JP2009514839A5 - - Google Patents
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- JP2009514839A5 JP2009514839A5 JP2008538418A JP2008538418A JP2009514839A5 JP 2009514839 A5 JP2009514839 A5 JP 2009514839A5 JP 2008538418 A JP2008538418 A JP 2008538418A JP 2008538418 A JP2008538418 A JP 2008538418A JP 2009514839 A5 JP2009514839 A5 JP 2009514839A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- composition according
- influenza virus
- component
- cytokine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 48
- 241000712461 unidentified influenza virus Species 0.000 claims 21
- 239000000427 antigen Substances 0.000 claims 13
- 102000036639 antigens Human genes 0.000 claims 13
- 108091007433 antigens Proteins 0.000 claims 13
- 102000004127 Cytokines Human genes 0.000 claims 11
- 108090000695 Cytokines Proteins 0.000 claims 11
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 239000000839 emulsion Substances 0.000 claims 7
- 230000001939 inductive effect Effects 0.000 claims 7
- 241000700605 Viruses Species 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 4
- 238000004113 cell culture Methods 0.000 claims 4
- 239000000411 inducer Substances 0.000 claims 4
- 239000007764 o/w emulsion Substances 0.000 claims 4
- 239000000872 buffer Substances 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000004094 surface-active agent Substances 0.000 claims 3
- 229960001295 tocopherol Drugs 0.000 claims 3
- 239000011732 tocopherol Substances 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 230000000840 anti-viral effect Effects 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229940031999 pneumococcal conjugate vaccine Drugs 0.000 claims 2
- -1 sorbitan ester Chemical class 0.000 claims 2
- 229930003799 tocopherol Natural products 0.000 claims 2
- 235000010384 tocopherol Nutrition 0.000 claims 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 1
- RHKWIGHJGOEUSM-UHFFFAOYSA-N 3h-imidazo[4,5-h]quinoline Chemical class C1=CN=C2C(N=CN3)=C3C=CC2=C1 RHKWIGHJGOEUSM-UHFFFAOYSA-N 0.000 claims 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims 1
- 241000287828 Gallus gallus Species 0.000 claims 1
- 108010068370 Glutens Proteins 0.000 claims 1
- 101710154606 Hemagglutinin Proteins 0.000 claims 1
- 101000763579 Homo sapiens Toll-like receptor 1 Proteins 0.000 claims 1
- 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 claims 1
- 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 claims 1
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims 1
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims 1
- 101000800483 Homo sapiens Toll-like receptor 8 Proteins 0.000 claims 1
- 101000800479 Homo sapiens Toll-like receptor 9 Proteins 0.000 claims 1
- 241000712431 Influenza A virus Species 0.000 claims 1
- 102000008070 Interferon-gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 1
- 108010058846 Ovalbumin Proteins 0.000 claims 1
- 108010064983 Ovomucin Proteins 0.000 claims 1
- 101710176177 Protein A56 Proteins 0.000 claims 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 1
- 239000007983 Tris buffer Substances 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 239000008346 aqueous phase Substances 0.000 claims 1
- 239000006172 buffering agent Substances 0.000 claims 1
- 108091092356 cellular DNA Proteins 0.000 claims 1
- 239000007979 citrate buffer Substances 0.000 claims 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 1
- 235000013601 eggs Nutrition 0.000 claims 1
- 239000002158 endotoxin Substances 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 235000021312 gluten Nutrition 0.000 claims 1
- 239000000185 hemagglutinin Substances 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 102000056142 human TLR1 Human genes 0.000 claims 1
- 102000045718 human TLR2 Human genes 0.000 claims 1
- 102000045716 human TLR3 Human genes 0.000 claims 1
- 102000045717 human TLR4 Human genes 0.000 claims 1
- 102000045715 human TLR7 Human genes 0.000 claims 1
- 102000045720 human TLR8 Human genes 0.000 claims 1
- 102000045710 human TLR9 Human genes 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 208000037797 influenza A Diseases 0.000 claims 1
- 208000037798 influenza B Diseases 0.000 claims 1
- 229960003130 interferon gamma Drugs 0.000 claims 1
- 239000004816 latex Substances 0.000 claims 1
- 229920000126 latex Polymers 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims 1
- 229910052753 mercury Inorganic materials 0.000 claims 1
- 229940035032 monophosphoryl lipid a Drugs 0.000 claims 1
- 229940031346 monovalent vaccine Drugs 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229940066429 octoxynol Drugs 0.000 claims 1
- 229920002113 octoxynol Polymers 0.000 claims 1
- 229940092253 ovalbumin Drugs 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000008363 phosphate buffer Substances 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 229920003023 plastic Polymers 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 229940031439 squalene Drugs 0.000 claims 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 1
- 239000008362 succinate buffer Substances 0.000 claims 1
