JP2009082138A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009082138A5 JP2009082138A5 JP2008301520A JP2008301520A JP2009082138A5 JP 2009082138 A5 JP2009082138 A5 JP 2009082138A5 JP 2008301520 A JP2008301520 A JP 2008301520A JP 2008301520 A JP2008301520 A JP 2008301520A JP 2009082138 A5 JP2009082138 A5 JP 2009082138A5
- Authority
- JP
- Japan
- Prior art keywords
- temperature
- medium
- hmba
- cell line
- days
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36824602P | 2002-03-27 | 2002-03-27 | |
| US36824802P | 2002-03-27 | 2002-03-27 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003580502A Division JP2005521401A (ja) | 2002-03-27 | 2003-03-27 | ポリペプチド産生を増加させる方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009082138A JP2009082138A (ja) | 2009-04-23 |
| JP2009082138A5 true JP2009082138A5 (enExample) | 2009-06-04 |
| JP4414472B2 JP4414472B2 (ja) | 2010-02-10 |
Family
ID=28678222
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003580502A Pending JP2005521401A (ja) | 2002-03-27 | 2003-03-27 | ポリペプチド産生を増加させる方法 |
| JP2008024395A Expired - Lifetime JP4414466B2 (ja) | 2002-03-27 | 2008-02-04 | ポリペプチド産生を増加させる方法 |
| JP2008301520A Expired - Lifetime JP4414472B2 (ja) | 2002-03-27 | 2008-11-26 | ポリペプチド産生を増加させる方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003580502A Pending JP2005521401A (ja) | 2002-03-27 | 2003-03-27 | ポリペプチド産生を増加させる方法 |
| JP2008024395A Expired - Lifetime JP4414466B2 (ja) | 2002-03-27 | 2008-02-04 | ポリペプチド産生を増加させる方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6872549B2 (enExample) |
| EP (1) | EP1497444B1 (enExample) |
| JP (3) | JP2005521401A (enExample) |
| AU (1) | AU2003220529B2 (enExample) |
| CA (1) | CA2480121C (enExample) |
| ES (1) | ES2557741T3 (enExample) |
| MX (1) | MXPA04009381A (enExample) |
| PL (1) | PL376821A1 (enExample) |
| WO (1) | WO2003083066A2 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050005310A1 (en) * | 1999-07-12 | 2005-01-06 | Genentech, Inc. | Expression vectors and methods |
| ES2557741T3 (es) * | 2002-03-27 | 2016-01-28 | Immunex Corporation | Procedimientos para incrementar la producción de polipéptidos |
| US20050019925A1 (en) * | 2002-11-14 | 2005-01-27 | Genentech, Inc. | Intron fusion construct and method of using for selecting high-expressing production cell lines |
| MXPA05011486A (es) * | 2003-04-25 | 2006-04-18 | Immunex Corp | Inductores de expresion de proteina recombinante. |
| WO2005019061A1 (en) * | 2003-08-21 | 2005-03-03 | Duchesnay Inc. | Micronutrient supplement dispensing package |
| CN1835759B (zh) * | 2003-08-21 | 2012-05-02 | 达切斯内公司 | 微量营养素补充剂 |
| WO2005063813A2 (en) * | 2003-12-23 | 2005-07-14 | Applied Research Systems Ars Holding N.V. | Process for the production of tumor necrosis factor-binding proteins |
| JP2008543839A (ja) | 2005-06-14 | 2008-12-04 | アムジェン インコーポレーテッド | 自己緩衝タンパク質製剤 |
| WO2007049567A1 (ja) * | 2005-10-24 | 2007-05-03 | Kyowa Hakko Kogyo Co., Ltd. | 物質の製造方法 |
| AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
| PT2253644E (pt) | 2005-12-20 | 2014-01-23 | Bristol Myers Squibb Co | Composições e métodos para a produção de uma composição |
| US20070249014A1 (en) | 2006-02-10 | 2007-10-25 | Invitrogen Corporation | Labeling and detection of post translationally modified proteins |
| EP2054726B1 (en) * | 2006-08-14 | 2010-10-27 | BioControl Systems, Inc. | Method for detecting listeria |
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| TW201516149A (zh) | 2006-09-13 | 2015-05-01 | Abbvie Inc | 細胞培養改良 |
| EP2129787A4 (en) * | 2007-03-28 | 2012-05-02 | Medarex Inc | Methods of gene amplification and expression |
| TW200902708A (en) * | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
| US20090023186A1 (en) * | 2007-07-22 | 2009-01-22 | Excellgene Sa | Use of valproic acid for enhancing production of recombinant proteins in mammalian cells |
| JP2011512877A (ja) * | 2008-03-12 | 2011-04-28 | ワイス・エルエルシー | 組換えタンパク質の大スケール産生に適した細胞を同定する方法 |
| EP2507267B1 (en) * | 2009-12-02 | 2016-09-14 | Acceleron Pharma, Inc. | Compositions and methods for increasing serum half-life of fc fusion proteins |
| WO2012043754A1 (ja) | 2010-09-30 | 2012-04-05 | ダイキン工業株式会社 | ドリップ防止剤、並びに、樹脂組成物 |
| MY163081A (en) * | 2010-12-28 | 2017-08-15 | Chugai Pharmaceutical Co Ltd | Animal cell culturing method |
| WO2012149197A2 (en) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| US8883982B2 (en) | 2011-06-08 | 2014-11-11 | Acceleron Pharma, Inc. | Compositions and methods for increasing serum half-life |
| SI2726600T1 (sl) | 2011-07-01 | 2017-07-31 | Amgen Inc. | Sesalska celična kultura |
| EP2653548A1 (de) | 2012-04-17 | 2013-10-23 | Greenovation Biotech GmbH | Verfahren zur Erhöhung der Sekretion rekombinanter Proteine |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
| HK1211981A1 (en) | 2012-09-02 | 2016-06-03 | Abbvie Inc. | Methods to control protein heterogeneity |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| SG11201507230PA (en) | 2013-03-12 | 2015-10-29 | Abbvie Inc | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| US9937184B2 (en) * | 2013-03-15 | 2018-04-10 | Theocorp Holding Company, Llc | Theobromine compositions useful for increasing fetal weight gain and enhancing bone properties |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| ES3064802T3 (en) | 2016-10-21 | 2026-04-29 | Amgen Inc | Pharmaceutical formulations and methods of making the same |
| KR102190790B1 (ko) * | 2018-10-19 | 2020-12-15 | 주식회사 프로젠 | 변형된 egf 단백질의 생산 방법 |
| CN111836826B (zh) * | 2017-10-23 | 2024-01-02 | 普罗根有限公司 | 修饰的egf蛋白,其制备方法及其用途 |
| EP4267717A1 (en) | 2020-12-22 | 2023-11-01 | Amgen Inc. | Cell culture method |
| WO2026009803A1 (ja) * | 2024-07-05 | 2026-01-08 | 国立大学法人九州大学 | ヘパリン様物質を製造する方法 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3824286A (en) | 1970-07-07 | 1974-07-16 | Lever Brothers Ltd | Preparation of polyacetylalkylene diamines |
| EP0005476B1 (de) | 1978-05-17 | 1981-12-30 | Dr. Karl Thomae GmbH | Verfahren zur Herstellung von Humaninterferon |
| US4301249A (en) * | 1980-07-23 | 1981-11-17 | Merck & Co., Inc. | High titer production of hepatitis A virus |
| US4357422A (en) | 1980-08-14 | 1982-11-02 | Massachusetts Institute Of Technology | Method of enhancing interferon production |
| US4416986A (en) | 1981-01-16 | 1983-11-22 | Merck & Co., Inc. | Methods of producing HBsAg |
| US4473647A (en) | 1981-02-27 | 1984-09-25 | Amf Inc. | Tissue culture medium |
| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| AU588819B2 (en) | 1984-10-29 | 1989-09-28 | Immunex Corporation | Cloning of human granulocyte-macrophage colony stimulating factor gene |
| US4992472A (en) | 1987-06-16 | 1991-02-12 | The United States Of America As Represented By The Department Of Health And Human Services | Chemical differentiating agents |
| US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
| US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
