JP2008543972A5 - - Google Patents
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- JP2008543972A5 JP2008543972A5 JP2008519471A JP2008519471A JP2008543972A5 JP 2008543972 A5 JP2008543972 A5 JP 2008543972A5 JP 2008519471 A JP2008519471 A JP 2008519471A JP 2008519471 A JP2008519471 A JP 2008519471A JP 2008543972 A5 JP2008543972 A5 JP 2008543972A5
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- JP
- Japan
- Prior art keywords
- substituted
- alkyl
- occurrence
- independently
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 105
- 125000000623 heterocyclic group Chemical group 0.000 claims 79
- 229910052760 oxygen Inorganic materials 0.000 claims 65
- 125000005842 heteroatom Chemical group 0.000 claims 50
- 229910052717 sulfur Inorganic materials 0.000 claims 48
- 229910052799 carbon Inorganic materials 0.000 claims 45
- 125000004432 carbon atom Chemical group C* 0.000 claims 42
- 229910052731 fluorine Inorganic materials 0.000 claims 30
- 229910052739 hydrogen Inorganic materials 0.000 claims 29
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 28
- 229910052801 chlorine Inorganic materials 0.000 claims 27
- 125000003118 aryl group Chemical group 0.000 claims 24
- 229910052794 bromium Inorganic materials 0.000 claims 21
- 150000001721 carbon Chemical group 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 17
- 125000002837 carbocyclic group Chemical group 0.000 claims 16
- 125000003342 alkenyl group Chemical group 0.000 claims 14
- 125000000304 alkynyl group Chemical group 0.000 claims 14
- 125000003545 alkoxy group Chemical group 0.000 claims 13
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 13
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 13
- 125000001072 heteroaryl group Chemical group 0.000 claims 12
- -1 4,4,5,5- tetramethyl 1,3,2 dioxaborolanyl Chemical group 0.000 claims 11
- 125000004429 atom Chemical group 0.000 claims 10
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 229910052710 silicon Inorganic materials 0.000 claims 8
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 7
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 6
- 208000001435 Thromboembolism Diseases 0.000 claims 5
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 4
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 4
- 125000004414 alkyl thio group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 235000019000 fluorine Nutrition 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000004438 haloalkoxy group Chemical group 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrug Drugs 0.000 claims 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 2
- 125000001960 7 membered carbocyclic group Chemical group 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 208000007536 Thrombosis Diseases 0.000 claims 2
- 206010047249 Venous thrombosis Diseases 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims 1
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims 1
- 206010002388 Angina unstable Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 1
- 206010008088 Cerebral artery embolism Diseases 0.000 claims 1
- 206010008092 Cerebral artery thrombosis Diseases 0.000 claims 1
- 206010011091 Coronary artery thrombosis Diseases 0.000 claims 1
- 206010051055 Deep vein thrombosis Diseases 0.000 claims 1
- 208000005189 Embolism Diseases 0.000 claims 1
- 206010014513 Embolism arterial Diseases 0.000 claims 1
- 208000005764 Peripheral Arterial Disease Diseases 0.000 claims 1
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 claims 1
- 208000010378 Pulmonary Embolism Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000032109 Transient ischaemic attack Diseases 0.000 claims 1
- 208000007814 Unstable Angina Diseases 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004190 benzothiazol-2-yl group Chemical group [H]C1=C([H])C([H])=C2N=C(*)SC2=C1[H] 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 210000005242 cardiac chamber Anatomy 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 208000002528 coronary thrombosis Diseases 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 1
- 201000010849 intracranial embolism Diseases 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000000414 obstructive effect Effects 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 230000003836 peripheral circulation Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 201000005060 thrombophlebitis Diseases 0.000 claims 1
- 201000010875 transient cerebral ischemia Diseases 0.000 claims 1
- 208000004043 venous thromboembolism Diseases 0.000 claims 1
- 0 NC(*=Cc1ccccc1)=O Chemical compound NC(*=Cc1ccccc1)=O 0.000 description 10
- POTIYWUALSJREP-UHFFFAOYSA-O C(CC1)CC2C1[NH2+]CCC2 Chemical compound C(CC1)CC2C1[NH2+]CCC2 POTIYWUALSJREP-UHFFFAOYSA-O 0.000 description 1
- YRLORWPBJZEGBX-UHFFFAOYSA-N C1Nc(cccc2)c2OC1 Chemical compound C1Nc(cccc2)c2OC1 YRLORWPBJZEGBX-UHFFFAOYSA-N 0.000 description 1
