|
US3180193A
(en)
|
1963-02-25 |
1965-04-27 |
Benedict David |
Machines for cutting lengths of strip material
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4444887A
(en)
|
1979-12-10 |
1984-04-24 |
Sloan-Kettering Institute |
Process for making human antibody producing B-lymphocytes
|
|
US4433092A
(en)
|
1981-03-09 |
1984-02-21 |
Champion Spark Plug Company |
Green ceramic of lead-free glass, conductive carbon, silicone resin and AlPO4, useful, after firing, as an electrical resistor
|
|
US4873191A
(en)
|
1981-06-12 |
1989-10-10 |
Ohio University |
Genetic transformation of zygotes
|
|
US4474893A
(en)
|
1981-07-01 |
1984-10-02 |
The University of Texas System Cancer Center |
Recombinant monoclonal antibodies
|
|
US4714681A
(en)
|
1981-07-01 |
1987-12-22 |
The Board Of Reagents, The University Of Texas System Cancer Center |
Quadroma cells and trioma cells and methods for the production of same
|
|
US4716111A
(en)
|
1982-08-11 |
1987-12-29 |
Trustees Of Boston University |
Process for producing human antibodies
|
|
US4741900A
(en)
|
1982-11-16 |
1988-05-03 |
Cytogen Corporation |
Antibody-metal ion complexes
|
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
DE3586772T2
(de)
|
1984-07-24 |
1993-03-04 |
Coselco Mimotopes Pty Ltd |
Verfahren zur bestimmung von mimotopen.
|
|
US5807715A
(en)
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
|
EP0186084B1
(en)
|
1984-12-24 |
1991-09-04 |
Merck & Co. Inc. |
Brain-derived growth factor
|
|
US5049386A
(en)
|
1985-01-07 |
1991-09-17 |
Syntex (U.S.A.) Inc. |
N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US4946787A
(en)
|
1985-01-07 |
1990-08-07 |
Syntex (U.S.A.) Inc. |
N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US4897355A
(en)
|
1985-01-07 |
1990-01-30 |
Syntex (U.S.A.) Inc. |
N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US4631211A
(en)
|
1985-03-25 |
1986-12-23 |
Scripps Clinic & Research Foundation |
Means for sequential solid phase organic synthesis and methods using the same
|
|
EP0216846B2
(en)
|
1985-04-01 |
1995-04-26 |
Celltech Limited |
Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
|
|
US4980286A
(en)
|
1985-07-05 |
1990-12-25 |
Whitehead Institute For Biomedical Research |
In vivo introduction and expression of foreign genetic material in epithelial cells
|
|
EP0232262A4
(en)
|
1985-08-15 |
1989-09-19 |
Stauffer Chemical Co |
TRYPTOPHANE GENERATING MICROORGANISM.
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
LU86128A1
(fr)
|
1985-10-18 |
1987-06-02 |
Vander Poorten Henri |
Procede permettant l'impression ou le revetement de ceramique simultanement a son electroformage et conduisant en monocuisson a des produits decoratifs ou techniques
|
|
US5139941A
(en)
|
1985-10-31 |
1992-08-18 |
University Of Florida Research Foundation, Inc. |
AAV transduction vectors
|
|
GB8601597D0
(en)
|
1986-01-23 |
1986-02-26 |
Wilson R H |
Nucleotide sequences
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5073492A
(en)
|
1987-01-09 |
1991-12-17 |
The Johns Hopkins University |
Synergistic composition for endothelial cell growth
|
|
AU600575B2
(en)
|
1987-03-18 |
1990-08-16 |
Sb2, Inc. |
Altered antibodies
|
|
US5258498A
(en)
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
|
GB8717430D0
(en)
|
1987-07-23 |
1987-08-26 |
Celltech Ltd |
Recombinant dna product
|
|
JPS6438100A
(en)
|
1987-07-31 |
1989-02-08 |
Toray Industries |
Vascular endothelial cell growth factor
|
|
JPS6438100U
(enExample)
|
1987-08-26 |
1989-03-07 |
|
|
|
EP0633318A1
(en)
|
1987-09-11 |
1995-01-11 |
Whitehead Institute For Biomedical Research |
Transduced fibroblasts and uses therefor
|
|
US5336603A
(en)
|
1987-10-02 |
1994-08-09 |
Genentech, Inc. |
CD4 adheson variants
|
|
GB8725529D0
(en)
|
1987-10-30 |
1987-12-02 |
Delta Biotechnology Ltd |
Polypeptides
|
|
GB8809129D0
(en)
|
1988-04-18 |
1988-05-18 |
Celltech Ltd |
Recombinant dna methods vectors and host cells
|
|
AU631802B2
(en)
|
1988-06-14 |
1992-12-10 |
Cetus Oncology Corporation |
Coupling agents and sterically hindered disulfide linked conjugates prepared therefrom
|
|
CN1033030C
(zh)
|
1988-06-24 |
1996-10-16 |
唐化学原料公司 |
大环双官能螯合剂及其配合物和抗体共轭物的制备方法
|
|
US5756065A
(en)
|
1988-06-24 |
1998-05-26 |
The Dow Chemical Company |
Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents
|
|
US4925648A
(en)
|
1988-07-29 |