| US5075222A (en) | 1988-05-27 | 1991-12-24 | Synergen, Inc. | Interleukin-1 inhibitors |
| WO1990005183A1 (en) | 1988-10-31 | 1990-05-17 | Immunex Corporation | Interleukin-4 receptors |
| US5330744A (en) | 1988-11-14 | 1994-07-19 | Sloan-Kettering Institute For Cancer Research | Method for increasing sensitivity to chemically induced terminal differentiation |
| US5055608A (en) | 1988-11-14 | 1991-10-08 | Sloan-Kettering Institute For Cancer Research | Novel potent inducers of thermal differentiation and method of use thereof |
| ZA899421B (en) | 1988-12-14 | 1990-09-26 | Merrell Dow Pharma | Method of potentiating natural killer cell activity |
| CA2018228C (en) | 1989-06-05 | 1996-02-27 | Nancy L. Parenteau | Cell culture systems and media |
| US5395760A (en) | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
| DE59010908D1 (de) | 1989-09-12 | 2000-08-10 | Hoffmann La Roche | TNF-bindende Proteine |
| US6204363B1 (en) | 1989-10-16 | 2001-03-20 | Amgen Inc. | Stem cell factor |
| US5272064A (en) | 1989-12-19 | 1993-12-21 | Amgen Inc. | DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof |
| US5149792A (en) | 1989-12-19 | 1992-09-22 | Amgen Inc. | Platelet-derived growth factor B chain analogs |
| US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
| WO1991018982A1 (en) | 1990-06-05 | 1991-12-12 | Immunex Corporation | Type ii interleukin-1 receptors |
| US5350683A (en) | 1990-06-05 | 1994-09-27 | Immunex Corporation | DNA encoding type II interleukin-1 receptors |
| US5369108A (en) | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| PT672141E (pt) | 1992-10-23 | 2003-09-30 | Immunex Corp | Metodos de preparacao de proteinas oligomericas soluveis |
| US5420019A (en) * | 1993-02-02 | 1995-05-30 | Xoma Corporation | Stable bactericidal/permeability-increasing protein muteins |
| US5554512A (en) | 1993-05-24 | 1996-09-10 | Immunex Corporation | Ligands for flt3 receptors |
| US20010010922A1 (en) | 1994-06-09 | 2001-08-02 | Riccardo Dalla-Favera | Cloning and uses of the genetic locus bcl-6 |
| US5981713A (en) | 1994-10-13 | 1999-11-09 | Applied Research Systems Ars Holding N.V. | Antibodies to intereleukin-1 antagonists |
| US5705364A (en) | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
| CA2225378C (en) | 1995-06-29 | 2012-04-17 | Immunex Corporation | Cytokine that induces apoptosis |
| JP4306813B2 (ja) | 1995-09-19 | 2009-08-05 | アスビオファーマ株式会社 | 動物細胞の新規培養方法 |
| US6613544B1 (en) | 1995-12-22 | 2003-09-02 | Amgen Inc. | Osteoprotegerin |
| US6096728A (en) | 1996-02-09 | 2000-08-01 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| USRE37234E1 (en) | 1996-11-01 | 2001-06-19 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses |
| US6271349B1 (en) | 1996-12-23 | 2001-08-07 | Immunex Corporation | Receptor activator of NF-κB |
| WO1998028010A2 (en) | 1996-12-24 | 1998-07-02 | Hyal Pharmaceutical Corporation | Use of moieties for binding to hyaluronan and icam-1 |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| AU1663599A (en) | 1997-12-19 | 1999-07-12 | Novo Nordisk A/S | Method for producing heterologous proteins in eukaryotic cells on an industrial scale using nucleotide-manipulating agents |
| US6337072B1 (en) | 1998-04-03 | 2002-01-08 | Hyseq, Inc. | Interleukin-1 receptor antagonist and recombinant production thereof |
