JP2009519703A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009519703A5 JP2009519703A5 JP2006541713A JP2006541713A JP2009519703A5 JP 2009519703 A5 JP2009519703 A5 JP 2009519703A5 JP 2006541713 A JP2006541713 A JP 2006541713A JP 2006541713 A JP2006541713 A JP 2006541713A JP 2009519703 A5 JP2009519703 A5 JP 2009519703A5
- Authority
- JP
- Japan
- Prior art keywords
- snp
- polynucleotide
- seq
- group
- allele
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52488203P | 2003-11-26 | 2003-11-26 | |
| US60/524,882 | 2003-11-26 | ||
| US56821904P | 2004-05-06 | 2004-05-06 | |
| US60/568,219 | 2004-05-06 | ||
| PCT/US2004/039576 WO2005056837A2 (en) | 2003-11-26 | 2004-11-24 | Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011004344A Division JP2011115168A (ja) | 2003-11-26 | 2011-01-12 | 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009519703A JP2009519703A (ja) | 2009-05-21 |
| JP2009519703A5 true JP2009519703A5 (enExample) | 2009-07-02 |
| JP5649263B2 JP5649263B2 (ja) | 2015-01-07 |
Family
ID=34681478
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006541713A Expired - Fee Related JP5649263B2 (ja) | 2003-11-26 | 2004-11-24 | 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途 |
| JP2011004344A Withdrawn JP2011115168A (ja) | 2003-11-26 | 2011-01-12 | 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途 |
| JP2013166477A Withdrawn JP2014023533A (ja) | 2003-11-26 | 2013-08-09 | 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途 |
| JP2015204277A Expired - Fee Related JP6211042B2 (ja) | 2003-11-26 | 2015-10-16 | 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途 |
| JP2015204276A Expired - Fee Related JP6041960B2 (ja) | 2003-11-26 | 2015-10-16 | 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途 |
| JP2016246194A Expired - Fee Related JP6376612B2 (ja) | 2003-11-26 | 2016-12-20 | 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途 |
| JP2017233228A Expired - Fee Related JP6537150B2 (ja) | 2003-11-26 | 2017-12-05 | 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途 |
| JP2019004206A Expired - Fee Related JP6749431B2 (ja) | 2003-11-26 | 2019-01-15 | 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途 |
| JP2020041614A Withdrawn JP2020108390A (ja) | 2003-11-26 | 2020-03-11 | 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途 |
Family Applications After (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011004344A Withdrawn JP2011115168A (ja) | 2003-11-26 | 2011-01-12 | 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途 |
| JP2013166477A Withdrawn JP2014023533A (ja) | 2003-11-26 | 2013-08-09 | 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途 |
| JP2015204277A Expired - Fee Related JP6211042B2 (ja) | 2003-11-26 | 2015-10-16 | 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途 |
| JP2015204276A Expired - Fee Related JP6041960B2 (ja) | 2003-11-26 | 2015-10-16 | 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途 |
| JP2016246194A Expired - Fee Related JP6376612B2 (ja) | 2003-11-26 | 2016-12-20 | 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途 |
| JP2017233228A Expired - Fee Related JP6537150B2 (ja) | 2003-11-26 | 2017-12-05 | 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途 |
| JP2019004206A Expired - Fee Related JP6749431B2 (ja) | 2003-11-26 | 2019-01-15 | 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途 |
| JP2020041614A Withdrawn JP2020108390A (ja) | 2003-11-26 | 2020-03-11 | 心臓血管障害および薬物応答に関連した遺伝子多型、それらの検出方法および用途 |
Country Status (5)
| Country | Link |
|---|---|
| US (6) | US20050272054A1 (enExample) |
| EP (7) | EP2186913B1 (enExample) |
| JP (9) | JP5649263B2 (enExample) |
| CA (7) | CA3048093A1 (enExample) |
| WO (1) | WO2005056837A2 (enExample) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1318517B1 (it) * | 2000-05-12 | 2003-08-27 | Ist Naz Stud Cura Dei Tumori | Polinucleotidi codificanti per forme polimorfiche della proteinapthrp, le proteine codificate, e loro applicazioni terapeutiche. |
| WO2002038794A2 (en) | 2000-11-09 | 2002-05-16 | The Brigham And Women's Hospital, Inc. | Cardiovascular disease diagnostic and therapeutic targets |
| EP1801240A1 (en) * | 2001-06-05 | 2007-06-27 | Auckland Uniservices Limited | Methods and compositions for assessment of pulmonary function and disorders |
| WO2003094856A2 (en) | 2002-05-09 | 2003-11-20 | The Brigham And Women's Hospital, Inc. | 1l1rl-1 as a cardiovascular disease marker and therapeutic target |
| US8178294B2 (en) * | 2002-06-14 | 2012-05-15 | Cedars-Sinai Medical Center | Method of haplotype-based genetic analysis for determining risk for developing insulin resistance, coronary artery disease and other phenotypes |
| RS20060581A (sr) * | 2004-04-23 | 2008-11-28 | Amgen Inc., | Antitela na domene cd148 koji inhibiraju angiogenezu |
| US7306562B1 (en) * | 2004-04-23 | 2007-12-11 | Medical Software, Llc | Medical risk assessment method and program product |
| AU2005316169B2 (en) * | 2004-12-13 | 2011-11-17 | Alethia Biotherapeutics Inc. | Polynucleotides and polypeptide sequences involved in the process of bone remodeling |
| EP1880332A4 (en) * | 2005-04-27 | 2010-02-17 | Emiliem | NOVEL METHODS AND DEVICES FOR EVALUATING TOXIC SUBSTANCES |
| CA2608142A1 (en) * | 2005-05-10 | 2006-11-16 | Synergenz Bioscience Limited | Methods and compositions for assessment of pulmonary function and disorders |
| JP2008545390A (ja) * | 2005-05-19 | 2008-12-18 | シナージェンズ バイオサイエンス リミティド | 遺伝的多型を用いた肺癌を発達させるリスクの評価方法 |
| AU2006248200A1 (en) * | 2005-05-19 | 2006-11-23 | Synergenz Bioscience Limited | Methods and compositions for assessment of pulmonary function and disorders |
| AU2006248189A1 (en) * | 2005-05-20 | 2006-11-23 | Synergenz Bioscience Limited | Methods of analysis of polymorphisms and uses thereof |
| US20070099239A1 (en) * | 2005-06-24 | 2007-05-03 | Raymond Tabibiazar | Methods and compositions for diagnosis and monitoring of atherosclerotic cardiovascular disease |
| WO2007023148A2 (en) * | 2005-08-22 | 2007-03-01 | Innogenetics N.V. | Nucleic acid variants in the lbp gene associated with altered innate immunity |
| US7666584B2 (en) * | 2005-09-01 | 2010-02-23 | Philadelphia Health & Education Coporation | Identification of a pin specific gene and protein (PIN-1) useful as a diagnostic treatment for prostate cancer |
| US7799530B2 (en) | 2005-09-23 | 2010-09-21 | Celera Corporation | Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof |
| EP1795609A1 (en) * | 2005-12-06 | 2007-06-13 | Sanofi-Aventis Deutschland GmbH | Method for the diagnosis and treatment of cardiovascular diseases |
| WO2007127749A2 (en) * | 2006-04-24 | 2007-11-08 | Critical Care Diagnostics, Inc. | Predicting mortality and detecting severe disease |
| US20090305265A1 (en) * | 2006-04-27 | 2009-12-10 | Critical Care Diagnostics, Inc. | Interleukin-33 (il-33) for the diagnosis and prognosis of cardiovascular disease |
| PL2021796T3 (pl) * | 2006-05-01 | 2012-07-31 | Critical Care Diagnostics Inc | Diagnozowanie choroby sercowo-naczyniowej |
| HUE025058T2 (en) * | 2006-05-02 | 2016-01-28 | Critical Care Diagnostics Inc | Differential diagnosis of pulmonary and cardiovascular disease |
| JP4884180B2 (ja) * | 2006-11-21 | 2012-02-29 | 東京エレクトロン株式会社 | 基板処理装置および基板処理方法 |
| US20080131887A1 (en) * | 2006-11-30 | 2008-06-05 | Stephan Dietrich A | Genetic Analysis Systems and Methods |
| CA2679581C (en) * | 2007-02-21 | 2020-12-22 | Anna Helgadottir | Genetic susceptibility variants associated with arterial disease |
| US7695916B2 (en) * | 2007-03-22 | 2010-04-13 | Celera Corporation | Genetic polymorphisms associated with coronary events and drug response, methods of detection and uses thereof |
| WO2008136996A2 (en) * | 2007-04-30 | 2008-11-13 | The Ohio State University Research Foundation | Polymorphisms in genes affecting ace-related disorders and uses thereof |
| BRPI0811309B1 (pt) * | 2007-05-09 | 2022-03-03 | The Brigham And Women's Hospital, Inc. | Métodos in vitro para avaliar uma responsividade do gene apo(a) em uma amostra de ácido nucleico de um indivíduo humano ao tratamento com ácido acetilsalicílico para reduzir o risco de um evento cardiovascular futuro |
| US20090099789A1 (en) * | 2007-09-26 | 2009-04-16 | Stephan Dietrich A | Methods and Systems for Genomic Analysis Using Ancestral Data |
| CN101230392B (zh) * | 2007-12-06 | 2010-11-24 | 卫生部北京医院 | 一种预测2型糖尿病易感性的方法及试剂 |
| EP2229457A4 (en) | 2007-12-14 | 2011-01-26 | Minitube America Inc | SEX-SPECIFIC SEPARATION OF SPERM AND EMBRYOES |
| US20090221620A1 (en) * | 2008-02-20 | 2009-09-03 | Celera Corporation | Gentic polymorphisms associated with stroke, methods of detection and uses thereof |
| US20110112186A1 (en) * | 2008-02-29 | 2011-05-12 | Isis Innovation Limited | Diagnostic methods |
| CN102016552A (zh) * | 2008-03-05 | 2011-04-13 | 神谷来克斯公司 | 用于分子的高灵敏性检测的方法和组合物 |
| EP2276855B1 (en) | 2008-03-13 | 2016-05-11 | Celera Corporation | Genetic polymorphisms associated wiith venous thrombosis, methods of detection and uses thereof |
| HUE029880T2 (en) | 2008-04-18 | 2017-04-28 | Critical Care Diagnostics Inc | Predicting the risk of serious heart events |
| JP5797551B2 (ja) * | 2008-04-22 | 2015-10-21 | フエー・イー・ベー・フエー・ゼツト・ウエー | 肝特異的核酸調節要素ならびにその方法および用途 |
| ES2708826T3 (es) * | 2008-05-02 | 2019-04-11 | Orig3N Inc | Detección de la predisposición genética a afecciones asociadas a la osteoartritis |
| US9817001B2 (en) | 2008-05-27 | 2017-11-14 | Boston Heart Diagnostics Corporation | Methods for determining LDL cholesterol treatment |
| US8216786B2 (en) * | 2008-07-09 | 2012-07-10 | Celera Corporation | Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof |
| BRPI0918889A2 (pt) * | 2008-09-12 | 2015-12-01 | Navigenics Inc | método para gerar uma pontuação de um índice composto genético ambiental (egci) para uma doença ou condição de um indivíduo |
| US8470541B1 (en) | 2008-09-27 | 2013-06-25 | Boston Heart Diagnostics Corporation | Methods for separation and immuno-detection of biomolecules, and apparatus related thereto |
| CA2746003C (en) | 2008-12-04 | 2020-03-31 | Opko Curna, Llc | Treatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf |
| WO2010129477A1 (en) * | 2009-05-04 | 2010-11-11 | Duke University | Acid ceramidase polymorphisms and methods of predicting traits using the acid ceramidase polymorphisms |
| AU2010259022B2 (en) | 2009-06-08 | 2016-05-12 | Singulex, Inc. | Highly sensitive biomarker panels |
| US20110269735A1 (en) * | 2010-04-19 | 2011-11-03 | Celera Corporation | Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof |
| WO2011140484A1 (en) | 2010-05-06 | 2011-11-10 | Singulex, Inc | Methods for diagnosing, staging, predicting risk for developing and identifying treatment responders for rheumatoid arthritis |
| US20120108651A1 (en) * | 2010-11-02 | 2012-05-03 | Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) | Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof |
| US20140044668A1 (en) * | 2011-02-15 | 2014-02-13 | The Ohio State University | Methods for Predicting Cardiovascular Risks and Responsiveness to Statin Therapy Using SNPs |
| CN103718046B (zh) | 2011-03-17 | 2016-10-12 | 重症监护诊断股份有限公司 | 预测不良临床结果的风险的方法 |
| AU2012322018B2 (en) | 2011-10-13 | 2017-09-21 | Boston Heart Diagnostics | Compositions and methods for treating and preventing coronary heart disease |
| MX2014008299A (es) * | 2012-01-04 | 2014-08-21 | Mofa Group Llc | Identificacion de genero especifico de celulas espermaticas y embriones utilizando acidos nucleicos bloqueados. |
| JP6450679B2 (ja) | 2012-08-21 | 2019-01-09 | クリティカル ケア ダイアグノスティクス インコーポレイテッド | マルチマーカーリスク層別化 |
| US9938576B1 (en) | 2012-09-21 | 2018-04-10 | Ohio State Innovation Foundation | Materials and methods for determining metabolizer status in humans |
| US9828624B2 (en) | 2013-07-24 | 2017-11-28 | Boston Heart Diagnostics Corporation | Driving patient compliance with therapy |
| CA2968221A1 (en) | 2014-11-17 | 2016-05-26 | Boston Heart Diagnostic Corporation | Cardiovascular disease risk assessment |
| US20180137943A1 (en) * | 2016-11-01 | 2018-05-17 | Medarchon, Llc | Patient handoff device, system and predictive method |
| WO2019046814A1 (en) | 2017-09-01 | 2019-03-07 | Venn Biosciences Corporation | IDENTIFICATION AND USE OF GLYCOPEPTIDES AS BIOMARKERS FOR THE DIAGNOSIS AND MONITORING OF TREATMENT |
| WO2020002602A1 (fr) * | 2018-06-29 | 2020-01-02 | bioMérieux | Procédé pour déterminer in vitro ou ex vivo le statut immunitaire d'un individu |
| JP2020060975A (ja) * | 2018-10-10 | 2020-04-16 | トヨタ自動車株式会社 | 信用評価装置、信用評価方法およびプログラム |
| EP3935581A4 (en) | 2019-03-04 | 2022-11-30 | Iocurrents, Inc. | DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING |
| CA3167327A1 (en) * | 2020-02-28 | 2021-09-02 | J.R. Simplot Company | Potato transformation vectors |
| CN112410440B (zh) * | 2020-12-15 | 2022-08-02 | 吉林省农业科学院 | 一种检测绵羊肌肉脂肪含量的试剂、引物、试剂盒和应用 |
| US12406413B2 (en) * | 2021-05-10 | 2025-09-02 | Optum Services (Ireland) Limited | Predictive data analysis using image representations of genomic data |
| CN113549688B (zh) * | 2021-08-27 | 2023-08-04 | 河北医科大学第二医院 | 一组诊断冠状动脉疾病的分子标志物 |
| US20250121041A1 (en) * | 2022-01-07 | 2025-04-17 | The Government Of The United States, As Represented By The Secretary Of The Army | Hemostatic composition containing recombinant human clotting factors, and method of producing |
| JP7331325B1 (ja) * | 2022-08-30 | 2023-08-23 | 株式会社seeDNA | 2種以上の検査を実施可能な遺伝学的解析方法 |
| CN116949180A (zh) * | 2023-08-03 | 2023-10-27 | 中山大学孙逸仙纪念医院 | 用于胰腺导管腺癌的诊断、治疗和预后预测的产品及其应用 |
| CN118557734B (zh) * | 2024-07-24 | 2024-11-22 | 中山大学中山眼科中心 | Serpinb2抑制剂在制备用于治疗湿性年龄相关性黄斑变性药物中的应用 |
| CN118949044B (zh) * | 2024-10-15 | 2025-03-28 | 北京大学第一医院(北京大学第一临床医学院) | Lrp3在缺血性心脏病治疗中的应用 |
Family Cites Families (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US117329A (en) | 1871-07-25 | Improvement in parlor-skates | ||
| US4107288A (en) | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US4870009A (en) | 1982-11-22 | 1989-09-26 | The Salk Institute For Biological Studies | Method of obtaining gene product through the generation of transgenic animals |
| FR2540122B1 (fr) | 1983-01-27 | 1985-11-29 | Centre Nat Rech Scient | Nouveaux composes comportant une sequence d'oligonucleotide liee a un agent d'intercalation, leur procede de synthese et leur application |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| NO870613L (no) | 1986-03-05 | 1987-09-07 | Molecular Diagnostics Inc | Deteksjon av mikroorganismer i en prve inneholdende nukleinsyre. |
| US5004565A (en) | 1986-07-17 | 1991-04-02 | The Board Of Governors Of Wayne State University | Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5637677A (en) | 1987-07-16 | 1997-06-10 | The Trustees Of The University Of Pennsylvania | Biologically active compounds and methods of constructing and using the same |
| US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
| US5856522A (en) | 1995-05-04 | 1999-01-05 | Tropix, Inc. | Method of using synthesis of 1,2-dioxetanes and kits therefore |
| US4988617A (en) | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
| EP0451141B1 (en) | 1988-05-20 | 1998-11-18 | F. Hoffmann-La Roche Ag | Immobilized sequence-specific probes |
| US4988167A (en) | 1988-08-10 | 1991-01-29 | Fergason James L | Light blocking and vision restoration apparatus with glint control |
| US5118801A (en) | 1988-09-30 | 1992-06-02 | The Public Health Research Institute | Nucleic acid process containing improved molecular switch |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
| US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| US5994073A (en) | 1990-08-30 | 1999-11-30 | Tropix, Inc. | Enhancement of chemiluminescent assays |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5270184A (en) | 1991-11-19 | 1993-12-14 | Becton, Dickinson And Company | Nucleic acid target generation |
| EP0655090B1 (en) | 1992-04-27 | 2000-12-27 | The Trustees Of Dartmouth College | Detection of gene sequences in biological fluids |
| DE69333366T2 (de) | 1992-10-30 | 2004-09-16 | The General Hospital Corp., Boston | Ein neues zellzyklus kontrollprotein |
| DE69433811T2 (de) | 1993-01-07 | 2005-06-23 | Sequenom, Inc., San Diego | Dns - sequenzierung durch massenspektronomie |
| US5422252A (en) | 1993-06-04 | 1995-06-06 | Becton, Dickinson And Company | Simultaneous amplification of multiple targets |
| US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| US6027923A (en) | 1993-07-23 | 2000-02-22 | Bio-Rad Laboratories, Inc. | Linked linear amplification of nucleic acids |
| US5527675A (en) | 1993-08-20 | 1996-06-18 | Millipore Corporation | Method for degradation and sequencing of polymers which sequentially eliminate terminal residues |
| US5498531A (en) | 1993-09-10 | 1996-03-12 | President And Fellows Of Harvard College | Intron-mediated recombinant techniques and reagents |
| DE4331012A1 (de) | 1993-09-13 | 1995-03-16 | Bayer Ag | Nukleinsäuren-bindende Oligomere mit N-Verzweigung für Therapie und Diagnostik |
| AU8126694A (en) | 1993-10-26 | 1995-05-22 | Affymax Technologies N.V. | Arrays of nucleic acid probes on biological chips |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US6015880A (en) | 1994-03-16 | 2000-01-18 | California Institute Of Technology | Method and substrate for performing multiple sequential reactions on a matrix |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5705333A (en) | 1994-08-05 | 1998-01-06 | The Regents Of The University Of California | Peptide-based nucleic acid mimics(PENAMS) |
