JP2009521931A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009521931A5 JP2009521931A5 JP2008548747A JP2008548747A JP2009521931A5 JP 2009521931 A5 JP2009521931 A5 JP 2009521931A5 JP 2008548747 A JP2008548747 A JP 2008548747A JP 2008548747 A JP2008548747 A JP 2008548747A JP 2009521931 A5 JP2009521931 A5 JP 2009521931A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- compound
- heterocycle
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 21
- 150000001875 compounds Chemical group 0.000 claims 19
- 125000003118 aryl group Chemical group 0.000 claims 15
- 125000000623 heterocyclic group Chemical group 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 13
- 125000001424 substituent group Chemical group 0.000 claims 12
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 10
- -1 hydrate Substances 0.000 claims 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims 9
- 108010055717 JNK Mitogen-Activated Protein Kinases Proteins 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 7
- 239000003112 inhibitor Substances 0.000 claims 7
- 230000002401 inhibitory effect Effects 0.000 claims 7
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 6
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 6
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
- 125000004432 carbon atoms Chemical group C* 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 230000002519 immonomodulatory Effects 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000011780 sodium chloride Substances 0.000 claims 6
- 239000012453 solvate Substances 0.000 claims 6
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 210000000130 stem cell Anatomy 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 2
- 125000004423 acyloxy group Chemical group 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 239000000158 apoptosis inhibitor Substances 0.000 claims 2
- 125000004429 atoms Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000004963 sulfonylalkyl group Chemical group 0.000 claims 2
- 125000004001 thioalkyl group Chemical group 0.000 claims 2
- 125000001989 1,3-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([H])C([*:2])=C1[H] 0.000 claims 1
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 claims 1
- GQBONCZDJQXPLV-UHFFFAOYSA-N 4-aminoisoindole-1,3-dione Chemical compound NC1=CC=CC2=C1C(=O)NC2=O GQBONCZDJQXPLV-UHFFFAOYSA-N 0.000 claims 1
- KNCYXPMJDCCGSJ-UHFFFAOYSA-N Glutarimide Chemical compound O=C1CCCC(=O)N1 KNCYXPMJDCCGSJ-UHFFFAOYSA-N 0.000 claims 1
- GOTYRUGSSMKFNF-UHFFFAOYSA-N Lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims 1
- UVSMNLNDYGZFPF-UHFFFAOYSA-N Pomalidomide Chemical compound O=C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O UVSMNLNDYGZFPF-UHFFFAOYSA-N 0.000 claims 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 1
- 125000001118 alkylidene group Chemical group 0.000 claims 1
- 125000002431 aminoalkoxy group Chemical group 0.000 claims 1
- 125000001691 aryl alkyl amino group Chemical group 0.000 claims 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 1
- 125000001769 aryl amino group Chemical group 0.000 claims 1
- 125000005418 aryl aryl group Chemical group 0.000 claims 1
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000005605 benzo group Chemical group 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 1
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 1
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000005842 heteroatoms Chemical group 0.000 claims 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 230000000051 modifying Effects 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Claims (14)
- 幹細胞を単離する方法であって、前記幹細胞と、アポトーシス阻害剤を含む溶液とを接触させること、及び前記幹細胞を単離することを含む、前記方法。
- 前記アポトーシス阻害剤がc-Jun N末端キナーゼ(JNK)阻害剤である、請求項1記載の方法。
- 前記JNK阻害剤が前記単離前に前記幹細胞の分化又は増殖を調節しない、請求項2記載の方法。
- 前記JNK阻害剤がインダゾールである、請求項2記載の方法。
- 前記JNK阻害剤が以下の構造を有する化合物、又はその医薬として許容し得る塩、水和物、溶媒和物、包接化合物、鏡像異性体、ジアステレオ異性体、ラセミ体、若しくは立体異性体の混合物である、請求項2記載の方法:
Aは、直接結合、-(CH2)a-、-(CH2)bCH=CH(CH2)c-又は-(CH2)bC≡C(CH2)c-であり;
R1は、それぞれR3から独立に選択される1から4つの置換基で場合により置換された
アリール、ヘテロアリール、又はフェニルに縮合した複素環であり;
R2は、-R3、-R4、-(CH2)bC(=O)R5、-(CH2)bC(=O)OR5、-(CH2)bC(=O)NR5R6、-(CH2)bC(=O)NR5(CH2)cC(=O)R6、-(CH2)bNR5C(=O)R6、-(CH2)bNR5C(=O)NR6R7、-(CH2)bNR5R6、-(CH2)bOR5、-(CH2)bSOdR5又は-(CH2)bSO2NR5R6であり;
aは、1、2、3、4、5又は6であり;
b及びcは、同一又は異なっており、それぞれ出現するごとに独立に、0、1、2、3又は4から独立に選択され;
dは、それぞれ出現するごとに、0、1又は2であり;
R3は、それぞれ出現するごとに独立に、ハロゲン、ヒドロキシ、カルボキシ、アルキル、アルコキシ、ハロアルキル、アシルオキシ、チオアルキル、スルフィニルアルキル、スルホニルアルキル、ヒドロキシアルキル、アリール、アリールアルキル、複素環、ヘテロシクロアルキル、-C(=O)OR8、-OC(=O)R8、-C(=O)NR8R9、-C(=O)NR8OR9、-SO2NR8R9、-NR8SO2R9、-CN、-NO2、-NR8R9、-NR8C(=O)R9、-NR8C(=O)(CH2)bOR9、-NR8C(=O)(CH2)bR9、-O(CH2)bNR8R9、又はフェニルに縮合した複素環であり;
R4は、それぞれR3から独立に選択される1から4つの置換基で場合により置換されたアルキル、アリール、アリールアルキル、複素環又はヘテロシクロアルキルであり、或いはR4は、ハロゲン又はヒドロキシであり;
R5、R6及びR7は、同一又は異なっており、それぞれ出現するごとに独立に、水素、アルキル、アリール、アリールアルキル、複素環又はヘテロシクロアルキルであり、R5、R6及びR7の各々は、R3から独立に選択される1から4つの置換基で場合により置換されており;
