AU2003232078A1 - Diffusion-controlled dosage form and method of fabrication including three dimensional printing - Google Patents

Diffusion-controlled dosage form and method of fabrication including three dimensional printing Download PDF

Info

Publication number
AU2003232078A1
AU2003232078A1 AU2003232078A AU2003232078A AU2003232078A1 AU 2003232078 A1 AU2003232078 A1 AU 2003232078A1 AU 2003232078 A AU2003232078 A AU 2003232078A AU 2003232078 A AU2003232078 A AU 2003232078A AU 2003232078 A1 AU2003232078 A1 AU 2003232078A1
Authority
AU
Australia
Prior art keywords
dosage form
release
shell
polymer
api
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003232078A
Other languages
English (en)
Inventor
Esteban Bornancini
Monica Rewachand Motwani
Willie J. Roach
Chen-Chao Wang
Jaedeok Yoo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Original Assignee
Massachusetts Institute of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology filed Critical Massachusetts Institute of Technology
Publication of AU2003232078A1 publication Critical patent/AU2003232078A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10—Processes of additive manufacturing
    • B29C64/141—Processes of additive manufacturing using only solid materials
    • B29C64/153—Processes of additive manufacturing using only solid materials using layers of powder being selectively joined, e.g. by selective laser sintering or melting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00—Materials specially adapted for additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2003232078A 2002-05-06 2003-05-06 Diffusion-controlled dosage form and method of fabrication including three dimensional printing Abandoned AU2003232078A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US37844902P 2002-05-06 2002-05-06
US60/378,449 2002-05-06
US42509402P 2002-11-08 2002-11-08
US60/425,094 2002-11-08
PCT/US2003/014376 WO2003092633A2 (en) 2002-05-06 2003-05-06 Diffusion-controlled dosage form and method of fabrication including three dimensional printing

Publications (1)

Publication Number Publication Date
AU2003232078A1 true AU2003232078A1 (en) 2003-11-17

Family

ID=29406838

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003232078A Abandoned AU2003232078A1 (en) 2002-05-06 2003-05-06 Diffusion-controlled dosage form and method of fabrication including three dimensional printing

Country Status (9)

