JP2009215305A5 - - Google Patents
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- Publication number
- JP2009215305A5 JP2009215305A5 JP2009114753A JP2009114753A JP2009215305A5 JP 2009215305 A5 JP2009215305 A5 JP 2009215305A5 JP 2009114753 A JP2009114753 A JP 2009114753A JP 2009114753 A JP2009114753 A JP 2009114753A JP 2009215305 A5 JP2009215305 A5 JP 2009215305A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- binder
- active ingredients
- solid dosage
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 22
- 239000011230 binding agent Substances 0.000 claims 10
- 239000000463 material Substances 0.000 claims 10
- 239000004480 active ingredient Substances 0.000 claims 8
- 239000002552 dosage form Substances 0.000 claims 7
- 239000000843 powder Substances 0.000 claims 6
- 239000007909 solid dosage form Substances 0.000 claims 6
- 239000002245 particle Substances 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 239000012530 fluid Substances 0.000 claims 3
- 239000012254 powdered material Substances 0.000 claims 3
- 238000010146 3D printing Methods 0.000 claims 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 229930195725 Mannitol Natural products 0.000 claims 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000008101 lactose Substances 0.000 claims 2
- 239000000594 mannitol Substances 0.000 claims 2
- 235000010355 mannitol Nutrition 0.000 claims 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 238000007639 printing Methods 0.000 claims 2
- 239000000600 sorbitol Substances 0.000 claims 2
- 235000010356 sorbitol Nutrition 0.000 claims 2
- 238000003860 storage Methods 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000000811 xylitol Substances 0.000 claims 2
- 235000010447 xylitol Nutrition 0.000 claims 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 2
- 229960002675 xylitol Drugs 0.000 claims 2
- YQSHYGCCYVPRDI-UHFFFAOYSA-N (4-propan-2-ylphenyl)methanamine Chemical compound CC(C)C1=CC=C(CN)C=C1 YQSHYGCCYVPRDI-UHFFFAOYSA-N 0.000 claims 1
- CIVCELMLGDGMKZ-UHFFFAOYSA-N 2,4-dichloro-6-methylpyridine-3-carboxylic acid Chemical compound CC1=CC(Cl)=C(C(O)=O)C(Cl)=N1 CIVCELMLGDGMKZ-UHFFFAOYSA-N 0.000 claims 1
- SATHPVQTSSUFFW-UHFFFAOYSA-N 4-[6-[(3,5-dihydroxy-4-methoxyoxan-2-yl)oxymethyl]-3,5-dihydroxy-4-methoxyoxan-2-yl]oxy-2-(hydroxymethyl)-6-methyloxane-3,5-diol Chemical group OC1C(OC)C(O)COC1OCC1C(O)C(OC)C(O)C(OC2C(C(CO)OC(C)C2O)O)O1 SATHPVQTSSUFFW-UHFFFAOYSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- 239000001904 Arabinogalactan Substances 0.000 claims 1
- 229920000189 Arabinogalactan Polymers 0.000 claims 1
- 206010006326 Breath odour Diseases 0.000 claims 1
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 claims 1
- KBAUFVUYFNWQFM-UHFFFAOYSA-N Doxylamine succinate Chemical compound OC(=O)CCC(O)=O.C=1C=CC=NC=1C(C)(OCCN(C)C)C1=CC=CC=C1 KBAUFVUYFNWQFM-UHFFFAOYSA-N 0.000 claims 1
- 239000005715 Fructose Substances 0.000 claims 1
- 229930091371 Fructose Natural products 0.000 claims 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 208000032139 Halitosis Diseases 0.000 claims 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 206010028735 Nasal congestion Diseases 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 239000002269 analeptic agent Substances 0.000 claims 1
- 235000019312 arabinogalactan Nutrition 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 229940046978 chlorpheniramine maleate Drugs 0.000 claims 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 claims 1
- 229960003782 dextromethorphan hydrobromide Drugs 0.000 claims 1
- 239000008121 dextrose Substances 0.000 claims 1
- 229960000525 diphenhydramine hydrochloride Drugs 0.000 claims 1
- 229960005008 doxylamine succinate Drugs 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 238000005516 engineering process Methods 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000019634 flavors Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000000873 masking effect Effects 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- 239000000133 nasal decongestant Substances 0.000 claims 1
