JP2009502953A5 - - Google Patents
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- Publication number
- JP2009502953A5 JP2009502953A5 JP2008524168A JP2008524168A JP2009502953A5 JP 2009502953 A5 JP2009502953 A5 JP 2009502953A5 JP 2008524168 A JP2008524168 A JP 2008524168A JP 2008524168 A JP2008524168 A JP 2008524168A JP 2009502953 A5 JP2009502953 A5 JP 2009502953A5
- Authority
- JP
- Japan
- Prior art keywords
- cyclopropyl
- dione
- quinoline
- alkyl
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 Cc(c(*)c12)c(*)c(OC)c1N(*)C(SNC1=O)=C1C2=O Chemical compound Cc(c(*)c12)c(*)c(OC)c1N(*)C(SNC1=O)=C1C2=O 0.000 description 2
- DZCISUNWNZUFNA-UHFFFAOYSA-N CC(C)(C1CN(C)CC1)NC Chemical compound CC(C)(C1CN(C)CC1)NC DZCISUNWNZUFNA-UHFFFAOYSA-N 0.000 description 1
- ZBNGYAJEJQZYNL-UHFFFAOYSA-N CC1(CO)CNCC1 Chemical compound CC1(CO)CNCC1 ZBNGYAJEJQZYNL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70281105P | 2005-07-27 | 2005-07-27 | |
| US60/702,811 | 2005-07-27 | ||
| PCT/US2006/029302 WO2007014308A1 (en) | 2005-07-27 | 2006-07-27 | 8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009502953A JP2009502953A (ja) | 2009-01-29 |
| JP2009502953A5 true JP2009502953A5 (enExample) | 2009-09-03 |
| JP5143000B2 JP5143000B2 (ja) | 2013-02-13 |
Family
ID=37106335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008524168A Expired - Fee Related JP5143000B2 (ja) | 2005-07-27 | 2006-07-27 | 抗感染症薬としての８−メトキシ−９Ｈ−イソチアゾロ［５，４−ｂ］キノリン−３，４−ジオンおよび関連化合物 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US8044204B2 (enExample) |
| EP (1) | EP1913004B1 (enExample) |
| JP (1) | JP5143000B2 (enExample) |
| KR (1) | KR101272263B1 (enExample) |
| CN (1) | CN101263146B (enExample) |
| AT (1) | ATE482219T1 (enExample) |
| AU (1) | AU2006272571B2 (enExample) |
| BR (1) | BRPI0614456B8 (enExample) |
| CA (1) | CA2616768C (enExample) |
| DE (1) | DE602006017082D1 (enExample) |
| DK (1) | DK1913004T3 (enExample) |
| EA (1) | EA013244B1 (enExample) |
| ES (1) | ES2352799T3 (enExample) |
| IL (1) | IL189017A (enExample) |
| NO (1) | NO343376B1 (enExample) |
| NZ (1) | NZ566209A (enExample) |
| PL (1) | PL1913004T3 (enExample) |
| PT (1) | PT1913004E (enExample) |
| WO (1) | WO2007014308A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2695072A1 (en) | 2006-08-16 | 2008-02-21 | Achillion Pharmaceuticals, Inc. | Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones |
| NZ595448A (en) * | 2009-04-03 | 2013-01-25 | Achillion Pharmaceuticals Inc | Hydroxythienoquinolones and related compounds as anti-infective agents |
| WO2011031745A1 (en) | 2009-09-09 | 2011-03-17 | Achaogen, Inc. | Antibacterial fluoroquinolone analogs |
| MY161870A (en) * | 2009-10-16 | 2017-05-15 | Melinta Therapeutics Inc | Antimicrobial compounds and methods of making and using the same |
| CA2777739A1 (en) * | 2009-10-16 | 2011-04-21 | Rib-X Pharmaceuticals, Inc. | Antimicrobial compounds and methods of making and using the same |