R8及びR9は、同一又は異なっており、それぞれ出現するごとに独立に、水素、アルキル、アリール、アリールアルキル、複素環又はヘテロシクロアルキルであり、或いはR8及びR9は、それらが結合した1個以上の原子と一緒になって、複素環を形成し、R8、R9、並びに一緒になって複素環を形成するR8及びR9の各々は、R3から独立に選択される1から4つの置換基で場合により置換されている)。 - 前記JNK阻害剤が以下の構造を有する化合物、又はその医薬として許容し得る塩、水和物、溶媒和物、包接化合物、鏡像異性体、ジアステレオ異性体、ラセミ体、若しくは立体異性体の混合物である、請求項2記載の方法:
R1は、R7から独立に選択される1から4つの置換基で場合により置換された
アリール又はヘテロアリールであり;
R2は、水素であり;
R3は、水素又は低級アルキルであり;
R4は、1から4つの随意の置換基を表し、各置換基は、同一又は異なっており、ハロゲン、ヒドロキシ、低級アルキル及び低級アルコキシから独立に選択され;
R5及びR6は、同一又は異なっており、独立に、-R8、-(CH2)aC(=O)R9、-(CH2)aC(=O)OR9、-(CH2)aC(=O)NR9R10、-(CH2)aC(=O)NR9(CH2)bC(=O)R10、-(CH2)aNR9C(=O)R10、-(CH2)aNR11C(=O)NR9R10、-(CH2)aNR9R10、-(CH2)aOR9、-(CH2)aSOcR9又は-(CH2)aSO2NR9R10であり;
或いはR5及びR6は、それらが結合した窒素原子と一緒になって、複素環又は置換複素環を形成し;
R7は、それぞれ出現するごとに独立に、ハロゲン、ヒドロキシ、シアノ、ニトロ、カルボキシ、アルキル、アルコキシ、ハロアルキル、アシルオキシ、チオアルキル、スルフィニルアルキル、スルホニルアルキル、ヒドロキシアルキル、アリール、アリールアルキル、複素環、置換複素環、ヘテロシクロアルキル、-C(=O)OR8、-OC(=O)R8、-C(=O)NR8R9、-C(=O)NR8OR9、-SOcR8、-SOcNR8R9、-NR8SOcR9、-NR8R9、-NR8C(=O)R9、-NR8C(=O)(CH2)bOR9、-NR8C(=O)(CH2)bR9、-O(CH2)bNR8R9、又はフェニルに縮合した複素環であり;
R8、R9、R10及びR11は、同一又は異なっており、それぞれ出現するごとに独立に、水素、アルキル、アリール、アリールアルキル、複素環、ヘテロシクロアルキルであり;
或いはR8及びR9は、それらが結合した1個以上の原子と一緒になって、複素環を形成し;
a及びbは、同一又は異なっており、それぞれ出現するごとに、0、1、2、3又は4から独立に選択され;
cは、それぞれ出現するごとに、0、1又は2である)。 - 前記JNK阻害剤が以下の構造を有する化合物、又はその医薬として許容し得る塩、水和物、溶媒和物、包接化合物、鏡像異性体、ジアステレオ異性体、ラセミ体、若しくは立体異性体の混合物である、請求項2記載の方法:
R0は、-O-、-S-、-S(O)-、-S(O)2-、NH又は-CH2-であり;
構造(III)の化合物は、(i)非置換であり、(ii)一置換され、第1の置換基を有し、又は(iii)二置換され、第1の置換基及び第2の置換基を有し;
第1及び第2の置換基は、存在する場合は、3、4、5、7、8、9又は10位に存在し、第1及び第2の置換基は、存在する場合は、独立に、アルキル、ヒドロキシ、ハロゲン、ニトロ、トリフルオロメチル、スルホニル、カルボキシル、アルコキシカルボニル、アルコキシ、アリール、アリールオキシ、アリールアルキルオキシ、アリールアルキル、シクロアルキルアルキルオキシ、シクロアルキルオキシ、アルコキシアルキル、アルコキシアルコキシ、アミノアルコキシ、モノ-アルキルアミノアルコキシ、ジ-アルキルアミノアルコキシ、又は構造(a)、(b)、(c)、(d)、(e)又は(f):
R3及びR4は、一緒になって、アルキリデン又はヘテロ原子含有環式アルキリデンを表し、或いはR3及びR4は、独立に、水素、アルキル、シクロアルキル、アリール、アリールアルキル、シクロアルキルアルキル、アリールオキシアルキル、アルコキシアルキル、アミノアルキル、モノ-アルキルアミノアルキル又はジ-アルキルアミノアルキルであり;
R5は、水素、アルキル、シクロアルキル、アリール、アリールアルキル、シクロアルキルアルキル、アルコキシ、アルコキシアルキル、アルコキシカルボニルアルキル、アミノ、モノ-アルキルアミノ、ジ-アルキルアミノ、アリールアミノ、アリールアルキルアミノ、シクロアルキルアミノ、シクロアルキルアルキルアミノ、アミノアルキル、モノ-アルキルアミノアルキル又はジ-アルキルアミノアルキルである)。 - 幹細胞と免疫調節化合物とを接触させることをさらに含む、請求項2記載の方法。
- 前記免疫調節化合物が、3-(4-アミノ-1-オキソ-1,3-ジヒドロイソインドール-2-イル)-ピペリジン-2,6-ジオン;3-(4'-アミノイソリンドリン-1'-オン)-1-ピペリジン-2,6-ジオン;4-(アミノ)-2-(2,6-ジオキソ(3-ピペリジル))-イソインドリン-1,3-ジオン;又はα-(3-アミノフタルイミド)グルタルイミドである、請求項8記載の方法。
- 前記免疫調節化合物が、以下の構造を有する化合物、又はその医薬として許容し得る塩、水和物、溶媒和物、包接化合物、鏡像異性体、ジアステレオ異性体、ラセミ体、若しくは立体異性体の混合物である、請求項8記載の方法:
R1は、H、(C1〜C8)アルキル、(C3〜C7)シクロアルキル、(C2〜C8)アルケニル、(C2〜C8)アルキニル、ベンジル、アリール、(C0〜C4)アルキル-(C1〜C6)ヘテロシクロアルキル、(C0〜C4)アルキル-(C2〜C5)ヘテロアリール、C(O)R3、C(S)R3、C(O)OR4、(C1〜C8)アルキル-N(R6)2、(C1〜C8)アルキル-OR5、(C1〜C8)アルキル-C(O)OR5、C(O)NHR3、C(S)NHR3、C(O)NR3R3'、C(S)NR3R3'又は(C1〜C8)アルキル-O(CO)R5であり;
R2は、H、F、ベンジル、(C1〜C8)アルキル、(C2〜C8)アルケニル又は(C2〜C8)アルキニルであり;
R3及びR3'は、独立に、(C1〜C8)アルキル、(C3〜C7)シクロアルキル、(C2〜C8)アルケニル、(C2〜C8)アルキニル、ベンジル、アリール、(C0〜C4)アルキル-(C1〜C6)ヘテロシクロアルキル、(C0〜C4)アルキル-(C2〜C5)ヘテロアリール、(C0〜C8)アルキル-N(R6)2、(C1〜C8)アルキル-OR5、(C1〜C8)アルキル-C(O)OR5、(C1〜C8)アルキル-O(CO)R5又はC(O)OR5であり;
R4は、(C1〜C8)アルキル、(C2〜C8)アルケニル、(C2〜C8)アルキニル、(C1〜C4)アルキル-OR5、ベンジル、アリール、(C0〜C4)アルキル-(C1〜C6)ヘテロシクロアルキル又は(C0〜C4)アルキル-(C2〜C5)ヘテロアリールであり;
R5は、(C1〜C8)アルキル、(C2〜C8)アルケニル、(C2〜C8)アルキニル、ベンジル、アリール、又は(C2〜C5)ヘテロアリールであり;
R6は出現するごとに、独立に、H、(C1〜C8)アルキル、(C2〜C8)アルケニル、(C2〜C8)アルキニル、ベンジル、アリール、(C2〜C5)ヘテロアリール又は(C0〜C8)アルキル-C(O)O-R5であり、或いはR6基は、一緒になって、ヘテロシクロアルキル基を形成することが可能であり;
nは、0又は1であり;
*は、キラル-炭素中心を表す)。 - 前記免疫調節化合物が、以下の構造を有する化合物、又はその医薬として許容し得る塩、水和物、溶媒和物、包接化合物、鏡像異性体、ジアステレオ異性体、ラセミ体、若しくは立体異性体の混合物である、請求項8記載の方法:
X及びYの一方はC=Oであり、他方はCH2又はC=Oであり;
Rは、H又はCH2OCOR'であり;
(i)R1、R2、R3又はR4の各々は、互いに独立に、ハロ、1個から4個の炭素原子を有するアルキル又は1個から4個の炭素原子を有するアルコキシであり、或いは(ii)R1、R2、R3又はR4の1つは、ニトロ又は-NHR5であり、R1、R2、R3又はR4の残りは、水素であり;
R5は、水素、又は1個から8個の炭素原子を有するアルキルであり;
R6は、水素、1個から8個の炭素原子を有するアルキル、ベンゾ、クロロ又はフルオロであり;
R'は、R7-CHR10-N(R8R9)であり;
R7は、m-フェニレン又はp-フェニレン又は-(CnH2n)-であり、nは、0から4の値を有し、
R8及びR9の各々は、互いに独立に、水素、又は1個から8個の炭素原子を有するアルキルであり、或いはR8及びR9は、一緒になって、テトラメチレン、ペンタメチレン、ヘキサメチレン又は-CH2CH2X1CH2CH2-であり、X1は、-O-、-S-又は-NH-であり;
R10は、水素、1個から8個の炭素原子を有するアルキル、又はフェニルであり;
*は、キラル-炭素中心を表す)。 - 前記JNK阻害剤が約0.5μMから約10μMの濃度で存在する、請求項2記載の方法。
- 前記免疫調節化合物が約0.5μMから約10μMの濃度で存在する、請求項8記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75496905P | 2005-12-29 | 2005-12-29 | |
PCT/US2006/049493 WO2007079185A2 (en) | 2005-12-29 | 2006-12-28 | Improved composition for collecting and preserving placental stem cells and methods of using the composition |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2009521931A JP2009521931A (ja) | 2009-06-11 |
JP2009521931A5 true JP2009521931A5 (ja) | 2010-02-18 |
Family
ID=38228854
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008548747A Pending JP2009521931A (ja) | 2005-12-29 | 2006-12-28 | 胎盤幹細胞を収集及び保存するための改善された組成物、及び該組成物の使用方法 |
Country Status (11)
Country | Link |
---|---|
US (4) | US9598669B2 (ja) |
EP (1) | EP1974013A2 (ja) |
JP (1) | JP2009521931A (ja) |
KR (1) | KR20080097190A (ja) |
CN (1) | CN101374941A (ja) |
AU (1) | AU2006332680A1 (ja) |
CA (1) | CA2633980A1 (ja) |
IL (1) | IL191771A (ja) |
PE (1) | PE20071015A1 (ja) |
WO (1) | WO2007079185A2 (ja) |
ZA (1) | ZA200804717B (ja) |
