AR058625A1 - Produccion recombinante de proteinas de union a heparina - Google Patents

Produccion recombinante de proteinas de union a heparina

Info

Publication number
AR058625A1
AR058625A1 ARP060105732A ARP060105732A AR058625A1 AR 058625 A1 AR058625 A1 AR 058625A1 AR P060105732 A ARP060105732 A AR P060105732A AR P060105732 A ARP060105732 A AR P060105732A AR 058625 A1 AR058625 A1 AR 058625A1
Authority
AR
Argentina
Prior art keywords
heparin binding
binding protein
heparin
agent
renatured
Prior art date
Application number
ARP060105732A
Other languages
English (en)
Spanish (es)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Priority to TW095148610A priority Critical patent/TWI369362B/zh
Publication of AR058625A1 publication Critical patent/AR058625A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ARP060105732A 2005-12-22 2006-12-21 Produccion recombinante de proteinas de union a heparina AR058625A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
TW095148610A TWI369362B (en) 2005-12-22 2006-12-22 Recombinant production of heparin binding proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75361505P 2005-12-22 2005-12-22
US80743206P 2006-07-14 2006-07-14

Publications (1)

Publication Number Publication Date
AR058625A1 true AR058625A1 (es) 2008-02-13

Family

ID=38668202

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060105732A AR058625A1 (es) 2005-12-22 2006-12-21 Produccion recombinante de proteinas de union a heparina

Country Status (16)

Country Link
US (3) US20080032343A1 (https=)
EP (2) EP2336164A1 (https=)
JP (2) JP5036727B2 (https=)
KR (1) KR101067525B1 (https=)
AR (1) AR058625A1 (https=)
AT (1) ATE497973T1 (https=)
AU (1) AU2006343279B2 (https=)
BR (1) BRPI0621124A2 (https=)
CA (1) CA2633554C (https=)
DE (1) DE602007012412D1 (https=)
IL (1) IL191968A (https=)
MY (1) MY143274A (https=)
NZ (1) NZ568809A (https=)
RU (1) RU2385877C1 (https=)
TW (1) TWI369362B (https=)
WO (1) WO2007130154A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9994612B2 (en) 2006-07-14 2018-06-12 Genentech, Inc. Refolding of recombinant proteins

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0621124A2 (pt) 2005-12-22 2011-11-29 Genentech Inc métodos para recuperação de uma proteìna de ligação à heparina
JP5730211B2 (ja) 2008-11-20 2015-06-03 バイオジェン アイデック エムエー インコーポレイティドＢｉｏｇｅｎ Ｉｄｅｃ Ｉｎｃ． ウイルスのアルギニン不活化
EP3366692A1 (en) 2009-06-22 2018-08-29 Amgen, Inc Refolding proteins using a chemically controlled redox state
AU2010266093B2 (en) 2009-06-25 2013-06-27 Amgen Inc. Capture purification processes for proteins expressed in a non-mammalian system
EP2539521B1 (en) 2010-02-25 2023-06-07 John Clement Preston Scaffolding
KR102283127B1 (ko) * 2018-06-19 2021-07-29 주식회사 엠디헬스케어 류코노스톡속 균주를 포함하는 간 기능 개선용 조성물
SG11202110968VA (en) * 2019-12-06 2021-10-28 Regeneron Pharma Anti-vegf protein compositions and methods for producing the same
CN117069810A (zh) * 2022-05-09 2023-11-17 上海科技大学 一种膜蛋白的纯化方法

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4169950A (en) * 1977-12-08 1979-10-02 Research Organics Amino-hydroxy-alkyl sulfonic acid zwitterions
US4263428A (en) 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
US4565785A (en) * 1978-06-08 1986-01-21 The President And Fellows Of Harvard College Recombinant DNA molecule
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
DE3169595D1 (en) 1980-11-10 1985-05-02 Gersonde Klaus Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
JPS58118008A (ja) 1982-01-06 1983-07-13 Nec Corp デ−タ処理装置
DE3374837D1 (en) 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
DE3218121A1 (de) 1982-05-14 1983-11-17 Leskovar, Peter, Dr.-Ing., 8000 München Arzneimittel zur tumorbehandlung
EP0102324A3 (de) 1982-07-29 1984-11-07 Ciba-Geigy Ag Lipide und Tenside in wässriger Phase
US4673641A (en) 1982-12-16 1987-06-16 Molecular Genetics Research And Development Limited Partnership Co-aggregate purification of proteins
US4511502A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4512922A (en) * 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511503A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4710473A (en) 1983-08-10 1987-12-01 Amgen, Inc. DNA plasmids
DE3483949D1 (de) 1983-09-26 1991-02-21 Udo Dr Med Ehrenfeld Mittel und erzeugnis fuer die diagnose und therapie von tumoren sowie zur behandlung von schwaechen der zelligen und humoralen immunabwehr.
DE3474511D1 (en) 1983-11-01 1988-11-17 Terumo Corp Pharmaceutical composition containing urokinase
US4795706A (en) 1985-01-31 1989-01-03 Eli Lilly And Company Novel expression control sequences
ES8800957A1 (es) 1985-02-22 1987-12-01 Monsanto Co Un metodo para la solubilizacion y renaturalizacion de proteina somatotropina
US5453363A (en) * 1985-10-23 1995-09-26 Boehringer Mannheim Gmbh Process for the activation of t-PA or Ing after genetic expression in prokaryotes
AU614137B2 (en) 1988-06-06 1991-08-22 Takeda Chemical Industries Ltd. Stabilized fgf composition and production thereof
DE3835350A1 (de) * 1988-10-17 1990-04-19 Boehringer Mannheim Gmbh Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern
US5332671A (en) * 1989-05-12 1994-07-26 Genetech, Inc. Production of vascular endothelial cell growth factor and DNA encoding same
US5194596A (en) 1989-07-27 1993-03-16 California Biotechnology Inc. Production of vascular endothelial cell growth factor
US5288931A (en) 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
US5304472A (en) 1992-11-20 1994-04-19 Genentech, Inc. Method of controlling polypeptide production in bacterial cells
US5342763A (en) 1992-11-23 1994-08-30 Genentech, Inc. Method for producing polypeptide via bacterial fermentation
CA2150803C (en) 1992-12-02 2006-01-31 Henry Auer Controlled release growth hormone containing microspheres
US5331095A (en) 1993-04-12 1994-07-19 Scios Nova Inc. Process for purification of basic fibroblast growth factor
JP4098372B2 (ja) * 1993-07-28 2008-06-11 三菱化学株式会社 ヘパリン結合性増殖因子の生産方法
US5663304A (en) 1993-08-20 1997-09-02 Genentech, Inc. Refolding of misfolded insulin-like growth factor-I
US5464815A (en) 1993-09-08 1995-11-07 Genentech, Inc. Inhibition of heparin-binding
EP0751992B1 (en) * 1994-03-08 2005-11-09 Human Genome Sciences, Inc. Vascular endothelial growth factor 2
DE69530689T2 (de) * 1994-04-21 2004-03-25 Leukotech A/S Heparin-binding protein zur behandlung von sepsis