1990-05-15 |
Immunomedics, Inc. |
Detection and treatment of infectious and inflammatory lesions
|
|
US5601819A
(en)
|
1988-08-11 |
1997-02-11 |
The General Hospital Corporation |
Bispecific antibodies for selective immune regulation and for selective immune cell binding
|
|
EP1997891A1
(en)
|
1988-09-02 |
2008-12-03 |
Dyax Corporation |
Generation and selection of recombinant varied binding proteins
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
JPH02117698A
(ja)
|
1988-10-27 |
1990-05-02 |
Toray Ind Inc |
血管内皮細胞成長因子
|
|
KR900005995A
(ko)
|
1988-10-31 |
1990-05-07 |
우메모또 요시마사 |
변형 인터류킨-2 및 그의 제조방법
|
|
US5240848A
(en)
|
1988-11-21 |
1993-08-31 |
Monsanto Company |
Dna sequences encoding human vascular permeability factor having 189 amino acids
|
|
EP0401384B1
(en)
|
1988-12-22 |
1996-03-13 |
Kirin-Amgen, Inc. |
Chemically modified granulocyte colony stimulating factor
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5096815A
(en)
|
1989-01-06 |
1992-03-17 |
Protein Engineering Corporation |
Generation and selection of novel dna-binding proteins and polypeptides
|
|
US5198346A
(en)
|
1989-01-06 |
1993-03-30 |
Protein Engineering Corp. |
Generation and selection of novel DNA-binding proteins and polypeptides
|
|
US5703055A
(en)
|
1989-03-21 |
1997-12-30 |
Wisconsin Alumni Research Foundation |
Generation of antibodies through lipid mediated DNA delivery
|
|
DE69034168T3
(de)
|
1989-03-21 |
2013-04-11 |
Vical, Inc. |
Expression von exogenen Polynukleotidsequenzen in Wirbeltieren
|
|
US5693622A
(en)
|
1989-03-21 |
1997-12-02 |
Vical Incorporated |
Expression of exogenous polynucleotide sequences cardiac muscle of a mammal
|
|
EP0394827A1
(en)
|
1989-04-26 |
1990-10-31 |
F. Hoffmann-La Roche Ag |
Chimaeric CD4-immunoglobulin polypeptides
|
|
US5766883A
(en)
|
1989-04-29 |
1998-06-16 |
Delta Biotechnology Limited |
Polypeptides
|
|
ZA902949B
(en)
|
1989-05-05 |
1992-02-26 |
Res Dev Foundation |
A novel antibody delivery system for biological response modifiers
|
|
DE69024261T2
(de)
|
1989-05-24 |
1996-07-18 |
Merck & Co Inc |
Reinigung und Charakterisierung eines von einem Glioma abstammenden Wachstumsfaktors
|
|
ATE144793T1
(de)
|
1989-06-29 |
1996-11-15 |
Medarex Inc |
Bispezifische reagenzien für die aids-therapie
|
|
US5112946A
(en)
|
1989-07-06 |
1992-05-12 |
Repligen Corporation |
Modified pf4 compositions and methods of use
|
|
US5413923A
(en)
|
1989-07-25 |
1995-05-09 |
Cell Genesys, Inc. |
Homologous recombination for universal donor cells and chimeric mammalian hosts
|
|
US5194596A
(en)
|
1989-07-27 |
1993-03-16 |
California Biotechnology Inc. |
Production of vascular endothelial cell growth factor
|
|
US5219739A
(en)
|
1989-07-27 |
1993-06-15 |
Scios Nova Inc. |
DNA sequences encoding bVEGF120 and hVEGF121 and methods for the production of bovine and human vascular endothelial cell growth factors, bVEGF120 and hVEGF121
|
|
FR2650598B1
(fr)
|
1989-08-03 |
1994-06-03 |
Rhone Poulenc Sante |
Derives de l'albumine a fonction therapeutique
|
|
US5073627A
(en)
|
1989-08-22 |
1991-12-17 |
Immunex Corporation |
Fusion proteins comprising GM-CSF and IL-3
|
|
US5436146A
(en)
|
1989-09-07 |
1995-07-25 |
The Trustees Of Princeton University |
Helper-free stocks of recombinant adeno-associated virus vectors
|
|
CA2067194C
(en)
|
1989-10-05 |
2003-03-18 |
Glenn Kawasaki |
Cell-free synthesis and isolation of novel genes and polypeptides
|
|
GB8924021D0
(en)
|
1989-10-25 |
1989-12-13 |
Celltech Ltd |
Recombinant dna method and vectors for the use therein
|
|
WO1991006570A1
(en)
|
1989-10-25 |
1991-05-16 |
The University Of Melbourne |
HYBRID Fc RECEPTOR MOLECULES
|
|
US5676954A
(en)
|
1989-11-03 |
1997-10-14 |
Vanderbilt University |
Method of in vivo delivery of functioning foreign genes
|
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
|
WO1991010737A1
(en)
|
1990-01-11 |
1991-07-25 |
Molecular Affinities Corporation |
Production of antibodies using gene libraries
|
|
US5780225A
(en)
|
1990-01-12 |
1998-07-14 |
Stratagene |
Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
DE69133566T2
(de)
|
1990-01-12 |
2007-12-06 |
Amgen Fremont Inc. |
Bildung von xenogenen Antikörpern
|
|
US5314995A
(en)
|
1990-01-22 |
1994-05-24 |
Oncogen |
Therapeutic interleukin-2-antibody based fusion proteins
|
|
US5747334A
(en)
|
1990-02-15 |
1998-05-05 |
The University Of North Carolina At Chapel Hill |
Random peptide library
|
|
FI90454C
(fi)
|
1990-02-22 |
1994-02-10 |
Patenttitoimisto T Poutanen Oy |
Menetelmä naulalevykattotuolin valmistamiseksi
|
|
WO1991014438A1
(en)
|
1990-03-20 |
1991-10-03 |
The Trustees Of Columbia University In The City Of New York |
Chimeric antibodies with receptor binding ligands in place of their constant region
|
|
US5264618A
(en)
|
1990-04-19 |
1993-11-23 |
Vical, Inc. |
Cationic lipids for intracellular delivery of biologically active molecules
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
WO1991018088A1
(en)
|
1990-05-23 |
1991-11-28 |
The United States Of America, Represented By The Secretary, United States Department Of Commerce |
Adeno-associated virus (aav)-based eucaryotic vectors
|
|
US5349053A
(en)
|
1990-06-01 |
1994-09-20 |
Protein Design Labs, Inc. |
Chimeric ligand/immunoglobulin molecules and their uses
|
|
DK0464533T3
(da)
|
1990-06-28 |
1999-04-26 |
Gen Hospital Corp |
Fusionsproteiner med immunglobulindele, deres fremstilling og anvendelse
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
DE4025687A1
(de)
|
1990-08-14 |
1992-02-20 |
Ruetgerswerke Ag |
Durch strahlung vernetzbare bindemittelgemische
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
KR100272077B1
(ko)
|
1990-08-29 |
2000-11-15 |
젠팜인터내셔날,인코포레이티드 |
이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
CA2051796A1
(en)
|
1990-09-21 |
1992-03-22 |
Marvin L. Bayne |
Vascular endothelial cell growth factor ii
|
|
US5726152A
(en)
|
1990-09-21 |
1998-03-10 |
Merck & Co., Inc. |
Vascular endothelial cell growth factor II
|
|
US5698426A
(en)
|
1990-09-28 |
1997-12-16 |
Ixsys, Incorporated |
Surface expression libraries of heteromeric receptors
|
|
CA2092323A1
(en)
|
1990-10-01 |
1992-04-02 |
George Y. Wu |
Targeting viruses and cells for selective internalization by cells
|
|
AU667460B2
(en)
|
1990-10-05 |
1996-03-28 |
Medarex, Inc. |
Targeted immunostimulation with bispecific reagents
|
|
AU8727291A
(en)
|
1990-10-29 |
1992-06-11 |
Cetus Oncology Corporation |
Bispecific antibodies, method of production, and uses thereof
|
|
US5173414A
(en)
|
1990-10-30 |
1992-12-22 |
Applied Immune Sciences, Inc. |
Production of recombinant adeno-associated virus vectors
|
|
US5353535A
(en)
|
1990-11-05 |
1994-10-11 |
Plumly George W |
Floor type advertising apparatus
|
|
ATE218889T1
(de)
|
1990-11-09 |
2002-06-15 |
Stephen D Gillies |
Cytokine immunokonjugate
|
|
WO1992009690A2
(en)
|
1990-12-03 |
1992-06-11 |
Genentech, Inc. |
Enrichment method for variant proteins with altered binding properties
|
|
AU643109B2
(en)
|
1990-12-14 |
1993-11-04 |
Cell Genesys, Inc. |
Chimeric chains for receptor-associated signal transduction pathways
|
|
ATE221915T1
(de)
|
1991-02-22 |
2002-08-15 |
American Cyanamid Co |
Identifizierung eines menschlichen rezeptor- tyrosinkinasegens
|
|
EP0506477B1
(en)
|
1991-03-28 |
1999-06-23 |
Merck & Co. Inc. |
Vascular endothelial cell growth factor C subunit
|
|
US5185438A
(en)
|
1991-04-02 |
1993-02-09 |
The Trustees Of Princeton University |
Nucleic acids encoding hencatoporetic stem cell receptor flk-2
|
|
DE69233750D1
(de)
|
1991-04-10 |
2009-01-02 |
Scripps Research Inst |
Bibliotheken heterodimerer Rezeptoren mittels Phagemiden
|
|
US5234908A
(en)
|
1991-04-12 |
1993-08-10 |
Creative Biomolecules, Inc. |
Method of treating gastrointestinal ulcers with platelet derived growth factor
|
|
WO1992019973A1
(en)
|
1991-04-26 |
1992-11-12 |
Surface Active Limited |
Novel antibodies, and methods for their use
|
|
DE69231736T2
(de)
|
1991-05-14 |
2001-10-25 |
The Immune Response Corp., Carlsbad |
Gerichtete abgabe von genen, die immunogene proteine kodieren
|
|
DE69233482T2
(de)
|
1991-05-17 |
2006-01-12 |
Merck & Co., Inc. |
Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
|
|
DE69231385T2
(de)
|
1991-06-05 |
2001-04-12 |
The Board Of Regents Acting For And On Behalf Of The Unversity Of Michigan, Ann Arbor |
Zielgerichtete freisetzung von genen, die sekretorische proteine kodieren
|
|
WO1992022324A1
(en)
|
1991-06-14 |
1992-12-23 |
Xoma Corporation |
Microbially-produced antibody fragments and their conjugates
|
|
IL99120A0
(en)
|
1991-08-07 |
1992-07-15 |
Yeda Res & Dev |
Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them
|
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
|
US5641670A
(en)
|
1991-11-05 |
1997-06-24 |
Transkaryotic Therapies, Inc. |
Protein production and protein delivery
|
|
US6270989B1
(en)
|
1991-11-05 |
2001-08-07 |
Transkaryotic Therapies, Inc. |
Protein production and delivery
|
|
US5661133B1
(en)
|
1991-11-12 |
1999-06-01 |
Univ Michigan |
Collateral blood vessel formation in cardiac muscle by injecting a dna sequence encoding an angiogenic protein
|
|
ATE408012T1
(de)
|
1991-12-02 |
2008-09-15 |
Medical Res Council |
Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
|
|
WO1993014188A1
(en)
|
1992-01-17 |
1993-07-22 |
The Regents Of The University Of Michigan |
Targeted virus
|
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
|
US5399349A
(en)
|
1992-02-06 |
1995-03-21 |
Paunescu; Calin |
Treatment of acne
|
|
US5861301A
(en)
|
1992-02-20 |
1999-01-19 |
American Cayanamid Company |
Recombinant kinase insert domain containing receptor and gene encoding same
|
|
CA2131528C
(en)
|
1992-03-05 |
2004-07-13 |
Philip E. Thorpe |
Methods and compositions for targeting the vasculature of solid tumors
|
|
US5733743A
(en)
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
US5573905A
(en)
|
1992-03-30 |
1996-11-12 |
The Scripps Research Institute |
Encoded combinatorial chemical libraries
|
|
US5447851B1
(en)
|
1992-04-02 |
1999-07-06 |
Univ Texas System Board Of |
Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
|
|
WO1993020221A1
(en)
|
1992-04-03 |
1993-10-14 |
Young Alexander T |
Gene therapy using targeted viral vectors
|
|
ZA932522B
(en)
|
1992-04-10 |
1993-12-20 |
Res Dev Foundation |
Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
|
|
US5326695A
(en)
|
1992-05-15 |
1994-07-05 |
Ludwig Institute For Cancer Research |
Platelet derived growth factor agonists
|
|
ATE182651T1
(de)
|
1992-06-09 |
1999-08-15 |
Hoppe Ag |
Riegel und türschloss
|
|
WO1994002602A1
(en)
|
1992-07-24 |
1994-02-03 |
Cell Genesys, Inc. |
Generation of xenogeneic antibodies
|
|
EP0749475A4
(en)
|
1992-08-26 |
1997-05-07 |
Harvard College |
USE OF CYTOKINE IP-10 AS ANTI-TUMOR AGENT
|
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
|
US6824777B1
(en)
|
1992-10-09 |
2004-11-30 |
Licentia Ltd. |
Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy
|
|
CA2146747C
(en)
|
1992-10-09 |
2006-12-19 |
Brian A. Naughton |
Liver reserve cells
|
|
US5776755A
(en)
|
1992-10-09 |
1998-07-07 |
Helsinki University Licensing, Ltd. |
FLT4, a receptor tyrosine kinase
|
|
EP1321526A3
(en)
|
1992-11-18 |
2003-07-02 |
Arch Development Corporation |
Adenovirus-mediated gene transfer to cardiac and vascular smooth muscle
|
|
TW402639B
(en)
|
1992-12-03 |
2000-08-21 |
Transkaryotic Therapies Inc |
Protein production and protein delivery
|
|
CA2592997A1
(en)
|
1992-12-03 |
1994-06-09 |
Genzyme Corporation |
Pseudo-adenovirus vectors
|
|
US5478745A
(en)
|
1992-12-04 |
1995-12-26 |
University Of Pittsburgh |
Recombinant viral vector system
|
|
US5441050A
(en)
|
1992-12-18 |
1995-08-15 |
Neoprobe Corporation |
Radiation responsive surgical instrument
|
|
US5593972A
(en)
|
1993-01-26 |
1997-01-14 |
The Wistar Institute |
Genetic immunization
|
|
US5480971A
(en)
|
1993-06-17 |
1996-01-02 |
Houghten Pharmaceuticals, Inc. |
Peralkylated oligopeptide mixtures
|
|
US5994341A
(en)
|
1993-07-19 |
1999-11-30 |
Angiogenesis Technologies, Inc. |
Anti-angiogenic Compositions and methods for the treatment of arthritis
|
|
WO1995015982A2
(en)
|
1993-12-08 |
1995-06-15 |
Genzyme Corporation |
Process for generating specific antibodies
|
|
JP2552425B2
(ja)
|
1993-12-14 |
1996-11-13 |
コナミ株式会社 |
実況中継機能付きゲーム機
|
|
US5922572A
(en)
|
1994-01-25 |
1999-07-13 |
Human Genome Sciences, Inc. |
Polynucleotides encoding haemopoietic maturation factor
|
|
DK1231268T3
(da)
|
1994-01-31 |
2005-11-21 |
Univ Boston |
Polyklonale antistofbiblioteker
|
|
US5837458A
(en)
|
1994-02-17 |
1998-11-17 |
Maxygen, Inc. |
Methods and compositions for cellular and metabolic engineering
|
|
US5605793A
(en)
|
1994-02-17 |
1997-02-25 |
Affymax Technologies N.V. |
Methods for in vitro recombination
|
|
US5834252A
(en)
|
1995-04-18 |
1998-11-10 |
Glaxo Group Limited |
End-complementary polymerase reaction
|
|
ES2249762T3
(es)
|
1994-03-08 |
2006-04-01 |
Human Genome Sciences, Inc. |
Factor de crecimiento del endotelio vascular 2.