Families Citing this family (107)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8409846B2 (en) | 1997-09-23 | 2013-04-02 | The United States Of America As Represented By The Department Of Veteran Affairs | Compositions, methods and devices for maintaining an organ |
EP2322601A1 (en) | 2000-12-06 | 2011-05-18 | Anthrogenesis Corporation | Method of collecting placental stem cells |
US7311905B2 (en) * | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
KR100973615B1 (ko) | 2001-02-14 | 2010-08-02 | 안트로제네시스 코포레이션 | 산후 포유류의 태반, 이의 용도 및 태반 줄기세포 |
US7498171B2 (en) * | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
CA2505534A1 (en) * | 2002-11-26 | 2004-06-10 | Anthrogenesis Corporation | Cytotherapeutics, cytotherapeutic units and methods for treatments using them |
EP2312482A1 (en) * | 2004-03-26 | 2011-04-20 | Celgene Corporation | Systems and methods for providing a stem cell bank |
NZ591524A (en) | 2004-10-07 | 2012-09-28 | Transmedics Inc | Method for timing pulsatile flow of normothermic perfusate to the heart in ex-vivo organ care |
US12010987B2 (en) | 2004-10-07 | 2024-06-18 | Transmedics, Inc. | Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status |
US8304181B2 (en) | 2004-10-07 | 2012-11-06 | Transmedics, Inc. | Method for ex-vivo organ care and for using lactate as an indication of donor organ status |
US9078428B2 (en) | 2005-06-28 | 2015-07-14 | Transmedics, Inc. | Systems, methods, compositions and solutions for perfusing an organ |
CN101326281A (zh) * | 2005-10-13 | 2008-12-17 | 人类起源公司 | 用源自胎盘的干细胞制备少突胶质细胞 |
WO2007047468A2 (en) | 2005-10-13 | 2007-04-26 | Anthrogenesis Corporation | Immunomodulation using placental stem cells |
CA2634495A1 (en) * | 2005-12-22 | 2007-06-28 | Conjuchem Biotechnologies Inc. | Process for the production of preformed conjugates of albumin and a therapeutic agent |
EP1974013A2 (en) | 2005-12-29 | 2008-10-01 | Anthrogenesis Corporation | Improved composition for collecting and preserving placental stem cells and methods of using the composition |
NZ595786A (en) | 2005-12-29 | 2013-05-31 | Anthrogenesis Corp | Placental stem cell populations |
CA2633775A1 (en) * | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Co-culture of placental stem cells and stem cells from a second source |
US7993918B2 (en) * | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
US8372437B2 (en) | 2006-08-17 | 2013-02-12 | Mimedx Group, Inc. | Placental tissue grafts |
DK2084268T3 (en) | 2006-10-23 | 2019-01-21 | Celularity Inc | METHODS AND COMPOSITIONS FOR TREATING BONE JOIN DEFECTS WITH PLACENTACLE POPULATIONS |
KR20090109127A (ko) | 2007-02-12 | 2009-10-19 | 안트로제네시스 코포레이션 | 부착성 태반 줄기세포에서 유래한 간세포와 연골세포 및 cd34+, cd45- 태반 줄기세포가 농축된 세포군 |
JP5979811B2 (ja) | 2007-02-12 | 2016-08-31 | アンスロジェネシス コーポレーション | 胎盤幹細胞を使用した炎症性疾患の治療 |
US9457179B2 (en) | 2007-03-20 | 2016-10-04 | Transmedics, Inc. | Systems for monitoring and applying electrical currents in an organ perfusion system |
US8273526B2 (en) | 2007-06-18 | 2012-09-25 | Children's Hospital & Research Center At Oakland | Method of isolating stem and progenitor cells from placenta |
US9200253B1 (en) | 2007-08-06 | 2015-12-01 | Anthrogenesis Corporation | Method of producing erythrocytes |
WO2009021333A1 (en) * | 2007-08-14 | 2009-02-19 | Tissue Regeneration Therapeutics Inc. | Blood vessel extraction from umbilical cord |
EP3689421A1 (en) | 2007-09-07 | 2020-08-05 | MiMedx Group, Inc. | Placental tissue grafts and improved methods of preparing and using the same |
KR101955140B1 (ko) | 2007-09-28 | 2019-03-06 | 안트로제네시스 코포레이션 | 인간 태반 관류액 및 인간 태반-유래 중간체 천연 킬러 세포를 사용한 종양 억제 방법 |
PT103843B (pt) * | 2007-10-04 | 2008-08-12 | Medinfar Produtos Farmaceutico | Método de isolamento de células precursoras a partir do cordão umbilical humano |
US8455251B2 (en) * | 2007-11-09 | 2013-06-04 | Rnl Bio Co., Ltd. | Method for isolating and culturing adult stem cells derived from human amniotic epithelium |
US10750738B2 (en) | 2008-01-31 | 2020-08-25 | Transmedics, Inc. | Systems and methods for ex vivo lung care |
EP2303841A1 (en) | 2008-07-14 | 2011-04-06 | Gilead Sciences, Inc. | Oxindolyl inhibitor compounds |
KR20200143506A (ko) | 2008-08-20 | 2020-12-23 | 안트로제네시스 코포레이션 | 단리된 태반 세포를 사용한 뇌졸중 치료 |
KR20200011604A (ko) | 2008-08-20 | 2020-02-03 | 안트로제네시스 코포레이션 | 개선된 세포 조성물 및 그의 제조 방법 |
EP2633861B1 (en) | 2008-08-22 | 2015-08-12 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
WO2010026574A2 (en) * | 2008-09-02 | 2010-03-11 | Pluristem Ltd. | Adherent cells from placenta tissue and use thereof in therapy |
WO2010040262A1 (zh) * | 2008-10-10 | 2010-04-15 | 深圳市嘉天源生物科技有限公司 | 分离动物胚胎间质性干细胞并提取其分泌物的方法 |
AU2009316541B2 (en) | 2008-11-19 | 2015-08-06 | Celularity Inc. | Amnion derived adherent cells |
DK2375907T3 (da) | 2008-11-21 | 2019-06-11 | Celularity Inc | Behandling af sygdomme, lidelser eller tilstande i lungerne under anvendelse af placentaceller |