- 229960005489 paracetamol Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 229960003447 pseudoephedrine hydrochloride Drugs 0.000 claims 1
- BALXUFOVQVENIU-KXNXZCPBSA-N pseudoephedrine hydrochloride Chemical compound [H+].[Cl-].CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-KXNXZCPBSA-N 0.000 claims 1
- 210000003079 salivary gland Anatomy 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000003232 water-soluble binding agent Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3888397P | 1997-02-20 | 1997-02-20 | |
| US3828497P | 1997-02-20 | 1997-02-20 | |
| US60/038,883 | 1997-02-20 | ||
| US60/038,284 | 1997-02-20 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53687898A Division JP4563516B2 (ja) | 1997-02-20 | 1998-02-20 | 迅速分散性を示す投与剤形、その使用法並びにその製造方法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2009215305A JP2009215305A (ja) | 2009-09-24 |
| JP2009215305A5 true JP2009215305A5 (enExample) | 2009-11-05 |
| JP2009215305A6 JP2009215305A6 (ja) | 2009-12-24 |
| JP5091910B2 JP5091910B2 (ja) | 2012-12-05 |
Family
ID=26715043
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53687898A Expired - Lifetime JP4563516B2 (ja) | 1997-02-20 | 1998-02-20 | 迅速分散性を示す投与剤形、その使用法並びにその製造方法 |
| JP2009114753A Expired - Lifetime JP5091910B2 (ja) | 1997-02-20 | 2009-05-11 | 迅速分散性を示す投与剤形、その使用法並びにその製造方法 |
| JP2009256374A Withdrawn JP2010120938A (ja) | 1997-02-20 | 2009-11-09 | 迅速分散性を示す投与剤形医薬組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53687898A Expired - Lifetime JP4563516B2 (ja) | 1997-02-20 | 1998-02-20 | 迅速分散性を示す投与剤形、その使用法並びにその製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009256374A Withdrawn JP2010120938A (ja) | 1997-02-20 | 2009-11-09 | 迅速分散性を示す投与剤形医薬組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6471992B1 (enExample) |
| EP (1) | EP0973507B1 (enExample) |
| JP (3) | JP4563516B2 (enExample) |
| AT (1) | ATE421318T1 (enExample) |
| AU (1) | AU736912B2 (enExample) |
| CA (1) | CA2281473C (enExample) |
| DE (1) | DE69840495D1 (enExample) |
| ES (1) | ES2318869T3 (enExample) |
| WO (1) | WO1998036738A1 (enExample) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4563516B2 (ja) * | 1997-02-20 | 2010-10-13 | マサチューセッツ インスティテュート オブ テクノロジー | 迅速分散性を示す投与剤形、その使用法並びにその製造方法 |
| WO1999059544A2 (en) * | 1998-05-18 | 1999-11-25 | Takeda Chemical Industries, Ltd. | Orally disintegrable tablets |
| US6284270B1 (en) * | 1999-08-04 | 2001-09-04 | Drugtech Corporation | Means for creating a mass having structural integrity |
| EP1301177A2 (en) * | 2000-07-10 | 2003-04-16 | Therics, Inc. | Method and materials for controlling migration of binder liquid in a powder |
| HRP20031057B1 (hr) * | 2001-06-28 | 2013-05-31 | Ucb Farchim Sa, Z.I. Planchy | Tableta koja sadrži cetirizin i pseudoefedrin |
| EA005537B1 (ru) * | 2001-07-10 | 2005-04-28 | Тева Фармасьютикал Индастриес Лтд. | Система доставки лекарственного вещества по нулевому порядку, нулевому порядку - двухстадийной, возрастающей или убывающей доставки препарата |
| US20030099708A1 (en) * | 2001-10-29 | 2003-05-29 | Therics, Inc | Printing or dispensing a suspension such as three-dimensional printing of dosage forms |
| JP4845340B2 (ja) * | 2001-10-29 | 2011-12-28 | マサチューセッツ インスティテュート オブ テクノロジー | 三次元プリント投薬形態のような物品の一軸圧縮のためのシステムおよび方法 |
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- 1998-02-20 DE DE69840495T patent/DE69840495D1/de not_active Expired - Lifetime
- 1998-02-20 AU AU63314/98A patent/AU736912B2/en not_active Ceased
- 1998-02-20 EP EP98907531A patent/EP0973507B1/en not_active Expired - Lifetime
- 1998-02-20 AT AT98907531T patent/ATE421318T1/de not_active IP Right Cessation
- 1998-02-20 WO PCT/US1998/003256 patent/WO1998036738A1/en not_active Ceased
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