|
|
US7109308B1
(en)
*
|
1994-03-08 |
2006-09-19 |
Human Genome Sciences, Inc. |
Antibodies to human vascular endothelial growth factor 2
|
|
US7153827B1
(en)
*
|
1994-03-08 |
2006-12-26 |
Human Genome Sciences, Inc. |
Vascular endothelial growth factor 2 and methods of use
|
|
US5932540A
(en)
*
|
1994-03-08 |
1999-08-03 |
Human Genome Sciences, Inc. |
Vascular endothelial growth factor 2
|
|
US6734285B2
(en)
*
|
1994-03-08 |
2004-05-11 |
Human Genome Sciences, Inc. |
Vascular endothelial growth factor 2 proteins and compositions
|
|
US7186688B1
(en)
*
|
1994-03-08 |
2007-03-06 |
Human Genome Sciences, Inc. |
Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2
|
|
US6608182B1
(en)
*
|
1994-03-08 |
2003-08-19 |
Human Genome Sciences, Inc. |
Human vascular endothelial growth factor 2
|
|
US5817485A
(en)
|
1994-03-08 |
1998-10-06 |
Human Genome Sciences, Inc. |
Nucleic acids and cells for recombinant production of fibroblast growth factor-10
|
|
US5633147A
(en)
|
1994-03-08 |
1997-05-27 |
Human Genome Sciences, Inc. |
Transforming growth factor αH1
|
|
US6040157A
(en)
*
|
1994-03-08 |
2000-03-21 |
Human Genome Sciences, Inc. |
Vascular endothelial growth factor 2
|
|
US5516637A
(en)
|
1994-06-10 |
1996-05-14 |
Dade International Inc. |
Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
|
|
US5985660A
(en)
|
1994-06-15 |
1999-11-16 |
Systemix, Inc. |
Method of identifying biological response modifiers involved in dendritic and/or lymphoid progenitor cell proliferation and/or differentiation
|
|
AU3382595A
(en)
|
1994-07-29 |
1996-03-04 |
Smithkline Beecham Corporation |
Novel compounds
|
|
WO1996005856A1
(en)
|
1994-08-23 |
1996-02-29 |
Human Genome Sciences, Inc. |
Human chemokine polypeptides
|
|
US5652225A
(en)
|
1994-10-04 |
1997-07-29 |
St. Elizabeth's Medical Center Of Boston, Inc. |
Methods and products for nucleic acid delivery
|
|
US6130071A
(en)
|
1997-02-05 |
2000-10-10 |
Helsinki University Licensing, Ltd. |
Vascular endothelial growth factor C (VEGF-C) ΔCys156 protein and gene, and uses thereof
|
|
US6818220B1
(en)
|
1994-11-14 |
2004-11-16 |
Licentia Ltd. |
Vascular endothelial growth factor C (VEGF-C) protein and gene mutants thereof, and uses thereof
|
|
US6403088B1
(en)
|
1995-08-01 |
2002-06-11 |
Helsinki University Licensing, Ltd. |
Antibodies reactive with VEGF-C, a ligand for the Flt4 receptor tyrosine kinase (VEGFR-3)
|
|
US6645933B1
(en)
|
1995-08-01 |
2003-11-11 |
Helsinki University Licensing Ltd. Oy |
Receptor ligand VEGF-C
|
|
US6245530B1
(en)
|
1995-08-01 |
2001-06-12 |
Ludwig Institute For Cancer Research |
Receptor ligand
|
|
WO1998033917A1
(en)
|
1994-11-14 |
1998-08-06 |
The Ludwig Institute For Cancer Research |
Vascular endothelial growth factor c (vegf-c) protein and gene, mutants thereof, and uses thereof
|
|
US6221839B1
(en)
*
|
1994-11-14 |
2001-04-24 |
Helsinki University Licensing Ltd. Oy |
FIt4 ligand and methods of use
|
|
ATE238668T1
(de)
|
1995-01-17 |
2003-05-15 |
Brigham & Womens Hospital |
Rezeptorspezifischer transepithelialer transport von immunogenen
|
|
US6030613A
(en)
|
1995-01-17 |
2000-02-29 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
|
US5652224A
(en)
|
1995-02-24 |
1997-07-29 |
The Trustees Of The University Of Pennsylvania |
Methods and compositions for gene therapy for the treatment of defects in lipoprotein metabolism
|
|
US5792453A
(en)
|
1995-02-28 |
1998-08-11 |
The Regents Of The University Of California |
Gene transfer-mediated angiogenesis therapy
|
|
US5928939A
(en)
|
1995-03-01 |
1999-07-27 |
Ludwig Institute For Cancer Research |
Vascular endothelial growth factor-b and dna coding therefor
|
|
US5607918A
(en)
|
1995-03-01 |
1997-03-04 |
Ludwig Institute For Cancer Research |
Vascular endothelial growth factor-B and DNA coding therefor
|
|
US5516717A
(en)
|
1995-04-19 |
1996-05-14 |
United Microelectronics Corporation |
Method for manufacturing electrostatic discharge devices
|
|
JP4312259B2
(ja)
|
1995-04-27 |
2009-08-12 |
アムジェン フレモント インク． |
免疫したゼノマウス（ＸｅｎｏＭｏｕｓｅ）に由来するヒト抗体
|
|
EP0823941A4
(en)
|
1995-04-28 |
2001-09-19 |
Abgenix Inc |
HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES
|
|
US5705151A
(en)
|
1995-05-18 |
1998-01-06 |
National Jewish Center For Immunology & Respiratory Medicine |
Gene therapy for T cell regulation
|
|
US5804162A
(en)
|
1995-06-07 |
1998-09-08 |
Alliance Pharmaceutical Corp. |
Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
|
|
EP2258726A1
(en)
|
1995-06-14 |
2010-12-08 |
The Regents of the University of California |
High affinity human antibodies to c-erbB-2
|
|
US5811097A
(en)
|
1995-07-25 |
1998-09-22 |
The Regents Of The University Of California |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
|
US7423125B2
(en)
|
1995-08-01 |
2008-09-09 |
Vegenics Limited |
Antibodies to VEGF-C
|
|
US6361946B1
(en)
|
1997-02-05 |
2002-03-26 |
Licentia Ltd |
Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof
|
|
CA2229043C
(en)
*
|
1995-08-18 |
2016-06-07 |
Morphosys Gesellschaft Fur Proteinoptimierung Mbh |
Protein/(poly)peptide libraries
|
|
IL123332A
(en)
|
1995-09-08 |
2005-12-18 |
Genentech Inc |
Isolated biologically active human vascular endothelial growth factor (vegf) related protein
|
|
GB9601081D0
(en)
|
1995-10-06 |
1996-03-20 |
Cambridge Antibody Tech |
Specific binding members for human transforming growth factor beta;materials and methods
|
|
US6121246A
(en)
|
1995-10-20 |
2000-09-19 |
St. Elizabeth's Medical Center Of Boston, Inc. |
Method for treating ischemic tissue
|
|
AU1116297A
(en)
|
1995-11-08 |
1997-05-29 |
Immunex Corporation |
Flk-1 binding protein
|
|
US5641750A
(en)
|
1995-11-29 |
1997-06-24 |
Amgen Inc. |
Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product
|
|
JP2978435B2
(ja)
|
1996-01-24 |
1999-11-15 |
チッソ株式会社 |
アクリロキシプロピルシランの製造方法
|
|
WO1997033899A1
(en)
|
1996-03-14 |
1997-09-18 |
Human Genome Sciences, Inc. |
Apoptosis inducing molecule i
|
|
EP0904278A4
(en)
|
1996-03-22 |
1999-09-15 |
Human Genome Sciences Inc |
MOLECULE II INDUCER OF APOPTOSIS
|
|
JP2000512981A
(ja)
|
1996-06-06 |
2000-10-03 |
ラ ホヤ ファーマシューティカル カンパニー |
ａＰＬ免疫応答性ペプチド、その結合体およびａＰＬ抗体媒介病理のための処置方法
|
|
ES2212121T3
(es)
|
1996-08-13 |
2004-07-16 |
Human Genome Sciences, Inc. |
Mutantes de factor-2 de crecimiento queranocitico (kgf-2 o factor -12 de crecimiento fibroblastico, fgf-12).
|
|
EP1749836B1
(en)
|
1996-08-23 |
2009-06-17 |
Vegenics Limited |
Recombinant vascular endothelial cell growth factor D (VEGF-D)
|
|
US6225290B1
(en)
|
1996-09-19 |
2001-05-01 |
The Regents Of The University Of California |
Systemic gene therapy by intestinal cell transformation
|
|
US5916771A
(en)
|
1996-10-11 |
1999-06-29 |
Abgenix, Inc. |
Production of a multimeric protein by cell fusion method
|
|
DE69738539T2
(de)
|
1996-12-03 |
2009-03-26 |
Amgen Fremont Inc. |
Vollkommen humane Antikörper die EGFR binden
|
|
WO1998024811A2
(en)
|
1996-12-06 |
1998-06-11 |
Zymogenetics, Inc. |
Vascular endothelial growth factor
|
|
ATE296117T1
(de)
|
1997-03-07 |
2005-06-15 |
Wistar Inst |
Verwendung von adenoviralen vektoren, die pdgf oder vegf exprimieren, zur heilung von gewebsdefekten und zur induzierung der hypervaskulität in säugergeweben
|
|
US7863444B2
(en)
|
1997-03-19 |
2011-01-04 |
Abbott Laboratories |
4-aminopyrrolopyrimidines as kinase inhibitors
|
|
US6884879B1
(en)
*
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
|
BRPI9809391B8
(pt)
|
1997-04-14 |
2021-05-25 |
Amgen Res Munich Gmbh |
processo para a produção de um receptor de antígeno anti-humano, anticorpo humano e composição farmacêutica
|
|
IL132537A0
(en)
|
1997-04-25 |
2001-03-19 |
Collateral Therapeutics |
Truncated vegf-related proteins
|
|
CA2288351A1
(en)
|
1997-05-01 |
1998-11-05 |
Amgen Inc. |
Chimeric opg polypeptides
|
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
|
CA2293693A1
(en)
|
1997-06-06 |
1998-12-10 |
Asat Ag Applied Science & Technology |
Anti-gpiib/iiia recombinant antibodies
|
|
AU8536998A
(en)
|
1997-06-10 |
1998-12-30 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. |
Regulatory sequences involved in hypoxia regulated gene expression and uses thereof
|
|
EP1000082A2
(en)
|
1997-07-08 |
2000-05-17 |
Novopharm Biotech, Inc. |
Antigen binding fragments, designated 4b5, that specifically detect cancer cells, nucleotides encoding the fragments, and use thereof for the prophylaxis and detection of cancers
|
|
WO1999008522A1
(en)
|
1997-08-15 |
1999-02-25 |
Ludwig Institute For Cancer Research |
Stimulation, modulation and/or inhibition of endothelial proteolytic activity and/or angiogenic activity
|
|
GB9722131D0
(en)
*
|
1997-10-20 |
1997-12-17 |
Medical Res Council |
Method
|
|
AU751572B2
(en)
|
1997-10-27 |
2002-08-22 |
Merck & Co., Inc. |
Gene therapy for stimulation of angiogenesis
|
|
ES2303358T3
(es)
|
1997-11-03 |
2008-08-01 |
Human Genome Sciences, Inc. |
Vegi, un inhibidor de la angiogenesis y el crecimiento tumoral.