Country Link
US (2) US8088415B2 (enExample)
EP (1) EP1503741B1 (enExample)
JP (1) JP5041663B2 (enExample)
AT (1) ATE407665T1 (enExample)
AU (1) AU2003232078A1 (enExample)
CA (1) CA2483028C (enExample)
DE (1) DE60323482D1 (enExample)
ES (1) ES2316791T3 (enExample)
WO (1) WO2003092633A2 (enExample)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2483028C (en) 2002-05-06 2011-04-05 Massachusetts Institute Of Technology Diffusion-controlled dosage form and method of fabrication including three dimensional printing
AU2004314693B2 (en) * 2003-09-26 2011-04-07 Alza Corporation Drug coating providing high drug loading and methods for providing the same
US20060002594A1 (en) * 2004-06-09 2006-01-05 Clarke Allan J Method for producing a pharmaceutical product
US8101244B2 (en) * 2004-06-09 2012-01-24 Smithkline Beecham Corporation Apparatus and method for producing or processing a product or sample
TWI547431B (zh) * 2004-06-09 2016-09-01 史密斯克萊美占公司 生產藥物之裝置及方法
JPWO2006004069A1 (ja) * 2004-07-01 2008-04-24 日本碍子株式会社 微小カプセルおよびその製造方法
EP2131817A2 (en) * 2007-03-09 2009-12-16 Synthon B.V. Pharmaceutical composition of quetiapine fumarate
WO2009085832A2 (en) * 2007-12-21 2009-07-09 Mcneil-Ppc, Inc. Manufacture of tablet
CN101716162B (zh) * 2009-11-26 2012-11-14 扬州中宝制药有限公司 一种氨茶碱缓释胶囊及其制备方法
US8251837B2 (en) * 2010-08-11 2012-08-28 Nike, Inc. Floating golf ball
AU2011342893A1 (en) 2010-12-13 2013-05-02 Purdue Pharma L.P. Controlled release dosage forms
US9381154B2 (en) * 2011-06-09 2016-07-05 Xerox Corporation Direct inkjet fabrication of drug delivery devices
CN105666875B (zh) 2012-09-05 2017-09-12 阿普雷奇亚制药公司 三维打印系统和设备组件
US8888480B2 (en) 2012-09-05 2014-11-18 Aprecia Pharmaceuticals Company Three-dimensional printing system and equipment assembly
US20140099351A1 (en) * 2012-10-04 2014-04-10 Axxia Pharmaceuticals, Llc Process for making controlled release medical implant products
US9339489B2 (en) 2013-03-15 2016-05-17 Aprecia Pharmaceuticals Company Rapid disperse dosage form containing levetiracetam
HK1216513A1 (zh) 2013-03-15 2016-11-18 阿普雷奇亚制药有限责任公司 包含左乙拉西坦的快速分散劑型
CN105579161A (zh) 2013-08-16 2016-05-11 艾克斯温有限责任公司 三维打印的金属铸造模具和其制造方法
EP3057729A4 (en) 2013-10-17 2017-10-18 The Exone Company Three-dimensional printed hot isostatic pressing containers and processes for making same
EP2875933B1 (de) * 2013-11-25 2019-04-03 MTU Aero Engines GmbH Dokumentation generativer Herstellungsverfahren
MX2016007786A (es) 2013-12-16 2017-03-03 Massachusetts Inst Technology Formulaciones de sal de micronutrientes fortificadas.
EP3763383A1 (en) 2013-12-16 2021-01-13 Massachusetts Institute Of Technology Micromolded or 3-d printed pulsatile release vaccine formulations
WO2015100084A1 (en) 2013-12-23 2015-07-02 The Exone Company Method of three-dimensional printing using a multi-component build powder
WO2015100086A1 (en) 2013-12-23 2015-07-02 The Exone Company Methods and systems for three-dimensional printing utilizing multiple binder fluids
IL232696B (en) 2014-05-19 2018-08-30 Technion Res & Dev Foundation Compound and method for detecting molecules of interest
EP3148730A1 (en) 2014-05-29 2017-04-05 The Exone Company Process for making nickel-based superalloy articles by three-dimensional printing
EP3169499A2 (en) 2014-07-17 2017-05-24 The Exone Company Methods and apparatuses for curing three-dimensional printed articles
EP3505163B1 (en) * 2014-09-08 2023-01-18 University of Central Lancashire Solid dosage form production
US9844930B2 (en) 2014-11-05 2017-12-19 Xerox Corporation 3D printing of digestible shells for medicaments
WO2016089618A1 (en) 2014-12-03 2016-06-09 The Exone Company Process for making densified carbon articles by three dimensional printing
CN113133980A (zh) * 2015-06-03 2021-07-20 南京三迭纪医药科技有限公司 药品剂型及其使用
EP4512394A3 (en) 2015-06-03 2025-10-22 Triastek, Inc. Dosage forms and use thereof
US20180214383A1 (en) * 2015-07-16 2018-08-02 National University Of Singapore Printing drug tablets with fully customizable release profiles for personalized medicine
CA2996041A1 (en) 2015-08-21 2017-03-02 Aprecia Pharmaceuticals LLC Three-dimensional printing system and equipment assembly
