JP2009514839A5 - - Google Patents
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- JP2009514839A5 JP2009514839A5 JP2008538418A JP2008538418A JP2009514839A5 JP 2009514839 A5 JP2009514839 A5 JP 2009514839A5 JP 2008538418 A JP2008538418 A JP 2008538418A JP 2008538418 A JP2008538418 A JP 2008538418A JP 2009514839 A5 JP2009514839 A5 JP 2009514839A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- composition according
- influenza virus
- component
- cytokine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 48
- 241000712461 unidentified influenza virus Species 0.000 claims 21
- 239000000427 antigen Substances 0.000 claims 13
- 102000036639 antigens Human genes 0.000 claims 13
- 108091007433 antigens Proteins 0.000 claims 13
- 102000004127 Cytokines Human genes 0.000 claims 11
- 108090000695 Cytokines Proteins 0.000 claims 11
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 239000000839 emulsion Substances 0.000 claims 7
- 230000001939 inductive effect Effects 0.000 claims 7
- 241000700605 Viruses Species 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 4
- 238000004113 cell culture Methods 0.000 claims 4
- 239000000411 inducer Substances 0.000 claims 4
- 239000007764 o/w emulsion Substances 0.000 claims 4
- 239000000872 buffer Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000004094 surface-active agent Substances 0.000 claims 3
- 229960001295 tocopherol Drugs 0.000 claims 3
- 239000011732 tocopherol Substances 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 230000000840 anti-viral effect Effects 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229940031999 pneumococcal conjugate vaccine Drugs 0.000 claims 2
- -1 sorbitan ester Chemical class 0.000 claims 2
- 229930003799 tocopherol Natural products 0.000 claims 2
- 235000010384 tocopherol Nutrition 0.000 claims 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 1
- RHKWIGHJGOEUSM-UHFFFAOYSA-N 3h-imidazo[4,5-h]quinoline Chemical class C1=CN=C2C(N=CN3)=C3C=CC2=C1 RHKWIGHJGOEUSM-UHFFFAOYSA-N 0.000 claims 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims 1
- 241000287828 Gallus gallus Species 0.000 claims 1
- 108010068370 Glutens Proteins 0.000 claims 1
- 101710154606 Hemagglutinin Proteins 0.000 claims 1
- 101000763579 Homo sapiens Toll-like receptor 1 Proteins 0.000 claims 1
- 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 claims 1
- 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 claims 1
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims 1
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims 1
- 101000800483 Homo sapiens Toll-like receptor 8 Proteins 0.000 claims 1
- 101000800479 Homo sapiens Toll-like receptor 9 Proteins 0.000 claims 1
- 241000712431 Influenza A virus Species 0.000 claims 1
- 102000008070 Interferon-gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 1
- 108010058846 Ovalbumin Proteins 0.000 claims 1
- 108010064983 Ovomucin Proteins 0.000 claims 1
- 101710176177 Protein A56 Proteins 0.000 claims 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 1
- 239000007983 Tris buffer Substances 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 239000008346 aqueous phase Substances 0.000 claims 1
- 239000006172 buffering agent Substances 0.000 claims 1
- 108091092356 cellular DNA Proteins 0.000 claims 1
- 239000007979 citrate buffer Substances 0.000 claims 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 1
- 235000013601 eggs Nutrition 0.000 claims 1
- 239000002158 endotoxin Substances 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 235000021312 gluten Nutrition 0.000 claims 1
- 239000000185 hemagglutinin Substances 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 102000056142 human TLR1 Human genes 0.000 claims 1
- 102000045718 human TLR2 Human genes 0.000 claims 1
- 102000045716 human TLR3 Human genes 0.000 claims 1
- 102000045717 human TLR4 Human genes 0.000 claims 1
- 102000045715 human TLR7 Human genes 0.000 claims 1
- 102000045720 human TLR8 Human genes 0.000 claims 1
- 102000045710 human TLR9 Human genes 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 208000037797 influenza A Diseases 0.000 claims 1
- 208000037798 influenza B Diseases 0.000 claims 1
- 229960003130 interferon gamma Drugs 0.000 claims 1
- 239000004816 latex Substances 0.000 claims 1
- 229920000126 latex Polymers 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims 1
- 229910052753 mercury Inorganic materials 0.000 claims 1
- 229940035032 monophosphoryl lipid a Drugs 0.000 claims 1
- 229940031346 monovalent vaccine Drugs 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229940066429 octoxynol Drugs 0.000 claims 1
- 229920002113 octoxynol Polymers 0.000 claims 1
- 229940092253 ovalbumin Drugs 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 229920003023 plastic Polymers 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 229940031439 squalene Drugs 0.000 claims 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 1
- 239000008362 succinate buffer Substances 0.000 claims 1
- 238000004114 suspension culture Methods 0.000 claims 1
- 150000003505 terpenes Chemical class 0.000 claims 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73402605P | 2005-11-04 | 2005-11-04 | |
| US73527405P | 2005-11-11 | 2005-11-11 | |
| PCT/GB2006/004131 WO2007052056A1 (en) | 2005-11-04 | 2006-11-06 | Adjuvanted influenza vaccines including cytokine-inducing agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012129920A Division JP2012167123A (ja) | 2005-11-04 | 2012-06-07 | サイトカイン誘導剤を含むアジュバントインフルエンザワクチン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009514839A JP2009514839A (ja) | 2009-04-09 |
| JP2009514839A5 true JP2009514839A5 (https=) | 2009-10-15 |
Family
ID=37845320
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008538418A Pending JP2009514839A (ja) | 2005-11-04 | 2006-11-06 | サイトカイン誘導剤を含むアジュバントインフルエンザワクチン |
| JP2012129920A Pending JP2012167123A (ja) | 2005-11-04 | 2012-06-07 | サイトカイン誘導剤を含むアジュバントインフルエンザワクチン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012129920A Pending JP2012167123A (ja) | 2005-11-04 | 2012-06-07 | サイトカイン誘導剤を含むアジュバントインフルエンザワクチン |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20110180430A1 (https=) |
| EP (2) | EP1951298A1 (https=) |
| JP (2) | JP2009514839A (https=) |
| CN (1) | CN102755645A (https=) |
| AU (1) | AU2006310337B9 (https=) |
| CA (1) | CA2628424A1 (https=) |
| NZ (2) | NZ567979A (https=) |
| WO (1) | WO2007052056A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US20030129251A1 (en) * | 2000-03-10 | 2003-07-10 | Gary Van Nest | Biodegradable immunomodulatory formulations and methods for use thereof |
| CN102755645A (zh) * | 2005-11-04 | 2012-10-31 | 诺华疫苗和诊断有限公司 | 佐剂配制的包含细胞因子诱导剂的流感疫苗 |
| FR2896162B1 (fr) | 2006-01-13 | 2008-02-15 | Sanofi Pasteur Sa | Emulsion huile dans eau thermoreversible |
| MX2009000660A (es) * | 2006-07-17 | 2009-04-08 | Glaxosmithkline Biolog Sa | Vacuna de influenza. |
| PT2422810E (pt) * | 2006-07-17 | 2014-12-03 | Glaxosmithkline Biolog Sa | Vacina da gripe |
| JP5518041B2 (ja) | 2008-03-18 | 2014-06-11 | ノバルティス アーゲー | インフルエンザウイルスワクチン抗原の調製における改良 |
| AU2011295853A1 (en) | 2010-09-01 | 2013-04-04 | Irm Llc | Adsorption of immunopotentiators to insoluble metal salts |
| WO2012117377A1 (en) | 2011-03-02 | 2012-09-07 | Novartis Ag | Combination vaccines with lower doses of antigen and/or adjuvant |
| AU2012245620B2 (en) | 2011-04-18 | 2017-02-02 | University Of Georgia Research Foundation, Inc. | Vaccine delivery method |
| ES2729967T3 (es) * | 2012-02-07 | 2019-11-07 | Infectious Disease Res Inst | Formulaciones de adyuvante mejoradas que comprenden agonistas de TLR4 y métodos para usar las mismas |
| MX372965B (es) | 2012-03-08 | 2020-04-01 | Glaxosmithkline Biologicals Sa | Formulaciones adyuvadas de vacunas de difteria, tetanos y tos ferina (dtp) de refuerzo. |
| SG11201507454XA (en) * | 2013-03-13 | 2015-10-29 | Novartis Ag | Influenza b virus reassortment |
| CN105188710A (zh) * | 2013-03-15 | 2015-12-23 | 葛兰素史密丝克莱恩生物有限公司 | 包含缓冲的氨基烷基氨基葡糖苷磷酸酯衍生物的组合物及其用于增强免疫应答的用途 |
| RU2523554C1 (ru) * | 2013-03-27 | 2014-07-20 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" (ФБУН ГНЦ ВИ "Вектор") | Способ защиты организма от инфекции, вызванной штаммами субтипа h1n1 вируса гриппа а препаратом на основе альфа-2 интерферона человека |
| US20150166255A1 (en) * | 2013-12-12 | 2015-06-18 | ASCLEMED USA, INC. dba EnovaChem Manufacturing | Vitamin b-12 injection kit |
| ES2991988T3 (es) | 2017-10-30 | 2024-12-05 | Takeda Pharmaceuticals Co | Detergentes compatibles con el medio ambiente para la inactivación de virus con envoltura lipídica |
| CN113993542A (zh) * | 2019-01-30 | 2022-01-28 | 葛兰素史密丝克莱恩生物有限公司 | 用于自乳化的油/表面活性剂混合物 |
| WO2023118553A1 (en) * | 2021-12-24 | 2023-06-29 | Intervet International B.V. | Stable emulsions of antigens |
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-
2006
- 2006-11-06 CN CN2012102261242A patent/CN102755645A/zh active Pending
- 2006-11-06 CA CA002628424A patent/CA2628424A1/en not_active Abandoned
- 2006-11-06 AU AU2006310337A patent/AU2006310337B9/en not_active Ceased
- 2006-11-06 NZ NZ567979A patent/NZ567979A/en not_active IP Right Cessation
- 2006-11-06 US US12/092,285 patent/US20110180430A1/en not_active Abandoned
- 2006-11-06 NZ NZ592713A patent/NZ592713A/xx not_active IP Right Cessation
- 2006-11-06 JP JP2008538418A patent/JP2009514839A/ja active Pending
- 2006-11-06 EP EP06808426A patent/EP1951298A1/en not_active Withdrawn
- 2006-11-06 WO PCT/GB2006/004131 patent/WO2007052056A1/en not_active Ceased
- 2006-11-06 EP EP11162713.9A patent/EP2377551A3/en not_active Ceased
-
2012
- 2012-06-07 JP JP2012129920A patent/JP2012167123A/ja active Pending
-
2015
- 2015-05-14 US US14/712,229 patent/US20150246110A1/en not_active Abandoned
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