- 238000004114 suspension culture Methods 0.000 claims 1
- 150000003505 terpenes Chemical class 0.000 claims 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73402605P | 2005-11-04 | 2005-11-04 | |
| US73527405P | 2005-11-11 | 2005-11-11 | |
| PCT/GB2006/004131 WO2007052056A1 (en) | 2005-11-04 | 2006-11-06 | Adjuvanted influenza vaccines including cytokine-inducing agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012129920A Division JP2012167123A (ja) | 2005-11-04 | 2012-06-07 | サイトカイン誘導剤を含むアジュバントインフルエンザワクチン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009514839A JP2009514839A (ja) | 2009-04-09 |
| JP2009514839A5 true JP2009514839A5 (https=) | 2009-10-15 |
Family
ID=37845320
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008538418A Pending JP2009514839A (ja) | 2005-11-04 | 2006-11-06 | サイトカイン誘導剤を含むアジュバントインフルエンザワクチン |
| JP2012129920A Pending JP2012167123A (ja) | 2005-11-04 | 2012-06-07 | サイトカイン誘導剤を含むアジュバントインフルエンザワクチン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012129920A Pending JP2012167123A (ja) | 2005-11-04 | 2012-06-07 | サイトカイン誘導剤を含むアジュバントインフルエンザワクチン |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20110180430A1 (https=) |
| EP (2) | EP1951298A1 (https=) |
| JP (2) | JP2009514839A (https=) |
| CN (1) | CN102755645A (https=) |
| AU (1) | AU2006310337B9 (https=) |
| CA (1) | CA2628424A1 (https=) |
| NZ (2) | NZ592713A (https=) |
| WO (1) | WO2007052056A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US20030129251A1 (en) * | 2000-03-10 | 2003-07-10 | Gary Van Nest | Biodegradable immunomodulatory formulations and methods for use thereof |
| EP1951298A1 (en) * | 2005-11-04 | 2008-08-06 | Novartis Vaccines and Diagnostics S.r.l. | Adjuvanted influenza vaccines including cytokine-inducing agents |
| FR2896162B1 (fr) * | 2006-01-13 | 2008-02-15 | Sanofi Pasteur Sa | Emulsion huile dans eau thermoreversible |
| PT2043682E (pt) * | 2006-07-17 | 2014-07-11 | Glaxosmithkline Biolog Sa | Vacina da influenza |
| HRP20140488T1 (hr) * | 2006-07-17 | 2014-07-04 | Glaxosmithkline Biologicals S.A. | Cjepivo protiv influence |
| WO2009115917A2 (en) | 2008-03-18 | 2009-09-24 | Novartis Ag | Improvements in preparation of influenza virus vaccine antigens |
| ES2458355T3 (es) | 2010-09-01 | 2014-05-05 | Novartis Ag | Adsorción de inmunopotenciadores sobre sales metálicas insolubles |
| WO2012117377A1 (en) | 2011-03-02 | 2012-09-07 | Novartis Ag | Combination vaccines with lower doses of antigen and/or adjuvant |
| BR112013026661B1 (pt) | 2011-04-18 | 2020-12-01 | University Of Georgia Research Foundation, Inc. | composição de vacina, usos da mesma e método para produzir a referida composição |
| PL2811981T3 (pl) * | 2012-02-07 | 2019-09-30 | Infectious Disease Research Institute | Ulepszone formulacje adiuwantowe zawierające agonistę TLR4 oraz sposoby ich zastosowania |
| MX372965B (es) | 2012-03-08 | 2020-04-01 | Glaxosmithkline Biologicals Sa | Formulaciones adyuvadas de vacunas de difteria, tetanos y tos ferina (dtp) de refuerzo. |
| HK1218511A1 (zh) * | 2013-03-13 | 2017-02-24 | Novartis Ag | 乙型流感病毒重配 |
| ES2743465T3 (es) * | 2013-03-15 | 2020-02-19 | Glaxosmithkline Biologicals Sa | Composición que contiene derivados fosfato de aminoalquil glucosaminida tamponados y su uso para potenciar una respuesta inmunitaria |
| RU2523554C1 (ru) * | 2013-03-27 | 2014-07-20 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" (ФБУН ГНЦ ВИ "Вектор") | Способ защиты организма от инфекции, вызванной штаммами субтипа h1n1 вируса гриппа а препаратом на основе альфа-2 интерферона человека |
| US20150166255A1 (en) * | 2013-12-12 | 2015-06-18 | ASCLEMED USA, INC. dba EnovaChem Manufacturing | Vitamin b-12 injection kit |
| MX2020004151A (es) | 2017-10-30 | 2020-08-13 | Takeda Pharmaceuticals Co | Detergentes compatibles con el medio ambiente para la inactivacion de virus envueltos en lipidos. |
| WO2020160080A1 (en) * | 2019-01-30 | 2020-08-06 | Glaxosmithkline Llc | Oil/surfactant mixtures for self-emulsification |
| EP4452315A1 (en) * | 2021-12-24 | 2024-10-30 | Intervet International B.V. | Stable emulsions of antigens |
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-
2006
- 2006-11-06 EP EP06808426A patent/EP1951298A1/en not_active Withdrawn
- 2006-11-06 NZ NZ592713A patent/NZ592713A/xx not_active IP Right Cessation
- 2006-11-06 WO PCT/GB2006/004131 patent/WO2007052056A1/en not_active Ceased
- 2006-11-06 JP JP2008538418A patent/JP2009514839A/ja active Pending
- 2006-11-06 NZ NZ567979A patent/NZ567979A/en not_active IP Right Cessation
- 2006-11-06 AU AU2006310337A patent/AU2006310337B9/en not_active Ceased
- 2006-11-06 US US12/092,285 patent/US20110180430A1/en not_active Abandoned
- 2006-11-06 CA CA002628424A patent/CA2628424A1/en not_active Abandoned
- 2006-11-06 CN CN2012102261242A patent/CN102755645A/zh active Pending
- 2006-11-06 EP EP11162713.9A patent/EP2377551A3/en not_active Ceased
-
2012
- 2012-06-07 JP JP2012129920A patent/JP2012167123A/ja active Pending
-
2015
- 2015-05-14 US US14/712,229 patent/US20150246110A1/en not_active Abandoned
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