IT1318517B1 - Polinucleotidi codificanti per forme polimorfiche della proteinapthrp, le proteine codificate, e loro applicazioni terapeutiche. - Google Patents

Polinucleotidi codificanti per forme polimorfiche della proteinapthrp, le proteine codificate, e loro applicazioni terapeutiche.

Info

Publication number
IT1318517B1
IT1318517B1 IT2000MI001056A ITMI20001056A IT1318517B1 IT 1318517 B1 IT1318517 B1 IT 1318517B1 IT 2000MI001056 A IT2000MI001056 A IT 2000MI001056A IT MI20001056 A ITMI20001056 A IT MI20001056A IT 1318517 B1 IT1318517 B1 IT 1318517B1
Authority
IT
Italy
Prior art keywords
proteinapthrp
therapeutic applications
polymorphic forms
coding polynucleotides
coded proteins
Prior art date
Application number
IT2000MI001056A
Other languages
English (en)
Inventor
Tommaso A Dragani
Giacomo Manenti
Original Assignee
Ist Naz Stud Cura Dei Tumori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ist Naz Stud Cura Dei Tumori filed Critical Ist Naz Stud Cura Dei Tumori
Priority to IT2000MI001056A priority Critical patent/IT1318517B1/it
Publication of ITMI20001056A0 publication Critical patent/ITMI20001056A0/it
Priority to US10/276,231 priority patent/US20030165930A1/en
Priority to CA002408559A priority patent/CA2408559A1/en
Priority to AU2001269006A priority patent/AU2001269006A1/en
Priority to PCT/EP2001/005413 priority patent/WO2001085784A2/en
Priority to JP2001582383A priority patent/JP2003532407A/ja
Priority to EP01947276A priority patent/EP1287031A2/en
Publication of ITMI20001056A1 publication Critical patent/ITMI20001056A1/it
Application granted granted Critical
Publication of IT1318517B1 publication Critical patent/IT1318517B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IT2000MI001056A 2000-05-12 2000-05-12 Polinucleotidi codificanti per forme polimorfiche della proteinapthrp, le proteine codificate, e loro applicazioni terapeutiche. IT1318517B1 (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT2000MI001056A IT1318517B1 (it) 2000-05-12 2000-05-12 Polinucleotidi codificanti per forme polimorfiche della proteinapthrp, le proteine codificate, e loro applicazioni terapeutiche.
US10/276,231 US20030165930A1 (en) 2000-05-12 2001-05-11 Polynucleotides encoding for polymorphic isoforms of the pthrp protein, the encoded proteins and their therapeutic applications thereof
CA002408559A CA2408559A1 (en) 2000-05-12 2001-05-11 Polynucleotides encoding for polymorphic isoforms of the pthrp protein, the encoded proteins and their therapeutic applications thereof
AU2001269006A AU2001269006A1 (en) 2000-05-12 2001-05-11 Polynucleotides encoding for polymorphic isoforms of the pthrp protein, the encoded proteins and their therapeutic applications thereof
PCT/EP2001/005413 WO2001085784A2 (en) 2000-05-12 2001-05-11 POLYNUCLEOTIDES ENCODING FOR POLYMORPHIC ISOFORMS OF THE PTHrP PROTEIN, THE ENCODED PROTEINS AND THEIR THERAPEUTIC APPLICATIONS THEREOF
JP2001582383A JP2003532407A (ja) 2000-05-12 2001-05-11 多型イソ型ＰＴＨｒＰ蛋白質をコードするポリヌクレオチド、コードされた蛋白質、及びそれらの治療的適用
EP01947276A EP1287031A2 (en) 2000-05-12 2001-05-11 Polynucleotides encoding for polymorphic isoforms of the pthrp protein, the encoded proteins and their therapeutic applications thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000MI001056A IT1318517B1 (it) 2000-05-12 2000-05-12 Polinucleotidi codificanti per forme polimorfiche della proteinapthrp, le proteine codificate, e loro applicazioni terapeutiche.

Publications (3)

Publication Number Publication Date
ITMI20001056A0 ITMI20001056A0 (it) 2000-05-12
ITMI20001056A1 ITMI20001056A1 (it) 2001-11-12
IT1318517B1 true IT1318517B1 (it) 2003-08-27

Family

ID=11445036

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2000MI001056A IT1318517B1 (it) 2000-05-12 2000-05-12 Polinucleotidi codificanti per forme polimorfiche della proteinapthrp, le proteine codificate, e loro applicazioni terapeutiche.

Country Status (7)

Country Link
US (1) US20030165930A1 (it)
EP (1) EP1287031A2 (it)
JP (1) JP2003532407A (it)
AU (1) AU2001269006A1 (it)
CA (1) CA2408559A1 (it)
IT (1) IT1318517B1 (it)
WO (1) WO2001085784A2 (it)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003207512B2 (en) 2002-01-10 2008-06-12 Osteotrophin Llc Treatment of bone disorders with skeletal anabolic drugs
US20040005619A1 (en) * 2002-05-31 2004-01-08 Mcgill University PTHrP-based prediction and diagnosis of bone disease
FR2841788B1 (fr) 2002-07-05 2006-01-27 Univ Pasteur Utilisation d'antagonistes de la pthrp pour traiter le carcinome a cellules renales

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856094A (en) * 1995-05-12 1999-01-05 The Johns Hopkins University School Of Medicine Method of detection of neoplastic cells
JP2000513201A (ja) * 1995-07-20 2000-10-10 アイ・シー・エヌ・フアーマシユーテイカルズ 上皮小体ホルモン様たんぱく質に関連する化合物および方法
US6046049A (en) * 1999-07-19 2000-04-04 Isis Pharmaceuticals Inc. Antisense modulation of PI3 kinase p110 delta expression
EP2386658B1 (en) * 2003-11-26 2014-01-08 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof

Also Published As

Publication number Publication date
CA2408559A1 (en) 2001-11-15
WO2001085784A9 (en) 2002-08-08
US20030165930A1 (en) 2003-09-04
ITMI20001056A1 (it) 2001-11-12
WO2001085784A3 (en) 2002-04-04
JP2003532407A (ja) 2003-11-05
ITMI20001056A0 (it) 2000-05-12
WO2001085784A2 (en) 2001-11-15
AU2001269006A1 (en) 2001-11-20
EP1287031A2 (en) 2003-03-05

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