PT779806E (pt) 1994-09-09 2001-02-28 Takeda Chemical Industries Ltd Preparacao de libertacao sustentada contendo um sal metalico de um peptido
FR2729972B1 (fr) * 1995-01-31 1997-04-18 Sanofi Sa Procede d'extraction de proteines periplasmiques de microorganismes procaryotes en presence d'arginine
PT831787E (pt) 1995-06-07 2002-02-28 Alkermes Inc Composicao para libertacao sustentada da hormona de crescimento humano
ZA965368B (en) 1995-07-14 1997-01-14 Novo Nordisk As A pharmaceutical formulation
US6750044B1 (en) 1996-10-17 2004-06-15 Genentech, Inc. Variants of vascular endothelial cell growth factor having antagonistic properties, nucleic acids encoding the same and host cells comprising those nucleic acids
US6632425B1 (en) * 1997-03-20 2003-10-14 Human Genome Sciences, Inc. Chemokine compositions
DE19735711C2 (de) 1997-08-18 2001-04-26 Aventis Pharma Gmbh Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken
US6653098B1 (en) 1998-02-23 2003-11-25 G. D. Searle & Co. Method of producing mouse and human endostatin
DE69840035D1 (de) 1998-03-31 2008-10-30 Tonghua Gantech Biotechnology Chimäres protein welches eine intramolekulare chap zur insulinproduktion
EP1500661A1 (en) 1998-06-01 2005-01-26 Genetech, Inc. Separation of protein monomers from aggregates by use of ion-exchange chromatography
PT1124941E (pt) 1998-10-28 2004-02-27 Genentech Inc Processo para recuperar polipeptidos heterologos a partir de celulas bacterianas
US6783953B1 (en) * 1998-12-22 2004-08-31 Janssen Pharmaceutica N.V. Vascular endothelial growth factor-X
EP1183357A2 (en) * 1999-05-20 2002-03-06 Scios Inc. Vascular endothelial growth factor dimers
DE60034707T2 (de) 2000-01-25 2008-01-17 Oklahoma Medical Research Foundation, Oklahoma Allgemeines verfahren zur rückfaltung rekombinanter proteine
AUPQ568100A0 (en) * 2000-02-16 2000-03-09 Amrad Operations Pty. Limited A method for producing recombinant molecules
US20030120042A1 (en) * 2000-03-30 2003-06-26 Takao Yamada Process for producing recombinant protein
IL152804A0 (en) 2000-05-16 2003-06-24 Bolder Biotechnology Inc Methods for refolding proteins containing free cysteine residues
US7611711B2 (en) * 2001-01-17 2009-11-03 Vegenics Limited VEGFR-3 inhibitor materials and methods
IL157446A0 (en) 2001-02-23 2004-03-28 Immunex Corp Immunex Corp Increased recovery of active proteins
EP1501357A4 (en) 2002-05-06 2009-10-21 Genentech Inc USE OF VEGF FOR THE TREATMENT OF BONE DEFECTS
IL165392A0 (en) 2002-06-05 2006-01-15 Genentech Inc Compositions and methods for liver growth and liver protection
EP1581644B1 (en) 2003-01-09 2007-06-06 Genentech, Inc. Purification of polypeptides
EP1449848A1 (en) 2003-02-20 2004-08-25 GBF German Research Centre for Biotechnology Method for the production of cystine-knot proteins
EP2270163A1 (en) 2003-12-10 2011-01-05 Eli Lilly and Company Muteins of fibroblast growth factor 21
DE102004015965A1 (de) 2004-04-01 2005-10-20 Aventis Pharma Gmbh Verfahren zur Gewinnung von Insulinen durch verbesserte Luftbegasung der Faltung
CA2571781C (en) 2004-06-28 2015-05-12 Yeda Research And Development Co. Ltd Chimeric proteins and uses thereof
WO2006053568A1 (en) 2004-11-22 2006-05-26 Borean Pharma Aps Tnf antagonists
DE602006003108D1 (de) * 2005-03-03 2008-11-27 Ajinomoto Kk Methode zur Verbesserung der Ausbeute bei der Proteinreinigung mittels Gelfiltrationschromatographie und Arginin
BRPI0621124A2 (pt) 2005-12-22 2011-11-29 Genentech Inc métodos para recuperação de uma proteìna de ligação à heparina

