |
| US6759539B1 (en) * | 2003-02-27 | 2004-07-06 | Chaichem Pharmaceuticals International | Process for isolation and purification of paclitaxel from natural sources |
| US20040247624A1 (en) | 2003-06-05 | 2004-12-09 | Unger Evan Charles | Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility |
| US20050152979A1 (en) | 2003-09-05 | 2005-07-14 | Cell Therapeutics, Inc. | Hydrophobic drug compositions containing reconstitution enhancer |
| KR20050099311A (ko) * | 2004-04-09 | 2005-10-13 | 에이엔에이치 케어연구소(주) | 주사제용 항암제 조성물 |
| US7345093B2 (en) * | 2004-04-27 | 2008-03-18 | Formatech, Inc. | Methods of enhancing solubility of compounds |
| US8158152B2 (en) * | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
| BRPI0600194A (pt) * | 2006-01-30 | 2007-10-23 | Quiral Quimica Do Brasil S A | composições farmacêuticas contendo docetaxel e um inibidor de degradação e processo de obtenção das mesmas |
| CN1850056A (zh) * | 2006-03-06 | 2006-10-25 | 杨典忠 | 多西他赛冻干粉针及其制备方法 |
| AR063111A1 (es) * | 2007-10-03 | 2008-12-30 | Eriochem Sa | Una formulacion farmaceutica de taxano |
-
2006
- 2006-01-20 AR AR20060100208A patent/AR054215A1/es unknown
-
2007
- 2007-01-18 MX MX2008009358A patent/MX2008009358A/es unknown
- 2007-01-18 CA CA002637893A patent/CA2637893A1/en not_active Abandoned
- 2007-01-18 JP JP2008550785A patent/JP2009523770A/ja active Pending
- 2007-01-18 BR BRPI0706931-6A patent/BRPI0706931A2/pt not_active IP Right Cessation
- 2007-01-18 EP EP07712569A patent/EP1994925A4/en not_active Withdrawn
- 2007-01-18 WO PCT/ES2007/070012 patent/WO2007082978A1/es not_active Ceased
- 2007-01-18 RU RU2008133761/15A patent/RU2429837C2/ru not_active IP Right Cessation
- 2007-01-18 US US12/161,625 patent/US20090215883A1/en not_active Abandoned
- 2007-01-18 NZ NZ569783A patent/NZ569783A/en not_active IP Right Cessation
- 2007-01-19 BR BRPI0706932-4A patent/BRPI0706932A2/pt not_active IP Right Cessation
- 2007-01-19 UY UY30100A patent/UY30100A1/es not_active Application Discontinuation
- 2007-01-19 WO PCT/ES2007/070013 patent/WO2007082979A1/es not_active Ceased
- 2007-01-19 US US12/161,609 patent/US20090215882A1/en not_active Abandoned
- 2007-01-19 AU AU2007206877A patent/AU2007206877A1/en not_active Abandoned
- 2007-01-19 PE PE2007000062A patent/PE20070945A1/es not_active Application Discontinuation
- 2007-01-19 CA CA002638034A patent/CA2638034A1/en not_active Abandoned
- 2007-01-19 MX MX2008009357A patent/MX2008009357A/es not_active Application Discontinuation
- 2007-01-19 PE PE2007000063A patent/PE20071243A1/es not_active Application Discontinuation
- 2007-01-19 JP JP2008550786A patent/JP2009523771A/ja not_active Abandoned
- 2007-01-19 UY UY30099A patent/UY30099A1/es not_active Application Discontinuation
- 2007-01-19 EP EP07712570A patent/EP1982699A1/en not_active Withdrawn
- 2007-01-19 ZA ZA200805704A patent/ZA200805704B/xx unknown
- 2007-01-19 NZ NZ569968A patent/NZ569968A/en not_active IP Right Cessation
-
2008
- 2008-07-09 ZA ZA200805989A patent/ZA200805989B/xx unknown
- 2008-07-18 GT GT200800146A patent/GT200800146A/es unknown
- 2008-07-18 GT GT200800145A patent/GT200800145A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2008133761A (ru) | 2010-02-27 |
| MX2008009358A (es) | 2008-09-10 |
| JP2009523771A (ja) | 2009-06-25 |
| NZ569968A (en) | 2011-07-29 |
| PE20071243A1 (es) | 2008-02-03 |
| BRPI0706932A2 (pt) | 2011-04-19 |
| BRPI0706931A2 (pt) | 2011-04-19 |
| MX2008009357A (es) | 2008-09-10 |
| RU2429837C2 (ru) | 2011-09-27 |
| AU2007206877A1 (en) | 2007-07-26 |
| ZA200805989B (en) | 2009-05-27 |
| CA2637893A1 (en) | 2007-07-26 |
| GT200800146A (es) | 2008-12-15 |
| WO2007082978A1 (es) | 2007-07-26 |
| ZA200805704B (en) | 2009-11-25 |
| US20090215882A1 (en) | 2009-08-27 |
| UY30099A1 (es) | 2008-09-02 |
| AR054215A1 (es) | 2007-06-13 |
| EP1982699A1 (en) | 2008-10-22 |
| UY30100A1 (es) | 2008-09-02 |
| GT200800145A (es) | 2009-07-21 |
| CA2638034A1 (en) | 2007-07-26 |
| EP1994925A1 (en) | 2008-11-26 |
| NZ569783A (en) | 2011-04-29 |
| EP1994925A4 (en) | 2013-01-23 |
| WO2007082979A1 (es) | 2007-07-26 |
| JP2009523770A (ja) | 2009-06-25 |
| WO2007082978B1 (es) | 2007-09-07 |
| US20090215883A1 (en) | 2009-08-27 |
| AU2007206876A1 (en) | 2007-07-26 |
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