JP2009501202A5 - - Google Patents
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- Publication number
- JP2009501202A5 JP2009501202A5 JP2008520952A JP2008520952A JP2009501202A5 JP 2009501202 A5 JP2009501202 A5 JP 2009501202A5 JP 2008520952 A JP2008520952 A JP 2008520952A JP 2008520952 A JP2008520952 A JP 2008520952A JP 2009501202 A5 JP2009501202 A5 JP 2009501202A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- dihydrotetrabenazine
- cis
- composition according
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 208000024891 symptom Diseases 0.000 claims 4
- 208000023105 Huntington disease Diseases 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 238000011321 prophylaxis Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- WEQLWGNDNRARGE-DJIMGWMZSA-N (2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-ol Chemical compound C1CN2C[C@@H](CC(C)C)[C@H](O)C[C@@H]2C2=C1C=C(OC)C(OC)=C2 WEQLWGNDNRARGE-DJIMGWMZSA-N 0.000 claims 1
- 206010008748 Chorea Diseases 0.000 claims 1
- 208000012661 Dyskinesia Diseases 0.000 claims 1
- 208000015592 Involuntary movements Diseases 0.000 claims 1
- 206010028347 Muscle twitching Diseases 0.000 claims 1
- 206010044565 Tremor Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 208000012601 choreatic disease Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000005021 gait Effects 0.000 claims 1
- 101150113725 hd gene Proteins 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-M methanesulfonate group Chemical group CS(=O)(=O)[O-] AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 claims 1
- 230000017311 musculoskeletal movement, spinal reflex action Effects 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0514501.6A GB0514501D0 (en) | 2005-07-14 | 2005-07-14 | Pharmaceutical compounds |
| PCT/GB2006/002593 WO2007007105A1 (en) | 2005-07-14 | 2006-07-13 | Use of 3,1ib-cis-dihydrotetrabenazine for the treatment of symptons of huntington' s disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009501202A JP2009501202A (ja) | 2009-01-15 |
| JP2009501202A5 true JP2009501202A5 (enExample) | 2009-08-20 |
Family
ID=34897233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008520952A Pending JP2009501202A (ja) | 2005-07-14 | 2006-07-13 | ハンチントン病の症状の治療のための３，１１ｂ−シス−ジヒドロテトラベナジンの使用 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20080319000A1 (enExample) |
| EP (2) | EP2027861B1 (enExample) |
| JP (1) | JP2009501202A (enExample) |
| KR (1) | KR20080030666A (enExample) |
| CN (1) | CN101282726A (enExample) |
| AT (2) | ATE409481T1 (enExample) |
| AU (1) | AU2006268098B2 (enExample) |
| CA (1) | CA2615077A1 (enExample) |
| CY (1) | CY1108653T1 (enExample) |
| DE (1) | DE602006002982D1 (enExample) |
| DK (1) | DK1885363T3 (enExample) |
| ES (1) | ES2314931T3 (enExample) |
| GB (1) | GB0514501D0 (enExample) |
| HR (1) | HRP20080677T3 (enExample) |
| ME (1) | ME01629B (enExample) |
| NZ (1) | NZ565522A (enExample) |
| PL (1) | PL1885363T3 (enExample) |
| PT (1) | PT1885363E (enExample) |
| RS (1) | RS50626B (enExample) |
| RU (1) | RU2409365C2 (enExample) |
| SI (1) | SI1885363T1 (enExample) |
| WO (1) | WO2007007105A1 (enExample) |
| ZA (1) | ZA200800905B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2410947B (en) * | 2004-02-11 | 2008-09-17 | Cambridge Lab Ltd | Pharmaceutical compounds |
| GB0516168D0 (en) * | 2005-08-05 | 2005-09-14 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| CN101553487B (zh) | 2006-11-08 | 2012-06-13 | 纽罗克里生物科学有限公司 | 取代的3-异丁基-9,10-二甲氧基-1,3,4,6,7,11b-六氢-2H-吡啶并[2,1-a]异喹啉-2-醇化合物和与其相关的方法 |
| GB0810857D0 (en) * | 2008-06-13 | 2008-07-23 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| US20110053866A1 (en) * | 2008-08-12 | 2011-03-03 | Biovail Laboratories International (Barbados) S.R.L. | Pharmaceutical compositions |
| US20120208773A1 (en) * | 2008-08-12 | 2012-08-16 | Valeant International (Barbados) Srl | Pharmaceutical compositions with tetrabenazine |
| GB2462611A (en) * | 2008-08-12 | 2010-02-17 | Cambridge Lab | Pharmaceutical composition comprising tetrabenazine |
| GB2463451A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia |
| GB2463283A (en) * | 2008-09-08 | 2010-03-10 | Cambridge Lab | 3,11b-cis-dihydrotetrabenazine for use in treating asthma |
| GB2463452A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof |
| CA2771539A1 (en) * | 2009-08-12 | 2011-02-17 | Valeant International (Barbados) Srl | Pharmaceutical compositions with tetrabenzine |
| EP2576552A4 (en) * | 2010-06-01 | 2013-11-13 | Aupex Pharmaceutical Inc | BENZOQUINOLONE INHIBITORS OF VMAT2 |
| WO2012095548A2 (es) | 2011-01-13 | 2012-07-19 | Centro De Investigación Biomédica En Red De Enfermedades Neurodegenerativas (Ciberned) | Compuestos para el tratamiento de enfermedades neurodegenerativas |
| JP7250692B2 (ja) * | 2017-04-01 | 2023-04-03 | アデプティオ ファーマシューティカルズ リミテッド | 運動障害の治療における使用のためのジヒドロテトラベナジン |
| GB201705303D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705302D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705306D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705304D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| JP7386544B2 (ja) | 2018-04-25 | 2023-11-27 | シンケイ セラピューティクス インコーポレイテッド | テトラベナジン経皮送達デバイス |
| GB201808464D0 (en) * | 2018-05-23 | 2018-07-11 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compounds for use in treating huntington's disease |
| CN114502154A (zh) * | 2019-07-16 | 2022-05-13 | 拉什大学医学中心 | 含苯甲酸酯的组合物治疗神经退行性疾病的用途 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3132147A (en) * | 1964-05-05 | |||
| US3314966A (en) * | 1967-04-18 | Substituted benzo[a]quinolizines | ||
| US3009918A (en) * | 1961-11-21 | Chz ch | ||
| US2954382A (en) * | 1960-09-27 | Xpreparation of hexahydrobenzoquinol- | ||
| US2830993A (en) * | 1958-04-15 | Quinolizine derivatives | ||
| US2843591A (en) * | 1958-07-15 | Method for preparing same | ||
| US3209005A (en) * | 1965-09-28 | Hexahydro-llbh-benzo[a] quinolizines and processes therefor | ||
| US3095419A (en) * | 1963-06-25 | Process for preparing z-oxo-j- | ||
| US3159638A (en) * | 1964-12-01 | Xcha-chj | ||
| US3053845A (en) * | 1962-09-11 | Benzofykedocolines | ||
| US3123609A (en) * | 1964-03-03 | Benzo | ||
| US3079395A (en) * | 1963-02-26 | Novel z-oxq-benzoquinoliaine | ||
| US3045021A (en) * | 1959-09-24 | 1962-07-17 | Hoffmann La Roche | Preparation of substituted 2-oxobenzoquinolizines |
| GB999092A (en) * | 1959-11-24 | 1965-07-21 | Wellcome Found | Method for making benzo(a)-quinolizine derivatives |
| US3375254A (en) * | 1961-09-29 | 1968-03-26 | Burroughs Wellcome Co | Manufacture of 1, 2, 3, 4, 6, 7-hexahydro-2-oxo-11bh-benzo(a)quinolizines |
| US3105079A (en) * | 1961-12-29 | 1963-09-24 | Pfizer & Co C | 10-aminobenzopyridocolines |
| US3390152A (en) * | 1965-10-21 | 1968-06-25 | Abbott Lab | 9, 10-alkoxy-3-alkyl-2, 2-(dithiosubstituted)-benzoquinolizines |
| JPS4836303B1 (enExample) * | 1968-12-27 | 1973-11-02 | ||
| US3635986A (en) * | 1969-12-22 | 1972-01-18 | Miles Lab | 2-substituted amino-hexahydrobenzo(a)quinolizines |
| YU264675A (en) * | 1974-10-23 | 1982-05-31 | Chinoin Gyogyszer Es Vegyeszet | Process for obtaining benzo (a)-quinolizidine derivatives |
| GB1513824A (en) * | 1975-05-22 | 1978-06-14 | Wyeth John & Brother Ltd | 1,3,4,6,7,11b-hexahydro-2h-benzo(a)quinolizine derivative |
| US4133812A (en) * | 1975-11-21 | 1979-01-09 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | Process for producing benzo (a) quinolizine derivatives |
| US4304913A (en) * | 1978-11-20 | 1981-12-08 | Miles Laboratories, Inc. | Trans-2-substituted-amido-hexahydrobenzo [A]quinolizines |
| US4353656A (en) * | 1980-10-14 | 1982-10-12 | Xerox Corporation | Moving coil, multiple energy print hammer system including a closed loop servo |
| US4778054A (en) * | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
| GB2178965B (en) * | 1985-07-30 | 1988-08-03 | Glaxo Group Ltd | Devices for administering medicaments to patients |
| GB9004781D0 (en) * | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| US6087376A (en) * | 1997-02-05 | 2000-07-11 | University Of Kentucky Research Foundation | Use of lobeline compounds in the treatment of central nervous system diseases and pathologies |
| FR2794742B1 (fr) * | 1999-06-11 | 2005-06-03 | Sanofi Synthelabo | Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant |
| US6632666B2 (en) * | 2000-01-14 | 2003-10-14 | Biolife Solutions, Inc. | Normothermic, hypothermic and cryopreservation maintenance and storage of cells, tissues and organs in gel-based media |
| CA2398446A1 (en) * | 2000-04-18 | 2001-10-25 | Agouron Pharmaceuticals, Inc. | Pyrazoles for inhibiting protein kinases |
| EP1638529B1 (en) * | 2003-06-16 | 2016-08-10 | ANDRX Pharmaceuticals, LLC. | Oral extended-release composition |
| GB2410947B (en) * | 2004-02-11 | 2008-09-17 | Cambridge Lab Ltd | Pharmaceutical compounds |
| WO2006053067A2 (en) * | 2004-11-09 | 2006-05-18 | Prestwick Pharmaceuticals, Inc. | Combination of amantadine and a tetrabenazine compound for treating hyperkinetic disorders |
| KR100682506B1 (ko) * | 2005-01-18 | 2007-02-15 | (주)젠크로스 | 프라지콴텔, 또는 이의 염을 포함하는 약학 조성물 |
| GB0516168D0 (en) * | 2005-08-05 | 2005-09-14 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| US20110053866A1 (en) * | 2008-08-12 | 2011-03-03 | Biovail Laboratories International (Barbados) S.R.L. | Pharmaceutical compositions |
| GB2462611A (en) * | 2008-08-12 | 2010-02-17 | Cambridge Lab | Pharmaceutical composition comprising tetrabenazine |
| GB2463451A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia |
| GB2463283A (en) * | 2008-09-08 | 2010-03-10 | Cambridge Lab | 3,11b-cis-dihydrotetrabenazine for use in treating asthma |
| GB2463452A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof |
-
2005
- 2005-07-14 GB GBGB0514501.6A patent/GB0514501D0/en not_active Ceased
-
2006
- 2006-05-31 ME MEP-2008-916A patent/ME01629B/me unknown
- 2006-07-13 KR KR1020087003481A patent/KR20080030666A/ko not_active Withdrawn
- 2006-07-13 HR HR20080677T patent/HRP20080677T3/xx unknown
- 2006-07-13 RS RSP-2008/0492A patent/RS50626B/sr unknown
- 2006-07-13 PL PL06764942T patent/PL1885363T3/pl unknown
- 2006-07-13 NZ NZ565522A patent/NZ565522A/en not_active IP Right Cessation
- 2006-07-13 US US11/995,436 patent/US20080319000A1/en not_active Abandoned
- 2006-07-13 AU AU2006268098A patent/AU2006268098B2/en not_active Ceased
- 2006-07-13 PT PT06764942T patent/PT1885363E/pt unknown
- 2006-07-13 RU RU2008105590/15A patent/RU2409365C2/ru not_active IP Right Cessation
- 2006-07-13 ES ES06764942T patent/ES2314931T3/es active Active
- 2006-07-13 SI SI200630147T patent/SI1885363T1/sl unknown
- 2006-07-13 CA CA002615077A patent/CA2615077A1/en not_active Abandoned
- 2006-07-13 JP JP2008520952A patent/JP2009501202A/ja active Pending
- 2006-07-13 EP EP08017191A patent/EP2027861B1/en active Active
- 2006-07-13 CN CNA2006800339758A patent/CN101282726A/zh active Pending
- 2006-07-13 DK DK06764942T patent/DK1885363T3/da active
- 2006-07-13 EP EP06764942A patent/EP1885363B1/en active Active
- 2006-07-13 WO PCT/GB2006/002593 patent/WO2007007105A1/en not_active Ceased
- 2006-07-13 AT AT06764942T patent/ATE409481T1/de active
- 2006-07-13 AT AT08017191T patent/ATE522215T1/de not_active IP Right Cessation
- 2006-07-13 DE DE602006002982T patent/DE602006002982D1/de active Active
- 2006-07-13 ZA ZA200800905A patent/ZA200800905B/xx unknown
-
2008
- 2008-12-22 CY CY20081101475T patent/CY1108653T1/el unknown