US8771677B2 (en) | 2008-12-29 | 2014-07-08 | Vladimir B Serikov | Colony-forming unit cell of human chorion and method to obtain and use thereof |
WO2010111631A1 (en) | 2009-03-25 | 2010-09-30 | Anthrogenesis Corporation | Tumor suppression using human placenta-derived intermediate natural killer cells and immunomodulatory compounds |
US20100323446A1 (en) | 2009-06-05 | 2010-12-23 | Jill Renee Barnett | Method of collecting placental cells |
NZ596783A (en) | 2009-06-08 | 2014-01-31 | Gilead Sciences Inc | Cycloalkylcarbamate benzamide aniline hdac inhibitor compounds |
WO2010144371A1 (en) | 2009-06-08 | 2010-12-16 | Gilead Colorado, Inc. | Alkanoylamino benzamide aniline hdac inihibitor compounds |
EP3190179A1 (en) | 2009-07-02 | 2017-07-12 | Anthrogenesis Corporation | Method of producing erythrocytes without feeder cells |
EP2529007B1 (en) | 2010-01-26 | 2017-07-12 | Anthrogenesis Corporation | Treatment of bone-related cancers using placental stem cells |
TW201703777A (zh) | 2010-04-07 | 2017-02-01 | 安瑟吉納西斯公司 | 利用胎盤幹細胞之血管新生 |
TW201138792A (en) | 2010-04-08 | 2011-11-16 | Anthrogenesis Corp | Treatment of sarcoidosis using placental stem cells |
US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
ES2666746T3 (es) | 2010-07-13 | 2018-05-07 | Anthrogenesis Corporation | Métodos para generar linfocitos citolíticos naturales |
JP2012029623A (ja) * | 2010-07-30 | 2012-02-16 | Bio Link Inc | 細胞分離用酵素溶液及び細胞分離方法、並びに膵島分離方法 |
DE102010034330B4 (de) * | 2010-08-14 | 2013-10-31 | Cytonet Gmbh & Co. Kg | Verfahren zur Herstellung desinfizierter humaner Zellsuspensionen |
JP5341059B2 (ja) * | 2010-11-09 | 2013-11-13 | 株式会社大塚製薬工場 | 幹細胞懸濁液 |
JP5753874B2 (ja) * | 2010-11-09 | 2015-07-22 | 株式会社大塚製薬工場 | 細胞生存率低下抑制剤 |
US8574899B2 (en) | 2010-12-22 | 2013-11-05 | Vladimir B Serikov | Methods for augmentation collection of placental hematopoietic stem cells and uses thereof |
US20120171180A1 (en) | 2010-12-30 | 2012-07-05 | Sascha Abramson | Compositions comprising amnion derived adherent cells and platelet-rich plasma |
US20120171161A1 (en) | 2010-12-30 | 2012-07-05 | Sascha Abramson | Compositions comprising placental stem cells and platelet rich plasma, and methods of use thereof |
AR093183A1 (es) | 2010-12-31 | 2015-05-27 | Anthrogenesis Corp | Aumento de la potencia de celulas madre de placenta usando moleculas de arn moduladoras |
AU2012242578B2 (en) * | 2011-04-14 | 2016-07-21 | Transmedics, Inc. | Organ care solution for ex-vivo machine perfusion of donor lungs |
MX357749B (es) | 2011-06-01 | 2018-07-23 | Anthrogenesis Corp | Tratamiento contra el dolor utilizando células madre placentarias. |
RU2491337C2 (ru) * | 2011-06-09 | 2013-08-27 | Елена Владимировна Орлова | Средство и способы культивирования, хранения и криоконсервации стволовых и дифференцированных клеток человека и животных |
US10190092B2 (en) | 2011-08-11 | 2019-01-29 | Robert A. Dracker | Procurement of placental stem cells |
WO2013023212A2 (en) * | 2011-08-11 | 2013-02-14 | Dracker Robert A | Procurement of placental stem cells |
US9925221B2 (en) | 2011-09-09 | 2018-03-27 | Celularity, Inc. | Treatment of amyotrophic lateral sclerosis using placental stem cells |
WO2013110094A1 (en) * | 2012-01-17 | 2013-07-25 | Dracker Robert A | Procurement of placental stem cells and umbilical cord segments |
JP5432322B2 (ja) * | 2012-05-08 | 2014-03-05 | 株式会社大塚製薬工場 | トレハロース含有肺塞栓形成予防用哺乳動物細胞懸濁液 |
CN114134113A (zh) | 2012-08-13 | 2022-03-04 | 人类起源公司 | 自然杀伤细胞及其用途 |
AU2013359076A1 (en) | 2012-12-14 | 2015-07-02 | Anthrogenesis Corporation | Anoikis resistant placental stem cells and uses thereof |
AU2013204922B2 (en) | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
EP2953635A4 (en) | 2013-02-05 | 2016-10-26 | Anthrogenesis Corp | NATURAL KILLER CELLS FROM PLAZENTA |
EP3882336A1 (en) | 2013-03-14 | 2021-09-22 | Celularity Inc. | Enhanced placental stem cells and uses thereof |
SG11201508199QA (en) * | 2013-04-05 | 2015-11-27 | Claudia Zylberberg | Matrix metalloproteinases and uses thereof |
CN103756965B (zh) * | 2014-01-27 | 2016-04-06 | 山东省齐鲁干细胞工程有限公司 | 一种从胎盘中灌洗造血干细胞的方法 |
JP2017518301A (ja) | 2014-06-02 | 2017-07-06 | トランスメディクス, インク.Transmedics, Inc. | ex−vivoでの臓器管理システム |
CN104357396A (zh) * | 2014-11-03 | 2015-02-18 | 赛欧帕克(江苏)干细胞生物工程有限公司 | 一种提取早期造血前体干细胞的方法及其应用 |
BR112017010520B1 (pt) | 2014-12-12 | 2022-08-30 | Tevosol, Inc | Aparelho e método para perfusão de órgãos |
US10542743B2 (en) * | 2015-01-05 | 2020-01-28 | Hygieia Therapeutics Sdn Bhd | Isolation, expansion and characterization of wharton's jelly mesenchymal stem cells |
CN104774806B (zh) * | 2015-04-09 | 2019-02-15 | 广州赛莱拉干细胞科技股份有限公司 | 一种胎盘造血干细胞的制备方法 |
CN104711226B (zh) * | 2015-04-09 | 2018-09-21 | 广州赛莱拉干细胞科技股份有限公司 | 一种胎盘造血干细胞的制备方法 |
EP3297694A1 (en) | 2015-05-21 | 2018-03-28 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
CN107949419B (zh) | 2015-09-09 | 2021-03-05 | 特兰斯迈迪茨公司 | 离体器官护理系统用的主动脉插管 |
JP2018529683A (ja) | 2015-09-15 | 2018-10-11 | セルラリティ インコーポレイテッド | 胎盤細胞を使用した糖尿病性末梢神経障害の処置 |