| WO2000020576A2 (en) | 1998-10-02 | 2000-04-13 | The Government Of The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services, The National Institutes Of Health | Methods and compositions for inducing differentiation and apotosis in cells that overexpess the notch protein |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| CA2368797C (en) | 1999-04-26 | 2010-08-17 | Genentech, Inc. | Cell culture process |
| DK1222298T3 (da) | 1999-10-13 | 2006-04-10 | Immunex Corp | Vektorer og fremgangsmåder til rekombinant proteinekspression |
| AU1920301A (en) | 1999-11-17 | 2001-05-30 | Immunex Corporation | Receptor activator of nf-kappa b |
| EP1278778A2 (en) | 2000-05-03 | 2003-01-29 | Amgen Inc., | Modified peptides, comprising an fc domain, as therapeutic agents |
| ES2557741T3 (es) * | 2002-03-27 | 2016-01-28 | Immunex Corporation | Procedimientos para incrementar la producción de polipéptidos |
-
2003
- 2003-03-27 ES ES03716840.8T patent/ES2557741T3/es not_active Expired - Lifetime
- 2003-03-27 US US10/400,334 patent/US6872549B2/en not_active Expired - Lifetime
- 2003-03-27 JP JP2003580502A patent/JP2005521401A/ja active Pending
- 2003-03-27 MX MXPA04009381A patent/MXPA04009381A/es active IP Right Grant
- 2003-03-27 WO PCT/US2003/009266 patent/WO2003083066A2/en not_active Ceased
- 2003-03-27 EP EP03716840.8A patent/EP1497444B1/en not_active Expired - Lifetime
- 2003-03-27 AU AU2003220529A patent/AU2003220529B2/en not_active Expired
- 2003-03-27 PL PL376821A patent/PL376821A1/pl unknown
- 2003-03-27 CA CA2480121A patent/CA2480121C/en not_active Expired - Fee Related
-
2005
- 2005-02-04 US US11/051,149 patent/US7452695B2/en not_active Expired - Lifetime
-
2008
- 2008-02-04 JP JP2008024395A patent/JP4414466B2/ja not_active Expired - Lifetime
- 2008-11-26 JP JP2008301520A patent/JP4414472B2/ja not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2480121A1 (en) | Methods for increasing polypeptide production | |
| JP2013511280A5 (enExample) | ||
| RU2008152449A (ru) | Получение гликопротеинов | |
| BR112012027282A2 (pt) | meio de cultura de células aperfeiçoado | |
| RU2009132986A (ru) | Применение меди и глутамата в культуре клеток для производства полипептидов | |
| CN104651287A (zh) | 一种用于合成甘油葡糖苷的工程菌和应用 | |
| CN119101638A (zh) | 一种共表达d-甘露醇脱氢酶和d-葡萄糖脱氢酶的工程菌及应用 | |
| JPWO2022270598A5 (enExample) | ||
| AU2019400151A1 (en) | Recombinant Escherichia coli system, construction method thereof, and usage in synthesis of α-1,2-fucosylated oligosaccharide | |
| CN120192906B (zh) | 一种生产胞磷胆碱的大肠杆菌重组工程菌及其构建方法与应用 | |
| Pembroke et al. | Metabolic engineering of the model photoautotrophic cyanobacterium synechocystis for ethanol production: Optimization strategies and challenges | |
| CN108473993A (zh) | 中链氨基羧酸的生产方法 | |
| CN103160544B (zh) | 一种使微生物可同时发酵五碳糖与六碳糖的方法 | |
| Zhang et al. | Rapidly improving high light and high temperature tolerances of cyanobacterial cell factories through the convenient introduction of an AtpA-C252F mutation | |
| CN101880643B (zh) | 氧化葡萄糖酸杆菌基因工程菌及其构建方法 | |
| CN106574230A (zh) | 细菌菌蜕的补料分批生产方法 | |
| CN115895993B (zh) | 一种促进胞嘧啶核苷三磷酸合成的方法 | |
| CN119242547A (zh) | 一种提高l-组氨酸产量的大肠杆菌基因工程菌株的构建方法 | |
| CN118325930A (zh) | 一种高产烟酰胺单核苷酸大肠杆菌工程菌及其构建方法和应用 | |
| CN116287066A (zh) | 一种重组菌株生产脱氧胸苷三磷酸的方法 | |
| CN115851467B (zh) | 一株过表达Cna1基因的重组酿酒酵母及其构建方法与应用 | |
| CN102250820B (zh) | 氧化葡萄糖酸杆菌基因工程菌及其构建方法 | |
| Kim et al. | A novel bioreactor to study the dynamics of co-culture systems | |
| CN116042684B (zh) | 大肠杆菌及其在催化合成阿洛酮糖中的应用 | |
| CN110129381B (zh) | 一种高氮条件下发酵赤藓醇的重组酵母菌株及其构建方法与应用 |