ME01629B - Upotreba 3,11 b-cis-dihidrotetrabenazina za tretman simptoma huntington-ove bolesti - Google Patents
Upotreba 3,11 b-cis-dihidrotetrabenazina za tretman simptoma huntington-ove bolestiInfo
- Publication number
- ME01629B ME01629B MEP-2008-916A MEP91608A ME01629B ME 01629 B ME01629 B ME 01629B ME P91608 A MEP91608 A ME P91608A ME 01629 B ME01629 B ME 01629B
- Authority
- ME
- Montenegro
- Prior art keywords
- compound
- isomer
- dihydrotetrabenazine
- cis
- gene
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 20
- 208000024891 symptom Diseases 0.000 claims abstract 7
- 208000023105 Huntington disease Diseases 0.000 claims abstract 5
- 208000012661 Dyskinesia Diseases 0.000 claims abstract 3
- 208000015592 Involuntary movements Diseases 0.000 claims abstract 3
- 230000017311 musculoskeletal movement, spinal reflex action Effects 0.000 claims abstract 3
- 206010008748 Chorea Diseases 0.000 claims abstract 2
- 206010028347 Muscle twitching Diseases 0.000 claims abstract 2
- 206010044565 Tremor Diseases 0.000 claims abstract 2
- 208000012601 choreatic disease Diseases 0.000 claims abstract 2
- 108090000623 proteins and genes Proteins 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 6
- 238000011321 prophylaxis Methods 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- WEQLWGNDNRARGE-DJIMGWMZSA-N (2R,3R,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-ol Chemical compound C1CN2C[C@@H](CC(C)C)[C@H](O)C[C@@H]2C2=C1C=C(OC)C(OC)=C2 WEQLWGNDNRARGE-DJIMGWMZSA-N 0.000 claims 1
- 101150043522 HO gene Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- YKGMKSIHIVVYKY-UHFFFAOYSA-N dabrafenib mesylate Chemical group CS(O)(=O)=O.S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 YKGMKSIHIVVYKY-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000005022 impaired gait Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000036461 convulsion Effects 0.000 abstract 1
- 230000007850 degeneration Effects 0.000 abstract 1
- 230000005021 gait Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (15)
1.Jedinjenje, koje se upotrebljava za zadržavanje ili usporavanJe napredovanja jednog ili više simptoma Huntington-ove bolesti kod pacijenta kod koga se simptomi biraju između nevoljnih pokreta i narušenog hoda, naznačeno time, što to jedinjenje predstavlja (+)-izomer 3,11b-cis-dihidrotetrabenazina, ili njegova farmaceutski prihvatljiva so.
2.Upotreba jedinjenja prema Zahtevu 1, pri čemu se pomenuti simptomi nevoljnih pokreta biraju između nevoljne horeje, tremora i trzanja.
3.Upotreba jedinjenja (+)-izomera 3,11b-cis-dihidrotetrabenazina, ili njegove farmaceutski prihvatljive soli, kao što je definisano u Zahtevu 1, za profilaktički tretman Huntingtonove bolesti kod pacijenta koji je identifikovan da nosi mutirani gen odgovoran za Huntington-ovu bolest.
4.Upotreba jedinjenja prema Zahtevu 3, za profilaktički tretman pacijenta starosti između 15 i 50 godina, koji nosi mutirani oblik HO gena, a kod koga se još uvek nisu razvili simptomi ove bolesti, tako da ovaj profilaktički tretman ima za svrhu sprečavanje ili usporavanje pojave simptoma povezanih sa Huntigton ovom bolešću, pri čemu to jedinjenje predstavlja (+)-izomer 3,11b-cis dihidrotetrabenazina ili njegova farmaceutski prihvatljiva so, kao što je definisano u Zahtevu 1.
5.Jedinjenje koje se koristi prema bilo kom od Zahteva 1 do 4, naznačeno time, što (+)-izomer 3,11b-cic-dihidrotetrabenazina ima formulu (la):
6.Jedinjenje prema bilo kom od Zahteva 1 do 6, naznačeno time, što pomenuti (+)-izomer 3,11b-cis-dihidrotetrabenazina ima čistoću izomera veću od 90%.
