JP2009500005A5 - - Google Patents
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- JP2009500005A5 JP2009500005A5 JP2008517139A JP2008517139A JP2009500005A5 JP 2009500005 A5 JP2009500005 A5 JP 2009500005A5 JP 2008517139 A JP2008517139 A JP 2008517139A JP 2008517139 A JP2008517139 A JP 2008517139A JP 2009500005 A5 JP2009500005 A5 JP 2009500005A5
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- 150000007523 nucleic acids Chemical group 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 claims 7
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 7
- 102000001301 EGF receptor Human genes 0.000 claims 6
- 108060006698 EGF receptor Proteins 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 210000001519 tissue Anatomy 0.000 claims 5
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 206010014733 Endometrial cancer Diseases 0.000 claims 4
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 4
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 4
- 206010033128 Ovarian cancer Diseases 0.000 claims 4
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 4
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 4
- 206010060862 Prostate cancer Diseases 0.000 claims 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 4
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 4
- 208000004337 Salivary Gland Neoplasms Diseases 0.000 claims 4
- 206010061934 Salivary gland cancer Diseases 0.000 claims 4
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 4
- 208000029742 colonic neoplasm Diseases 0.000 claims 4
- 206010017758 gastric cancer Diseases 0.000 claims 4
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 201000002528 pancreatic cancer Diseases 0.000 claims 4
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 201000011549 stomach cancer Diseases 0.000 claims 4
- 102100029981 Receptor tyrosine-protein kinase erbB-4 Human genes 0.000 claims 3
- 101710100963 Receptor tyrosine-protein kinase erbB-4 Proteins 0.000 claims 3
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 3
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 3
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 3
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/154,103 | 2005-06-15 | ||
| US11/154,103 US7332585B2 (en) | 2002-04-05 | 2005-06-15 | Bispecific single chain Fv antibody molecules and methods of use thereof |
| PCT/US2006/023479 WO2007084181A2 (en) | 2005-06-15 | 2006-06-14 | Bispecific single chain fv antibody molecules and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009500005A JP2009500005A (ja) | 2009-01-08 |
| JP2009500005A5 true JP2009500005A5 (enExample) | 2009-09-10 |
| JP4945557B2 JP4945557B2 (ja) | 2012-06-06 |
Family
ID=38288069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008517139A Expired - Fee Related JP4945557B2 (ja) | 2005-06-15 | 2006-06-14 | 二重特異的単鎖Ｆｖ抗体分子およびその使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7332585B2 (enExample) |
| EP (2) | EP1912674B8 (enExample) |
| JP (1) | JP4945557B2 (enExample) |
| CN (1) | CN101355966B (enExample) |
| AT (1) | ATE530195T1 (enExample) |
| AU (1) | AU2006336279B2 (enExample) |
| BR (1) | BRPI0611829A2 (enExample) |
| CA (1) | CA2612467A1 (enExample) |
| DK (1) | DK1912674T3 (enExample) |
| ES (1) | ES2377098T3 (enExample) |
| WO (1) | WO2007084181A2 (enExample) |
Families Citing this family (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7563874B2 (en) * | 1998-08-31 | 2009-07-21 | The Regents Of The University Of California | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7332585B2 (en) | 2002-04-05 | 2008-02-19 | The Regents Of The California University | Bispecific single chain Fv antibody molecules and methods of use thereof |
| CA2490280A1 (en) * | 2002-07-01 | 2004-01-08 | Human Genome Sciences, Inc. | Antibodies that specifically bind to reg iv |
| TWI229650B (en) * | 2002-11-19 | 2005-03-21 | Sharp Kk | Substrate accommodating tray |
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| TWI296930B (en) * | 2005-05-11 | 2008-05-21 | Dev Center Biotechnology | Recombinant enterovirus 71 neutralizing antibodies and use thereof |
| HUE026303T2 (hu) | 2005-07-25 | 2016-06-28 | Emergent Product Dev Seattle | B-sejt csökkentés CD37-specifikus és CD20-specifikus kapcsoló molekulák alkalmazásával |
| US20070116825A1 (en) * | 2005-11-23 | 2007-05-24 | The Coca-Cola Company | Confection with High-Potency Sweetener |
| CN105837690A (zh) * | 2006-06-12 | 2016-08-10 | 新兴产品开发西雅图有限公司 | 具有效应功能的单链多价结合蛋白 |
| WO2008140493A2 (en) * | 2006-11-21 | 2008-11-20 | The Regents Of The University Of Californina | Anti-egfr family antibodies, bispecific anti-egfr family antibodies and methods of use thereof |
| CA2670471A1 (en) | 2006-11-22 | 2008-06-05 | Adnexus, A Bristol-Myers Squibb R&D Company (A Delaware Corporation) | Targeted therapeutics based on engineered proteins for tyrosine kinases receptors, including igf-ir |
| CA2680741A1 (en) | 2007-03-22 | 2009-01-15 | The Regents Of The University Of California | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
| JP2010532764A (ja) * | 2007-07-06 | 2010-10-14 | トゥルビオン・ファーマシューティカルズ・インコーポレーテッド | Ｃ末端に配置された特異的結合性ドメインを有する結合性ペプチド |
| WO2009030285A1 (en) * | 2007-09-07 | 2009-03-12 | Ablynx N.V. | Binding molecules with multiple binding sites, compositions comprising the same and uses thereof |
| KR101661770B1 (ko) | 2007-09-21 | 2016-10-04 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 표적화된 인터페론이 강력한 아폽토시스 및 항-종양 활성을 발휘함 |
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| US9000131B2 (en) * | 2008-07-31 | 2015-04-07 | The Regents Of The University Of California | Antibodies that neutralize botulinum neurotoxins |
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| DK2417156T3 (en) | 2009-04-07 | 2015-03-02 | Roche Glycart Ag | Trivalent, bispecific antibodies |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
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| EP2486052A4 (en) * | 2009-10-09 | 2013-05-01 | Merck Sharp & Dohme | GENERATION, LABELING AND USE OF ANTI-HER3 ANTIBODIES |
| JP5960598B2 (ja) * | 2009-11-04 | 2016-08-02 | アフィボディ・アーベー | Ｈｅｒ３結合ポリペプチド |
| WO2011072240A1 (en) | 2009-12-10 | 2011-06-16 | Cedars-Sinai Medical Center | Drug delivery of temozolomide for systemic based treatment of cancer |
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| EP2569334A4 (en) * | 2010-05-13 | 2014-01-22 | Fox Chase Cancer Ct | RECOMBINANT-PRODUCED ANTIBODIES FOR THE TARGETING OF ERBB SIGNALING MOLECULES AND METHOD FOR THEIR USE FOR DISEASE DIAGNOSIS AND TREATMENT |
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| WO2012047427A2 (en) | 2010-08-31 | 2012-04-12 | The Regents Of The University Of California | Antibodies for botulinum neurotoxins |
| TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
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| US9623041B2 (en) | 2010-12-30 | 2017-04-18 | Cedars-Sinai Medical Center | Polymalic acid-based nanobiopolymer compositions |
| CN102153650B (zh) * | 2011-01-27 | 2012-07-04 | 中国人民解放军军事医学科学院生物工程研究所 | 一种抗egfr人源化抗体l2-h3及其编码基因与应用 |
| CN103403025B (zh) | 2011-02-28 | 2016-10-12 | 弗·哈夫曼-拉罗切有限公司 | 单价抗原结合蛋白 |
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- 2006-06-14 CN CN200680029687.5A patent/CN101355966B/zh not_active Expired - Fee Related
- 2006-06-14 AU AU2006336279A patent/AU2006336279B2/en not_active Ceased
- 2006-06-14 EP EP11177829.6A patent/EP2425850B1/en not_active Not-in-force
- 2006-06-14 WO PCT/US2006/023479 patent/WO2007084181A2/en not_active Ceased
- 2006-06-14 CA CA002612467A patent/CA2612467A1/en not_active Abandoned
- 2006-06-14 JP JP2008517139A patent/JP4945557B2/ja not_active Expired - Fee Related
- 2006-06-14 BR BRPI0611829-1A patent/BRPI0611829A2/pt not_active Application Discontinuation
- 2006-06-19 DK DK06784990.1T patent/DK1912674T3/da active
- 2006-06-19 AT AT06784990T patent/ATE530195T1/de not_active IP Right Cessation
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- 2012-12-10 US US13/710,146 patent/US8980258B2/en not_active Expired - Fee Related
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