MXPA04009381A - Metodos para incrementar la produccion de polipeptidos. - Google Patents
Metodos para incrementar la produccion de polipeptidos.Info
- Publication number
- MXPA04009381A MXPA04009381A MXPA04009381A MXPA04009381A MXPA04009381A MX PA04009381 A MXPA04009381 A MX PA04009381A MX PA04009381 A MXPA04009381 A MX PA04009381A MX PA04009381 A MXPA04009381 A MX PA04009381A MX PA04009381 A MXPA04009381 A MX PA04009381A
- Authority
- MX
- Mexico
- Prior art keywords
- millimolar
- polypeptide
- temperature
- medium
- cell line
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/36—Lipids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36824802P | 2002-03-27 | 2002-03-27 | |
| US36824602P | 2002-03-27 | 2002-03-27 | |
| PCT/US2003/009266 WO2003083066A2 (en) | 2002-03-27 | 2003-03-27 | Methods for increasing polypeptide production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA04009381A true MXPA04009381A (es) | 2005-01-25 |
Family
ID=28678222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA04009381A MXPA04009381A (es) | 2002-03-27 | 2003-03-27 | Metodos para incrementar la produccion de polipeptidos. |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6872549B2 (enExample) |
| EP (1) | EP1497444B1 (enExample) |
| JP (3) | JP2005521401A (enExample) |
| AU (1) | AU2003220529B2 (enExample) |
| CA (1) | CA2480121C (enExample) |
| ES (1) | ES2557741T3 (enExample) |
| MX (1) | MXPA04009381A (enExample) |
| PL (1) | PL376821A1 (enExample) |
| WO (1) | WO2003083066A2 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050005310A1 (en) * | 1999-07-12 | 2005-01-06 | Genentech, Inc. | Expression vectors and methods |
| WO2003083066A2 (en) * | 2002-03-27 | 2003-10-09 | Immunex Corporation | Methods for increasing polypeptide production |
| AU2003298674A1 (en) * | 2002-11-14 | 2004-06-15 | Genentech Inc | Intron fusion construct and method of using for selecting high-expressing production cell lines |
| JP2007525176A (ja) * | 2003-04-25 | 2007-09-06 | イミュネックス・コーポレーション | 組換えタンパク質発現の誘導剤 |
| US20050112194A1 (en) * | 2003-08-21 | 2005-05-26 | Duchesnay Inc. | Micronutrient supplement dispensing package |
| JP5349752B2 (ja) * | 2003-08-21 | 2013-11-20 | デュシェネ インク | 微量栄養素サプリメント |
| EP1697414A2 (en) * | 2003-12-23 | 2006-09-06 | Applied Research Systems ARS Holding N.V. | Process for the production of tumor necrosis factor-binding proteins |
| EP1909831A4 (en) | 2005-06-14 | 2013-02-20 | Amgen Inc | SELF-BUFFING PROTEIN FORMULATIONS |
| WO2007049567A1 (ja) * | 2005-10-24 | 2007-05-03 | Kyowa Hakko Kogyo Co., Ltd. | 物質の製造方法 |
| AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
| TWI423986B (zh) | 2005-12-20 | 2014-01-21 | 必治妥美雅史谷比公司 | 組合物及製造組合物之方法 |
| US20070249014A1 (en) | 2006-02-10 | 2007-10-25 | Invitrogen Corporation | Labeling and detection of post translationally modified proteins |
| AU2007339423B2 (en) * | 2006-08-14 | 2012-11-15 | Biocontrol Systems, Inc. | Method for detecting pathogens |
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| EP2500413A1 (en) | 2006-09-13 | 2012-09-19 | Abbott Laboratories | Cell culture improvements |
| EP2129787A4 (en) * | 2007-03-28 | 2012-05-02 | Medarex Inc | Methods of gene amplification and expression |
| TW200902708A (en) * | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
| US20090023186A1 (en) * | 2007-07-22 | 2009-01-22 | Excellgene Sa | Use of valproic acid for enhancing production of recombinant proteins in mammalian cells |
| US20110014624A1 (en) * | 2008-03-12 | 2011-01-20 | Wyeth Llc | Methods For Identifying Cells Suitable For Large-Scale Production of Recombinant Proteins |
| RU2012127383A (ru) * | 2009-12-02 | 2014-01-10 | Акселерон Фарма Инк. | Композиции и способы для увеличения времени полужизни fc-слитых белков в сыворотке |
| EP2623556A4 (en) | 2010-09-30 | 2015-03-11 | Daikin Ind Ltd | DRIP AND RESIN CONNECTION |
| US20130295613A1 (en) * | 2010-12-28 | 2013-11-07 | Chugai Seiyaku Kabushiki Kaisha | Animal cell culturing method |
| EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| EP2718328A4 (en) | 2011-06-08 | 2014-12-24 | Acceleron Pharma Inc | COMPOSITIONS AND METHODS FOR INCREASING THE HALF TIME OF SERUM |
| HUE033279T2 (en) | 2011-07-01 | 2017-11-28 | Amgen Inc | Mammalian cell culture |
| EP2653548A1 (de) | 2012-04-17 | 2013-10-23 | Greenovation Biotech GmbH | Verfahren zur Erhöhung der Sekretion rekombinanter Proteine |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| WO2013158279A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Protein purification methods to reduce acidic species |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| WO2013176754A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| BR112015004467A2 (pt) | 2012-09-02 | 2017-03-21 | Abbvie Inc | método para controlar a heterogeneidade de proteínas |
| CA2905010A1 (en) | 2013-03-12 | 2014-09-18 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| US8921526B2 (en) | 2013-03-14 | 2014-12-30 | Abbvie, Inc. | Mutated anti-TNFα antibodies and methods of their use |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| CN105189736A (zh) * | 2013-03-15 | 2015-12-23 | 斯欧考普控股公司 | 适用于提高胎儿体重增加并增强骨特性的可可碱组合物 |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| AU2017345490B2 (en) | 2016-10-21 | 2022-07-07 | Amgen Inc. | Pharmaceutical formulations and methods of making the same |
| KR102190790B1 (ko) * | 2018-10-19 | 2020-12-15 | 주식회사 프로젠 | 변형된 egf 단백질의 생산 방법 |
| JP6963336B2 (ja) * | 2017-10-23 | 2021-11-05 | プロゲン・シーオー., エルティーディー.Progen Co., Ltd. | 改変egfタンパク質、その製造方法及びその使用 |
| EP4267717A1 (en) | 2020-12-22 | 2023-11-01 | Amgen Inc. | Cell culture method |
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|---|---|---|---|---|
| US3824286A (en) | 1970-07-07 | 1974-07-16 | Lever Brothers Ltd | Preparation of polyacetylalkylene diamines |
| EP0005476B1 (de) | 1978-05-17 | 1981-12-30 | Dr. Karl Thomae GmbH | Verfahren zur Herstellung von Humaninterferon |
| US4301249A (en) * | 1980-07-23 | 1981-11-17 | Merck & Co., Inc. | High titer production of hepatitis A virus |
| US4357422A (en) | 1980-08-14 | 1982-11-02 | Massachusetts Institute Of Technology | Method of enhancing interferon production |
| US4416986A (en) * | 1981-01-16 | 1983-11-22 | Merck & Co., Inc. | Methods of producing HBsAg |
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| ATE348173T1 (de) | 1999-04-26 | 2007-01-15 | Genentech Inc | Zellenzuchtverfahren für glycoproteine |
| ATE312186T1 (de) | 1999-10-13 | 2005-12-15 | Immunex Corp | Vektoren und verfahren für rekombinante proteinexpression |
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| AU2001259432B2 (en) | 2000-05-03 | 2005-04-21 | Amgen Inc. | Modified peptides, comprising an FC domain, as therapeutic agents |
| WO2003083066A2 (en) * | 2002-03-27 | 2003-10-09 | Immunex Corporation | Methods for increasing polypeptide production |
-
2003
- 2003-03-27 WO PCT/US2003/009266 patent/WO2003083066A2/en not_active Ceased
- 2003-03-27 EP EP03716840.8A patent/EP1497444B1/en not_active Expired - Lifetime
- 2003-03-27 ES ES03716840.8T patent/ES2557741T3/es not_active Expired - Lifetime
- 2003-03-27 JP JP2003580502A patent/JP2005521401A/ja active Pending
- 2003-03-27 AU AU2003220529A patent/AU2003220529B2/en not_active Expired
- 2003-03-27 MX MXPA04009381A patent/MXPA04009381A/es active IP Right Grant
- 2003-03-27 CA CA2480121A patent/CA2480121C/en not_active Expired - Fee Related
- 2003-03-27 US US10/400,334 patent/US6872549B2/en not_active Expired - Lifetime
- 2003-03-27 PL PL376821A patent/PL376821A1/pl unknown
-
2005
- 2005-02-04 US US11/051,149 patent/US7452695B2/en not_active Expired - Lifetime
-
2008
- 2008-02-04 JP JP2008024395A patent/JP4414466B2/ja not_active Expired - Lifetime
- 2008-11-26 JP JP2008301520A patent/JP4414472B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6872549B2 (en) | 2005-03-29 |
| EP1497444B1 (en) | 2015-11-04 |
| US7452695B2 (en) | 2008-11-18 |
| AU2003220529A1 (en) | 2003-10-13 |
| WO2003083066A3 (en) | 2004-02-26 |
| JP4414466B2 (ja) | 2010-02-10 |
| WO2003083066A2 (en) | 2003-10-09 |
| JP2008167760A (ja) | 2008-07-24 |
| AU2003220529B2 (en) | 2006-09-07 |
| PL376821A1 (pl) | 2006-01-09 |
| CA2480121C (en) | 2012-02-28 |
| JP2009082138A (ja) | 2009-04-23 |
| ES2557741T3 (es) | 2016-01-28 |
| JP4414472B2 (ja) | 2010-02-10 |
| EP1497444A4 (en) | 2006-08-30 |
| CA2480121A1 (en) | 2003-10-09 |
| US20030211579A1 (en) | 2003-11-13 |
| EP1497444A2 (en) | 2005-01-19 |
| US20050233415A1 (en) | 2005-10-20 |
| JP2005521401A (ja) | 2005-07-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |