JP2009504650A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009504650A5 JP2009504650A5 JP2008526082A JP2008526082A JP2009504650A5 JP 2009504650 A5 JP2009504650 A5 JP 2009504650A5 JP 2008526082 A JP2008526082 A JP 2008526082A JP 2008526082 A JP2008526082 A JP 2008526082A JP 2009504650 A5 JP2009504650 A5 JP 2009504650A5
- Authority
- JP
- Japan
- Prior art keywords
- mepeg
- formulation
- glycol
- peptide compound
- polyethylene glycol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 28
- 108090000765 processed proteins & peptides Proteins 0.000 claims 28
- 238000009472 formulation Methods 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 20
- 239000002202 Polyethylene glycol Substances 0.000 claims 14
- 229920001223 polyethylene glycol Polymers 0.000 claims 14
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 12
- 229920000642 polymer Polymers 0.000 claims 9
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 6
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 claims 5
- 229920001477 hydrophilic polymer Polymers 0.000 claims 4
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 claims 4
- 241000255930 Chironomidae Species 0.000 claims 3
- 229920000954 Polyglycolide Polymers 0.000 claims 3
- 229920000747 poly(lactic acid) Polymers 0.000 claims 3
- 239000004633 polyglycolic acid Substances 0.000 claims 3
- 239000004626 polylactic acid Substances 0.000 claims 3
- 229920001451 polypropylene glycol Polymers 0.000 claims 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 3
- 108010077895 Sarcosine Proteins 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 229940043230 sarcosine Drugs 0.000 claims 2
- GODZNYBQGNSJJN-UHFFFAOYSA-N 1-aminoethane-1,2-diol Chemical compound NC(O)CO GODZNYBQGNSJJN-UHFFFAOYSA-N 0.000 claims 1
- 102100034195 Thrombopoietin Human genes 0.000 claims 1
- 229940123936 Thrombopoietin agonist Drugs 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- JLQFVGYYVXALAG-CFEVTAHFSA-N yasmin 28 Chemical group OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1.C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 JLQFVGYYVXALAG-CFEVTAHFSA-N 0.000 claims 1
- JPZXHKDZASGCLU-LBPRGKRZSA-N β-(2-naphthyl)-alanine Chemical compound C1=CC=CC2=CC(C[C@H](N)C(O)=O)=CC=C21 JPZXHKDZASGCLU-LBPRGKRZSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/200,416 US7723295B2 (en) | 2003-08-28 | 2005-08-09 | Peptides and compounds that bind to a receptor |
| PCT/US2006/030359 WO2007021572A2 (en) | 2005-08-09 | 2006-08-03 | Use of peptides that bind to tpo receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009504650A JP2009504650A (ja) | 2009-02-05 |
| JP2009504650A5 true JP2009504650A5 (cg-RX-API-DMAC10.html) | 2009-06-04 |
Family
ID=37734435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008526082A Pending JP2009504650A (ja) | 2005-08-09 | 2006-08-03 | Ｔｐｏ受容体と結合するペプチドの使用 |
Country Status (34)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7091311B2 (en) * | 1996-06-07 | 2006-08-15 | Smithkline Beecham Corporation | Peptides and compounds that bind to a receptor |
| DK1542714T3 (da) * | 2002-09-18 | 2014-05-26 | Janssen Pharmaceuticals Inc | Fremgangsmåder til forøgelse af produktion af blodplader og hæmatopoietiske stamceller |
| US20040149235A1 (en) * | 2002-10-04 | 2004-08-05 | Pogue Albert S. | Apparatus and method for removal of waste from animal production facilities |
| US7615533B2 (en) * | 2004-08-16 | 2009-11-10 | Janssen Pharmaceutica N.V. | TPO peptide compounds for treatment of anemia |
| EP1986677A2 (en) * | 2006-01-25 | 2008-11-05 | Amgen Inc. | Thrombopoietic compounds |
| KR20110015448A (ko) * | 2008-06-03 | 2011-02-15 | 얀센 파마슈티카 엔.브이. | 암 치료와 관련된 혈액 질환을 예방하기 위한 ｔｐｏ 모방 펩티드 |
| CN103635514B (zh) * | 2011-06-23 | 2016-01-20 | 株式会社岛津制作所 | 支链型两亲性嵌段聚合物、使用其的分子聚集体及药物输送系统 |
| JP7481252B2 (ja) | 2017-07-26 | 2024-05-10 | ヤンセン ファーマシューティカ エヌ．ベー． | 標的放射線治療誘発性血管完全性を保護する方法 |
| US20200237872A1 (en) | 2019-01-25 | 2020-07-30 | Janssen Pharmaceutica Nv | Methods of enhancing protection against organ and vascular injury, hematopoietic recovery and survival in response to total body radiation/chemical exposure |
| MA54820A (fr) | 2019-01-25 | 2021-12-01 | Janssen Pharmaceutica Nv | Méthodes d'atténuation d'une lésion hépatique et de promotion d'une hypertrophie hépatique, de régénération du foie et de prise de greffe de cellules hépatiques conjointement avec des traitements par radiothérapie et/ou radiomimétiques |
| US11273203B2 (en) | 2019-01-25 | 2022-03-15 | Janssen Pharmaceutica Nv | Methods of mitigating toxic effects of vesicants and caustic gas |
| WO2022182920A1 (en) * | 2021-02-24 | 2022-09-01 | Purdue Research Foundation | Osteotropic compositions and uses thereof |
| CN118660955A (zh) | 2021-10-01 | 2024-09-17 | 詹森药业有限公司 | 增加祖细胞生产的方法 |
| WO2024095178A1 (en) | 2022-11-01 | 2024-05-10 | Janssen Pharmaceutica Nv | Thrombopoietin mimetic for use in the treatment of acute liver failure |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5326558A (en) | 1989-08-08 | 1994-07-05 | Genetics Institute, Inc. | Megakaryocytopoietic factor |
| IL96477A0 (en) | 1989-12-01 | 1991-08-16 | Amgen Inc | Megakaryocyte production |
| DK167813B1 (da) | 1989-12-07 | 1993-12-20 | Carlbiotech Ltd As | Pentapeptidderivat, farmaceutisk acceptable salte heraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat |
| US5571508A (en) | 1989-12-18 | 1996-11-05 | Amrad Corporation Limited | Method for the treatment of thrombocytopenia and pharmaceutical compositions useful therefor |
| IT1241395B (it) | 1990-04-02 | 1994-01-10 | Eniricerche Spa | Composti immunogenici,il procedimento per la loro sintesi e loro impiego per la preparazione di vaccini antimalaria |
| US5141851A (en) | 1990-04-18 | 1992-08-25 | Board Of Regents, The University Of Texas System | Isolated farnesyl protein transferase enzyme |
| US5250732A (en) | 1991-07-18 | 1993-10-05 | Genentech, Inc. | Ketamine analogues for treatment of thrombocytopenia |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| AU680422B2 (en) | 1992-06-11 | 1997-07-31 | Alkermes Controlled Therapeutics, Inc. | Erythropoietin drug delivery system |
| EP0945504A3 (en) | 1992-12-11 | 1999-12-08 | The University Of Florida | Materials and method for control of pests |
| WO1995011922A1 (en) | 1993-10-29 | 1995-05-04 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| GB2285446B (en) | 1994-01-03 | 1999-07-28 | Genentech Inc | Thrombopoietin |
