JP2009521232A5 - - Google Patents

Download PDF

Info

Publication number
JP2009521232A5
JP2009521232A5 JP2008547733A JP2008547733A JP2009521232A5 JP 2009521232 A5 JP2009521232 A5 JP 2009521232A5 JP 2008547733 A JP2008547733 A JP 2008547733A JP 2008547733 A JP2008547733 A JP 2008547733A JP 2009521232 A5 JP2009521232 A5 JP 2009521232A5
Authority
JP
Japan
Prior art keywords
vegf
support
buffer solution
chromatography support
hydrophobic interaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008547733A
Other languages
English (en)
Japanese (ja)
Other versions
JP5036727B2 (ja
JP2009521232A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/062320 external-priority patent/WO2007130154A2/en
Publication of JP2009521232A publication Critical patent/JP2009521232A/ja
Publication of JP2009521232A5 publication Critical patent/JP2009521232A5/ja
Application granted granted Critical
Publication of JP5036727B2 publication Critical patent/JP5036727B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2008547733A 2005-12-22 2006-12-19 ヘパリン結合タンパク質の組み換え体産生 Active JP5036727B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US75361505P 2005-12-22 2005-12-22
US60/753,615 2005-12-22
US80743206P 2006-07-14 2006-07-14
US60/807,432 2006-07-14
PCT/US2006/062320 WO2007130154A2 (en) 2005-12-22 2006-12-19 Recombinant production of heparin binding proteins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011174491A Division JP2011254831A (ja) 2005-12-22 2011-08-10 ヘパリン結合タンパク質の組み換え体産生

Publications (3)

Publication Number Publication Date
JP2009521232A JP2009521232A (ja) 2009-06-04
JP2009521232A5 true JP2009521232A5 (https=) 2011-09-29
JP5036727B2 JP5036727B2 (ja) 2012-09-26

Family

ID=38668202

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008547733A Active JP5036727B2 (ja) 2005-12-22 2006-12-19 ヘパリン結合タンパク質の組み換え体産生
JP2011174491A Pending JP2011254831A (ja) 2005-12-22 2011-08-10 ヘパリン結合タンパク質の組み換え体産生

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011174491A Pending JP2011254831A (ja) 2005-12-22 2011-08-10 ヘパリン結合タンパク質の組み換え体産生

Country Status (16)

Country Link
US (3) US20080032343A1 (https=)
EP (2) EP2336164A1 (https=)
JP (2) JP5036727B2 (https=)
KR (1) KR101067525B1 (https=)
AR (1) AR058625A1 (https=)
AT (1) ATE497973T1 (https=)
AU (1) AU2006343279B2 (https=)
BR (1) BRPI0621124A2 (https=)
CA (1) CA2633554C (https=)
DE (1) DE602007012412D1 (https=)
IL (1) IL191968A (https=)
MY (1) MY143274A (https=)
NZ (1) NZ568809A (https=)
RU (1) RU2385877C1 (https=)
TW (1) TWI369362B (https=)
WO (1) WO2007130154A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0621124A2 (pt) 2005-12-22 2011-11-29 Genentech Inc métodos para recuperação de uma proteìna de ligação à heparina
AR062069A1 (es) 2006-07-14 2008-10-15 Genentech Inc Replegado de proteinas recombinantes
JP5730211B2 (ja) 2008-11-20 2015-06-03 バイオジェン アイデック エムエー インコーポレイティドBiogen Idec Inc. ウイルスのアルギニン不活化
EP3366692A1 (en) 2009-06-22 2018-08-29 Amgen, Inc Refolding proteins using a chemically controlled redox state
AU2010266093B2 (en) 2009-06-25 2013-06-27 Amgen Inc. Capture purification processes for proteins expressed in a non-mammalian system
EP2539521B1 (en) 2010-02-25 2023-06-07 John Clement Preston Scaffolding
KR102283127B1 (ko) * 2018-06-19 2021-07-29 주식회사 엠디헬스케어 류코노스톡속 균주를 포함하는 간 기능 개선용 조성물
SG11202110968VA (en) * 2019-12-06 2021-10-28 Regeneron Pharma Anti-vegf protein compositions and methods for producing the same
CN117069810A (zh) * 2022-05-09 2023-11-17 上海科技大学 一种膜蛋白的纯化方法

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4169950A (en) * 1977-12-08 1979-10-02 Research Organics Amino-hydroxy-alkyl sulfonic acid zwitterions
US4263428A (en) 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
US4565785A (en) * 1978-06-08 1986-01-21 The President And Fellows Of Harvard College Recombinant DNA molecule
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
DE3169595D1 (en) 1980-11-10 1985-05-02 Gersonde Klaus Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
JPS58118008A (ja) 1982-01-06 1983-07-13 Nec Corp デ−タ処理装置
DE3374837D1 (en) 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
DE3218121A1 (de) 1982-05-14 1983-11-17 Leskovar, Peter, Dr.-Ing., 8000 München Arzneimittel zur tumorbehandlung
EP0102324A3 (de) 1982-07-29 1984-11-07 Ciba-Geigy Ag Lipide und Tenside in wässriger Phase
US4673641A (en) 1982-12-16 1987-06-16 Molecular Genetics Research And Development Limited Partnership Co-aggregate purification of proteins
US4511502A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4512922A (en) * 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511503A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4710473A (en) 1983-08-10 1987-12-01 Amgen, Inc. DNA plasmids
DE3483949D1 (de) 1983-09-26 1991-02-21 Udo Dr Med Ehrenfeld Mittel und erzeugnis fuer die diagnose und therapie von tumoren sowie zur behandlung von schwaechen der zelligen und humoralen immunabwehr.
DE3474511D1 (en) 1983-11-01 1988-11-17 Terumo Corp Pharmaceutical composition containing urokinase
US4795706A (en) 1985-01-31 1989-01-03 Eli Lilly And Company Novel expression control sequences
ES8800957A1 (es) 1985-02-22 1987-12-01 Monsanto Co Un metodo para la solubilizacion y renaturalizacion de proteina somatotropina
US5453363A (en) * 1985-10-23 1995-09-26 Boehringer Mannheim Gmbh Process for the activation of t-PA or Ing after genetic expression in prokaryotes
AU614137B2 (en) 1988-06-06 1991-08-22 Takeda Chemical Industries Ltd. Stabilized fgf composition and production thereof
DE3835350A1 (de) * 1988-10-17 1990-04-19 Boehringer Mannheim Gmbh Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern
US5332671A (en) * 1989-05-12 1994-07-26 Genetech, Inc. Production of vascular endothelial cell growth factor and DNA encoding same
US5194596A (en) 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5288931A (en) 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
US5304472A (en) 1992-11-20 1994-04-19 Genentech, Inc. Method of controlling polypeptide production in bacterial cells
US5342763A (en) 1992-11-23 1994-08-30 Genentech, Inc. Method for producing polypeptide via bacterial fermentation
CA2150803C (en) 1992-12-02 2006-01-31 Henry Auer Controlled release growth hormone containing microspheres
US5331095A (en) 1993-04-12 1994-07-19 Scios Nova Inc. Process for purification of basic fibroblast growth factor
JP4098372B2 (ja) * 1993-07-28 2008-06-11 三菱化学株式会社 ヘパリン結合性増殖因子の生産方法
US5663304A (en) 1993-08-20 1997-09-02 Genentech, Inc. Refolding of misfolded insulin-like growth factor-I
US5464815A (en) 1993-09-08 1995-11-07 Genentech, Inc. Inhibition of heparin-binding
EP0751992B1 (en) * 1994-03-08 2005-11-09 Human Genome Sciences, Inc. Vascular endothelial growth factor 2
DE69530689T2 (de) * 1994-04-21 2004-03-25 Leukotech A/S Heparin-binding protein zur behandlung von sepsis
PT779806E (pt) 1994-09-09 2001-02-28 Takeda Chemical Industries Ltd Preparacao de libertacao sustentada contendo um sal metalico de um peptido
FR2729972B1 (fr) * 1995-01-31 1997-04-18 Sanofi Sa Procede d'extraction de proteines periplasmiques de microorganismes procaryotes en presence d'arginine
PT831787E (pt) 1995-06-07 2002-02-28 Alkermes Inc Composicao para libertacao sustentada da hormona de crescimento humano
ZA965368B (en) 1995-07-14 1997-01-14 Novo Nordisk As A pharmaceutical formulation
US6750044B1 (en) 1996-10-17 2004-06-15 Genentech, Inc. Variants of vascular endothelial cell growth factor having antagonistic properties, nucleic acids encoding the same and host cells comprising those nucleic acids
US6632425B1 (en) * 1997-03-20 2003-10-14 Human Genome Sciences, Inc. Chemokine compositions
DE19735711C2 (de) 1997-08-18 2001-04-26 Aventis Pharma Gmbh Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken
US6653098B1 (en) 1998-02-23 2003-11-25 G. D. Searle & Co. Method of producing mouse and human endostatin
DE69840035D1 (de) 1998-03-31 2008-10-30 Tonghua Gantech Biotechnology Chimäres protein welches eine intramolekulare chap zur insulinproduktion
EP1500661A1 (en) 1998-06-01 2005-01-26 Genetech, Inc. Separation of protein monomers from aggregates by use of ion-exchange chromatography
PT1124941E (pt) 1998-10-28 2004-02-27 Genentech Inc Processo para recuperar polipeptidos heterologos a partir de celulas bacterianas
US6783953B1 (en) * 1998-12-22 2004-08-31 Janssen Pharmaceutica N.V. Vascular endothelial growth factor-X
EP1183357A2 (en) * 1999-05-20 2002-03-06 Scios Inc. Vascular endothelial growth factor dimers
DE60034707T2 (de) 2000-01-25 2008-01-17 Oklahoma Medical Research Foundation, Oklahoma Allgemeines verfahren zur rückfaltung rekombinanter proteine
AUPQ568100A0 (en) * 2000-02-16 2000-03-09 Amrad Operations Pty. Limited A method for producing recombinant molecules
US20030120042A1 (en) * 2000-03-30 2003-06-26 Takao Yamada Process for producing recombinant protein
IL152804A0 (en) 2000-05-16 2003-06-24 Bolder Biotechnology Inc Methods for refolding proteins containing free cysteine residues
US7611711B2 (en) * 2001-01-17 2009-11-03 Vegenics Limited VEGFR-3 inhibitor materials and methods
IL157446A0 (en) 2001-02-23 2004-03-28 Immunex Corp Immunex Corp Increased recovery of active proteins
EP1501357A4 (en) 2002-05-06 2009-10-21 Genentech Inc USE OF VEGF FOR THE TREATMENT OF BONE DEFECTS
IL165392A0 (en) 2002-06-05 2006-01-15 Genentech Inc Compositions and methods for liver growth and liver protection
EP1581644B1 (en) 2003-01-09 2007-06-06 Genentech, Inc. Purification of polypeptides
EP1449848A1 (en) 2003-02-20 2004-08-25 GBF German Research Centre for Biotechnology Method for the production of cystine-knot proteins
EP2270163A1 (en) 2003-12-10 2011-01-05 Eli Lilly and Company Muteins of fibroblast growth factor 21
DE102004015965A1 (de) 2004-04-01 2005-10-20 Aventis Pharma Gmbh Verfahren zur Gewinnung von Insulinen durch verbesserte Luftbegasung der Faltung
CA2571781C (en) 2004-06-28 2015-05-12 Yeda Research And Development Co. Ltd Chimeric proteins and uses thereof
WO2006053568A1 (en) 2004-11-22 2006-05-26 Borean Pharma Aps Tnf antagonists
DE602006003108D1 (de) * 2005-03-03 2008-11-27 Ajinomoto Kk Methode zur Verbesserung der Ausbeute bei der Proteinreinigung mittels Gelfiltrationschromatographie und Arginin
BRPI0621124A2 (pt) 2005-12-22 2011-11-29 Genentech Inc métodos para recuperação de uma proteìna de ligação à heparina