7.Jedinjenje prema Zahtevu 6, naznačeno time, što pomenuti (+)-izomer 3,11b-cis-dihidrotetrabenazina ima čistoću izomera veću od 95%.
8.Jedinjenje prema Zahtevu 7, naznačeno time, što pomenuti (+)-izomer 3,11b-cis-dihidrotetrabenazina ima čistoću izomera veću od 98%.
9.Jedinjenje prema bilo kom od prethodnih Zahteva, naznačeno time, što je pomenuti (+)-izomer 3,11b-cis-dihidrotetrabenazina u obliku kisele adicione soli.
10.Jedinjenje prema Zahtevu 9, naznačeno time, što pomenutu so predstavlja metansulfonatna so.
11.Jedinjenje koje se koristi prema bilo kom od prethodnih Zahteva, naznačeno time, što pacijent, kome se ordinira to jedinjenje, nosi mutirani oblik gena u kome je broj ponavljanja CAG na genu IT-15 najmanje 35.
12.Jedinjenje koje se koristi prema Zahtevu 11, naznačeno time, što pacijent, kome se ordinira to jedinjenje, nosi mutirani oblik gena u kome je broj ponavljanja CAG na genu IT-15 najmanje 40.
13.Jedinjenje koje se koristi prema Zahtevu 12, naznačeno time, što pacijent, kome se ordinira to jedinjenje, nosi mutirani oblik gena u kome je broj ponavljanja CAG na genu IT-15 najmanje 50.
14.Upotreba jedinjenja prema Zahtevu 4, gde pomenuti profilaktički tretman predstavlja prevencija ili usporavanje sub-kliničkog napredovanja ove bolesti u pacijentu.
15.Upotreba (+)-izomera 3,11b-cis-dihidrotetrabenazina ili njegove farmaceutski prihvaltjive soli za proizvodnju medikamenta koji se koristi kako je definisano u bilo kom od Zahteva 1 do 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0514501.6A GB0514501D0 (en) | 2005-07-14 | 2005-07-14 | Pharmaceutical compounds |
| PCT/GB2006/002593 WO2007007105A1 (en) | 2005-07-14 | 2006-07-13 | Use of 3,1ib-cis-dihydrotetrabenazine for the treatment of symptons of huntington' s disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME01629B true ME01629B (me) | 2010-06-30 |
Family
ID=34897233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2008-916A ME01629B (me) | 2005-07-14 | 2006-05-31 | Upotreba 3,11 b-cis-dihidrotetrabenazina za tretman simptoma huntington-ove bolesti |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20080319000A1 (me) |
| EP (2) | EP1885363B1 (me) |
| JP (1) | JP2009501202A (me) |
| KR (1) | KR20080030666A (me) |
| CN (1) | CN101282726A (me) |
| AT (2) | ATE409481T1 (me) |
| AU (1) | AU2006268098B2 (me) |
| CA (1) | CA2615077A1 (me) |
| CY (1) | CY1108653T1 (me) |
| DE (1) | DE602006002982D1 (me) |
| DK (1) | DK1885363T3 (me) |
| ES (1) | ES2314931T3 (me) |
| GB (1) | GB0514501D0 (me) |
| HR (1) | HRP20080677T3 (me) |
| ME (1) | ME01629B (me) |
| NZ (1) | NZ565522A (me) |
| PL (1) | PL1885363T3 (me) |
| PT (1) | PT1885363E (me) |
| RS (1) | RS50626B (me) |
| RU (1) | RU2409365C2 (me) |
| SI (1) | SI1885363T1 (me) |
| WO (1) | WO2007007105A1 (me) |
| ZA (1) | ZA200800905B (me) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2410947B (en) * | 2004-02-11 | 2008-09-17 | Cambridge Lab Ltd | Pharmaceutical compounds |
| GB0516168D0 (en) * | 2005-08-05 | 2005-09-14 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| EP2081929B1 (en) | 2006-11-08 | 2013-01-09 | Neurocrine Biosciences, Inc. | Substituted 3-isobutyl-9, 10-dimethoxy-1,3,4,6,7,11b-hexahydro-2h-pyrido[2,1-a]isoquinolin-2-ol compounds and methods relating thereto |