| WO1995021919A2 (en) | 1994-02-14 | 1995-08-17 | Kirin Brewery Company, Limited | Protein having tpo activity |
| WO1995021920A1 (en) | 1994-02-14 | 1995-08-17 | Zymogenetics, Inc. | Hematopoietic protein and materials and methods for making it |
| EP0723456A1 (en) | 1994-02-14 | 1996-07-31 | The University Of Washington | Methods for stimulating erythropoiesis using thrombopoietin |
| EP0668352A1 (en) | 1994-02-14 | 1995-08-23 | Kirin Brewery Company, Ltd. | Protein having TPO activity |
| EE9600121A (et) | 1994-03-31 | 1997-04-15 | Amgen Inc. | Megakarüotsüütide kasvu ja diferentseerumist stimuleerivad kompositsioonid ja meetodid |
| US5571686A (en) | 1994-04-14 | 1996-11-05 | Massachusetts Institute Of Technology | Method of using megapoietin for prolonging the survival & viability of platlets |
| WO1996017062A1 (en) | 1994-11-30 | 1996-06-06 | Zymogenetics, Inc. | Low molecular weight thrombopoietin |
| WO1996034016A1 (en) | 1995-04-26 | 1996-10-31 | Kyowa Hakko Kogyo Co., Ltd. | Novel polypeptides |
| US6251864B1 (en) * | 1995-06-07 | 2001-06-26 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| CN1966520B (zh) | 1995-06-07 | 2012-07-11 | 葛兰素集团有限公司 | 结合血小板生成素受体的肽和化合物 |
| US5869451A (en) | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| US6060052A (en) | 1995-10-30 | 2000-05-09 | Systemix, Inc. | Methods for use of Mpl ligands with primitive human hematopoietic stem cells |
| US5932546A (en) | 1996-10-04 | 1999-08-03 | Glaxo Wellcome Inc. | Peptides and compounds that bind to the thrombopoietin receptor |
| AU771460B2 (en) | 1999-09-24 | 2004-03-25 | Smithkline Beecham Corporation | Thrombopoietin mimetics |
| AU2002307062A1 (en) | 2001-04-02 | 2002-10-15 | Purdue Pharma L.P. | Thrombopoietin (tpo) synthebody for stimulation of platelet production |
| DK1542714T3 (da) * | 2002-09-18 | 2014-05-26 | Janssen Pharmaceuticals Inc | Fremgangsmåder til forøgelse af produktion af blodplader og hæmatopoietiske stamceller |
| RS20060141A (sr) * | 2003-08-28 | 2008-08-07 | Ortho-Mcneil Pharmaceutical Inc., | Peptidi i jedinjenja koja se vežu za receptor |
-
2005
- 2005-08-09 US US11/200,416 patent/US7723295B2/en active Active
-
2006
- 2006-08-03 EA EA200800535A patent/EA200800535A1/ru unknown
- 2006-08-03 DK DK06789357.8T patent/DK1957517T3/da active
- 2006-08-03 KR KR1020087005576A patent/KR20080048026A/ko not_active Ceased
- 2006-08-03 PT PT67893578T patent/PT1957517E/pt unknown
- 2006-08-03 EP EP06789357A patent/EP1957517B1/en not_active Expired - Lifetime
- 2006-08-03 ES ES06789357T patent/ES2419005T3/es not_active Expired - Lifetime
- 2006-08-03 CA CA002618958A patent/CA2618958A1/en active Pending
- 2006-08-03 PL PL06789357T patent/PL1957517T3/pl unknown
- 2006-08-03 RS RS20130193A patent/RS52802B/sr unknown
- 2006-08-03 UA UAA200801217A patent/UA96418C2/ru unknown
- 2006-08-03 WO PCT/US2006/030359 patent/WO2007021572A2/en not_active Ceased
- 2006-08-03 CN CNA2006800376102A patent/CN101287749A/zh active Pending
- 2006-08-03 HR HRP20130518TT patent/HRP20130518T1/hr unknown
- 2006-08-03 AU AU2006280230A patent/AU2006280230B2/en not_active Ceased
- 2006-08-03 NZ NZ565497A patent/NZ565497A/en not_active IP Right Cessation
- 2006-08-03 SI SI200631599T patent/SI1957517T1/sl unknown
- 2006-08-03 BR BRPI0614647-3A patent/BRPI0614647A2/pt not_active Application Discontinuation
- 2006-08-03 JP JP2008526082A patent/JP2009504650A/ja active Pending
- 2006-08-07 MY MYPI20063814 patent/MY152177A/en unknown
- 2006-08-07 PE PE2006000953A patent/PE20070416A1/es not_active Application Discontinuation
- 2006-08-07 GT GT200600361A patent/GT200600361A/es unknown
- 2006-08-08 AR ARP060103451A patent/AR055114A1/es unknown
- 2006-08-08 TW TW095128950A patent/TWI400081B/zh not_active IP Right Cessation
- 2006-08-08 JO JO2006266A patent/JO2859B1/en active
- 2006-08-09 UY UY29736A patent/UY29736A1/es not_active Application Discontinuation
- 2006-08-09 SV SV2006002648A patent/SV2008002648A/es not_active Application Discontinuation
-
2008
- 2008-02-07 NI NI200800040A patent/NI200800040A/es unknown
- 2008-02-07 IL IL189361A patent/IL189361A/en active IP Right Grant
- 2008-02-08 EC EC2008008169A patent/ECSP088169A/es unknown
- 2008-03-06 CR CR9798A patent/CR9798A/es not_active Application Discontinuation
- 2008-03-07 ZA ZA200802184A patent/ZA200802184B/xx unknown
- 2008-03-10 NO NO20081298A patent/NO344405B1/no unknown
-
2013
- 2013-06-06 CY CY20131100452T patent/CY1114032T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4490291B2 (ja) | 薬物送達媒体としてのマルチアーム（ｍｕｌｔｉ−ａｒｍ）ポリペプチド−ポリ（エチレングリコール）ブロックコポリマー | |
| JP5277439B2 (ja) | 核酸内包高分子ミセル複合体 | |
| EA023503B1 (ru) | Галогенводородная солевая форма конъюгата многолучевого полимера и лекарственного средства, способ ее приготовления, композиции и способ лечения рака | |
| US10717825B2 (en) | Cationic mucic acid polymer-based delivery system | |
| US20130338352A1 (en) | Derivative of hyaluronic acid modified with amino-carboxylic acid | |
| US20250360187A1 (en) | Hepcidin mimetics for treatment of sickle cell disease | |
| US20100069500A1 (en) | Amide dendrimer compositions | |
| EP2838550A1 (en) | Polymeric conjugates of c1-inhibitors | |
| WO2006105172A2 (en) | Peg-polyacetal and peg-polyacetal-poe graft copolymers and pharmaceutical compositions | |
| US20150011645A1 (en) | Amine dendrimers | |
| JP2008542399A5 (cg-RX-API-DMAC10.html) | ||
| US10730999B2 (en) | Dendrimer-drug conjugates | |
| JP2023534812A5 (cg-RX-API-DMAC10.html) | ||
| JP2007504132A5 (cg-RX-API-DMAC10.html) | ||
| US20150094379A1 (en) | Dendrimer Compositions | |
| HRP20170810T1 (hr) | Peptidi i spojevi koji se vežu za receptore trombopoietina | |
| CN101899091A (zh) | 脂肪烷基五肽缀合物及其制备方法和在医学中的应用 | |
| NZ532719A (en) | Thymosin alpha 1 peptide polymer conjugates for increasing half life of the peptide in serum | |
| WO2011065916A1 (en) | Crosslinking branched molecule through thiol-disulfide exchange to form hydrogel | |
| ES3015278T3 (en) | Mucoadhesive microgel compositions and methods for using the same | |
| KR101828613B1 (ko) | 올리고머-칼슘 모방체 컨쥬게이트 및 관련 화합물 | |
| KR20170041509A (ko) | 의약용 단백질의 지속방출을 위한 약물전달체 및 이의 제조방법 | |
| US11583587B2 (en) | Polymer | |
| MXPA06010764A (es) | Metodos y composiciones de proteinas quimicamente modificadas. | |
| US20130004453A1 (en) | Nylon-3 co-polymers and synthetic lung surfactant compositions containing same |