JP2009235107A5 - - Google Patents
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- Publication number
- JP2009235107A5 JP2009235107A5 JP2009171142A JP2009171142A JP2009235107A5 JP 2009235107 A5 JP2009235107 A5 JP 2009235107A5 JP 2009171142 A JP2009171142 A JP 2009171142A JP 2009171142 A JP2009171142 A JP 2009171142A JP 2009235107 A5 JP2009235107 A5 JP 2009235107A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- inhibitor
- hypertension
- combination according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000003839 salts Chemical class 0.000 claims 21
- 206010020772 Hypertension Diseases 0.000 claims 7
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 claims 4
- 102000003729 Neprilysin Human genes 0.000 claims 4
- 108090000028 Neprilysin Proteins 0.000 claims 4
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 claims 4
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 208000010125 myocardial infarction Diseases 0.000 claims 4
- 239000002461 renin inhibitor Substances 0.000 claims 4
- 229940086526 renin-inhibitors Drugs 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 229960000528 amlodipine Drugs 0.000 claims 3
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 claims 3
- 208000029078 coronary artery disease Diseases 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 229940123338 Aldosterone synthase inhibitor Drugs 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 229940127291 Calcium channel antagonist Drugs 0.000 claims 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 2
- 206010048554 Endothelial dysfunction Diseases 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 2
- 229940123934 Reductase inhibitor Drugs 0.000 claims 2
- 208000001647 Renal Insufficiency Diseases 0.000 claims 2
- 206010042957 Systolic hypertension Diseases 0.000 claims 2
- 239000002170 aldosterone antagonist Substances 0.000 claims 2
- 229940083712 aldosterone antagonist Drugs 0.000 claims 2
- 239000002333 angiotensin II receptor antagonist Substances 0.000 claims 2
- 239000000400 angiotensin II type 1 receptor blocker Substances 0.000 claims 2
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 2
- 239000000480 calcium channel blocker Substances 0.000 claims 2
- 239000002934 diuretic Substances 0.000 claims 2
- 230000001882 diuretic effect Effects 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 230000009977 dual effect Effects 0.000 claims 2
- 230000008694 endothelial dysfunction Effects 0.000 claims 2
- 239000002308 endothelin receptor antagonist Substances 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 201000006370 kidney failure Diseases 0.000 claims 2
- 208000037803 restenosis Diseases 0.000 claims 2
- 230000004083 survival effect Effects 0.000 claims 2
- ZGGHKIMDNBDHJB-NRFPMOEYSA-M (3R,5S)-fluvastatin sodium Chemical compound [Na+].C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 ZGGHKIMDNBDHJB-NRFPMOEYSA-M 0.000 claims 1
- CLPFFLWZZBQMAO-UHFFFAOYSA-N 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile Chemical group C1=CC(C#N)=CC=C1C1N2C=NC=C2CCC1 CLPFFLWZZBQMAO-UHFFFAOYSA-N 0.000 claims 1
- XPCFTKFZXHTYIP-PMACEKPBSA-N Benazepril Chemical group C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C2=CC=CC=C2CC1)=O)CC1=CC=CC=C1 XPCFTKFZXHTYIP-PMACEKPBSA-N 0.000 claims 1
- 239000004072 C09CA03 - Valsartan Substances 0.000 claims 1
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 claims 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 1
- 108010061435 Enalapril Proteins 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 208000035150 Hypercholesterolemia Diseases 0.000 claims 1
- 206010022489 Insulin Resistance Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 1
- 238000002399 angioplasty Methods 0.000 claims 1
- 230000001028 anti-proliverative effect Effects 0.000 claims 1
- 229960004530 benazepril Drugs 0.000 claims 1
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 claims 1
- GJPICJJJRGTNOD-UHFFFAOYSA-N bosentan Chemical group COC1=CC=CC=C1OC(C(=NC(=N1)C=2N=CC=CN=2)OCCO)=C1NS(=O)(=O)C1=CC=C(C(C)(C)C)C=C1 GJPICJJJRGTNOD-UHFFFAOYSA-N 0.000 claims 1
- 229960003065 bosentan Drugs 0.000 claims 1
- 210000004351 coronary vessel Anatomy 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000033679 diabetic kidney disease Diseases 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 230000001258 dyslipidemic effect Effects 0.000 claims 1
- 229960000873 enalapril Drugs 0.000 claims 1
- GBXSMTUPTTWBMN-XIRDDKMYSA-N enalapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 GBXSMTUPTTWBMN-XIRDDKMYSA-N 0.000 claims 1
- 229960001208 eplerenone Drugs 0.000 claims 1
- JUKPWJGBANNWMW-VWBFHTRKSA-N eplerenone Chemical group C([C@@H]1[C@]2(C)C[C@H]3O[C@]33[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)C(=O)OC)C[C@@]21CCC(=O)O1 JUKPWJGBANNWMW-VWBFHTRKSA-N 0.000 claims 1
- 229950011548 fadrozole Drugs 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 229960003765 fluvastatin Drugs 0.000 claims 1
- 229960002003 hydrochlorothiazide Drugs 0.000 claims 1
- 208000020346 hyperlipoproteinemia Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- LVRLSYPNFFBYCZ-VGWMRTNUSA-N omapatrilat Chemical group C([C@H](S)C(=O)N[C@H]1CCS[C@H]2CCC[C@H](N2C1=O)C(=O)O)C1=CC=CC=C1 LVRLSYPNFFBYCZ-VGWMRTNUSA-N 0.000 claims 1
- 229960002797 pitavastatin Drugs 0.000 claims 1
- VGYFMXBACGZSIL-MCBHFWOFSA-N pitavastatin Chemical compound OC(=O)C[C@H](O)C[C@H](O)\C=C\C1=C(C2CC2)N=C2C=CC=CC2=C1C1=CC=C(F)C=C1 VGYFMXBACGZSIL-MCBHFWOFSA-N 0.000 claims 1
- 238000007634 remodeling Methods 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 claims 1
- 229960004699 valsartan Drugs 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0028151A GB0028151D0 (en) | 2000-11-17 | 2000-11-17 | Combination of organic compounds |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002542381A Division JP2004513920A (ja) | 2000-11-17 | 2001-11-15 | 循環器系疾患のためのレニン阻害剤を含む相乗的組合せ剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013148269A Division JP6089278B2 (ja) | 2000-11-17 | 2013-07-17 | 循環器系疾患のためのレニン阻害剤を含む相乗的組合せ剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009235107A JP2009235107A (ja) | 2009-10-15 |
| JP2009235107A5 true JP2009235107A5 (https=) | 2012-03-22 |
Family
ID=9903412
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002542381A Withdrawn JP2004513920A (ja) | 2000-11-17 | 2001-11-15 | 循環器系疾患のためのレニン阻害剤を含む相乗的組合せ剤 |
| JP2009171142A Withdrawn JP2009235107A (ja) | 2000-11-17 | 2009-07-22 | 循環器系疾患のためのレニン阻害剤を含む相乗的組合せ剤 |
| JP2013148269A Expired - Lifetime JP6089278B2 (ja) | 2000-11-17 | 2013-07-17 | 循環器系疾患のためのレニン阻害剤を含む相乗的組合せ剤 |
| JP2016214552A Expired - Lifetime JP6373931B2 (ja) | 2000-11-17 | 2016-11-01 | 循環器系疾患のためのレニン阻害剤を含む相乗的組合せ剤 |
| JP2017232474A Expired - Lifetime JP6577994B2 (ja) | 2000-11-17 | 2017-12-04 | 循環器系疾患のためのレニン阻害剤を含む相乗的組合せ剤 |
| JP2018103151A Expired - Lifetime JP6603757B2 (ja) | 2000-11-17 | 2018-05-30 | 循環器系疾患のためのレニン阻害剤を含む相乗的組合せ剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002542381A Withdrawn JP2004513920A (ja) | 2000-11-17 | 2001-11-15 | 循環器系疾患のためのレニン阻害剤を含む相乗的組合せ剤 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013148269A Expired - Lifetime JP6089278B2 (ja) | 2000-11-17 | 2013-07-17 | 循環器系疾患のためのレニン阻害剤を含む相乗的組合せ剤 |
| JP2016214552A Expired - Lifetime JP6373931B2 (ja) | 2000-11-17 | 2016-11-01 | 循環器系疾患のためのレニン阻害剤を含む相乗的組合せ剤 |
| JP2017232474A Expired - Lifetime JP6577994B2 (ja) | 2000-11-17 | 2017-12-04 | 循環器系疾患のためのレニン阻害剤を含む相乗的組合せ剤 |
