JP2009261392A5 - - Google Patents
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- Publication number
- JP2009261392A5 JP2009261392A5 JP2009101953A JP2009101953A JP2009261392A5 JP 2009261392 A5 JP2009261392 A5 JP 2009261392A5 JP 2009101953 A JP2009101953 A JP 2009101953A JP 2009101953 A JP2009101953 A JP 2009101953A JP 2009261392 A5 JP2009261392 A5 JP 2009261392A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide
- nucleic acid
- sequence
- target nucleic
- nucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091033319 polynucleotide Proteins 0.000 claims description 56
- 239000002157 polynucleotide Substances 0.000 claims description 56
- 102000040430 polynucleotide Human genes 0.000 claims description 56
- 239000002773 nucleotide Substances 0.000 claims description 53
- 125000003729 nucleotide group Chemical group 0.000 claims description 53
- 150000007523 nucleic acids Chemical class 0.000 claims description 31
- 238000000034 method Methods 0.000 claims description 17
- 230000000295 complement effect Effects 0.000 claims description 15
- 239000012634 fragment Substances 0.000 claims description 14
- 102000039446 nucleic acids Human genes 0.000 claims description 14
- 108020004707 nucleic acids Proteins 0.000 claims description 14
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 13
- 108091028664 Ribonucleotide Proteins 0.000 claims description 12
- 239000002336 ribonucleotide Substances 0.000 claims description 12
- 125000002652 ribonucleotide group Chemical group 0.000 claims description 12
- 230000003321 amplification Effects 0.000 claims description 10
- 238000010348 incorporation Methods 0.000 claims description 10
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 10
- 108091093088 Amplicon Proteins 0.000 claims description 8
- 108090000790 Enzymes Proteins 0.000 claims description 8
- 102000004190 Enzymes Human genes 0.000 claims description 8
- 239000011942 biocatalyst Substances 0.000 claims description 8
- 239000005547 deoxyribonucleotide Substances 0.000 claims description 8
- 125000002637 deoxyribonucleotide group Chemical group 0.000 claims description 8
- 238000001514 detection method Methods 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 5
- 108700028369 Alleles Proteins 0.000 claims description 4
- 108091028733 RNTP Proteins 0.000 claims description 4
- 230000000903 blocking effect Effects 0.000 claims description 4
- 238000012705 nitroxide-mediated radical polymerization Methods 0.000 claims description 2
- 239000002777 nucleoside Substances 0.000 claims description 2
- -1 nucleoside monophosphate Chemical class 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 239000011541 reaction mixture Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4672008P | 2008-04-21 | 2008-04-21 | |
| US61/046,720 | 2008-04-21 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009261392A JP2009261392A (ja) | 2009-11-12 |
| JP2009261392A5 true JP2009261392A5 (enExample) | 2012-04-12 |
| JP5483403B2 JP5483403B2 (ja) | 2014-05-07 |
Family
ID=40810047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009101953A Active JP5483403B2 (ja) | 2008-04-21 | 2009-04-20 | リボヌクレオチド標識核酸検出 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10150990B2 (enExample) |
| EP (1) | EP2112230B1 (enExample) |
| JP (1) | JP5483403B2 (enExample) |
| CN (1) | CN101649354B (enExample) |
| CA (1) | CA2663302C (enExample) |
| ES (1) | ES2392783T3 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2180065A1 (en) * | 2008-10-24 | 2010-04-28 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Method of reducing the molecular weight of at least one PCR product for its detection while maintaining its identity |
| JP2015530096A (ja) * | 2012-09-24 | 2015-10-15 | シービー バイオテクノロジーズ インコーポレイテッド | 非干渉性、ノイズキャンセル性のポリヌクレオチド識別タグを用いたマルチプレックスパイロシーケンシング |
| US9828629B2 (en) | 2013-03-15 | 2017-11-28 | Roche Molecular Systems, Inc. | Nucleic acid target identification by structure based probe cleavage |
| US10106842B2 (en) | 2013-03-15 | 2018-10-23 | Roche Molecular Systems, Inc. | Nucleic acid target identification by structure based probe cleavage |
| US9637791B2 (en) | 2013-12-20 | 2017-05-02 | Roche Molecular Systems, Inc. | Multiplexed nucleic acid target identification by strucutre based probe cleavage |
| WO2016041591A1 (en) * | 2014-09-17 | 2016-03-24 | Roche Diagnostics Gmbh | Nucleic acid target identification by structure based probe cleavage |
| DK3512959T3 (da) | 2016-09-15 | 2021-10-18 | Hoffmann La Roche | Fremgangsmåder til udførelse af multipleks PCR |
| WO2023212662A2 (en) * | 2022-04-28 | 2023-11-02 | Oregon Health & Science University | Compositions and methods for modulating antigen binding activity |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| DE3529478A1 (de) | 1985-08-16 | 1987-02-19 | Boehringer Mannheim Gmbh | 7-desaza-2'desoxyguanosin-nukleotide, verfahren zu deren herstellung und deren verwendung zur nukleinsaeure-sequenzierung |
| US5466591A (en) | 1986-08-22 | 1995-11-14 | Hoffmann-La Roche Inc. | 5' to 3' exonuclease mutations of thermostable DNA polymerases |
| US5374553A (en) | 1986-08-22 | 1994-12-20 | Hoffmann-La Roche Inc. | DNA encoding a thermostable nucleic acid polymerase enzyme from thermotoga maritima |
| US5795762A (en) | 1986-08-22 | 1998-08-18 | Roche Molecular Systems, Inc. | 5' to 3' exonuclease mutations of thermostable DNA polymerases |
| US4889818A (en) | 1986-08-22 | 1989-12-26 | Cetus Corporation | Purified thermostable enzyme |
| US5455170A (en) | 1986-08-22 | 1995-10-03 | Hoffmann-La Roche Inc. | Mutated thermostable nucleic acid polymerase enzyme from Thermus species Z05 |
| US5618711A (en) | 1986-08-22 | 1997-04-08 | Hoffmann-La Roche Inc. | Recombinant expression vectors and purification methods for Thermus thermophilus DNA polymerase |
| US5216141A (en) | 1988-06-06 | 1993-06-01 | Benner Steven A | Oligonucleotide analogs containing sulfur linkages |
| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| US5386023A (en) | 1990-07-27 | 1995-01-31 | Isis Pharmaceuticals | Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling |
| JP2709311B2 (ja) | 1990-09-28 | 1998-02-04 | エフ．ホフマン−ラ ロシュ アクチェンゲゼルシャフト | 熱安定性ｄｎａポリメラーゼの５→３′のエキソヌクレアーゼ突然変異 |
| EP0637965B1 (en) | 1991-11-26 | 2002-10-16 | Isis Pharmaceuticals, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| US5484908A (en) | 1991-11-26 | 1996-01-16 | Gilead Sciences, Inc. | Oligonucleotides containing 5-propynyl pyrimidines |
| TW393513B (en) | 1991-11-26 | 2000-06-11 | Isis Pharmaceuticals Inc | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| US5644048A (en) | 1992-01-10 | 1997-07-01 | Isis Pharmaceuticals, Inc. | Process for preparing phosphorothioate oligonucleotides |
| US5637684A (en) | 1994-02-23 | 1997-06-10 | Isis Pharmaceuticals, Inc. | Phosphoramidate and phosphorothioamidate oligomeric compounds |
| CZ293215B6 (cs) | 1996-08-06 | 2004-03-17 | F. Hoffmann-La Roche Ag | Rekombinantní tepelně stálá DNA polymeráza, způsob její přípravy a prostředek, který ji obsahuje |
| AU3274600A (en) | 1999-03-18 | 2000-10-09 | Exiqon A/S | One step sample preparation and detection of nucleic acids in complex biologicalsamples |
| IL145496A0 (en) | 1999-03-24 | 2002-06-30 | Exiqon As | Improved synthesis of [2.2.1] bicyclo nucleosides |
| US6734291B2 (en) | 1999-03-24 | 2004-05-11 | Exiqon A/S | Synthesis of [2.2.1]bicyclo nucleosides |
| DE60020830T2 (de) | 1999-04-30 | 2006-07-27 | Sequenom, Inc., San Diego | Diagnostische sequenzierung durch eine kombination von spezifischer spaltung und massenspektrometrie |
| AU2001250572A1 (en) | 2000-04-07 | 2001-10-23 | Epigenomics Ag | Detection of single nucleotide polymorphisms (snp's) and cytosine-methylations |
| US7179590B2 (en) | 2000-04-18 | 2007-02-20 | Roche Molecular Systems, Inc | High temperature reverse transcription using mutant DNA polymerases |
| US7148049B2 (en) | 2002-04-02 | 2006-12-12 | Roche Molecular Systems, Inc. | Thermostable or thermoactive DNA polymerase molecules with attenuated 3′-5′ exonuclease activity |
| CN1197976C (zh) | 2003-01-31 | 2005-04-20 | 中国人民解放军南京军区联勤部军事医学研究所 | 基因多态性检测方法 |
| EP1493824A1 (en) | 2003-07-02 | 2005-01-05 | Consortium National de Recherche en Genomique (CNRG) | Method for detection of mutations in DNA |
| US7745125B2 (en) | 2004-06-28 | 2010-06-29 | Roche Molecular Systems, Inc. | 2′-terminator related pyrophosphorolysis activated polymerization |
| US7928207B2 (en) | 2004-06-28 | 2011-04-19 | Roche Molecular Systems, Inc | Synthesis and compositions of nucleic acids comprising 2′-terminator nucleotides |
| US7890268B2 (en) * | 2004-12-28 | 2011-02-15 | Roche Molecular Systems, Inc. | De-novo sequencing of nucleic acids |
| US20070068573A1 (en) * | 2005-08-22 | 2007-03-29 | Applera Corporation | Device and method for microfluidic control of a first fluid in contact with a second fluid, wherein the first and second fluids are immiscible |
| US8673567B2 (en) * | 2006-03-08 | 2014-03-18 | Atila Biosystems, Inc. | Method and kit for nucleic acid sequence detection |
| US8962293B2 (en) | 2006-10-18 | 2015-02-24 | Roche Molecular Systems, Inc. | DNA polymerases and related methods |
| US8026091B2 (en) | 2007-07-13 | 2011-09-27 | Roche Molecular Systems, Inc. | DNA polymerases and related methods |
-
2009
- 2009-04-09 US US12/421,188 patent/US10150990B2/en active Active
- 2009-04-17 ES ES09005451T patent/ES2392783T3/es active Active
- 2009-04-17 EP EP09005451A patent/EP2112230B1/en active Active
- 2009-04-20 CA CA2663302A patent/CA2663302C/en active Active
- 2009-04-20 JP JP2009101953A patent/JP5483403B2/ja active Active
- 2009-04-20 CN CN200910203986.1A patent/CN101649354B/zh active Active
-
2012
- 2012-12-19 US US13/720,881 patent/US20130096027A1/en not_active Abandoned
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