JP2005524702A5 - - Google Patents
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- Publication number
- JP2005524702A5 JP2005524702A5 JP2004500818A JP2004500818A JP2005524702A5 JP 2005524702 A5 JP2005524702 A5 JP 2005524702A5 JP 2004500818 A JP2004500818 A JP 2004500818A JP 2004500818 A JP2004500818 A JP 2004500818A JP 2005524702 A5 JP2005524702 A5 JP 2005524702A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- polymer
- release
- shell
- api
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002552 dosage form Substances 0.000 claims 18
- 229920000642 polymer Polymers 0.000 claims 12
- 239000008186 active pharmaceutical agent Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 239000000843 powder Substances 0.000 claims 8
- 239000007788 liquid Substances 0.000 claims 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 6
- 229920002689 polyvinyl acetate Polymers 0.000 claims 5
- 239000011118 polyvinyl acetate Substances 0.000 claims 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 4
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 claims 4
- 238000000151 deposition Methods 0.000 claims 4
- BALXUFOVQVENIU-KXNXZCPBSA-N pseudoephedrine hydrochloride Chemical group [H+].[Cl-].CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-KXNXZCPBSA-N 0.000 claims 4
- 229960003447 pseudoephedrine hydrochloride Drugs 0.000 claims 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000000377 silicon dioxide Substances 0.000 claims 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 2
- CIVCELMLGDGMKZ-UHFFFAOYSA-N 2,4-dichloro-6-methylpyridine-3-carboxylic acid Chemical compound CC1=CC(Cl)=C(C(O)=O)C(Cl)=N1 CIVCELMLGDGMKZ-UHFFFAOYSA-N 0.000 claims 2
- 241000416162 Astragalus gummifer Species 0.000 claims 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 2
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 claims 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 2
- DBAKFASWICGISY-DASCVMRKSA-N Dexchlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C1([C@H](CCN(C)C)C=2N=CC=CC=2)=CC=C(Cl)C=C1 DBAKFASWICGISY-DASCVMRKSA-N 0.000 claims 2
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 claims 2
- 239000001856 Ethyl cellulose Substances 0.000 claims 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 2
- 229920002148 Gellan gum Polymers 0.000 claims 2
- 229920002907 Guar gum Polymers 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims 2
- 229920000161 Locust bean gum Polymers 0.000 claims 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 2
- 229920001615 Tragacanth Polymers 0.000 claims 2
- FQPFAHBPWDRTLU-UHFFFAOYSA-N aminophylline Chemical compound NCCN.O=C1N(C)C(=O)N(C)C2=C1NC=N2.O=C1N(C)C(=O)N(C)C2=C1NC=N2 FQPFAHBPWDRTLU-UHFFFAOYSA-N 0.000 claims 2
- 229960003556 aminophylline Drugs 0.000 claims 2
- 239000011230 binding agent Substances 0.000 claims 2
- 229960003108 brompheniramine maleate Drugs 0.000 claims 2
- SRGKFVAASLQVBO-BTJKTKAUSA-N brompheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Br)C=C1 SRGKFVAASLQVBO-BTJKTKAUSA-N 0.000 claims 2
- 229960001948 caffeine Drugs 0.000 claims 2
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 2
- 229940046978 chlorpheniramine maleate Drugs 0.000 claims 2
- 238000013270 controlled release Methods 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 229960000525 diphenhydramine hydrochloride Drugs 0.000 claims 2
- 238000001035 drying Methods 0.000 claims 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims 2
- 229920001249 ethyl cellulose Polymers 0.000 claims 2
- 235000010492 gellan gum Nutrition 0.000 claims 2
- 239000000216 gellan gum Substances 0.000 claims 2
- 235000010417 guar gum Nutrition 0.000 claims 2
- 239000000665 guar gum Substances 0.000 claims 2
- 229960002154 guar gum Drugs 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 235000010420 locust bean gum Nutrition 0.000 claims 2
- 239000000711 locust bean gum Substances 0.000 claims 2
- 229920000609 methyl cellulose Polymers 0.000 claims 2
- 239000001923 methylcellulose Substances 0.000 claims 2
- 235000010981 methylcellulose Nutrition 0.000 claims 2
- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 claims 2
- 229960002237 metoprolol Drugs 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 2
- 235000012239 silicon dioxide Nutrition 0.000 claims 2
- 235000010413 sodium alginate Nutrition 0.000 claims 2
- 239000000661 sodium alginate Substances 0.000 claims 2
- 229940005550 sodium alginate Drugs 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 235000010487 tragacanth Nutrition 0.000 claims 2
- 239000000196 tragacanth Substances 0.000 claims 2
- 229940116362 tragacanth Drugs 0.000 claims 2
- 235000010493 xanthan gum Nutrition 0.000 claims 2
- 239000000230 xanthan gum Substances 0.000 claims 2
- 229920001285 xanthan gum Polymers 0.000 claims 2
- 229940082509 xanthan gum Drugs 0.000 claims 2
- 238000010146 3D printing Methods 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- 101710110406 Rho GTPase-activating protein 17 Proteins 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- USFMMZYROHDWPJ-UHFFFAOYSA-N trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium Chemical compound CC(=C)C(=O)OCC[N+](C)(C)C USFMMZYROHDWPJ-UHFFFAOYSA-N 0.000 claims 1
- -1 trimethylammonio Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37844902P | 2002-05-06 | 2002-05-06 | |
| US60/378,449 | 2002-05-06 | ||
| US42509402P | 2002-11-08 | 2002-11-08 | |
| US60/425,094 | 2002-11-08 | ||
| PCT/US2003/014376 WO2003092633A2 (en) | 2002-05-06 | 2003-05-06 | Diffusion-controlled dosage form and method of fabrication including three dimensional printing |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005524702A JP2005524702A (ja) | 2005-08-18 |
| JP2005524702A5 true JP2005524702A5 (enExample) | 2006-06-08 |
| JP5041663B2 JP5041663B2 (ja) | 2012-10-03 |
Family
ID=29406838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004500818A Expired - Lifetime JP5041663B2 (ja) | 2002-05-06 | 2003-05-06 | 拡散支配剤形および三次元印刷を含む作製方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8088415B2 (enExample) |
| EP (1) | EP1503741B1 (enExample) |
| JP (1) | JP5041663B2 (enExample) |
| AT (1) | ATE407665T1 (enExample) |
| AU (1) | AU2003232078A1 (enExample) |
| CA (1) | CA2483028C (enExample) |
| DE (1) | DE60323482D1 (enExample) |
| ES (1) | ES2316791T3 (enExample) |
| WO (1) | WO2003092633A2 (enExample) |
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| DE60323482D1 (de) | 2002-05-06 | 2008-10-23 | Massachusetts Inst Technology | Diffusionskontrollierte arzneiform sowie herstellungsmethode mittels dreidimensionalem drucken |
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| US8101244B2 (en) * | 2004-06-09 | 2012-01-24 | Smithkline Beecham Corporation | Apparatus and method for producing or processing a product or sample |
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-
2003
- 2003-05-06 DE DE60323482T patent/DE60323482D1/de not_active Expired - Lifetime
- 2003-05-06 CA CA2483028A patent/CA2483028C/en not_active Expired - Lifetime
- 2003-05-06 JP JP2004500818A patent/JP5041663B2/ja not_active Expired - Lifetime
- 2003-05-06 EP EP03747680A patent/EP1503741B1/en not_active Expired - Lifetime
- 2003-05-06 AT AT03747680T patent/ATE407665T1/de not_active IP Right Cessation
- 2003-05-06 WO PCT/US2003/014376 patent/WO2003092633A2/en not_active Ceased
- 2003-05-06 AU AU2003232078A patent/AU2003232078A1/en not_active Abandoned
- 2003-05-06 ES ES03747680T patent/ES2316791T3/es not_active Expired - Lifetime
- 2003-05-06 US US10/431,353 patent/US8088415B2/en active Active
-
2011
- 2011-11-29 US US13/306,393 patent/US8465777B2/en not_active Expired - Fee Related
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