| JP2018103151A Expired - Lifetime JP6603757B2 (ja) | 2000-11-17 | 2018-05-30 | 循環器系疾患のためのレニン阻害剤を含む相乗的組合せ剤 |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US8168616B1 (https=) |
| EP (7) | EP1915993B1 (https=) |
| JP (6) | JP2004513920A (https=) |
| KR (6) | KR20100114904A (https=) |
| CN (4) | CN100404024C (https=) |
| AT (2) | ATE317692T1 (https=) |
| AU (2) | AU2368002A (https=) |
| BR (1) | BR0115411A (https=) |
| CA (2) | CA2763223A1 (https=) |
| CY (5) | CY1105603T1 (https=) |
| CZ (2) | CZ299749B6 (https=) |
| DE (3) | DE60134349D1 (https=) |
| DK (3) | DK1341533T3 (https=) |
| EC (1) | ECSP034603A (https=) |
| ES (4) | ES2308347T3 (https=) |
| GB (1) | GB0028151D0 (https=) |
| HU (2) | HUP0301841A3 (https=) |
| IL (3) | IL155707A (https=) |
| LU (2) | LU91563I2 (https=) |
| MX (1) | MXPA03004358A (https=) |
| NL (2) | NL300385I1 (https=) |
| NO (2) | NO334002B1 (https=) |
| NZ (6) | NZ550896A (https=) |
| PL (3) | PL400914A1 (https=) |
| PT (3) | PT1341533E (https=) |
| RU (2) | RU2310443C2 (https=) |
| SG (1) | SG135969A1 (https=) |
| SI (3) | SI1341533T1 (https=) |
| SK (1) | SK287881B6 (https=) |
| WO (1) | WO2002040007A1 (https=) |
| ZA (1) | ZA200303497B (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1448190A2 (en) * | 2001-10-18 | 2004-08-25 | Novartis AG | Salts formed of an at1-receptor antagonist and a cardiovascular agent |
| DK1507558T3 (da) * | 2002-05-17 | 2011-12-05 | Novartis Pharma Ag | Farmaceutisk sammensætning omfattende en renininhibitor, en calciumkanalblokker og et diuretikum |
| GB0212410D0 (en) * | 2002-05-29 | 2002-07-10 | Novartis Ag | Organic compounds |
| WO2004002466A1 (en) * | 2002-06-28 | 2004-01-08 | Speedel Pharma Ag | Pharmaceutical formulation comprising non-peptide renin inhibitor and surfactant |
| CA2490811A1 (en) * | 2002-06-28 | 2004-01-08 | Novartis Ag | Use of organic compounds |
| SE0300988D0 (sv) * | 2003-04-03 | 2003-04-03 | Astrazeneca Ab | New use |
| TW200513461A (en) | 2003-10-01 | 2005-04-16 | Speedel Experimenta Ag | Organische verbindungen |
| GB0325605D0 (en) * | 2003-11-03 | 2003-12-10 | Novartis Ag | Combination of organic compounds |
| AU2004293178B8 (en) * | 2003-11-26 | 2009-01-08 | Novartis Ag | Organic compounds |
| GB0327839D0 (en) * | 2003-12-01 | 2003-12-31 | Novartis Ag | Organic compounds |
| AR047445A1 (es) * | 2004-01-23 | 2006-01-18 | Speedel Experimenta Ag | Compuestos derivados de amino alcohol con actividad inhibidora de la renina y su uso en composiciones farmaceuticas. |
| DE602005022060D1 (de) * | 2004-01-23 | 2010-08-12 | Novartis Ag | Diaminoalkohole und deren verwendung als renininhibitoren |
| TW200529837A (en) * | 2004-01-23 | 2005-09-16 | Speedel Experimenta Ag | Organic compounds |
| NZ549535A (en) * | 2004-03-17 | 2010-11-26 | Novartis Ag | Use of aliskiren for treating renal and other disorders |
| MY148773A (en) | 2004-03-17 | 2013-05-31 | Novartis Ag | Galenic formulations of organic compounds |
| JP4927704B2 (ja) * | 2004-03-19 | 2012-05-09 | シュペーデル・エクスペリメンタ・アーゲー | 有機化合物 |
| WO2005099695A1 (en) * | 2004-04-19 | 2005-10-27 | Novartis Ag | Drug delivery systems for the prevention and treatment of vascular diseases |
| AU2005294318A1 (en) * | 2004-10-08 | 2006-04-20 | Novartis Ag | Use of renin inhibitors for the prevention or treatment of diastolic dysfunction or diastolic heart failure |
| GB0428250D0 (en) * | 2004-12-23 | 2005-01-26 | Novartis Ag | Organic compounds |
| MY146830A (en) * | 2005-02-11 | 2012-09-28 | Novartis Ag | Combination of organic compounds |
| TW200722424A (en) | 2005-03-31 | 2007-06-16 | Speedel Experimenta Ag | Substituted piperidines |