| GB0810857D0 (en) * | 2008-06-13 | 2008-07-23 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| WO2011019956A2 (en) * | 2009-08-12 | 2011-02-17 | Biovail Laboratories International (Barbados) S.R.L. | Pharmaceutical compositions |
| GB2462611A (en) * | 2008-08-12 | 2010-02-17 | Cambridge Lab | Pharmaceutical composition comprising tetrabenazine |
| US20110053866A1 (en) * | 2008-08-12 | 2011-03-03 | Biovail Laboratories International (Barbados) S.R.L. | Pharmaceutical compositions |
| US20120208773A1 (en) * | 2008-08-12 | 2012-08-16 | Valeant International (Barbados) Srl | Pharmaceutical compositions with tetrabenazine |
| GB2463452A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof |
| GB2463451A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia |
| GB2463283A (en) * | 2008-09-08 | 2010-03-10 | Cambridge Lab | 3,11b-cis-dihydrotetrabenazine for use in treating asthma |
| WO2011153157A2 (en) * | 2010-06-01 | 2011-12-08 | Auspex Pharmaceutical, Inc. | Benzoquinolone inhibitors of vmat2 |
| WO2012095548A2 (es) | 2011-01-13 | 2012-07-19 | Centro De Investigación Biomédica En Red De Enfermedades Neurodegenerativas (Ciberned) | Compuestos para el tratamiento de enfermedades neurodegenerativas |
| GB201705305D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705303D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| CN110691596A (zh) * | 2017-04-01 | 2020-01-14 | 阿德普蒂奥制药有限公司 | 药物组合物 |
| GB201705302D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705306D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| GB201705304D0 (en) | 2017-04-01 | 2017-05-17 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compositions |
| AU2019261403B2 (en) | 2018-04-25 | 2025-05-15 | Shinkei Therapeutics, Inc. | Tetrabenazine transdermal delivery device |
| GB201808464D0 (en) * | 2018-05-23 | 2018-07-11 | Adeptio Pharmaceuticals Ltd | Pharmaceutical compounds for use in treating huntington's disease |
| AU2020315331A1 (en) | 2019-07-16 | 2022-02-03 | Rush University Medical Center | Use of a benzoate containing composition to treat neurodegenerative disorders |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US2830993A (en) * | 1958-04-15 | Quinolizine derivatives | ||
| US3209005A (en) * | 1965-09-28 | Hexahydro-llbh-benzo[a] quinolizines and processes therefor | ||
| US3159638A (en) * | 1964-12-01 | Xcha-chj | ||
| US3053845A (en) * | 1962-09-11 | Benzofykedocolines | ||
| US3314966A (en) * | 1967-04-18 | Substituted benzo[a]quinolizines | ||
| US3009918A (en) * | 1961-11-21 | Chz ch | ||
| US2954382A (en) * | 1960-09-27 | Xpreparation of hexahydrobenzoquinol- | ||
| US3123609A (en) * | 1964-03-03 | Benzo | ||
| US3095419A (en) * | 1963-06-25 | Process for preparing z-oxo-j- | ||
| US2843591A (en) * | 1958-07-15 | Method for preparing same | ||
| US3132147A (en) * | 1964-05-05 | |||
| US3079395A (en) * | 1963-02-26 | Novel z-oxq-benzoquinoliaine | ||
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| GB999092A (en) * | 1959-11-24 | 1965-07-21 | Wellcome Found | Method for making benzo(a)-quinolizine derivatives |
| US3375254A (en) * | 1961-09-29 | 1968-03-26 | Burroughs Wellcome Co | Manufacture of 1, 2, 3, 4, 6, 7-hexahydro-2-oxo-11bh-benzo(a)quinolizines |
| US3105079A (en) * | 1961-12-29 | 1963-09-24 | Pfizer & Co C | 10-aminobenzopyridocolines |
| US3390152A (en) * | 1965-10-21 | 1968-06-25 | Abbott Lab | 9, 10-alkoxy-3-alkyl-2, 2-(dithiosubstituted)-benzoquinolizines |
| JPS4836303B1 (me) * | 1968-12-27 | 1973-11-02 | ||
| US3635986A (en) * | 1969-12-22 | 1972-01-18 | Miles Lab | 2-substituted amino-hexahydrobenzo(a)quinolizines |
| YU264675A (en) * | 1974-10-23 | 1982-05-31 | Chinoin Gyogyszer Es Vegyeszet | Process for obtaining benzo (a)-quinolizidine derivatives |
| GB1513824A (en) * | 1975-05-22 | 1978-06-14 | Wyeth John & Brother Ltd | 1,3,4,6,7,11b-hexahydro-2h-benzo(a)quinolizine derivative |
| US4133812A (en) * | 1975-11-21 | 1979-01-09 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | Process for producing benzo (a) quinolizine derivatives |
| US4304913A (en) * | 1978-11-20 | 1981-12-08 | Miles Laboratories, Inc. | Trans-2-substituted-amido-hexahydrobenzo [A]quinolizines |
| US4353656A (en) * | 1980-10-14 | 1982-10-12 | Xerox Corporation | Moving coil, multiple energy print hammer system including a closed loop servo |
| US4778054A (en) * | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
| PT83094B (pt) * | 1985-07-30 | 1993-07-30 | Glaxo Group Ltd | Dispositivos proprios para a administracao de medicamentos a pacientes |
| GB9004781D0 (en) * | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| US6087376A (en) * | 1997-02-05 | 2000-07-11 | University Of Kentucky Research Foundation | Use of lobeline compounds in the treatment of central nervous system diseases and pathologies |
| FR2794742B1 (fr) * | 1999-06-11 | 2005-06-03 | Sanofi Synthelabo | Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant |
| US6632666B2 (en) * | 2000-01-14 | 2003-10-14 | Biolife Solutions, Inc. | Normothermic, hypothermic and cryopreservation maintenance and storage of cells, tissues and organs in gel-based media |
| JP2004501083A (ja) * | 2000-04-18 | 2004-01-15 | アゴーロン・ファーマシューティカルズ・インコーポレイテッド | プロテインキナーゼを阻害するためのピラゾール |
| AU2004249211A1 (en) * | 2003-06-16 | 2004-12-29 | Andrx Pharmaceuticals, Llc | Oral extended-release composition |
| GB2410947B (en) * | 2004-02-11 | 2008-09-17 | Cambridge Lab Ltd | Pharmaceutical compounds |
| WO2006053067A2 (en) * | 2004-11-09 | 2006-05-18 | Prestwick Pharmaceuticals, Inc. | Combination of amantadine and a tetrabenazine compound for treating hyperkinetic disorders |
| KR100682506B1 (ko) * | 2005-01-18 | 2007-02-15 | (주)젠크로스 | 프라지콴텔, 또는 이의 염을 포함하는 약학 조성물 |
| GB0516168D0 (en) * | 2005-08-05 | 2005-09-14 | Cambridge Lab Ireland Ltd | Pharmaceutical compounds |
| GB2462611A (en) * | 2008-08-12 | 2010-02-17 | Cambridge Lab | Pharmaceutical composition comprising tetrabenazine |
| US20110053866A1 (en) * | 2008-08-12 | 2011-03-03 | Biovail Laboratories International (Barbados) S.R.L. | Pharmaceutical compositions |
| GB2463283A (en) * | 2008-09-08 | 2010-03-10 | Cambridge Lab | 3,11b-cis-dihydrotetrabenazine for use in treating asthma |
| GB2463452A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof |
| GB2463451A (en) * | 2008-09-08 | 2010-03-17 | Cambridge Lab | 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia |
-
2005
- 2005-07-14 GB GBGB0514501.6A patent/GB0514501D0/en not_active Ceased
-
2006
- 2006-05-31 ME MEP-2008-916A patent/ME01629B/me unknown
- 2006-07-13 CN CNA2006800339758A patent/CN101282726A/zh active Pending
- 2006-07-13 AT AT06764942T patent/ATE409481T1/de active
- 2006-07-13 EP EP06764942A patent/EP1885363B1/en active Active
- 2006-07-13 PL PL06764942T patent/PL1885363T3/pl unknown
- 2006-07-13 US US11/995,436 patent/US20080319000A1/en not_active Abandoned
- 2006-07-13 HR HR20080677T patent/HRP20080677T3/xx unknown
- 2006-07-13 ZA ZA200800905A patent/ZA200800905B/xx unknown
- 2006-07-13 RS RSP-2008/0492A patent/RS50626B/sr unknown
- 2006-07-13 SI SI200630147T patent/SI1885363T1/sl unknown
- 2006-07-13 JP JP2008520952A patent/JP2009501202A/ja active Pending
- 2006-07-13 EP EP08017191A patent/EP2027861B1/en active Active
- 2006-07-13 WO PCT/GB2006/002593 patent/WO2007007105A1/en not_active Ceased
- 2006-07-13 NZ NZ565522A patent/NZ565522A/en not_active IP Right Cessation
- 2006-07-13 DK DK06764942T patent/DK1885363T3/da active
- 2006-07-13 KR KR1020087003481A patent/KR20080030666A/ko not_active Withdrawn
- 2006-07-13 ES ES06764942T patent/ES2314931T3/es active Active
- 2006-07-13 AU AU2006268098A patent/AU2006268098B2/en not_active Ceased
- 2006-07-13 AT AT08017191T patent/ATE522215T1/de not_active IP Right Cessation
- 2006-07-13 PT PT06764942T patent/PT1885363E/pt unknown
- 2006-07-13 RU RU2008105590/15A patent/RU2409365C2/ru not_active IP Right Cessation
- 2006-07-13 CA CA002615077A patent/CA2615077A1/en not_active Abandoned
- 2006-07-13 DE DE602006002982T patent/DE602006002982D1/de active Active
-
2008
- 2008-12-22 CY CY20081101475T patent/CY1108653T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB0514501D0 (en) | 2005-08-24 |
| EP1885363B1 (en) | 2008-10-01 |
| EP2027861A1 (en) | 2009-02-25 |
| NZ565522A (en) | 2010-04-30 |
| RU2008105590A (ru) | 2009-08-20 |
| PT1885363E (pt) | 2009-01-08 |
| JP2009501202A (ja) | 2009-01-15 |
| CN101282726A (zh) | 2008-10-08 |
| RS50626B (sr) | 2010-06-30 |
| ATE522215T1 (de) | 2011-09-15 |
| WO2007007105A1 (en) | 2007-01-18 |
| HK1111085A1 (en) | 2008-08-01 |
| HRP20080677T3 (hr) | 2009-02-28 |
| DE602006002982D1 (de) | 2008-11-13 |
| DK1885363T3 (da) | 2008-12-08 |
| CY1108653T1 (el) | 2014-04-09 |
| US20080319000A1 (en) | 2008-12-25 |
| AU2006268098A1 (en) | 2007-01-18 |
| CA2615077A1 (en) | 2007-01-18 |
| EP2027861B1 (en) | 2011-08-31 |
| KR20080030666A (ko) | 2008-04-04 |
| RU2409365C2 (ru) | 2011-01-20 |
| EP1885363A1 (en) | 2008-02-13 |
| AU2006268098B2 (en) | 2011-02-17 |
| ZA200800905B (en) | 2010-04-28 |
| SI1885363T1 (sl) | 2009-02-28 |
| ATE409481T1 (de) | 2008-10-15 |
| PL1885363T3 (pl) | 2009-05-29 |
| ES2314931T3 (es) | 2009-03-16 |
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