AU2006268098B2 - Use of 3,1IB-CIS-dihydrotetrabenazine for the treatment of symptoms of Huntington's disease - Google Patents

Use of 3,1IB-CIS-dihydrotetrabenazine for the treatment of symptoms of Huntington's disease Download PDF

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Publication number
AU2006268098B2
AU2006268098B2 AU2006268098A AU2006268098A AU2006268098B2 AU 2006268098 B2 AU2006268098 B2 AU 2006268098B2 AU 2006268098 A AU2006268098 A AU 2006268098A AU 2006268098 A AU2006268098 A AU 2006268098A AU 2006268098 B2 AU2006268098 B2 AU 2006268098B2
Authority
AU
Australia
Prior art keywords
dihydrotetrabenazine
cis
disease
isomer
huntington
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2006268098A
Other languages
English (en)
Other versions
AU2006268098A1 (en
Inventor
Thierry Filloux
Robert Tridgett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Valeant Laboratories International Bermuda SRL
Original Assignee
Biovail Laboratories International Barbados SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovail Laboratories International Barbados SRL filed Critical Biovail Laboratories International Barbados SRL
Publication of AU2006268098A1 publication Critical patent/AU2006268098A1/en
Assigned to BIOVAIL LABORATORIES INTERNATIONAL (BARBADOS) SRL reassignment BIOVAIL LABORATORIES INTERNATIONAL (BARBADOS) SRL Request for Assignment Assignors: CAMBRIDGE LABORATORIES (IRELAND) LIMITED
Application granted granted Critical
Publication of AU2006268098B2 publication Critical patent/AU2006268098B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2006268098A 2005-07-14 2006-07-13 Use of 3,1IB-CIS-dihydrotetrabenazine for the treatment of symptoms of Huntington's disease Ceased AU2006268098B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0514501.6 2005-07-14
GBGB0514501.6A GB0514501D0 (en) 2005-07-14 2005-07-14 Pharmaceutical compounds
PCT/GB2006/002593 WO2007007105A1 (en) 2005-07-14 2006-07-13 Use of 3,1ib-cis-dihydrotetrabenazine for the treatment of symptons of huntington' s disease

Publications (2)

Publication Number Publication Date
AU2006268098A1 AU2006268098A1 (en) 2007-01-18
AU2006268098B2 true AU2006268098B2 (en) 2011-02-17

Family

ID=34897233

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006268098A Ceased AU2006268098B2 (en) 2005-07-14 2006-07-13 Use of 3,1IB-CIS-dihydrotetrabenazine for the treatment of symptoms of Huntington's disease

Country Status (23)

Country Link
US (1) US20080319000A1 (enExample)
EP (2) EP1885363B1 (enExample)
JP (1) JP2009501202A (enExample)
KR (1) KR20080030666A (enExample)
CN (1) CN101282726A (enExample)
AT (2) ATE522215T1 (enExample)
AU (1) AU2006268098B2 (enExample)
CA (1) CA2615077A1 (enExample)
CY (1) CY1108653T1 (enExample)
DE (1) DE602006002982D1 (enExample)
DK (1) DK1885363T3 (enExample)
ES (1) ES2314931T3 (enExample)
GB (1) GB0514501D0 (enExample)
HR (1) HRP20080677T3 (enExample)
ME (1) ME01629B (enExample)
NZ (1) NZ565522A (enExample)
PL (1) PL1885363T3 (enExample)
PT (1) PT1885363E (enExample)
RS (1) RS50626B (enExample)
RU (1) RU2409365C2 (enExample)
SI (1) SI1885363T1 (enExample)
WO (1) WO2007007105A1 (enExample)
ZA (1) ZA200800905B (enExample)

