JP2009143956A5 - - Google Patents
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- Publication number
- JP2009143956A5 JP2009143956A5 JP2009036918A JP2009036918A JP2009143956A5 JP 2009143956 A5 JP2009143956 A5 JP 2009143956A5 JP 2009036918 A JP2009036918 A JP 2009036918A JP 2009036918 A JP2009036918 A JP 2009036918A JP 2009143956 A5 JP2009143956 A5 JP 2009143956A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- substituted
- unsubstituted
- azabicycloalkyl
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000003839 salts Chemical group 0.000 claims 10
- 239000002253 acid Substances 0.000 claims 9
- 239000012458 free base Substances 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- -1 cyano, formyl Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000002541 furyl group Chemical group 0.000 claims 3
- 125000001977 isobenzofuranyl group Chemical group C=1(OC=C2C=CC=CC12)* 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000001544 thienyl group Chemical group 0.000 claims 3
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 1
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims 1
- 206010053643 Neurodegenerative disease Diseases 0.000 claims 1
- 206010037175 Psychiatric disease Diseases 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000008024 pharmaceutical diluent Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 1
- 125000005329 tetralinyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0220581.3 | 2002-09-04 | ||
| GB0220581A GB0220581D0 (en) | 2002-09-04 | 2002-09-04 | Organic Compound |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004533455A Division JP4348422B2 (ja) | 2002-09-04 | 2003-09-03 | アザビシクロアルキルエーテルおよびそのα７−ＮＡＣＨＲアゴニストとしての使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009143956A JP2009143956A (ja) | 2009-07-02 |
| JP2009143956A5 true JP2009143956A5 (US20080242721A1-20081002-C00053.png) | 2009-08-13 |
| JP5124714B2 JP5124714B2 (ja) | 2013-01-23 |
Family
ID=9943515
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004533455A Expired - Lifetime JP4348422B2 (ja) | 2002-09-04 | 2003-09-03 | アザビシクロアルキルエーテルおよびそのα７−ＮＡＣＨＲアゴニストとしての使用 |
| JP2009036918A Expired - Fee Related JP5124714B2 (ja) | 2002-09-04 | 2009-02-19 | アザビシクロアルキルエーテルおよびそのα７−ＮＡＣＨＲアゴニストとしての使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004533455A Expired - Lifetime JP4348422B2 (ja) | 2002-09-04 | 2003-09-03 | アザビシクロアルキルエーテルおよびそのα７−ＮＡＣＨＲアゴニストとしての使用 |
Country Status (26)
Families Citing this family (50)
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| KR101475088B1 (ko) | 2006-08-21 | 2014-12-23 | 제넨테크, 인크. | 아자-벤조티오페닐 화합물 및 사용 방법 |
| RU2476220C2 (ru) * | 2007-08-02 | 2013-02-27 | Таргасепт, Инк. | (2s,3r)-n-(2-((3-пиридинил)метил)-1-азабицикло[2.2.2]окт-3-ил)бензофуран-2-карбоксамид, новые солевые формы и способы их применения |
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| CN102137847B (zh) | 2008-07-01 | 2015-06-10 | 健泰科生物技术公司 | 作为mek激酶抑制剂的二环杂环 |
| CN102137843A (zh) | 2008-07-01 | 2011-07-27 | 健泰科生物技术公司 | 作为mek激酶抑制剂的异吲哚酮衍生物及其使用方法 |
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| TWI558398B (zh) * | 2009-09-22 | 2016-11-21 | 諾華公司 | 菸鹼乙醯膽鹼受體α７活化劑之用途 |
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| CN105837566B (zh) | 2010-05-17 | 2018-02-06 | 富瑞姆制药公司 | (R)‑7‑氯‑N‑(奎宁环‑3‑基)苯并[b]噻吩‑2‑甲酰胺盐酸盐单水合物的晶型 |
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| TWI589576B (zh) * | 2011-07-15 | 2017-07-01 | 諾華公司 | 氮雜－雙環二芳基醚之鹽類及製造彼等或其前驅物之方法 |
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