EA200101093A1 - Экспрессия гепарин-связывающего протеина в рекомбинантных клетках млекопитающих - Google Patents

Экспрессия гепарин-связывающего протеина в рекомбинантных клетках млекопитающих

Info

Publication number
EA200101093A1
EA200101093A1 EA200101093A EA200101093A EA200101093A1 EA 200101093 A1 EA200101093 A1 EA 200101093A1 EA 200101093 A EA200101093 A EA 200101093A EA 200101093 A EA200101093 A EA 200101093A EA 200101093 A1 EA200101093 A1 EA 200101093A1
Authority
EA
Eurasian Patent Office
Prior art keywords
heparin
binding protein
mammalian cells
recombinant mammalian
expression
Prior art date
Application number
EA200101093A
Other languages
English (en)
Inventor
Ганс Якоб Флодгаард
Поль Баад Расмуссен
Сёрн Бьёрн
Иван Свендсен
Original Assignee
Лейкотек А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лейкотек А/С filed Critical Лейкотек А/С
Publication of EA200101093A1 publication Critical patent/EA200101093A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Настоящее изобретение относится к способам получения гепарин-связывающего протеина (НВР - heparin-binding protein) в рекомбинантных клетках млекопитающих, которые можно выращивать в анаэробных условиях после трансфекции указанных клеток нуклеиновой кислотой, кодирующей указанный гепарин-связывающий протеин. Данное изобретение также относится к указанным рекомбинантным клеткам млекопитающих.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200101093A 1999-04-29 2000-04-28 Экспрессия гепарин-связывающего протеина в рекомбинантных клетках млекопитающих EA200101093A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13157499P 1999-04-29 1999-04-29
DKPA199900612 1999-05-06
PCT/DK2000/000216 WO2000066627A1 (en) 1999-04-29 2000-04-28 Expression of heparin-binding protein in recombinant mammalian cells

Publications (1)

Publication Number Publication Date
EA200101093A1 true EA200101093A1 (ru) 2002-04-25

Family

ID=26064312

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200101093A EA200101093A1 (ru) 1999-04-29 2000-04-28 Экспрессия гепарин-связывающего протеина в рекомбинантных клетках млекопитающих

Country Status (13)

Country Link
EP (1) EP1179017A1 (ru)
JP (1) JP2002542813A (ru)
KR (1) KR20020034073A (ru)
CN (1) CN1357007A (ru)
AU (1) AU4286100A (ru)
CA (1) CA2407714A1 (ru)
EA (1) EA200101093A1 (ru)
HK (1) HK1046005A1 (ru)
IL (1) IL146128A0 (ru)
NO (1) NO20015181L (ru)
NZ (1) NZ515762A (ru)
PL (1) PL351499A1 (ru)
WO (1) WO2000066627A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003226907A1 (en) * 2002-03-27 2003-10-08 Leukotech A/S Method for the preparation of recombinant mammalian heparin-binding protein (hbp)
EP1739179A1 (en) * 2005-06-30 2007-01-03 Octapharma AG Serum-free stable transfection and production of recombinant human proteins in human cell lines
GB201102108D0 (en) * 2011-02-07 2011-03-23 Hansa Medical Ab Diagnostic method
CN110643586B (zh) * 2019-10-15 2022-06-10 山东大学 一种肝素骨架合酶及其编码基因与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU617795B2 (en) * 1988-03-17 1991-12-05 Leukotech A/S Heparin-binding proteins, dna coding for them, processes for producing them as well as therapeutic preparations containing them
RU2200573C2 (ru) * 1994-04-21 2003-03-20 Леукотех А/С Связывающий гепарин белок для лечения сепсиса
WO1999000417A1 (en) * 1997-06-25 1999-01-07 Novo Nordisk A/S Production of heparin-binding protein in mammalian cells

Also Published As

Publication number Publication date
AU4286100A (en) 2000-11-17
IL146128A0 (en) 2002-07-25
KR20020034073A (ko) 2002-05-08
CN1357007A (zh) 2002-07-03
NZ515762A (en) 2002-11-26
JP2002542813A (ja) 2002-12-17
CA2407714A1 (en) 2000-11-09
PL351499A1 (en) 2003-04-22
HK1046005A1 (zh) 2002-12-20
NO20015181L (no) 2001-12-20
NO20015181D0 (no) 2001-10-23
WO2000066627A1 (en) 2000-11-09
EP1179017A1 (en) 2002-02-13

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