Similar Documents

Publication Publication Date Title
Clark Protein refolding for industrial processes
US5728804A (en) Use of cyclodextrins for protein renaturation
De Bernardez Clark et al. Oxidative renaturation of hen egg‐white lysozyme. Folding vs aggregation
Guise et al. Protein folding in vivo and renaturation of recombinant proteins from inclusion bodies
JP3646195B2 (ja) ポリペプチドの水性多相単離
JP3648242B2 (ja) 組み換えインスリン様成長因子igf−i様ポリペプチドの再折りたたみ
Jungbauer et al. Current status of technical protein refolding
US8710197B2 (en) High pressure refolding of protein aggregates and inclusion bodies
Li et al. In vitro protein refolding by chromatographic procedures
EP0215625B1 (en) Protein recovery
IE61756B1 (en) Purification and activation of proteins from insoluble inclusion bodies
Wingfield et al. Folding and purification of insoluble (inclusion body) proteins from Escherichia coli
JP2009521232A5 (https=)
US20220340630A1 (en) Composition of renaturation buffer solution for dimeric proteins and method of renaturation dimeric proteins using the composition thereof
Hagen et al. Protein refolding in reversed micelles: Interactions of the protein with micelle components
Gautam et al. Non-chromatographic strategies for protein refolding
CN105732820B (zh) 一种重组人胰岛素原融合蛋白的复性方法
Lin et al. Enhanced protein renaturation by temperature‐responsive polymers
Khodarahmi et al. Refolding of chemically denatured α-amylase in dilution additive mode
JP5036727B2 (ja) ヘパリン結合タンパク質の組み換え体産生
JP3930051B2 (ja) 正しく折畳まれた生物学的に活性の組換えタンパク質の製造方法
MATSUBARA et al. " Loose folding" and" delayed oxidation" procedures successfully applied for refolding of fully reduced hen egg white lysozyme
US20180037604A1 (en) Process for the purification of recombinant proteins
CN1220703C (zh) 在水性溶剂中贮存蛋白质期间稳定复杂混合物中的蛋白质的方法
Nian et al. Chaperone-assisted column refolding of gloshedobin with the use of refolding cocktail