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GB0516168D0 (en) * 2005-08-05 2005-09-14 Cambridge Lab Ireland Ltd Pharmaceutical compounds
DK2081929T3 (da) 2006-11-08 2013-04-15 Neurocrine Biosciences Inc Substituerede 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11B-hexahydro-2H-pyrido[2,1-A]isoquinolin-2-ol-forbindelser og fremgangsmåder angående disse
GB0810857D0 (en) * 2008-06-13 2008-07-23 Cambridge Lab Ireland Ltd Pharmaceutical compounds
US20120208773A1 (en) * 2008-08-12 2012-08-16 Valeant International (Barbados) Srl Pharmaceutical compositions with tetrabenazine
GB2462611A (en) * 2008-08-12 2010-02-17 Cambridge Lab Pharmaceutical composition comprising tetrabenazine
US20110053866A1 (en) * 2008-08-12 2011-03-03 Biovail Laboratories International (Barbados) S.R.L. Pharmaceutical compositions
GB2463451A (en) * 2008-09-08 2010-03-17 Cambridge Lab 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia
GB2463452A (en) * 2008-09-08 2010-03-17 Cambridge Lab Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof
GB2463283A (en) * 2008-09-08 2010-03-10 Cambridge Lab 3,11b-cis-dihydrotetrabenazine for use in treating asthma
JP2013501810A (ja) * 2009-08-12 2013-01-17 ヴァリーント インターナショナル（バルバドス）エスアールエル 医薬組成物
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GB201705304D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
GB201705302D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
GB201705305D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
GB201705306D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
GB201705303D0 (en) 2017-04-01 2017-05-17 Adeptio Pharmaceuticals Ltd Pharmaceutical compositions
RU2768738C2 (ru) * 2017-04-01 2022-03-24 Адептио Фармасьютикалз Лимитед ПРИМЕНЕНИЕ (-)-α-ДИГИДРОТЕТРАБЕНАЗИНА ИЛИ ЕГО КОМБИНАЦИИ С (+)-α-ДИГИДРОТЕТРАБЕНАЗИНОМ В ЛЕЧЕНИИ ГИПЕРКИНЕТИЧЕСКОГО ДВИГАТЕЛЬНОГО РАССТРОЙСТВА, А ТАКЖЕ СООТВЕТСТВУЮЩИЕ СПОСОБЫ
DK3784237T3 (da) 2018-04-25 2024-01-08 Shinkei Therapeutics Inc Indretning til transdermal levering af tetrabenazin
GB201808464D0 (en) 2018-05-23 2018-07-11 Adeptio Pharmaceuticals Ltd Pharmaceutical compounds for use in treating huntington's disease
JP2022541021A (ja) * 2019-07-16 2022-09-21 ラッシュ・ユニバーシティ・メディカル・センター 神経変性障害を治療するためのベンゾエート含有組成物の使用

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US20110053866A1 (en) * 2008-08-12 2011-03-03 Biovail Laboratories International (Barbados) S.R.L. Pharmaceutical compositions
GB2463452A (en) * 2008-09-08 2010-03-17 Cambridge Lab Desmethyl derivatives of tetrabenazine and pharmaceutical compositions thereof
GB2463283A (en) * 2008-09-08 2010-03-10 Cambridge Lab 3,11b-cis-dihydrotetrabenazine for use in treating asthma
GB2463451A (en) * 2008-09-08 2010-03-17 Cambridge Lab 3, 11b cis-dihydrotetrabenazine compounds for use in the treatment of dementia

Also Published As

Publication number Publication date
SI1885363T1 (sl) 2009-02-28
CN101282726A (zh) 2008-10-08
GB0514501D0 (en) 2005-08-24
ATE409481T1 (de) 2008-10-15
ES2314931T3 (es) 2009-03-16
RS50626B (sr) 2010-06-30
CY1108653T1 (el) 2014-04-09
EP2027861A1 (en) 2009-02-25
RU2409365C2 (ru) 2011-01-20
PL1885363T3 (pl) 2009-05-29
EP2027861B1 (en) 2011-08-31
RU2008105590A (ru) 2009-08-20
NZ565522A (en) 2010-04-30
ME01629B (me) 2010-06-30
HRP20080677T3 (hr) 2009-02-28
DK1885363T3 (da) 2008-12-08
US20080319000A1 (en) 2008-12-25
WO2007007105A1 (en) 2007-01-18
PT1885363E (pt) 2009-01-08
AU2006268098A1 (en) 2007-01-18
EP1885363B1 (en) 2008-10-01
ATE522215T1 (de) 2011-09-15
DE602006002982D1 (de) 2008-11-13
JP2009501202A (ja) 2009-01-15
KR20080030666A (ko) 2008-04-04
ZA200800905B (en) 2010-04-28
CA2615077A1 (en) 2007-01-18
HK1111085A1 (en) 2008-08-01
EP1885363A1 (en) 2008-02-13

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Legal Events

Date Code Title Description
DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ USE OF 3,1IB-CIS-DIHYDROTETRABENAZINE FOR THE TREATMENT OF SYMPTOMS OF HUNTINGTON S DISEASE

PC1 Assignment before grant (sect. 113)

Owner name: BIOVAIL LABORATORIES INTERNATIONAL (BARBADOS) SRL

Free format text: FORMER APPLICANT(S): CAMBRIDGE LABORATORIES (IRELAND) LIMITED

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired