JP2009502953A5 - - Google Patents
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- Publication number
- JP2009502953A5 JP2009502953A5 JP2008524168A JP2008524168A JP2009502953A5 JP 2009502953 A5 JP2009502953 A5 JP 2009502953A5 JP 2008524168 A JP2008524168 A JP 2008524168A JP 2008524168 A JP2008524168 A JP 2008524168A JP 2009502953 A5 JP2009502953 A5 JP 2009502953A5
- Authority
- JP
- Japan
- Prior art keywords
- cyclopropyl
- dione
- quinoline
- alkyl
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 Cc(c(*)c12)c(*)c(OC)c1N(*)C(SNC1=O)=C1C2=O Chemical compound Cc(c(*)c12)c(*)c(OC)c1N(*)C(SNC1=O)=C1C2=O 0.000 description 2
- DZCISUNWNZUFNA-UHFFFAOYSA-N CC(C)(C1CN(C)CC1)NC Chemical compound CC(C)(C1CN(C)CC1)NC DZCISUNWNZUFNA-UHFFFAOYSA-N 0.000 description 1
- ZBNGYAJEJQZYNL-UHFFFAOYSA-N CC1(CO)CNCC1 Chemical compound CC1(CO)CNCC1 ZBNGYAJEJQZYNL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70281105P | 2005-07-27 | 2005-07-27 | |
| US60/702,811 | 2005-07-27 | ||
| PCT/US2006/029302 WO2007014308A1 (en) | 2005-07-27 | 2006-07-27 | 8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009502953A JP2009502953A (ja) | 2009-01-29 |
| JP2009502953A5 true JP2009502953A5 (cg-RX-API-DMAC10.html) | 2009-09-03 |
| JP5143000B2 JP5143000B2 (ja) | 2013-02-13 |
Family
ID=37106335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008524168A Expired - Fee Related JP5143000B2 (ja) | 2005-07-27 | 2006-07-27 | 抗感染症薬としての８−メトキシ−９Ｈ−イソチアゾロ［５，４−ｂ］キノリン−３，４−ジオンおよび関連化合物 |
Country Status (19)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008021491A2 (en) * | 2006-08-16 | 2008-02-21 | Achillion Pharmaceuticals, Inc. | Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones |
| US8173636B2 (en) * | 2009-04-03 | 2012-05-08 | Achillion Pharmaceuticals, Inc. | Hydroxylthienoquinolones and related compounds as anti-infective agents |
| WO2011031745A1 (en) | 2009-09-09 | 2011-03-17 | Achaogen, Inc. | Antibacterial fluoroquinolone analogs |
| NZ623384A (en) * | 2009-10-16 | 2016-06-24 | Melinta Therapeutics Inc | Antimicrobial compounds and methods of making and using the same |
| JP6274723B2 (ja) * | 2009-10-16 | 2018-02-07 | メリンタ セラピューティクス，インコーポレイテッド | 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 |
| JP2013508299A (ja) | 2009-10-16 | 2013-03-07 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 |
| TN2010000566A1 (en) * | 2010-12-03 | 2012-05-24 | Rekik Raouf | Folic acid - ramipril combination : cell protective neuroprotective and retinoprotective ophtalmologic drugs |
| CN103819401B (zh) * | 2012-11-19 | 2016-04-13 | 浙江中欣氟材股份有限公司 | 1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹啉-3-羧酸的合成方法 |
| MX2016002975A (es) | 2013-09-09 | 2016-10-21 | Melinta Therapeutics Inc | Compuestos antimicrobianos y métodos de fabricación y utilización de los mismos. |
| US9937183B2 (en) | 2013-09-09 | 2018-04-10 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| WO2015114317A1 (en) * | 2014-01-28 | 2015-08-06 | Redx Pharma Plc | 5h-isothiazolo[4,5-c]pyridine-3,4-dione or 5h-pyrazolo[4,3-c]pyridin-3,4-dione as antibacterial compounds |
| WO2016145417A1 (en) | 2015-03-11 | 2016-09-15 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| US11098047B2 (en) | 2016-05-06 | 2021-08-24 | BioVersys AG | Antimicrobials and methods of making and using same |
| CN109562107A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的杂环降解决定子体 |
| CN109562113A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的螺环降解决定子体 |
| WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
| CN121974842A (zh) | 2016-05-10 | 2026-05-05 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| EP4717317A3 (en) | 2017-06-20 | 2026-06-03 | C4 Therapeutics, Inc. | N/o-linked degrons and degronimers for protein degradation |
| AU2020216470B2 (en) * | 2019-02-01 | 2023-05-04 | Alcon Inc. | Compounds, compositions and methods for treatment of myopia |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4767762A (en) | 1985-12-23 | 1988-08-30 | Abbott Laboratories | Tricyclic quinoline and naphthyride antibacterials |
| JPH01160985A (ja) | 1987-12-17 | 1989-06-23 | Otsuka Pharmaceut Co Ltd | ベンゾヘテロ環化合物 |
| JPH01193275A (ja) | 1988-01-28 | 1989-08-03 | Otsuka Pharmaceut Co Ltd | ベンゾヘテロ環化合物 |
| JP2681190B2 (ja) | 1988-04-13 | 1997-11-26 | 塩野義製薬株式会社 | ピリドン系抗菌剤 |
| CA2001203C (en) | 1988-10-24 | 2001-02-13 | Thomas P. Demuth, Jr. | Novel antimicrobial dithiocarbamoyl quinolones |
| US5328908A (en) | 1988-10-24 | 1994-07-12 | Procter & Gamble Pharmaceuticals, Inc. | Antimicrobial quinolone thioureas |
| JPH02174784A (ja) | 1988-12-27 | 1990-07-06 | Hokuriku Seiyaku Co Ltd | イソチアゾロキノリン誘導体 |
| JPH02243692A (ja) | 1989-03-16 | 1990-09-27 | Dainippon Pharmaceut Co Ltd | 三環式化合物 |
| JPH02255687A (ja) | 1989-03-27 | 1990-10-16 | Dainippon Pharmaceut Co Ltd | 三環式化合物 |
| FR2645862B1 (fr) | 1989-04-18 | 1991-07-12 | Esteve Labor Dr | Derives d'isothiazolo-pyrydone azetidinyl substitues, leur preparation et leur application en tant que medicaments |
| JP2787713B2 (ja) | 1989-07-28 | 1998-08-20 | 富山化学工業株式会社 | 新規なイソチアゾローナフチリジンおよびイソチアゾローキノリン誘導体並びにそれらの塩 |
| US5071848A (en) | 1989-10-23 | 1991-12-10 | Abbott Laboratories | Tricyclic quinoline antineoplastic agents |
| JP2939280B2 (ja) | 1990-01-10 | 1999-08-25 | 三共株式会社 | フッ素置換メトキシキノロンカルボン酸誘導体 |
| US5580872A (en) | 1990-05-02 | 1996-12-03 | Abbott Laboratories | Quinolizinone type compounds |
| NO304832B1 (no) | 1992-05-27 | 1999-02-22 | Ube Industries | Aminokinolonderivater samt middel mot HIV |
| US5646163A (en) | 1992-10-30 | 1997-07-08 | The Procter & Gamble Company | Quinolone 5-(N-heterosubstituted amino) antimicrobials |
| EP0878194A1 (en) | 1996-01-31 | 1998-11-18 | Sankyo Company Limited | Remedies or preventives for aids |
| JP3616454B2 (ja) | 1996-04-19 | 2005-02-02 | 栄研化学株式会社 | 生体成分測定用試薬 |
| JPH10130149A (ja) | 1996-07-12 | 1998-05-19 | Sankyo Co Ltd | Ｔｎｆ産生抑制剤 |
| DE19652219A1 (de) | 1996-12-16 | 1998-06-18 | Bayer Ag | Verwendung von 7-(1-Aminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl)-chinolon- und naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen |
| ATE304539T1 (de) * | 2000-12-14 | 2005-09-15 | Procter & Gamble | Antimikrobielle chinolone |
| WO2006089054A1 (en) * | 2005-02-16 | 2006-08-24 | Achillion Pharmaceuticals, Inc. | New isothiazoloquinolones and related compounds as anti-infective agents |
| KR20060069836A (ko) * | 2003-08-12 | 2006-06-22 | 아칠리온 파르마세우티칼스 인코포레이티드 | 항-감염제로서의 이소티아졸로퀴놀론 및 관련 화합물 |
| EP1809639B1 (en) * | 2004-11-11 | 2009-10-14 | Achillion Pharmaceuticals, Inc. | 8a, 9-dihydro-4a-h-isothiazolo[5,4-b] quinoline-3, 4-diones and related compounds as anti-infective agents |
| US8173636B2 (en) | 2009-04-03 | 2012-05-08 | Achillion Pharmaceuticals, Inc. | Hydroxylthienoquinolones and related compounds as anti-infective agents |
-
2006
- 2006-07-27 ES ES06800428T patent/ES2352799T3/es not_active Expired - Lifetime
- 2006-07-27 WO PCT/US2006/029302 patent/WO2007014308A1/en not_active Ceased
- 2006-07-27 EP EP06800428A patent/EP1913004B1/en not_active Expired - Lifetime
- 2006-07-27 PL PL06800428T patent/PL1913004T3/pl unknown
- 2006-07-27 KR KR1020087004769A patent/KR101272263B1/ko not_active Expired - Lifetime
- 2006-07-27 US US11/494,205 patent/US8044204B2/en active Active
- 2006-07-27 CA CA2616768A patent/CA2616768C/en not_active Expired - Fee Related
- 2006-07-27 DE DE602006017082T patent/DE602006017082D1/de not_active Expired - Lifetime
- 2006-07-27 NZ NZ566209A patent/NZ566209A/en unknown
- 2006-07-27 CN CN200680033548XA patent/CN101263146B/zh not_active Expired - Fee Related
- 2006-07-27 JP JP2008524168A patent/JP5143000B2/ja not_active Expired - Fee Related
- 2006-07-27 AT AT06800428T patent/ATE482219T1/de active
- 2006-07-27 AU AU2006272571A patent/AU2006272571B2/en not_active Ceased
- 2006-07-27 PT PT06800428T patent/PT1913004E/pt unknown
- 2006-07-27 EA EA200800444A patent/EA013244B1/ru unknown
- 2006-07-27 DK DK06800428.2T patent/DK1913004T3/da active
- 2006-07-27 BR BRPI0614456A patent/BRPI0614456B8/pt not_active IP Right Cessation
-
2008
- 2008-01-24 IL IL189017A patent/IL189017A/en active IP Right Grant
- 2008-02-27 NO NO20081005A patent/NO343376B1/no unknown
-
2011
- 2011-10-24 US US13/279,852 patent/US8946422B2/en not_active Expired - Lifetime
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