GB201519128D0 (en) 2015-10-29 2015-12-16 Univ Central Lancashire Solid forms and methods of preparing the same
AU2017261372B2 (en) 2016-05-05 2019-02-14 Triastek, Inc. Controlled release dosage form
US12303603B2 (en) * 2016-06-20 2025-05-20 Sciperio, Inc Real-time compounding 3D printer
US10765658B2 (en) 2016-06-22 2020-09-08 Mastix LLC Oral compositions delivering therapeutically effective amounts of cannabinoids
GB201612853D0 (en) 2016-07-25 2016-09-07 Univ Central Lancashire Solid dosage form production
EP3321002A1 (en) * 2016-11-15 2018-05-16 Höganäs AB Feedstock for an additive manufacturing method, additive manufacturing method using the same, and article obtained therefrom
DE102017200773A1 (de) 2017-01-18 2018-07-19 Eos Gmbh Electro Optical Systems Verfahren zum Nachbehandeln und Nachbehandlungssytem
CN110290781A (zh) * 2017-01-26 2019-09-27 南京三迭纪医药科技有限公司 胃肠特定部位控制释放的剂型
US10369557B2 (en) 2017-04-12 2019-08-06 International Business Machines Corporation Three-dimensional printed objects for chemical reaction control
US20210213678A1 (en) * 2017-04-28 2021-07-15 Hewlett-Packard Development Company, L.P. Producing diffusion-controlled release devices
WO2019025869A1 (en) * 2017-07-31 2019-02-07 Teva Pharmaceutical Industries Limited GALENIC FORMS WITH CONTROLLED RELEASE MANUFACTURED IN ADDITIVE MANNER
US11642841B2 (en) 2017-10-13 2023-05-09 Ut-Battelle, Llc Indirect additive manufacturing process
CN111698983B (zh) 2018-01-09 2022-10-18 南京三迭纪医药科技有限公司 一种包含固定剂量adhd非兴奋剂和adhd兴奋剂的复方口服药物剂型
US10350822B1 (en) 2018-01-09 2019-07-16 Triastek Inc. Dosage forms with desired release profiles and methods of designing and making thereof
ES3040411T3 (en) 2018-03-22 2025-10-30 Incarda Therapeutics Inc A novel method to slow ventricular rate
DE102018107585B3 (de) * 2018-03-29 2019-03-28 Universität Rostock Vorrichtung zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen mit Wirkstoffdepots, sowie Verfahren zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen
WO2019199328A1 (en) * 2018-04-13 2019-10-17 Hewlett-Packard Development Company, L.P. Three-dimensional printing
CN108939162B (zh) * 2018-07-10 2021-11-19 上海理工大学 一种介孔生物玻璃/海藻酸钠-海藻酸钠分层骨组织工程支架的制备方法
GB201813186D0 (en) 2018-08-13 2018-09-26 Univ Central Lancashire Solid dosage from production
CN112739331A (zh) * 2018-09-14 2021-04-30 默克专利股份有限公司 制备包衣的固体药物剂型的方法
ES2930199T3 (es) 2018-10-15 2022-12-07 Aprecia Pharmaceuticals LLC Método y sistema para formar una forma farmacéutica dentro de un envase
US11254617B2 (en) 2019-01-09 2022-02-22 Ut-Battelle, Llc Indirect additive manufacturing process using amine-containing adhesive polymers
US12103229B2 (en) * 2019-03-15 2024-10-01 Ricoh Company, Ltd. Jettable temporary binders to create removable support materials
US11724486B2 (en) 2019-07-09 2023-08-15 Kyndryl, Inc. Printing customized medication based on current user data and medical records of the user
CN114269545A (zh) * 2019-08-14 2022-04-01 默克专利股份有限公司 产品的增材制造方法、制造装置和固体药物剂型
GB201913972D0 (en) 2019-09-27 2019-11-13 Univ Ulster Pharmaceutical Delivery Device and method of manufacture
ES2828509B2 (es) 2019-11-26 2022-03-09 Fund Idonial Composicion para la impresion 3d de farmacos semisolidos
EP3871859A1 (en) * 2020-02-26 2021-09-01 Hewlett-Packard Development Company, L.P. Three-dimensional printing
WO2021176360A1 (en) * 2020-03-02 2021-09-10 Craft Health Pte Ltd Oral dosage forms for extended drug release
AU2021270750B2 (en) 2020-05-13 2024-06-13 Massachusetts Institute Of Technology Compositions of polymeric microdevices and their use in cancer immunotherapy
JP2023533478A (ja) 2020-06-26 2023-08-03 アプレシア・ファーマスーティカルズ・エルエルシー 内部空洞を有する迅速口内分散可能な錠剤
KR20230098628A (ko) 2020-10-30 2023-07-04 트리아스텍 인코포레이티드 위장관 약학적 제형
US12251208B2 (en) 2020-11-30 2025-03-18 International Business Machines Corporation Time controlled medication
KR102723494B1 (ko) * 2020-12-24 2024-10-31 동아제약 주식회사 적층 방식으로 제조된 방출 조절용 약제학적 조성물
CN112940690B (zh) * 2021-02-05 2021-11-02 中国科学院苏州纳米技术与纳米仿生研究所南昌研究院 一种具有豆荚结构的相变储能材料及其制备方法与应用
EP4618958A1 (en) * 2022-11-18 2025-09-24 Aprecia Pharmaceuticals LLC Functionally-dividable orodispersive dosage form

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US948297A (en) * 1909-07-24 1910-02-01 John A Stone Corn-husker.
US986148A (en) * 1910-05-09 1911-03-07 Hoechst Ag Derivative of oxyarylarsinic acids and process of making same.
ZA822995B (en) * 1981-05-21 1983-12-28 Wyeth John & Brother Ltd Slow release pharmaceutical composition
WO1985003436A1 (en) * 1984-02-10 1985-08-15 A/S Alfred Benzon Diffusion coated multiple-units dosage form
US4810502A (en) * 1987-02-27 1989-03-07 Alza Corporation Pseudoephedrine brompheniramine therapy
US5133974A (en) * 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5204055A (en) 1989-12-08 1993-04-20 Massachusetts Institute Of Technology Three-dimensional printing techniques
NZ242065A (en) * 1991-03-26 1996-06-25 Csl Ltd Delayed release implant having a degradable or rupturable polymeric coating
US5775402A (en) 1995-10-31 1998-07-07 Massachusetts Institute Of Technology Enhancement of thermal properties of tooling made by solid free form fabrication techniques
US5490882A (en) 1992-11-30 1996-02-13 Massachusetts Institute Of Technology Process for removing loose powder particles from interior passages of a body
US6280771B1 (en) 1997-02-20 2001-08-28 Therics, Inc. Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof
US5490962A (en) 1993-10-18 1996-02-13 Massachusetts Institute Of Technology Preparation of medical devices by solid free-form fabrication methods
ATE292456T1 (de) * 1996-09-13 2005-04-15 Shionogi & Co Zubereitung mit verlängerter freisetzung unter verwendung einer thermischen umwandlung sowie verfahren zu deren herstellung
DE69840495D1 (de) 1997-02-20 2009-03-12 Massachusetts Inst Technology Darreichungsform, welche rasche dispersionseigenschaften entfaltet, anwendungsverfahren sowie verfahren zur herstellung derselben
WO1998043762A2 (en) 1997-03-31 1998-10-08 Therics, Inc. Method for dispensing of powders
US6213168B1 (en) 1997-03-31 2001-04-10 Therics, Inc. Apparatus and method for dispensing of powders
US6547994B1 (en) 1998-11-13 2003-04-15 Therics, Inc. Rapid prototyping and manufacturing process
US6485746B1 (en) * 2000-08-25 2002-11-26 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
DE19961897A1 (de) * 1999-12-20 2001-06-28 Basf Ag Verwendung eines Filmüberzuges als geschmacksmaskierendes Coating von pharmazeutischen Darreichungsformen
DE10015479A1 (de) * 2000-03-29 2001-10-11 Basf Ag Feste orale Darreichungsformen mit retardierter Wirkstofffreisetzung und hoher mechanischer Stabilität
WO2001087272A2 (en) 2000-05-18 2001-11-22 Therics, Inc. Encapsulating a toxic core within a non-toxic region in an oral dosage form
WO2002038280A2 (en) * 2000-11-10 2002-05-16 Therics, Inc. A wetting-resistant nozzle for dispensing small volumes of liquid and a method for manufacturing a wetting-resistant nozzle
CA2483028C (en) 2002-05-06 2011-04-05 Massachusetts Institute Of Technology Diffusion-controlled dosage form and method of fabrication including three dimensional printing
US20050015728A1 (en) * 2003-07-17 2005-01-20 International Business Machines Corporation Method, system, and program product for customizing a user interface

Also Published As

Publication number Publication date
DE60323482D1 (de) 2008-10-23
US8465777B2 (en) 2013-06-18
ES2316791T3 (es) 2009-04-16
ATE407665T1 (de) 2008-09-15
WO2003092633A3 (en) 2004-04-08
EP1503741B1 (en) 2008-09-10
CA2483028A1 (en) 2003-11-13
US20120177696A1 (en) 2012-07-12
EP1503741A2 (en) 2005-02-09
CA2483028C (en) 2011-04-05
JP5041663B2 (ja) 2012-10-03
US20040005360A1 (en) 2004-01-08
JP2005524702A (ja) 2005-08-18
US8088415B2 (en) 2012-01-03
WO2003092633A2 (en) 2003-11-13

Similar Documents

Publication Publication Date Title
CA2483028C (en) Diffusion-controlled dosage form and method of fabrication including three dimensional printing
CN105101952B (zh) 托法替布口服持续释放剂型
FI121620B (fi) Menetelmiä aktiivisen aineen kontrolloidusti vapautuvan formulaation saamiseksi
CA2408956C (en) Method and form of a drug delivery device,such as encapsulating a toxic core within a non-toxic region in an oral dosage form
Murthy et al. Current perspectives on the dissolution stability of solid oral dosage forms
HRP960554A2 (en) Pharmaceutical formulations
DK2303020T3 (en) Preparation of Skeletal Muscle Relaxing Dosage Forms with Controlled Release
CA2848666C (en) Coating material for solid medicine and solid medicine formed with the same
Macchi et al. Enteric-coating of pulsatile-release HPC capsules prepared by injection molding
EP1516616A1 (en) A controlled-release preparation having specific pore forming agents in the coating
EP2910243A1 (en) Pharmaceutic osmotic pump preparation
WO2011039686A1 (en) Latrepirdine oral sustained release dosage forms
US7858119B1 (en) Extended release pharmaceuticals
KR20070000439A (ko) 벤라팍신 히드로클로라이드의 방출연장형 코팅 미니정제
KR20060136409A (ko) 벤라팍신 히드로클로라이드의 방출연장형 코팅 미니정제
WO2007117110A2 (en) Sustained-release pellets containing tamsulosin hydrochloride and processes for preparing the same
Colombo et al. Swellable and rigid matrices: controlled release matrices with cellulose ethers
Wen et al. Oral extended release hydrophilic matrices: formulation and design
AU2003224358A1 (en) Monocompartment osmotic controlled drug delivery system
RS63628B1 (sr) Pelete sa višeslojnom strukturom za odloženo oslobađanje aktivnog sredstva u distalnom kolonu
Di Colo et al. A site-specific controlled-release system for metformin
JPH06190267A (ja) マイクロカプセル
Harris et al. Aqueous Polymeric Coating for Modified-Release Oral Dosage Forms
Jadhav et al. EXTENDED RELEASE PELLETS: NOVEL APPROACH TO TARGETED DRUG DELIVERY SYSTEM
Pai et al. Multiple Unit Particle System (MUPS): Novel technology for preparation of Extended Release (ER) tablets

Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period