| EA023350B1 (ru) | 2009-10-16 | 2016-05-31 | Мелинта Терапьютикс, Инк. | Противомикробные соединения, способы их получения и применение |
| TN2010000566A1 (en) * | 2010-12-03 | 2012-05-24 | Rekik Raouf | Folic acid - ramipril combination : cell protective neuroprotective and retinoprotective ophtalmologic drugs |
| CN103819401B (zh) * | 2012-11-19 | 2016-04-13 | 浙江中欣氟材股份有限公司 | 1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹啉-3-羧酸的合成方法 |
| CA2923179A1 (en) | 2013-09-09 | 2015-03-12 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| KR20160070066A (ko) | 2013-09-09 | 2016-06-17 | 멜린타 테라퓨틱스, 인크. | 항균 화합물, 및 이의 제조 방법 및 이용 방법 |
| WO2015114317A1 (en) * | 2014-01-28 | 2015-08-06 | Redx Pharma Plc | 5h-isothiazolo[4,5-c]pyridine-3,4-dione or 5h-pyrazolo[4,3-c]pyridin-3,4-dione as antibacterial compounds |
| SG11201707346RA (en) | 2015-03-11 | 2017-10-30 | Melinta Therapeutics Inc | Antimicrobial compounds and methods of making and using the same |
| EP3452479A1 (en) | 2016-05-06 | 2019-03-13 | Melinta Therapeutics, Inc. | Antimicrobials and methods of making and using same |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| WO2017197055A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| EP3454862B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| JP7665519B2 (ja) * | 2019-02-01 | 2025-04-21 | アルコン インコーポレイティド | 近視を治療するための化合物、組成物及び医薬組成物 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4767762A (en) | 1985-12-23 | 1988-08-30 | Abbott Laboratories | Tricyclic quinoline and naphthyride antibacterials |
| JPH01160985A (ja) | 1987-12-17 | 1989-06-23 | Otsuka Pharmaceut Co Ltd | ベンゾヘテロ環化合物 |
| JPH01193275A (ja) | 1988-01-28 | 1989-08-03 | Otsuka Pharmaceut Co Ltd | ベンゾヘテロ環化合物 |
| JP2681190B2 (ja) | 1988-04-13 | 1997-11-26 | 塩野義製薬株式会社 | ピリドン系抗菌剤 |
| CA2001203C (en) | 1988-10-24 | 2001-02-13 | Thomas P. Demuth, Jr. | Novel antimicrobial dithiocarbamoyl quinolones |
| US5328908A (en) | 1988-10-24 | 1994-07-12 | Procter & Gamble Pharmaceuticals, Inc. | Antimicrobial quinolone thioureas |
| JPH02174784A (ja) | 1988-12-27 | 1990-07-06 | Hokuriku Seiyaku Co Ltd | イソチアゾロキノリン誘導体 |
| JPH02243692A (ja) | 1989-03-16 | 1990-09-27 | Dainippon Pharmaceut Co Ltd | 三環式化合物 |
| JPH02255687A (ja) | 1989-03-27 | 1990-10-16 | Dainippon Pharmaceut Co Ltd | 三環式化合物 |
| FR2645862B1 (fr) | 1989-04-18 | 1991-07-12 | Esteve Labor Dr | Derives d'isothiazolo-pyrydone azetidinyl substitues, leur preparation et leur application en tant que medicaments |
| JP2787713B2 (ja) | 1989-07-28 | 1998-08-20 | 富山化学工業株式会社 | 新規なイソチアゾローナフチリジンおよびイソチアゾローキノリン誘導体並びにそれらの塩 |
| US5071848A (en) | 1989-10-23 | 1991-12-10 | Abbott Laboratories | Tricyclic quinoline antineoplastic agents |
| JP2939280B2 (ja) | 1990-01-10 | 1999-08-25 | 三共株式会社 | フッ素置換メトキシキノロンカルボン酸誘導体 |