JP6781752B2 (ja) * | 2015-10-08 | 2020-11-04 | 高雄醫學大學Kaohsiung Medical University | 脂肪間質細胞を急速分離する組成物 |
JP6774494B2 (ja) | 2016-02-19 | 2020-10-21 | インターコンチネンタル グレート ブランズ エルエルシー | バイオマス源から複数の有用なストリームを形成するためのプロセス |
CN105695302B (zh) * | 2016-03-14 | 2018-07-24 | 广州赛莱拉干细胞科技股份有限公司 | 一种离体胎盘造血干细胞的制备方法 |
AU2017373862A1 (en) | 2016-12-05 | 2019-06-27 | Celularity Inc. | Treatment of lymphedema and related conditions using placental adherent cells |
TWI793151B (zh) | 2017-08-23 | 2023-02-21 | 瑞士商諾華公司 | 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途 |
PT3784663T (pt) | 2018-04-23 | 2023-10-10 | Celgene Corp | Compostos de 4-aminoisoindolina-1,3-diona substituídos e o seu uso para tratar linfoma |
AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
WO2020012334A1 (en) | 2018-07-10 | 2020-01-16 | Novartis Ag | 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and their use in the treatment of ikaros family zinc finger 2 (ikzf2)-dependent diseases |
US11116206B2 (en) | 2018-10-01 | 2021-09-14 | Cook Medical Technologies Llc | Cryocontainer |
WO2020102195A1 (en) | 2018-11-13 | 2020-05-22 | Biotheryx, Inc. | Substituted isoindolinones |
CA3119427A1 (en) | 2018-11-30 | 2020-06-04 | Celularity Inc. | Expansion of natural killer cells and ilc3 cells with novel aromatic compounds |
CN113661006A (zh) | 2019-02-05 | 2021-11-16 | 林迪生物科学公司 | 分离的细胞培养物组分以及用于从液体细胞培养基中分离其的方法 |
US20220265712A1 (en) | 2019-06-14 | 2022-08-25 | Celularity Inc. | Populations of natural killer cells for treating cancers |
US20220273716A1 (en) | 2019-07-25 | 2022-09-01 | Celularity Inc. | Populations of natural killer cells comprising a cd38 chimeric antigen receptor |
WO2021022229A1 (en) | 2019-07-31 | 2021-02-04 | Celularity Inc. | Populations of natural killer cells comprising a cleavage resistant cd16 |
WO2021113849A1 (en) | 2019-12-05 | 2021-06-10 | Celularity Inc. | Her2+ cancer treatment with populations of natural killer cells comprising a cleavage resistant cd16 |
US20220000919A1 (en) | 2020-01-29 | 2022-01-06 | Celularity Inc. | Placental derived natural killer cells for treatment of coronavirus infections |
US20230210909A1 (en) | 2020-05-08 | 2023-07-06 | Celularity Inc. | Placenta-derived adherent (pda) stem cell for the treatment of adults with sars-cov-2 related acute respiratory failure and ards (covid-19) |
CN111700063B (zh) * | 2020-06-29 | 2021-03-30 | 广州瑞铂茵健康科技有限公司 | 一种脐带标本的保存方法 |
CN112941009B (zh) * | 2021-02-22 | 2024-03-01 | 新格元(南京)生物科技有限公司 | 一种ffpe样本预处理液及从ffpe样本中分离单细胞的方法 |
WO2023278628A1 (en) | 2021-06-29 | 2023-01-05 | Celularity Inc. | Human placental hematopoietic stem cell derived natural killer cells in acute myeloid leukemia (aml) remission with minimal residual disease (mrd) or relapsed/refractory aml |
WO2023010123A1 (en) | 2021-07-29 | 2023-02-02 | Celularity Inc. | Placenta-dervied nk cells as a senolytic for therapeutic and other uses |
WO2023137344A1 (en) | 2022-01-11 | 2023-07-20 | Celularity Inc. | Cleavage resistant cd16 constructs and uses thereof |
Family Cites Families (111)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4798824A (en) * | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
US5197985A (en) | 1990-11-16 | 1993-03-30 | Caplan Arnold I | Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells |
US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
US5552267A (en) * | 1992-04-03 | 1996-09-03 | The Trustees Of Columbia University In The City Of New York | Solution for prolonged organ preservation |
US5698579A (en) | 1993-07-02 | 1997-12-16 | Celgene Corporation | Cyclic amides |
HU228769B1 (en) | 1996-07-24 | 2013-05-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha |
ATE229521T3 (de) * | 1996-07-24 | 2002-12-15 | Celgene Corp | Substituierte 2-(2,6-dioxopiperidin-3-yl)- phthalimide und -1-oxoisoindoline und verfahren zur reduzierung des tnf-alpha-spiegels |
US6281230B1 (en) | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
US5635517B1 (en) * | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
US5798368A (en) * | 1996-08-22 | 1998-08-25 | Celgene Corporation | Tetrasubstituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines and method of reducing TNFα levels |
US5929117A (en) * | 1996-08-12 | 1999-07-27 | Celgene Corporation | Immunotherapeutic agents |
US6497890B2 (en) * | 1996-12-03 | 2002-12-24 | Parvin Youssefyeh | Anti-wrinkle preparation and method of reducing wrinkles in facial skin and neck |
CA2242648A1 (en) * | 1997-07-10 | 1999-01-10 | Kyowa Hakko Kogyo Co., Ltd. | Method of reconstructing animal organs |
US5955476A (en) * | 1997-11-18 | 1999-09-21 | Celgene Corporation | Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels |
US5874448A (en) * | 1997-11-18 | 1999-02-23 | Celgene Corporation | Substituted 2-(2,6 dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing TNFα levels |
US20010055809A1 (en) * | 1998-01-30 | 2001-12-27 | Harpal S. Mangat | Extending tissue preservation |