| US5773628A (en) | 1994-11-14 | 1998-06-30 | Tropix, Inc. | 1,2-dioxetane compounds with haloalkoxy groups, methods preparation and use |
| US5591591A (en) | 1995-02-09 | 1997-01-07 | Tropix, Inc. | Dioxetane compounds for the chemiluminescent detection of proteases, methods of use and kits therefore |
| US5589136A (en) | 1995-06-20 | 1996-12-31 | Regents Of The University Of California | Silicon-based sleeve devices for chemical reactions |
| GB9517779D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| GB9517780D0 (en) | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| US5801115A (en) | 1995-09-05 | 1998-09-01 | Kataleuna Gmbh | Catalyst composition and methods for using and preparing same |
| US5679803A (en) | 1995-10-25 | 1997-10-21 | Tropix, Inc. | 1,2 chemiluminescent dioxetanes of improved performance |
| EP2368897B1 (en) | 1996-02-09 | 2016-10-19 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| US5885470A (en) | 1997-04-14 | 1999-03-23 | Caliper Technologies Corporation | Controlled fluid transport in microfabricated polymeric substrates |
| WO1997040462A2 (en) | 1996-04-19 | 1997-10-30 | Spectra Biomedical, Inc. | Correlating polymorphic forms with multiple phenotypes |
| EP2369007B1 (en) | 1996-05-29 | 2015-07-29 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
| US6117635A (en) | 1996-07-16 | 2000-09-12 | Intergen Company | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US5866336A (en) | 1996-07-16 | 1999-02-02 | Oncor, Inc. | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US6233205B1 (en) | 1996-09-17 | 2001-05-15 | Xilinx, Inc. | Built-in self test method for measuring clock to out delays |
| US5800999A (en) | 1996-12-16 | 1998-09-01 | Tropix, Inc. | Dioxetane-precursor-labeled probes and detection assays employing the same |
| AU6956798A (en) * | 1997-04-10 | 1998-10-30 | Genetics Institute Inc. | Secreted expressed sequence tags (sests) |
| KR100351531B1 (ko) | 1997-04-25 | 2002-09-11 | 캘리퍼 테크놀로지스 코포레이션 | 기하형상이 개선된 채널을 채용하는 미소 유체 장치 |
| AU8286998A (en) * | 1997-07-03 | 1999-01-25 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Genes for niemann-pick type c disease |
| US6119096A (en) | 1997-07-31 | 2000-09-12 | Eyeticket Corporation | System and method for aircraft passenger check-in and boarding using iris recognition |
| GB9717766D0 (en) * | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Methods |
| US20030082677A1 (en) * | 1997-09-30 | 2003-05-01 | Holtzman Douglas A. | Novel EDIRF, MTR-1, LSP-1, TAP-1, and PA-I molecules and uses therefor |
| WO1999018243A1 (en) * | 1997-10-06 | 1999-04-15 | Millennium Pharmaceuticals, Inc. | Signal peptide containing proteins and uses therefor |
| AU4158799A (en) * | 1998-06-06 | 1999-12-30 | Genostic Pharma Limited | Probes used for genetic filing |
| US6506594B1 (en) | 1999-03-19 | 2003-01-14 | Cornell Res Foundation Inc | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| DE10019058A1 (de) * | 2000-04-06 | 2001-12-20 | Epigenomics Ag | Detektion von Variationen des DNA-Methylierungsprofils |
| US6812339B1 (en) * | 2000-09-08 | 2004-11-02 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
| AU2001289861A1 (en) * | 2000-09-19 | 2002-04-02 | Epidauros Biotechnologie Ag | Polymorphisms in human genes of cardiovascular regulators and their use in diagnostic and therapeutic applications |
| AU2002224774A1 (en) * | 2000-10-10 | 2002-04-22 | Bayer Aktiengesellschaft | Human phospholipase a2-like enzyme |
| USH2191H1 (en) * | 2000-10-24 | 2007-06-05 | Snp Consortium | Identification and mapping of single nucleotide polymorphisms in the human genome |
| FR2815970A1 (fr) * | 2000-10-31 | 2002-05-03 | Aventis Pharma Sa | Sequences polymorphes du gene humain abca1, leurs utilisations, les methodes et kits de detection |
| WO2002044994A2 (en) * | 2000-11-30 | 2002-06-06 | Third Wave Technologies, Inc. | Systems and methods for detection assay ordering, design, production, inventory, sales and analysis for use with or in a production facility |
| US20030104470A1 (en) * | 2001-08-14 | 2003-06-05 | Third Wave Technologies, Inc. | Electronic medical record, library of electronic medical records having polymorphism data, and computer systems and methods for use thereof |
| DE10061279A1 (de) * | 2000-12-08 | 2002-07-25 | Vinzenz Hombach | Verfahren und Diagnose-Kit zur Bestimmung der Prädisposition für Herz-Kreislauf-Krankheiten und Arteriosklerose |
| US20030152924A1 (en) * | 2000-12-19 | 2003-08-14 | Ullman Edwin F. | Strand displacement detection of target nucleic acid |
| WO2002052044A2 (en) * | 2000-12-27 | 2002-07-04 | Riken | Detection of genetic polymorphisms in genes associated with pharmacogenomics |
| WO2002068579A2 (en) * | 2001-01-10 | 2002-09-06 | Pe Corporation (Ny) | Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof |
| WO2002072889A2 (en) | 2001-01-12 | 2002-09-19 | Applera Corporation | Methods and compositions for microarray control |
| US20030036057A1 (en) * | 2001-03-09 | 2003-02-20 | Andreas Braun | Genes and polymorphisms associated with cardiovascular disease and their use |
| CA2448484A1 (en) * | 2001-05-25 | 2002-12-05 | Xenon Genetics, Inc. | Diagnostic methods for cardiovascular disease, low hdl-cholesterol levels, and high triglyceride levels |
| CA2486789A1 (en) * | 2001-06-29 | 2003-01-09 | Dnaprint Genomics, Inc. | Compositions and methods for inferring a response to a statin |
| US20030124536A1 (en) * | 2001-07-20 | 2003-07-03 | Vitivity, Inc. | Diagnosis and treatment of vascular disease |
| WO2003027264A2 (en) * | 2001-09-27 | 2003-04-03 | University Of Delaware | Coisogenic eukaryotic cell collections |
| US7468244B2 (en) * | 2001-09-27 | 2008-12-23 | University Of Delaware | Polymorphism detection and separation |
| EP1298220A1 (en) * | 2001-10-01 | 2003-04-02 | Bayer Ag | Single nucleotide polymorphisms predicting cardiovascular disease |
| EP1978108A3 (en) * | 2002-01-08 | 2009-01-07 | Siemens Healthcare Diagnostics GmbH | Single nucleotide polymorphisms predicting cardiovascular disease and medication efficacy |
| JP2006510341A (ja) * | 2002-02-27 | 2006-03-30 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 有害薬剤反応および薬剤効力を予測する単一ヌクレオチド多型 |
-
2004
- 2004-11-24 EP EP10153674.6A patent/EP2186913B1/en not_active Expired - Lifetime
- 2004-11-24 EP EP11177523.5A patent/EP2386659B1/en not_active Expired - Lifetime
- 2004-11-24 CA CA3048093A patent/CA3048093A1/en not_active Withdrawn
- 2004-11-24 CA CA2547072A patent/CA2547072C/en not_active Expired - Lifetime
- 2004-11-24 EP EP11177511.0A patent/EP2386657B1/en not_active Expired - Lifetime
- 2004-11-24 EP EP11177504.5A patent/EP2386656B1/en not_active Expired - Lifetime
- 2004-11-24 JP JP2006541713A patent/JP5649263B2/ja not_active Expired - Fee Related
- 2004-11-24 CA CA2991249A patent/CA2991249C/en not_active Expired - Lifetime
- 2004-11-24 CA CA3050151A patent/CA3050151C/en not_active Expired - Lifetime
- 2004-11-24 US US10/995,561 patent/US20050272054A1/en not_active Abandoned
- 2004-11-24 WO PCT/US2004/039576 patent/WO2005056837A2/en not_active Ceased
- 2004-11-24 EP EP11177519.3A patent/EP2386658B1/en not_active Expired - Lifetime
- 2004-11-24 CA CA2832293A patent/CA2832293C/en not_active Expired - Lifetime
- 2004-11-24 EP EP11177508.6A patent/EP2405023B1/en not_active Expired - Lifetime
- 2004-11-24 EP EP04812154A patent/EP1711622A2/en not_active Withdrawn
- 2004-11-24 CA CA2860272A patent/CA2860272C/en not_active Expired - Lifetime
- 2004-11-24 CA CA2921196A patent/CA2921196C/en not_active Expired - Lifetime
-
2010
- 2010-01-06 US US12/683,099 patent/US20100190172A1/en not_active Abandoned
-
2011
- 2011-01-12 JP JP2011004344A patent/JP2011115168A/ja not_active Withdrawn
-
2013
- 2013-08-09 JP JP2013166477A patent/JP2014023533A/ja not_active Withdrawn
- 2013-10-03 US US14/045,416 patent/US20140221484A1/en not_active Abandoned
-
2015
- 2015-10-16 JP JP2015204277A patent/JP6211042B2/ja not_active Expired - Fee Related
- 2015-10-16 JP JP2015204276A patent/JP6041960B2/ja not_active Expired - Fee Related
-
2016
- 2016-05-31 US US15/168,632 patent/US9932637B2/en not_active Expired - Lifetime
- 2016-12-20 JP JP2016246194A patent/JP6376612B2/ja not_active Expired - Fee Related
-
2017
- 2017-12-05 JP JP2017233228A patent/JP6537150B2/ja not_active Expired - Fee Related
-
2018
- 2018-02-12 US US15/894,253 patent/US10982281B2/en not_active Expired - Fee Related
-
2019
- 2019-01-15 JP JP2019004206A patent/JP6749431B2/ja not_active Expired - Fee Related
-
2020
- 2020-03-11 JP JP2020041614A patent/JP2020108390A/ja not_active Withdrawn
-
2021
- 2021-02-26 US US17/186,574 patent/US11708610B2/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009519703A5 (enExample) | ||
| JP2009519001A5 (enExample) | ||
| JP2009509508A5 (enExample) | ||
| JP2009523005A5 (enExample) | ||
| JP2009521905A5 (enExample) | ||
| JP2012503985A5 (enExample) | ||
| Litos et al. | Genotyping of single-nucleotide polymorphisms by primer extension reaction in a dry-reagent dipstick format | |
| JP2010528590A5 (enExample) | ||
| JP2006521812A5 (enExample) | ||
| JP2009523006A5 (enExample) | ||
| WO2005072151A2 (en) | Apoe genetic markers associated with age of onset of alzheimer's disease | |
| US20070196849A1 (en) | Double-ligation Method for Haplotype and Large-scale Polymorphism Detection | |
| JP5681217B2 (ja) | 分枝状dna複合体の形成促進を通じた核酸検出方法 | |
| US20160060696A1 (en) | Method for the identification by molecular techniques of genetic variants that encode no d antigen (d-) and altered c antigen (c+w) | |
| JP2008079604A (ja) | アルコール分解能と宿酔の耐性とを予測するためのプライマーセット、プローブセット、方法及びキット | |
| young Mun et al. | SNPs detection by a single-strand specific nuclease on a PNA zip-code microarray | |
| US20050255498A1 (en) | APOC1 genetic markers associated with age of onset of Alzheimer's Disease | |
| WO2005037204A2 (en) | Ntrk1 genetic markers associated with age of onset of alzheimer's disease | |
| KR101267291B1 (ko) | 표적 유전자에 대한 검출신호의 선택적 증강을 위한 프로브 조성물 및 배경신호의 감소를 위한 프로브 조성물, 이러한 프로브의 설계 방법 및 이를 이용한 표적 유전자 검출방법 | |
| JP2007514417A (ja) | アルツハイマー病の進行に関連するntrk1遺伝子マーカー | |
| US20060154265A1 (en) | LDLR genetic markers associated with age of onset of Alzheimer's Disease | |
| JP2005245272A (ja) | アルコール脱水素酵素遺伝子多型の簡易検出方法および検出用試薬 | |
| WO2005059104A2 (en) | Slc5a7 genetic markers associated with age of onset of alzheimer's disease | |
| KR100790871B1 (ko) | 심근 경색에 관련된 유전자 다형성 및 그의 용도 | |
| US20050250122A1 (en) | APOA4 genetic markers associated with progression of Alzheimer's disease |