| EP1897879A3 (en) | 2005-03-31 | 2008-06-11 | Speedel Experimenta AG | 2,4,5-substituted piperidines as renin inhibitors |
| MX2007013471A (es) * | 2005-04-27 | 2008-01-22 | Novartis Ag | Metodos de tratamiento de aterosclerosis. |
| GB0511686D0 (en) * | 2005-06-08 | 2005-07-13 | Novartis Ag | Organic compounds |
| CN1732952B (zh) * | 2005-09-02 | 2010-04-07 | 姚俊华 | 一种治疗高血压的复方分散片 |
| DK1797885T3 (da) * | 2005-09-28 | 2008-07-14 | Teva Pharma | Stabil kombination af amlodipinbesylat og benazeprilhydrochlorid |
| US8158146B2 (en) | 2005-09-28 | 2012-04-17 | Teva Pharmaceutical Industries Ltd. | Stable combinations of amlodipine besylate and benazepril hydrochloride |
| RU2008122712A (ru) * | 2005-11-08 | 2009-12-20 | Новартис АГ (CH) | Комбинация органических соединений |
| AR057882A1 (es) | 2005-11-09 | 2007-12-26 | Novartis Ag | Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra |
| MX2008011842A (es) * | 2006-03-13 | 2008-10-02 | Encysive Pharmaceuticals Inc | Procedimientos y composiciones para el tratamiento de insuficiencia cardiaca diastolica. |
| US20070260203A1 (en) * | 2006-05-04 | 2007-11-08 | Allergan, Inc. | Vasoactive agent intraocular implant |
| GB0612540D0 (en) | 2006-06-23 | 2006-08-02 | Novartis Ag | Galenical formulations of organic compounds |
| TW200831463A (en) * | 2006-09-12 | 2008-08-01 | Speedel Experimenta Ag | Nitrate esters of aminoalcohols |
| KR100888131B1 (ko) * | 2006-10-10 | 2009-03-11 | 한올제약주식회사 | 시간차 투약 원리를 이용한 심혈관계 질환 치료용 복합제제 |
| KR20090090384A (ko) * | 2006-12-15 | 2009-08-25 | 노파르티스 아게 | 비만 환자에서 고혈압의 예방 및 치료를 위한 레닌 억제제 |
| CA2677822A1 (en) * | 2007-02-14 | 2008-08-21 | Gilead Colorado, Inc. | Antihypertensive drug combination |
| TW200924737A (en) * | 2007-09-28 | 2009-06-16 | Novartis Ag | Galenical formulations of organic compounds |
| EP2062874B1 (en) | 2007-11-20 | 2014-12-17 | KRKA, tovarna zdravil, d.d., Novo mesto | Process and intermediates for the preparation of aliskiren |
| EP2255796A2 (en) | 2008-02-22 | 2010-12-01 | HanAll Biopharma Co., Ltd. | Pharmaceutical preparation |
| WO2009125981A2 (ko) | 2008-04-10 | 2009-10-15 | 한올제약주식회사 | 약제학적 제제 |
| WO2009127251A1 (en) * | 2008-04-16 | 2009-10-22 | Novartis Ag | Combinations comprising a renin inhibitor |
| US20110117194A1 (en) | 2008-04-29 | 2011-05-19 | Hanall Biopharma Co., Ltd. | Pharmaceutical formulation containing angiotensin-ii receptor blocker |
| WO2010024772A1 (en) * | 2008-08-29 | 2010-03-04 | Medivir Ab | Aspartyl protease inhibitors |
| SI2189442T1 (sl) | 2008-11-20 | 2015-03-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Postopek in intermediati za pripravo aliskirena |
| AR075880A1 (es) | 2009-03-20 | 2011-05-04 | Novartis Ag | Formulaciones galenicas de compuestos organicos que comprenden alisquireno y valsartan. uso. metodo. |
| CN101926793B (zh) * | 2010-08-05 | 2012-08-15 | 成都自豪药业有限公司 | 一种含替米沙坦和阿利吉伦的联合用药物及其制备方法 |
| WO2012152718A1 (en) | 2011-05-06 | 2012-11-15 | Farmicom Pharmaceutical Company D.O.O. | Composition comprising angiotensin ii receptor antagonist and antioxidant for maintaining and/or improving skin properties |
| RU2483750C1 (ru) * | 2012-03-19 | 2013-06-10 | Общество с ограниченной ответственностью "СупраГен" | Способ лечения больных с острым инфарктом миокарда с подъемом сегмента st |
| US9808529B2 (en) * | 2012-05-18 | 2017-11-07 | Luoda Pharma Pty Ltd | Liquid formulation |
| RU2554815C1 (ru) * | 2014-06-18 | 2015-06-27 | Общество с ограниченной ответственностью "Нанолек" | Гипотензивное средство |
| CN106572977A (zh) | 2014-07-30 | 2017-04-19 | 默克专利股份有限公司 | 可直接压制的聚乙烯醇类 |
| CN109890389B (zh) * | 2016-10-27 | 2022-07-01 | 达米安制药股份公司 | 醛固酮合酶抑制剂 |
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