JP2009520691A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009520691A5 JP2009520691A5 JP2008543748A JP2008543748A JP2009520691A5 JP 2009520691 A5 JP2009520691 A5 JP 2009520691A5 JP 2008543748 A JP2008543748 A JP 2008543748A JP 2008543748 A JP2008543748 A JP 2008543748A JP 2009520691 A5 JP2009520691 A5 JP 2009520691A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody molecule
- purified antibody
- nucleic acid
- asn
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05027090.9 | 2005-12-12 | ||
| EP05027090 | 2005-12-12 | ||
| PCT/EP2006/011914 WO2007068429A1 (en) | 2005-12-12 | 2006-12-11 | Antibodies against amyloid beta 4 with glycosylated in the variable region |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009520691A JP2009520691A (ja) | 2009-05-28 |
| JP2009520691A5 true JP2009520691A5 (https=) | 2010-01-14 |
| JP5145241B2 JP5145241B2 (ja) | 2013-02-13 |
Family
ID=37745986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008543748A Active JP5145241B2 (ja) | 2005-12-12 | 2006-12-11 | 可変領域におけるグリコシル化を有するアミロイドβに対する抗体 |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US8906370B2 (https=) |
| EP (2) | EP1960428B1 (https=) |
| JP (1) | JP5145241B2 (https=) |
| KR (2) | KR20080077132A (https=) |
| CN (2) | CN102659943B (https=) |
| AR (1) | AR057233A1 (https=) |
| AT (1) | ATE517923T1 (https=) |
| AU (1) | AU2006326301B2 (https=) |
| BR (1) | BRPI0619605B8 (https=) |
| CA (1) | CA2632828C (https=) |
| CR (1) | CR10000A (https=) |
| CY (1) | CY1114783T1 (https=) |
| DK (1) | DK1960428T3 (https=) |
| DO (1) | DOP2006000278A (https=) |
| EC (1) | ECSP088524A (https=) |
| ES (1) | ES2368591T3 (https=) |
| IL (1) | IL191004A (https=) |
| JO (1) | JO2824B1 (https=) |
| MA (1) | MA30038B1 (https=) |
| MY (1) | MY155286A (https=) |
| NO (1) | NO346105B1 (https=) |
| NZ (1) | NZ568241A (https=) |
| PE (3) | PE20100684A1 (https=) |
| PL (1) | PL1960428T3 (https=) |
| PT (1) | PT1960428E (https=) |
| RS (1) | RS52004B (https=) |
| RU (1) | RU2438706C2 (https=) |
| SI (1) | SI1960428T1 (https=) |
| TW (1) | TWI382990B (https=) |
| UA (1) | UA99097C2 (https=) |
| UY (1) | UY30003A1 (https=) |
| WO (1) | WO2007068429A1 (https=) |
| ZA (1) | ZA200805038B (https=) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR038568A1 (es) * | 2002-02-20 | 2005-01-19 | Hoffmann La Roche | Anticuerpos anti-a beta y su uso |
| DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| RU2432362C2 (ru) | 2005-11-30 | 2011-10-27 | Эбботт Лэборетриз | Моноклональные антитела и их применения |
| PL2289909T3 (pl) | 2005-11-30 | 2015-04-30 | Abbvie Inc | Sposób przeszukiwania, proces oczyszczania niedyfundujących oligomerów Abeta, selektywne przeciwciała przeciw niedyfundującym oligomerom Abeta i sposób wytwarzania tych przeciwciał |
| UA99097C2 (ru) * | 2005-12-12 | 2012-07-25 | Ф. Хоффманн-Ля Рош Аг | Композиция, содержащая антитела к амилоиду бета 4, имеющие гликозилированный вариабельный участок |
| US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
| JP2010512356A (ja) * | 2006-12-11 | 2010-04-22 | エフ.ホフマン−ラ ロシュ アーゲー | 非経口aベータ抗体製剤 |
| EP2124952A2 (en) | 2007-02-27 | 2009-12-02 | Abbott GmbH & Co. KG | Method for the treatment of amyloidoses |
| US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| LT2167540T (lt) * | 2007-06-29 | 2018-04-25 | F. Hoffmann-La Roche Ag | Sunkioji grandinė mutantė, pagerinanti imunoglobulino gamybą |
| ES2473623T3 (es) * | 2007-08-20 | 2014-07-07 | Glaxo Group Limited | Procedimiento de producción |
| RS53174B (sr) | 2007-10-05 | 2014-06-30 | Genentech Inc. | Upotreba antiamiloidnog beta antitela u slučaju oboljenja oka |
| KR101247418B1 (ko) * | 2007-12-21 | 2013-03-25 | 에프. 호프만-라 로슈 아게 | 항체 제형 |
| US8163551B2 (en) * | 2008-05-02 | 2012-04-24 | Seattle Genetics, Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
| US20140213465A1 (en) * | 2011-12-02 | 2014-07-31 | Plaxgen, Inc. | Plaque array methods and compositions for forming and detecting plaques |
| US20120282654A1 (en) * | 2009-04-29 | 2012-11-08 | Schering Corporation | Antibody purification |
| WO2011090720A2 (en) * | 2009-12-29 | 2011-07-28 | Dr. Reddy's Laboratories Ltd | Purification of proteins |
| UY33253A (es) | 2010-03-03 | 2011-09-30 | Boehringer Ingelheim Int | Polipéptidos de unión a a-beta |
| ES2684475T3 (es) | 2010-04-15 | 2018-10-03 | Abbvie Inc. | Proteínas que se unen a beta amiloide |
| RU2607368C2 (ru) | 2010-07-30 | 2017-01-10 | Ац Иммуне С.А. | Безопасные и функциональные гуманизированные антитела |
| CN103298833B (zh) | 2010-08-14 | 2015-12-16 | Abbvie公司 | β淀粉样蛋白结合蛋白 |
| WO2012142301A2 (en) | 2011-04-12 | 2012-10-18 | Quanterix Corporation | Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury |
| SG10201604104PA (en) * | 2011-10-25 | 2016-07-28 | Prothena Therapeutics Ltd | Antibody formulations and methods |
| ES2564281T3 (es) * | 2012-03-08 | 2016-03-21 | F. Hoffmann-La Roche Ag | Formulación de anticuerpos Abeta |
| RU2711552C2 (ru) * | 2012-08-29 | 2020-01-17 | Ф. Хоффманн-Ля Рош Аг | Шаттл для гематоэнцефалического барьера |
| CN102998454A (zh) * | 2012-12-11 | 2013-03-27 | 华中师范大学 | 一种检测生物体内邻苯二甲酸二丁酯相对含量的方法 |
| ES2862950T3 (es) * | 2012-12-18 | 2021-10-08 | Univ Rockefeller | Anticuerpos anti-CD4 modificados con glicanos para la prevención y terapia del VIH |
| US9587022B2 (en) | 2012-12-18 | 2017-03-07 | The Rockefeller University | Glycan-modified anti-CD4 antibody with improved HIV-1 neutralizing activity |
| EP3594231A1 (en) | 2013-02-13 | 2020-01-15 | Laboratoire Français du Fractionnement et des Biotechnologies | Highly galactosylated anti-tnf-alpha antibodies and uses thereof |
| JP6169885B2 (ja) | 2013-05-07 | 2017-07-26 | 株式会社日立製作所 | 精製装置及び精製方法 |
| EP4331605A3 (en) | 2013-09-13 | 2024-05-22 | F. Hoffmann-La Roche AG | Methods and compositions comprising purified recombinant polypeptides |
| ES2915378T3 (es) | 2013-09-13 | 2022-06-22 | Hoffmann La Roche | Procedimientos para detectar y cuantificar una proteína de célula huésped en líneas celulares |
| CN105899192B (zh) | 2013-11-22 | 2019-08-13 | 国立大学法人东京大学 | 药物递送用载体、偶联物及含有这些成分的组合物以及它们的施予方法 |
| JP6744856B2 (ja) | 2014-04-08 | 2020-08-19 | プロセナ・バイオサイエンシズ・リミテッド | α−シヌクレインを認識する抗体を含む血液脳関門シャトル |
| WO2015165961A1 (en) | 2014-04-29 | 2015-11-05 | Affiris Ag | Treatment and prevention of alzheimer's disease (ad) |
| MX391086B (es) | 2015-06-24 | 2025-03-21 | Hoffmann La Roche | Anticuerpos anti-receptor de transferrina con afinidad diseñada. |
| FR3038517B1 (fr) | 2015-07-06 | 2020-02-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation de fragments fc modifies en immunotherapie |
| IL257146B2 (en) | 2015-08-21 | 2025-01-01 | Hoffmann La Roche | Method for reducing host cell proteins by affinity chromatography |
| NZ741067A (en) | 2015-10-02 | 2023-07-28 | Hoffmann La Roche | Bispecific anti-human cd20/human transferrin receptor antibodies and methods of use |
| AR106189A1 (es) * | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
| ES2903156T3 (es) * | 2015-10-16 | 2022-03-31 | Hoffmann La Roche | Un procedimiento para hacer funcionar un sistema y un sistema |
| US10772969B2 (en) | 2015-11-09 | 2020-09-15 | The University Of British Columbia | N-terminal epitopes in amyloid beta and conformationally-selective antibodies thereto |
| CA3004494A1 (en) | 2015-11-09 | 2017-05-18 | The University Of British Columiba | Epitopes in amyloid beta mid-region and conformationally-selective antibodies thereto |
| US10759837B2 (en) | 2015-11-09 | 2020-09-01 | The University Of British Columbia | Anti-amyloid beta antibodies binding to a cyclic amyloid beta peptide |
| US10792477B2 (en) * | 2016-02-08 | 2020-10-06 | Orbusneich Medical Pte. Ltd. | Drug eluting balloon |
| EP3427183A1 (en) * | 2016-03-10 | 2019-01-16 | Genomic Vision | Method of curvilinear signal detection and analysis and associated platform |
| EP3448874A4 (en) * | 2016-04-29 | 2020-04-22 | Voyager Therapeutics, Inc. | COMPOSITIONS FOR TREATING A DISEASE |
| TWI798751B (zh) | 2016-07-01 | 2023-04-11 | 美商美國禮來大藥廠 | 抗-N3pGlu類澱粉β肽抗體及其用途 |
| CN109476729A (zh) | 2016-07-18 | 2019-03-15 | 英属哥伦比亚大学 | 淀粉样蛋白β的抗体 |
| US20180125920A1 (en) | 2016-11-09 | 2018-05-10 | The University Of British Columbia | Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions |
| EP3632421B1 (en) * | 2017-05-30 | 2025-08-13 | Morinaga Milk Industry Co., Ltd. | Acetic acid and/or an acetic acid salt for use in the treatment of alzheimer-type dementia |
| US12286469B2 (en) | 2017-07-18 | 2025-04-29 | The University Of British Columbia | Humanized antibodies binding to amyloid-beta (A-beta) |
| ES2984844T3 (es) | 2017-07-18 | 2024-10-31 | Univ British Columbia | Anticuerpos contra beta amiloide |
| CN108048477A (zh) * | 2017-12-15 | 2018-05-18 | 南京理工大学 | 基于大肠杆菌表达系统的制备多肽的方法 |
| EP3778875A1 (en) | 2019-08-14 | 2021-02-17 | MaxiVax SA | Immortalized myoblast cell lines and uses thereof |
| MX2023000949A (es) | 2020-07-23 | 2023-02-22 | Othair Prothena Ltd | Anticuerpos anti-beta-amiloide (abeta). |
| PE20231556A1 (es) * | 2020-11-16 | 2023-10-03 | Hoffmann La Roche | Glucoformas de fab ricas en manosa |
| TW202300517A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗類澱粉β抗體及其用途 |
| WO2022251048A1 (en) | 2021-05-24 | 2022-12-01 | Eli Lilly And Company | Anti-amyloid beta antibodies and uses thereof |
| CN114720543B (zh) * | 2022-04-06 | 2026-02-24 | 苏州大学 | 一种基于固相糖蛋白t抗原糖肽富集和酶切分析的方法 |
| CN114591429B (zh) * | 2022-05-07 | 2022-08-09 | 北京第一生物化学药业有限公司 | 结合β-淀粉样蛋白的抗体及其用途 |
| TW202434629A (zh) | 2023-01-26 | 2024-09-01 | 愛爾蘭商歐薩爾普羅席納有限公司 | 以抗類澱粉β (ABETA)抗體治療神經病症之方法 |
| KR20260051039A (ko) | 2023-08-09 | 2026-04-15 | 에프. 호프만-라 로슈 아게 | 항-a-베타 단백질 항체, 이의 제조 방법 및 용도 |
| AU2024323186A1 (en) | 2023-08-09 | 2026-01-15 | F. Hoffmann-La Roche Ag | Mono and multispecific anti-trem2 antibodies, methods and uses thereof |
| CN117783359B (zh) * | 2023-12-28 | 2024-12-31 | 中国计量科学研究院 | 一种基于串联质谱的转基因蛋白多靶同检方法 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4666829A (en) | 1985-05-15 | 1987-05-19 | University Of California | Polypeptide marker for Alzheimer's disease and its use for diagnosis |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US5811310A (en) | 1986-09-30 | 1998-09-22 | Albert Einstein College Of Medicine Of Yeshiva Univ. | The Alz-50 monoclonal antibody and diagnostic assay for alzheimer's disease |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| CA1339014C (en) | 1987-10-08 | 1997-03-25 | Ronald E. Majocha | Antibodies to a4 amyloid peptide |
| JP2780507B2 (ja) | 1991-03-29 | 1998-07-30 | 松下電器産業株式会社 | 内燃機関用フィルタ再生装置 |
| US5955317A (en) | 1993-01-25 | 1999-09-21 | Takeda Chemical Industries, Ltd. | Antibodies to β-amyloids or their derivatives and use thereof |
| EP0683234B2 (en) | 1993-01-25 | 2007-06-06 | Takeda Chemical Industries, Ltd. | Antibody against beta-amyloid or their derivative and use thereof |
| US5443953A (en) * | 1993-12-08 | 1995-08-22 | Immunomedics, Inc. | Preparation and use of immunoconjugates |
| GB9416007D0 (en) * | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Anthracyclinone derivatives |
| US5688651A (en) | 1994-12-16 | 1997-11-18 | Ramot University Authority For Applied Research And Development Ltd. | Prevention of protein aggregation |
| CA2222522A1 (en) * | 1995-06-06 | 1996-12-12 | Stemcell Therapeutics L.L.C. | Glycoprotein gp105 on bl3 hematopoietic stem cells |
| AU725609C (en) | 1995-08-18 | 2002-01-03 | Morphosys Ag | Protein/(poly)peptide libraries |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| EP1161449B1 (en) * | 1999-03-04 | 2007-07-04 | Praecis Pharmaceuticals Incorporated | Modulators of beta-amyloid peptide aggregation comprising d-amino acids |
| WO2000077178A1 (en) | 1999-06-16 | 2000-12-21 | Boston Biomedical Research Institute | IMMUNOLOGICAL CONTROL OF β-AMYLOID LEVELS IN VIVO |
| AU6722300A (en) | 1999-08-31 | 2001-03-26 | Ramot University Authority For Applied Research And Industrial Development Ltd. | Peptides and substances, methods and devices using same for diagnosing and treating neurodegenerative disorders |
| US20020094335A1 (en) | 1999-11-29 | 2002-07-18 | Robert Chalifour | Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases |
| NZ540564A (en) | 1999-11-29 | 2007-04-27 | Neurochem Int Ltd | Vaccine for the prevention and treatment of Alzheimer's and amyloid related diseases |
| EP1125905A1 (en) | 2000-02-16 | 2001-08-22 | Pepscan Systems B.V. | Segment synthesis |
| BRPI0108676B8 (pt) | 2000-02-24 | 2021-05-25 | Lilly Co Eli | anticorpos humanizados que sequestram peptídeo amilóide beta e seus usos no tratamento de condições caracterizadas por formação de placas amiloides, bem como composição farmacêutica que compreende os referidos anticorpos |
| CA2313828A1 (en) | 2000-08-01 | 2002-02-01 | Institut De Recherches Cliniques De Montreal/Ircm | Post-translational processing of .beta.-secretase (bace): the pro-and transmembrane/cytosolic domains affect its cellular activity and amyloid a.beta. production |
| TWI255272B (en) | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| JP2005501220A (ja) | 2000-12-19 | 2005-01-13 | パラチン テクノロジーズ インク. | ペプチドおよび蛋白質の標的特異的折りたたみ部位の識別 |
| ES2437875T3 (es) | 2001-04-30 | 2014-01-14 | Eli Lilly And Company | Anticuerpos humanizados que reconocen el péptido beta-amiloide |
| US7320790B2 (en) | 2001-04-30 | 2008-01-22 | Eli Lilly And Company | Humanized antibodies |
| JP2005503789A (ja) * | 2001-08-17 | 2005-02-10 | イーライ・リリー・アンド・カンパニー | 抗Aβ抗体 |
| PT1944040E (pt) * | 2001-08-17 | 2012-10-31 | Univ Washington | Método de avaliação para a doença de alzheimer |
| AR038568A1 (es) | 2002-02-20 | 2005-01-19 | Hoffmann La Roche | Anticuerpos anti-a beta y su uso |
| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| MXPA05003621A (es) | 2002-10-09 | 2005-10-19 | Rinat Neuroscience Corp | Metodos de tratamiento de la enfermedad de alzheimer usando anticuerpos dirigidos contra el peptido beta amiloide y composiciones de los mismos. |
| DE10303974A1 (de) * | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
| UA99097C2 (ru) * | 2005-12-12 | 2012-07-25 | Ф. Хоффманн-Ля Рош Аг | Композиция, содержащая антитела к амилоиду бета 4, имеющие гликозилированный вариабельный участок |
| JP2010512356A (ja) * | 2006-12-11 | 2010-04-22 | エフ.ホフマン−ラ ロシュ アーゲー | 非経口aベータ抗体製剤 |
-
2006
- 2006-12-11 UA UAA200808791A patent/UA99097C2/ru unknown
- 2006-12-11 UY UY30003A patent/UY30003A1/es unknown
- 2006-12-11 NO NO20082874A patent/NO346105B1/no unknown
- 2006-12-11 PE PE2010000354A patent/PE20100684A1/es not_active Application Discontinuation
- 2006-12-11 PE PE2006001587A patent/PE20071002A1/es not_active Application Discontinuation
- 2006-12-11 WO PCT/EP2006/011914 patent/WO2007068429A1/en not_active Ceased
- 2006-12-11 PL PL06829502T patent/PL1960428T3/pl unknown
- 2006-12-11 RS RS20110401A patent/RS52004B/sr unknown
- 2006-12-11 DO DO2006000278A patent/DOP2006000278A/es unknown
- 2006-12-11 PT PT06829502T patent/PT1960428E/pt unknown
- 2006-12-11 US US12/086,309 patent/US8906370B2/en active Active
- 2006-12-11 CA CA2632828A patent/CA2632828C/en active Active
- 2006-12-11 JO JO2006444A patent/JO2824B1/en active
- 2006-12-11 BR BRPI0619605A patent/BRPI0619605B8/pt active IP Right Grant
- 2006-12-11 KR KR1020087012289A patent/KR20080077132A/ko not_active Ceased
- 2006-12-11 KR KR1020127010552A patent/KR101401159B1/ko active Active
- 2006-12-11 CN CN201210137369.8A patent/CN102659943B/zh active Active
- 2006-12-11 SI SI200631096T patent/SI1960428T1/sl unknown
- 2006-12-11 TW TW095146304A patent/TWI382990B/zh active
- 2006-12-11 CN CN2006800463079A patent/CN101351476B/zh active Active
- 2006-12-11 ES ES06829502T patent/ES2368591T3/es active Active
- 2006-12-11 AR ARP060105433A patent/AR057233A1/es unknown
- 2006-12-11 MY MYPI20081349A patent/MY155286A/en unknown
- 2006-12-11 PE PE2010000560A patent/PE20100748A1/es active IP Right Grant
- 2006-12-11 NZ NZ568241A patent/NZ568241A/en unknown
- 2006-12-11 EP EP06829502A patent/EP1960428B1/en active Active
- 2006-12-11 AU AU2006326301A patent/AU2006326301B2/en active Active
- 2006-12-11 DK DK06829502.1T patent/DK1960428T3/da active
- 2006-12-11 AT AT06829502T patent/ATE517923T1/de active
- 2006-12-11 JP JP2008543748A patent/JP5145241B2/ja active Active
- 2006-12-11 EP EP11169488A patent/EP2377886A1/en not_active Withdrawn
- 2006-12-11 RU RU2008128138/10A patent/RU2438706C2/ru active
-
2008
- 2008-04-27 IL IL191004A patent/IL191004A/en active IP Right Grant
- 2008-05-20 CR CR10000A patent/CR10000A/es unknown
- 2008-06-09 MA MA31014A patent/MA30038B1/fr unknown
- 2008-06-10 ZA ZA200805038A patent/ZA200805038B/xx unknown
- 2008-06-10 EC EC2008008524A patent/ECSP088524A/es unknown
-
2011
- 2011-09-16 CY CY20111100899T patent/CY1114783T1/el unknown
-
2014
- 2014-11-07 US US14/536,262 patent/US9272031B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009520691A5 (https=) | ||
| CA2632828A1 (en) | Antibodies against amyloid beta with glycosylation in the variable region | |
| CA3058482C (en) | Anti-n3pglu amyloid beta peptide antibodies and uses thereof | |
| EP3042917B1 (en) | Anti-n3pglu amyloid beta peptide antibodies and uses thereof | |
| EP3172221B1 (en) | Purification platform for bispecific antibodies | |
| EP3581245B1 (en) | Antibodies to tau and uses thereof | |
| US7820800B2 (en) | Process for the purification of IL-18 binding protein | |
| AU2008277888B2 (en) | Chromatographic methods | |
| EP2281000A2 (en) | Antibody purification process | |
| JP2005508165A5 (https=) | ||
| AU2018225493B2 (en) | Early detection of glial cell activation in neurodegenerative or neuroinflammatory diseases | |
| CA2692612C (en) | Purification of pegylated polypeptides | |
| JP2008543881A5 (https=) | ||
| EP1596809A2 (en) | Abeta binding molecules | |
| JP2012507557A5 (https=) | ||
| CN101365722A (zh) | 纯化抗Aβ抗体的方法 | |
| JP2010502737A (ja) | アフィニティークロマトグラフィーを使用するタンパク質精製におけるアルギニン洗浄 | |
| WO2018031361A2 (en) | Combination therapy | |
| AU2014305658A1 (en) | An antibody therapy for amyloid beta disease | |
| CA2569795C (en) | Process for the purification of il-18 binding protein | |
| JP2025508308A (ja) | 神経変性性または神経学的な疾患または障害に対する顆粒球マクロファージコロニー刺激因子ベースの治療 | |
| CN117264054B (zh) | 靶向il-6的纳米抗体、组合物、方法及用途 | |
| IL305560A (en) | Anti-n3pglu amyloid beta antibodies and uses thereof | |
| TH72362B (th) | แอนติบอดีไกลโคซิลเลชันในบริเวณผันแปร | |
| TH90393A (th) | แอนติบอดีไกลโคซิลเลชันในบริเวณผันแปร |