|
|
KR20010034576A
(ko)
*
|
1998-03-13 |
2001-04-25 |
벤슨 로버트 에이치. |
혈관 내피 성장 인자 2
|
|
US5930540A
(en)
*
|
1998-07-01 |
1999-07-27 |
Eastman Kodak Company |
Camera with multiple spring drive
|
|
US6713474B2
(en)
|
1998-09-18 |
2004-03-30 |
Abbott Gmbh & Co. Kg |
Pyrrolopyrimidines as therapeutic agents
|
|
NZ511408A
(en)
|
1998-10-09 |
2004-04-30 |
Licentia Ltd |
Flt4 (VEGFR-3) as a target for tumor imaging and anti-tumor therapy
|
|
NZ511115A
(en)
|
1998-10-19 |
2005-01-28 |
Ludwig Inst Cancer Res |
A neuropilin and vascular endothelial growth factor (VEGF) complex and uses thereof in hibitng bioactiviy of growth factors in tumor cells
|
|
US6958147B1
(en)
|
1998-10-26 |
2005-10-25 |
Licentia Ltd |
Use of VEGF-C to prevent restenosis
|
|
CA2340593C
(en)
|
1998-10-26 |
2012-05-08 |
Kari Alitalo |
Use of vegf-c or vegf-d gene or protein to prevent restenosis
|
|
DE69930872T8
(de)
|
1998-12-21 |
2007-05-03 |
Ludwig Institute For Cancer Research |
Antikörper gegen verkürzten vegf-d und deren verwendungen
|
|
CA2361615A1
(en)
|
1999-02-08 |
2000-08-10 |
Human Genome Sciences, Inc. |
The use of vascular endothelial growth factor 2 antagonist in the treatment of an injury to or disorder of an eye
|
|
US7223724B1
(en)
*
|
1999-02-08 |
2007-05-29 |
Human Genome Sciences, Inc. |
Use of vascular endothelial growth factor to treat photoreceptor cells
|
|
US6764820B2
(en)
|
1999-03-26 |
2004-07-20 |
Ludwig Institute For Cancer Research |
Screening for lymphatic disorders involving the FLT4 receptor tyrosine kinase (VEGFR-3)
|
|
WO2000058511A1
(en)
|
1999-03-26 |
2000-10-05 |
Ludwig Institute For Cancer Research |
Screening and therapy for lymphatic disorders involving the flt4 receptor tyrosine kinase (vegfr-3)
|
|
US6297238B1
(en)
|
1999-04-06 |
2001-10-02 |
Basf Aktiengesellschaft |
Therapeutic agents
|
|
AU4972900A
(en)
|
1999-04-08 |
2000-11-14 |
Arch Development Corporation |
Use of anti-vegf antibody to enhance radiation in cancer therapy
|
|
EP1169052B1
(en)
|
1999-04-15 |
2005-07-20 |
Caritas St. Elizabeth's Medical Center of Boston, Inc. |
Vegf angiogenic growth factors for treatment of peripheral neuropathy
|
|
BR0010034A
(pt)
|
1999-04-26 |
2002-01-15 |
Aventis Pharma Sa |
Utilização de um vetor, processo de preparação de um medicamento útil para a prevenção, a melhoria e/ou o tratamento da hipertensão arterial pulmonar, e, composição farmacêutica
|
|
CN1308347C
(zh)
*
|
1999-04-28 |
2007-04-04 |
德克萨斯大学董事会 |
用于通过选择性抑制vegf来治疗癌症的组合物和方法
|
|
US6468543B1
(en)
|
1999-05-03 |
2002-10-22 |
Zymogenetics, Inc. |
Methods for promoting growth of bone using ZVEGF4
|
|
EP1181058A2
(de)
*
|
1999-05-27 |
2002-02-27 |
Max-Delbrück-Centrum Für Molekulare Medizin |
Vakzine gegen konformationsabhängige antigene sowie gegen antigene, die keine oder nicht ausschliesslich proteine oder peptide sind
|
|
CN1402733A
(zh)
|
1999-06-03 |
2003-03-12 |
人体基因组科学有限公司 |
血管生成蛋白及其应用
|
|
EP1183358A1
(en)
|
1999-06-07 |
2002-03-06 |
Edwards Lifesciences Corporation |
Targeted angiogenesis
|
|
US6921763B2
(en)
|
1999-09-17 |
2005-07-26 |
Abbott Laboratories |
Pyrazolopyrimidines as therapeutic agents
|
|
PT1212327E
(pt)
|
1999-09-17 |
2004-01-30 |
Abbott Gmbh & Co Kg |
Pirazolopirimidinas como agentes terapeuticos
|
|
US6420378B1
(en)
|
1999-10-15 |
2002-07-16 |
Supergen, Inc. |
Inhibition of abnormal cell proliferation with camptothecin and combinations including the same
|
|
AU2001229254B2
(en)
|
2000-01-19 |
2006-07-27 |
Gill, Parkash S. |
Pharmaceutical compositions and methods of treatment based on VEGF antisense oligonucleotides
|
|
US7740841B1
(en)
|
2000-01-28 |
2010-06-22 |
Sunnybrook Health Science Center |
Therapeutic method for reducing angiogenesis
|
|
ES2293973T3
(es)
|
2000-02-03 |
2008-04-01 |
Millennium Pharm Inc |
Anticuerpos anti-ccr2 humanizados y metodos de uso de los mismos.
|
|
CA2399148A1
(en)
*
|
2000-02-10 |
2001-08-16 |
Abbott Laboratories |
Antibodies that bind human interleukin-18 and methods of making and using
|
|
DK1297016T3
(da)
|
2000-05-12 |
2006-07-10 |
Vlaams Interuniv Inst Biotech |
Anvendelse af placentavækstfaktorinhibitorer til behandling af patologisk angiogenese, patologisk arteriogenese, inflammation, tumordannelse og/eller vaskulær lækage
|
|
US20020013261A1
(en)
|
2000-05-18 |
2002-01-31 |
Robert Pawliuk |
Methods and compositions for promoting angiogenesis using polyethylene glycol (PEG) polymers
|
|
AU2001261737A1
(en)
|
2000-05-18 |
2001-11-26 |
Genetix Pharmaceuticals, Inc. |
Methods and compositions for promoting angiogenesis using monocytes
|
|
MXPA02003434A
(es)
|
2000-08-04 |
2002-09-02 |
Human Genome Sciences Inc |
Factor de crecimiento endotelial vascular 2.
|
|
AU2001294633A1
(en)
|
2000-09-29 |
2002-04-15 |
St. Elizabeth's Medical Center |
Endothelial cell mitogen bioassay
|
|
AU2001296521A1
(en)
|
2000-10-02 |
2002-04-15 |
St. Elizabeth's Medical Center Of Boston, Inc. |
Use of lymphangiogenic agents to treat lymphatic disorders
|
|
US6793918B2
(en)
|
2000-11-01 |
2004-09-21 |
Ludwig Institute For Cancer Research |
In vivo stimulation of angiogenic activity
|
|
US20030211988A1
(en)
|
2001-01-09 |
2003-11-13 |
Epstein Stephen E |
Enhancing lymph channel development and treatment of lymphatic obstructive disease
|
|
EP1404868A2
(en)
|
2001-02-28 |
2004-04-07 |
Chondrogene Inc. |
Compositions and methods relating to osteoarthritis
|
|
NZ527975A
(en)
|
2001-03-09 |
2005-02-25 |
Janssen Pharmaceutica Nv |
Modulation of smooth muscle cell proliferation
|
|
MXPA03008560A
(es)
|
2001-03-22 |
2004-06-30 |
Abbot Gmbh & Co Kg |
Pirazolopirimidinas como agentes terapeuticos.
|
|
EP2228389B1
(en)
|
2001-04-13 |
2015-07-08 |
Human Genome Sciences, Inc. |
Antibodies against vascular endothelial growth factor 2
|
|
CA2444624A1
(en)
*
|
2001-04-13 |
2002-10-24 |
Human Genome Sciences, Inc. |
Vascular endothelial growth factor 2
|
|
AU2002256172A1
(en)
|
2001-04-13 |
2002-10-28 |
Human Genome Sciences, Inc. |
Vascular endothelial growth factor 2
|
|
US20050232921A1
(en)
*
|
2001-04-13 |
2005-10-20 |
Rosen Craig A |
Vascular endothelial growth factor 2
|
|
US7402312B2
(en)
*
|
2001-04-13 |
2008-07-22 |
Human Genome Sciences, Inc. |
Antibodies to vascular endothelial growth factor 2 (VEGF-2)
|
|
US7709450B2
(en)
|
2001-06-20 |
2010-05-04 |
Ludwig Institute For Cancer Research |
Stimulation of vascularization with VEGF-B-186
|
|
EP1423095B1
(en)
|
2001-08-14 |
2016-09-28 |
Tel Aviv University Future Technology Development L.P. |
Lipidated glycosaminoglycan particles and their use in drug and gene delivery for diagnosis and therapy
|
|
US7981863B2
(en)
|
2001-09-19 |
2011-07-19 |
Neuronova Ab |
Treatment of Parkinson's disease with PDGF
|
|
US20040031067A1
(en)
|
2001-10-11 |
2004-02-12 |
Meenhard Herlyn |
Regulation of human skin healing
|
|
US20030139333A1
(en)
|
2002-01-18 |
2003-07-24 |
Genetix Pharmaceuticals, Inc. |
Methods and compositions for promoting angiogenesis
|
|
US20030158132A1
(en)
|
2002-01-22 |
2003-08-21 |
Genvec, Inc. |
Method for enhancing bone density or formation
|
|
US20030199525A1
(en)
|
2002-03-21 |
2003-10-23 |
Hirst Gavin C. |
Kinase inhibitors
|
|
US20030225098A1
(en)
|
2002-03-21 |
2003-12-04 |
Hirst Gavin C. |
Kinase inhibitors
|
|
WO2003097660A1
(en)
|
2002-04-12 |
2003-11-27 |
Human Genome Sciences, Inc. |
Vascular endothelial growth factor 2
|
|
JP3906747B2
(ja)
|
2002-06-14 |
2007-04-18 |
株式会社日立製作所 |
低沸点燃料を使用する燃料供給装置およびその制御方法
|
|
WO2004057005A1
(en)
|
2002-12-20 |
2004-07-08 |
Fit Biotech Oyj Plc |
Vectors lacking an origin of replication functioning in mammalian cells and expressing growth factors
|
|
US20040120950A1
(en)
|
2002-12-20 |
2004-06-24 |
Kari Alitalo |
Modulation of VEGF-C/VEGFR-3 interactions in the treatment of rheumatoid arthritis
|
|
US20050032697A1
(en)
|
2003-06-12 |
2005-02-10 |
Kari Alitalo |
Heparin binding VEGFR-3 ligands
|
|
ATE507240T1
(de)
|
2004-03-05 |
2011-05-15 |
Vegenics Pty Ltd |
Materialien und verfahren für wachstumsfaktorbindende konstrukte
|
|
US11284893B2
(en)
|
2019-04-02 |
2022-03-29 |
Covidien Lp |
Stapling device with articulating tool assembly
|