| US5580872A (en) | 1990-05-02 | 1996-12-03 | Abbott Laboratories | Quinolizinone type compounds |
| NO304832B1 (no) | 1992-05-27 | 1999-02-22 | Ube Industries | Aminokinolonderivater samt middel mot HIV |
| US5646163A (en) | 1992-10-30 | 1997-07-08 | The Procter & Gamble Company | Quinolone 5-(N-heterosubstituted amino) antimicrobials |
| HUP9901642A3 (en) | 1996-01-31 | 2000-07-28 | Ube Ind Ltd Ube Shi | Remedies or preventives for aids |
| JP3616454B2 (ja) | 1996-04-19 | 2005-02-02 | 栄研化学株式会社 | 生体成分測定用試薬 |
| JPH10130149A (ja) | 1996-07-12 | 1998-05-19 | Sankyo Co Ltd | Ｔｎｆ産生抑制剤 |
| DE19652219A1 (de) | 1996-12-16 | 1998-06-18 | Bayer Ag | Verwendung von 7-(1-Aminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl)-chinolon- und naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen |
| AU3089102A (en) | 2000-12-14 | 2002-06-24 | Procter & Gamble | Antimicrobial quinolones |
| UA84879C2 (ru) | 2003-08-12 | 2008-12-10 | Акилайон Фармасьютикалз, Инк. | Изотиазолохинолоны и родственные соединения с противомикробным действием |
| JP2008519842A (ja) * | 2004-11-11 | 2008-06-12 | アキリオン ファーマシューティカルズ，インコーポレーテッド | 抗感染剤としての８ａ，９−ジヒドロ−４ａ−ｈ−イソチアゾロ［５，４−ｂ］キノリン−３，４−ジオンおよび関連化合物 |
| EA200701734A1 (ru) * | 2005-02-16 | 2008-02-28 | Ачиллион Фармасьютикалз, Инк. | Новые изотиазолохинолоны и родственные им соединения как антиинфекционные средства |
| NZ595448A (en) | 2009-04-03 | 2013-01-25 | Achillion Pharmaceuticals Inc | Hydroxythienoquinolones and related compounds as anti-infective agents |
-
2006
- 2006-07-27 DK DK06800428.2T patent/DK1913004T3/da active
- 2006-07-27 CA CA2616768A patent/CA2616768C/en not_active Expired - Fee Related
- 2006-07-27 EA EA200800444A patent/EA013244B1/ru unknown
- 2006-07-27 ES ES06800428T patent/ES2352799T3/es active Active
- 2006-07-27 WO PCT/US2006/029302 patent/WO2007014308A1/en not_active Ceased
- 2006-07-27 DE DE602006017082T patent/DE602006017082D1/de active Active
- 2006-07-27 US US11/494,205 patent/US8044204B2/en active Active
- 2006-07-27 AT AT06800428T patent/ATE482219T1/de active
- 2006-07-27 KR KR1020087004769A patent/KR101272263B1/ko active Active
- 2006-07-27 PT PT06800428T patent/PT1913004E/pt unknown
- 2006-07-27 NZ NZ566209A patent/NZ566209A/en unknown
- 2006-07-27 CN CN200680033548XA patent/CN101263146B/zh active Active
- 2006-07-27 JP JP2008524168A patent/JP5143000B2/ja not_active Expired - Fee Related
- 2006-07-27 AU AU2006272571A patent/AU2006272571B2/en not_active Ceased
- 2006-07-27 PL PL06800428T patent/PL1913004T3/pl unknown
- 2006-07-27 EP EP06800428A patent/EP1913004B1/en active Active
- 2006-07-27 BR BRPI0614456A patent/BRPI0614456B8/pt active IP Right Grant
-
2008
- 2008-01-24 IL IL189017A patent/IL189017A/en active IP Right Grant
- 2008-02-27 NO NO20081005A patent/NO343376B1/no unknown
-
2011
- 2011-10-24 US US13/279,852 patent/US8946422B2/en active Active
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