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9994612B2 (en) 2006-07-14 2018-06-12 Genentech, Inc. Refolding of recombinant proteins

Also Published As

Publication number Publication date
US20080032343A1 (en) 2008-02-07
JP2011254831A (ja) 2011-12-22
TWI369362B (en) 2012-08-01
EP1973942A2 (en) 2008-10-01
IL191968A (en) 2013-06-27
US20130217867A1 (en) 2013-08-22
DE602007012412D1 (de) 2011-03-24
KR101067525B1 (ko) 2011-09-27
MY143274A (en) 2011-04-15
TW200734351A (en) 2007-09-16
JP5036727B2 (ja) 2012-09-26
BRPI0621124A2 (pt) 2011-11-29
WO2007130154A8 (en) 2008-04-17
US8906648B2 (en) 2014-12-09
EP1973942B1 (en) 2011-02-09
AU2006343279A1 (en) 2007-11-15
CA2633554C (en) 2012-11-13
RU2385877C1 (ru) 2010-04-10
US20100261888A1 (en) 2010-10-14
RU2008130072A (ru) 2010-01-27
NZ568809A (en) 2011-08-26
KR20080087128A (ko) 2008-09-30
WO2007130154A2 (en) 2007-11-15
EP2336164A1 (en) 2011-06-22
CA2633554A1 (en) 2007-11-15
JP2009521232A (ja) 2009-06-04
HK1119188A1 (en) 2009-07-17
AU2006343279B2 (en) 2012-03-29
ATE497973T1 (de) 2011-02-15
WO2007130154A3 (en) 2008-06-26
IL191968A0 (en) 2008-12-29

Similar Documents

Publication Publication Date Title
ES2533874T3 (es) Armazón proteico
Li et al. In vitro protein refolding by chromatographic procedures
RU2009105080A (ru) Рефолдинг рекомбинантных белков
CO5601037A2 (es) Anticuerpos anti-a beta y sus usos
AR044170A1 (es) Composiciones inmunoprofilacticas y terapeuticas estables derivadas de celulas de plantas transgenicas y metodos para su produccion
AR058625A1 (es) Produccion recombinante de proteinas de union a heparina
CL2008002349A1 (es) Molecula de anticuerpo que se une a cd37 humano; molecula de adn que la codifica; vector de expresion y celula huesped; metodo para producir dicho anticuerpo; composicion farmaceutica que la comprende; método in vitro para suprimir células b que expresan cd37 en una población de células.
WO2006042158A3 (en) Methods and compositions for improving recombinant protein production
BR112012016320A2 (pt) "método para tratar material celulósico, polipeptídeo, molécula de ácido nucleico isolada, vetor de expressão recombinante, célula hospedeira, processos para produzir um polipeptídeo, e para obter uma preparação de enzima, preparação de enzima, e, uso do polipeptídeo ou da preparação de enzima."
WO2024159985A1 (zh) 一种重组人源化I型胶原蛋白α1及表达载体和应用
CN102757974B (zh) 一种重组人表皮生长因子的新型制备方法
WO2006079546A3 (en) Production of antibodies in plants with plus -sense single -stranded viral rna vectors
AR086200A1 (es) Hongos filamentosos que tienen un fenotipo de viscosidad alterado
RU2010131632A (ru) Среды для культур клеток млекопитающих, которые содержат надосадочную жидкость стадий фракционирования по кону, и их применение
CN112500495A (zh) 一种elp-ⅲ型胶原蛋白的纯化方法及应用
CN102994601B (zh) 一种利用海洋胶原蛋白酶mcp-01制备胶原蛋白小肽的方法
CN102167733A (zh) 一种可酸切高拷贝降血压肽串联基因的构建、表达及应用
DK1861504T3 (da) Glycoengineering i svampe
RU2007147414A (ru) Способ рекомбинантного получения моноклонального антитела к cd52, предназначенного для лечения хронического лимфолейкоза
CN104263747B (zh) 一种长效蛋白质药物表达复性修饰的双标签载体及方法
Ling et al. Approaches for the generation of active papain-like cysteine proteases from inclusion bodies of Escherichia coli
DE60219361D1 (de) Verfahren zur rekombinanten herstellung von plazenta wachstumsfaktor
MX9600380A (es) Proceso de extraccion de proteinas periplasmicas de microorganismos procarioticos en presencia de arginina.
EP1739167A4 (en) PROCESS FOR VIRUS PRODUCTION
EA200101093A1 (ru) Экспрессия гепарин-связывающего протеина в рекомбинантных клетках млекопитающих

Legal Events

Date Code Title Description
FG Grant, registration