TR200101500T2 (tr) * | 1998-03-16 | 2002-06-21 | Celgene Corporation | 2-(2,6-dioksopiperidin-3-il)izoindolin türevleri, bunların hazırlanması ve enflamatuarn sitokinlerin inhibitörleri olarak kullanımı. |
JP2002523487A (ja) | 1998-08-28 | 2002-07-30 | スミスクライン・ビーチャム・コーポレイション | 3−ヒドロキシ−4−アミノ−ベンゾニトリルの改良された合成方法 |
JP2002532493A (ja) * | 1998-12-17 | 2002-10-02 | エフ.ホフマン−ラ ロシュ アーゲー | Jnkプロテインキナーゼ阻害剤としての4−アリールオキシインドール |
DE69938258T2 (de) | 1998-12-17 | 2009-02-26 | F. Hoffmann-La Roche Ag | 4,5-pyrazinoxindole als proteinkinasehemmer |
US6288089B1 (en) * | 1998-12-21 | 2001-09-11 | Michael Zawada | Use of kinase inhibitors for treating neurodegenerative diseases |
GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
ATE306469T1 (de) * | 1999-03-18 | 2005-10-15 | Celgene Corp | Substituierte 1-oxo- und 1,3-dioxoisoindoline und ihre verwendung in pharmazeutischen zusammensetzungen zur senkung des spiegels inflammatorisch wirkender cytokine |
GB9906566D0 (en) | 1999-03-23 | 1999-05-19 | Zeneca Ltd | Chemical compounds |
ATE425142T1 (de) | 1999-04-23 | 2009-03-15 | Vertex Pharma | Inhibitoren von c-jun n-terminal kinasen (jnk) |
AU4860900A (en) | 1999-06-02 | 2000-12-18 | Lifebank Services, L.L.C. | Methods of isolation, cryopreservation, and therapeutic use of human amniotic epithelial cells |
AU5316900A (en) | 1999-06-03 | 2000-12-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) |
KR20020030791A (ko) | 1999-08-12 | 2002-04-25 | 버텍스 파마슈티칼스 인코포레이티드 | c-JUN N-말단 키나제(JNK) 및 기타의 단백질키나제 억제제 |
US7119114B1 (en) | 1999-08-19 | 2006-10-10 | Signal Pharmaceuticals, Llc | Pyrazoloanthrone and derivatives thereof as JNK inhibitors and compositions and methods related thereto |
NZ517578A (en) | 1999-08-19 | 2004-02-27 | Signal Pharm Inc | Pyrazoloanthrone and derivatives thereof as JNK inhibitors and their compositions |
US20040072888A1 (en) * | 1999-08-19 | 2004-04-15 | Bennett Brydon L. | Methods for treating inflammatory conditions or inhibiting JNK |
GB9919778D0 (en) | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
EP1088821A1 (en) | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonamide derivatives |
GB9924092D0 (en) | 1999-10-13 | 1999-12-15 | Zeneca Ltd | Pyrimidine derivatives |
WO2001029062A2 (en) * | 1999-10-18 | 2001-04-26 | University Technology Corporation | Method for modulation of cell phenotype |
US6428785B1 (en) * | 1999-10-28 | 2002-08-06 | Immunolytics Inc. | Method and composition for treating prostate cancer |
EP1110957A1 (en) | 1999-12-24 | 2001-06-27 | Applied Research Systems ARS Holding N.V. | Benzazole derivatives and their use as JNK modulators |
AU782878B2 (en) | 2000-02-05 | 2005-09-08 | Vertex Pharmaceuticals Incorporated | Pyrazole compositions useful as inhibitors of erk |
WO2001058448A1 (fr) | 2000-02-09 | 2001-08-16 | Shionogi & Co., Ltd. | Inhibiteur d'apoptose |
EP1289523A1 (en) | 2000-06-01 | 2003-03-12 | Merck & Co., Inc. | Use of (di-substituted-phenyl)-pyrimidinyl-imidazole derivatives as jnk-inhibitors |
US20050009876A1 (en) * | 2000-07-31 | 2005-01-13 | Bhagwat Shripad S. | Indazole compounds, compositions thereof and methods of treatment therewith |
US6897231B2 (en) | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
US7211594B2 (en) * | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
PE20020506A1 (es) | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
US6458810B1 (en) | 2000-11-14 | 2002-10-01 | George Muller | Pharmaceutically active isoindoline derivatives |
EP2322601A1 (en) * | 2000-12-06 | 2011-05-18 | Anthrogenesis Corporation | Method of collecting placental stem cells |
US20080152629A1 (en) * | 2000-12-06 | 2008-06-26 | James Edinger | Placental stem cell populations |
US7429599B2 (en) * | 2000-12-06 | 2008-09-30 | Signal Pharmaceuticals, Llc | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK |
US7129242B2 (en) | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
US7122544B2 (en) | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
US7311905B2 (en) * | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
US7091353B2 (en) * | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
US20030045552A1 (en) | 2000-12-27 | 2003-03-06 | Robarge Michael J. | Isoindole-imide compounds, compositions, and uses thereof |
KR100973615B1 (ko) | 2001-02-14 | 2010-08-02 | 안트로제네시스 코포레이션 | 산후 포유류의 태반, 이의 용도 및 태반 줄기세포 |
NZ541541A (en) * | 2001-02-14 | 2007-04-27 | Anthrogenesis Corp | A composition suitable for transplantation which comprises a population of hematopoietic stem cells comprising placental stem cells that are CD34+ and CD38- |
US6987184B2 (en) * | 2001-02-15 | 2006-01-17 | Signal Pharmaceuticals, Llc | Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof as JNK inhibitors and compositions and methods related |
WO2002068603A2 (en) * | 2001-02-28 | 2002-09-06 | The Henry M. Jackson Foundation | Materials and methods for the induction of premature chromosome condensation |
DE10139783C1 (de) | 2001-08-14 | 2003-04-17 | Transtissue Technologies Gmbh | Zellzusammensetzungen zur Behandlung von Osteoarthrose, sowie Verfahren zu deren Herstellung |
US7799324B2 (en) | 2001-12-07 | 2010-09-21 | Geron Corporation | Using undifferentiated embryonic stem cells to control the immune system |
KR20110036114A (ko) | 2002-02-13 | 2011-04-06 | 안트로제네시스 코포레이션 | 산후 포유류 태반으로부터 유래한 배아-유사 줄기 세포와 그 세포를 사용한 용도 및 치료방법 |
US20030187515A1 (en) * | 2002-03-26 | 2003-10-02 | Hariri Robert J. | Collagen biofabric and methods of preparing and using the collagen biofabric |
EP1538913A2 (en) | 2002-04-12 | 2005-06-15 | Celgene Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
WO2003086373A1 (en) * | 2002-04-12 | 2003-10-23 | Celgene Corporation | Methods for identification of modulators of angiogenesis, compounds discovered thereby, and methods of treatment using the compounds |
US7498171B2 (en) * | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
US7968569B2 (en) * | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
MXPA04011851A (es) * | 2002-05-30 | 2005-03-31 | Celgene Corp | Metodos para utilizar inhibidores de jnk o mkk para modular diferenciacion de celula y para tratar desordenes mieloproliferativos y sindromes mielodispl??sticos. |
CA2500196A1 (en) * | 2002-09-25 | 2004-04-08 | University Of Rochester | Caspase inhibitors as anticancer agents |
US7189740B2 (en) * | 2002-10-15 | 2007-03-13 | Celgene Corporation | Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes |
US7563810B2 (en) * | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
CA2505534A1 (en) * | 2002-11-26 | 2004-06-10 | Anthrogenesis Corporation | Cytotherapeutics, cytotherapeutic units and methods for treatments using them |
EP1601248A4 (en) | 2003-02-13 | 2010-01-27 | Anthrogenesis Corp | USE OF UMBILICAL CORD BLOOD FOR TREATING INDIVIDUALS WITH DISEASE, DISORDER OR PATHOLOGY |
WO2005001080A2 (en) * | 2003-06-27 | 2005-01-06 | Ethicon, Incorporated | Postpartum-derived cells for use in treatment of disease of the heart and circulatory system |
US20050158311A1 (en) * | 2003-10-24 | 2005-07-21 | California Institute Of Technology | Methods and compositions for inhibiting cell growth and proliferation |
CA2546493A1 (en) * | 2003-11-19 | 2005-06-09 | Signal Pharmaceuticals, Llc | Indazole compounds and methods of use thereof as protein kinase inhibitors |
CA2547570A1 (en) * | 2003-12-02 | 2005-06-23 | Celgene Corporation | 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione for induction of fetal hemoglobin in individuals having anemia |
WO2005056763A2 (en) * | 2003-12-04 | 2005-06-23 | University Of Utah Research Foundation | Process and formulation to improve viability of stored cells and tissue |
WO2005065354A2 (en) * | 2003-12-31 | 2005-07-21 | The Burnham Institute | Defined media for pluripotent stem cell culture |
US20050266391A1 (en) | 2004-01-15 | 2005-12-01 | Bennett Brydon L | Methods for preserving tissue |
EP2312482A1 (en) | 2004-03-26 | 2011-04-20 | Celgene Corporation | Systems and methods for providing a stem cell bank |
US7244759B2 (en) * | 2004-07-28 | 2007-07-17 | Celgene Corporation | Isoindoline compounds and methods of making and using the same |
US7909806B2 (en) * | 2004-09-23 | 2011-03-22 | Anthrogenesis Corporation | Cord blood and placenta collection kit |
US7147626B2 (en) * | 2004-09-23 | 2006-12-12 | Celgene Corporation | Cord blood and placenta collection kit |
JP2008520730A (ja) * | 2004-11-23 | 2008-06-19 | セルジーン・コーポレーション | 中枢神経系傷害の治療用jnk阻害剤 |
MX2007015541A (es) * | 2005-06-10 | 2008-03-06 | Celgene Corp | Composiciones de colageno de placenta humana proceso para su preparacion, metodos de uso y equipos que contienen las composiciones. |
KR20080026198A (ko) * | 2005-06-30 | 2008-03-24 | 안트로제네시스 코포레이션 | 태반 유도된 콜라겐 바이오패브릭을 사용한 고막의 복원 |
EP1919500A2 (en) * | 2005-07-13 | 2008-05-14 | Anthrogenesis Corporation | Treatment of leg ulcers using placenta derived collagen biofabric |
EP1919365A2 (en) * | 2005-07-13 | 2008-05-14 | Anthrogenesis Corporation | Ocular plug formed from placenta derived collagen biofabric |
US20070065414A1 (en) * | 2005-09-16 | 2007-03-22 | Boston Scientific Scimed, Inc. | Enhanced delivery of cells |
WO2007047468A2 (en) * | 2005-10-13 | 2007-04-26 | Anthrogenesis Corporation | Immunomodulation using placental stem cells |
CN101326281A (zh) * | 2005-10-13 | 2008-12-17 | 人类起源公司 | 用源自胎盘的干细胞制备少突胶质细胞 |
CA2633775A1 (en) * | 2005-12-29 | 2007-07-12 | Anthrogenesis Corporation | Co-culture of placental stem cells and stem cells from a second source |
EP1974013A2 (en) | 2005-12-29 | 2008-10-01 | Anthrogenesis Corporation | Improved composition for collecting and preserving placental stem cells and methods of using the composition |
NZ595786A (en) * | 2005-12-29 | 2013-05-31 | Anthrogenesis Corp | Placental stem cell populations |
US20080044848A1 (en) * | 2006-06-09 | 2008-02-21 | Heidaran Mohammad A | Placental niche and use thereof to culture stem cells |
US7993918B2 (en) | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
US8105634B2 (en) * | 2006-08-15 | 2012-01-31 | Anthrogenesis Corporation | Umbilical cord biomaterial for medical use |
US8122763B2 (en) * | 2006-09-01 | 2012-02-28 | Avair, Llc | Breathing gas supply visual broadcast apparatus |
WO2008042441A1 (en) * | 2006-10-03 | 2008-04-10 | Anthrogenesis Corporation | Use of umbilical cord biomaterial for ocular surgery |
WO2008060377A2 (en) * | 2006-10-04 | 2008-05-22 | Anthrogenesis Corporation | Placental or umbilical cord tissue compositions |
NZ597223A (en) * | 2006-10-06 | 2013-09-27 | Anthrogenesis Corp | Native (telopeptide) placental collagen compositions |
DK2084268T3 (en) | 2006-10-23 | 2019-01-21 | Celularity Inc | METHODS AND COMPOSITIONS FOR TREATING BONE JOIN DEFECTS WITH PLACENTACLE POPULATIONS |
JP5979811B2 (ja) * | 2007-02-12 | 2016-08-31 | アンスロジェネシス コーポレーション | 胎盤幹細胞を使用した炎症性疾患の治療 |
KR20090109127A (ko) * | 2007-02-12 | 2009-10-19 | 안트로제네시스 코포레이션 | 부착성 태반 줄기세포에서 유래한 간세포와 연골세포 및 cd34+, cd45- 태반 줄기세포가 농축된 세포군 |
BRPI0818191A8 (pt) * | 2007-09-26 | 2017-10-03 | Celgene Cellular Therapeutics | Métodos para a formação de vasos a partir de uma população de células de perfusado placentário, e, uso de uma população de células de perfusado placentário e de perfusado placentário humano ou células de perfusado placentário humano |
KR101955140B1 (ko) | 2007-09-28 | 2019-03-06 | 안트로제네시스 코포레이션 | 인간 태반 관류액 및 인간 태반-유래 중간체 천연 킬러 세포를 사용한 종양 억제 방법 |
KR20170116221A (ko) * | 2007-11-07 | 2017-10-18 | 안트로제네시스 코포레이션 | 조산 합병증의 치료에 있어서의 제대혈의 용도 |
KR20200011604A (ko) * | 2008-08-20 | 2020-02-03 | 안트로제네시스 코포레이션 | 개선된 세포 조성물 및 그의 제조 방법 |
KR20200143506A (ko) * | 2008-08-20 | 2020-12-23 | 안트로제네시스 코포레이션 | 단리된 태반 세포를 사용한 뇌졸중 치료 |
EP2633861B1 (en) * | 2008-08-22 | 2015-08-12 | Anthrogenesis Corporation | Methods and compositions for treatment of bone defects with placental cell populations |
AU2009316541B2 (en) * | 2008-11-19 | 2015-08-06 | Celularity Inc. | Amnion derived adherent cells |
DK2375907T3 (da) * | 2008-11-21 | 2019-06-11 | Celularity Inc | Behandling af sygdomme, lidelser eller tilstande i lungerne under anvendelse af placentaceller |
-
2006
- 2006-12-28 EP EP06848282A patent/EP1974013A2/en not_active Withdrawn
- 2006-12-28 ZA ZA200804717A patent/ZA200804717B/xx unknown
- 2006-12-28 US US11/648,812 patent/US9598669B2/en active Active
- 2006-12-28 KR KR1020087018724A patent/KR20080097190A/ko not_active Application Discontinuation
- 2006-12-28 WO PCT/US2006/049493 patent/WO2007079185A2/en active Application Filing
- 2006-12-28 AU AU2006332680A patent/AU2006332680A1/en not_active Abandoned
- 2006-12-28 CA CA002633980A patent/CA2633980A1/en not_active Abandoned
- 2006-12-28 CN CNA2006800529409A patent/CN101374941A/zh active Pending
- 2006-12-28 JP JP2008548747A patent/JP2009521931A/ja active Pending
- 2006-12-29 PE PE2006001721A patent/PE20071015A1/es not_active Application Discontinuation
-
2008
- 2008-05-27 IL IL191771A patent/IL191771A/en active IP Right Grant
-
2010
- 2010-07-29 US US12/846,765 patent/US9725694B2/en active Active
-
2017
- 2017-07-28 US US15/663,475 patent/US10590381B2/en active Active
-
2019
- 2019-08-22 US US16/548,720 patent/US20190376027A1/en not_active Abandoned
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2009521931A5 (ja) | ||
RU2338745C1 (ru) | ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ | |
RU2020112759A (ru) | Гетероциклические соединения в качестве ингибиторов PAD | |
JP2013518129A5 (ja) | ||
AR054688A1 (es) | Alquil-piridinas como inhibidores 11-beta de la diabetes | |
AR052559A1 (es) | Derivados de pirazol para inhibir cdk's y gsk's | |
JP2012511588A5 (ja) | ||
JP2014516074A5 (ja) | ||
JP2006500348A5 (ja) | ||
RU2017125025A (ru) | Конденсированные кольцевые гетероарильные соединения и их применение в качестве ингибиторов trk | |
JP2008528469A5 (ja) | ||
MX2007016185A (es) | Inhibidores de aspartil proteasa heterociclicos macrociclicos. | |
RU2014122035A (ru) | Соединения с нематоцидной активностью | |
BRPI0918750B1 (pt) | derivado de 2-carboxamida cicloamino ureia, seu uso e sua composição farmacêutica | |
JP2007517059A (ja) | 中枢神経系障害治療用の免疫調節化合物 | |
AR052232A1 (es) | Derivados de 5-heteroariltiazoles | |
HK1093688A1 (en) | 5-phenyl-4-methyl-thiazol-2-yl-amine derivatives as inhibitors of phosphatidylinositol 3 kinase enzymes (pi3) for the treatment of inflammatory airway diseases | |
SI3009428T1 (en) | DIAMINO HETEROCYCLIC CARBOSAMIDE COMPOUNDS | |
JP2005505551A5 (ja) | ||
HUP0105113A2 (hu) | Benzoheterociklusos vegyületek és MEK inhibitorokként történő alkalmazásuk és a vegyületeket tartalmazó gyógyászati készítmények | |
JP2004526699A5 (ja) | ||
JP2005526794A5 (ja) | ベンズイミダゾールおよびマイトジェン活性化およびrhoキナーゼ阻害剤としてのその使用 | |
CA2749040A1 (en) | Triazolo and tetrazolo pyrimidine derivatives as hne inhibitors for treating copd | |
JP2009501745A5 (ja) | ||
PE20161369A1 (es) | Inhibidores de monoacilglicerol aciltransferasa 2 (mgat2) de dihidropiridinona sustituidos con tetrazolona |