- YBBLSBDJIKMXNQ-UHFFFAOYSA-N C1Nc(cccc2)c2SC1 Chemical compound C1Nc(cccc2)c2SC1 YBBLSBDJIKMXNQ-UHFFFAOYSA-N 0.000 description 1
- FUABVWOOSMWJLQ-UHFFFAOYSA-N C1Nc(cccc2)c2[SiH+]C1 Chemical compound C1Nc(cccc2)c2[SiH+]C1 FUABVWOOSMWJLQ-UHFFFAOYSA-N 0.000 description 1
- SKEPYJIOOUMIOM-UHFFFAOYSA-N CCC(CCCC1)C1NI Chemical compound CCC(CCCC1)C1NI SKEPYJIOOUMIOM-UHFFFAOYSA-N 0.000 description 1
- DEOHVFJWJUKWLC-UHFFFAOYSA-N CNC1C(CCI)CCCC1 Chemical compound CNC1C(CCI)CCCC1 DEOHVFJWJUKWLC-UHFFFAOYSA-N 0.000 description 1
- UJOBWOGCFQCDNV-UHFFFAOYSA-N c(cc1)cc2c1[nH]c1c2cccc1 Chemical compound c(cc1)cc2c1[nH]c1c2cccc1 UJOBWOGCFQCDNV-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69459605P | 2005-06-27 | 2005-06-27 | |
| US79706406P | 2006-05-02 | 2006-05-02 | |
| PCT/US2006/024914 WO2007002637A1 (en) | 2005-06-27 | 2006-06-26 | N-linked heterocyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008543972A JP2008543972A (ja) | 2008-12-04 |
| JP2008543972A5 true JP2008543972A5 (enExample) | 2009-08-13 |
Family
ID=37087734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008519471A Pending JP2008543972A (ja) | 2005-06-27 | 2006-06-26 | 血栓症状の治療に有用なｐ２ｙ１受容体のｎ−結合複素環式アンタゴニスト |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7728008B2 (enExample) |
| EP (1) | EP1896466B1 (enExample) |
| JP (1) | JP2008543972A (enExample) |
| KR (1) | KR20080027890A (enExample) |
| AR (1) | AR056867A1 (enExample) |
| AT (1) | ATE505468T1 (enExample) |
| AU (1) | AU2006261828A1 (enExample) |
| DE (1) | DE602006021306D1 (enExample) |
| MX (1) | MX2007016501A (enExample) |
| NO (1) | NO20076424L (enExample) |
| PE (1) | PE20070016A1 (enExample) |
| TW (1) | TW200726764A (enExample) |
| WO (1) | WO2007002637A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7550499B2 (en) | 2004-05-12 | 2009-06-23 | Bristol-Myers Squibb Company | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| MX2007008434A (es) * | 2005-01-19 | 2007-07-25 | Squibb Bristol Myers Co | Derivados de 2-fenoxi-n-(1,3,4-tiadizol-2il)piridin-3-amina y compuestos relacionados como inhibidores del receptor p2y1 para el tratamiento de trastornos tromboembolicos. |
| WO2007002634A1 (en) * | 2005-06-27 | 2007-01-04 | Bristol-Myers Squibb Company | Carbocycle and heterocycle antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
| ATE485269T1 (de) * | 2005-06-27 | 2010-11-15 | Bristol Myers Squibb Co | C-verknüpfte zyklische antagonisten des p2y1- rezeptors mit eignung bei der behandlung thrombotischer leiden |
| WO2007002584A1 (en) | 2005-06-27 | 2007-01-04 | Bristol-Myers Squibb Company | Linear urea mimics antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
| US7960569B2 (en) * | 2006-10-17 | 2011-06-14 | Bristol-Myers Squibb Company | Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| JP5951600B2 (ja) | 2010-05-21 | 2016-07-13 | インフィニティー ファーマシューティカルズ， インコーポレイテッド | キナーゼ調節のための、化合物、組成物および方法 |
| US9056877B2 (en) | 2011-07-19 | 2015-06-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| PE20141371A1 (es) | 2011-08-29 | 2014-10-13 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos y usos de los mismos |
| US9120798B2 (en) | 2012-08-01 | 2015-09-01 | Bristol-Myers Squibb Company | Amino-heteroaryl 7-hydroxy-spiropiperidine indolinyl antagonists of P2Y1 receptor |
| US9428504B2 (en) | 2012-08-01 | 2016-08-30 | Bristol-Myers Squibb Company | 7-hydroxy-spiropipiperidine indolinyl antagonists of P2Y1 receptor |
| WO2014022343A1 (en) | 2012-08-01 | 2014-02-06 | Bristol-Myers Squibb Company | 7-hydroxy-indolinyl antagonists of p2y1 receptor |
| EP2922847A1 (en) | 2012-11-20 | 2015-09-30 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase |
| US9481667B2 (en) | 2013-03-15 | 2016-11-01 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
| JP7337174B2 (ja) | 2018-09-18 | 2023-09-01 | ニカング セラピューティクス， インコーポレイテッド | Ｓｒｃホモロジー－２ホスファターゼ阻害剤としての三置換ヘテロアリール誘導体 |
| CN110305141B (zh) * | 2019-07-18 | 2022-01-11 | 深圳市三启药物开发有限公司 | 一种螺(3,3’-异丙基吡咯烷氧化吲哚)类肝x受体调节剂及其制备方法和应用 |
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2006
- 2006-06-26 AR ARP060102745A patent/AR056867A1/es unknown
- 2006-06-26 AT AT06774067T patent/ATE505468T1/de not_active IP Right Cessation
- 2006-06-26 US US11/474,888 patent/US7728008B2/en active Active
- 2006-06-26 DE DE602006021306T patent/DE602006021306D1/de not_active Expired - Lifetime
- 2006-06-26 TW TW095122981A patent/TW200726764A/zh unknown
- 2006-06-26 EP EP06774067A patent/EP1896466B1/en not_active Expired - Lifetime
- 2006-06-26 WO PCT/US2006/024914 patent/WO2007002637A1/en not_active Ceased
- 2006-06-26 MX MX2007016501A patent/MX2007016501A/es not_active Application Discontinuation
- 2006-06-26 AU AU2006261828A patent/AU2006261828A1/en not_active Abandoned
- 2006-06-26 JP JP2008519471A patent/JP2008543972A/ja active Pending
- 2006-06-26 KR KR1020087002124A patent/KR20080027890A/ko not_active Withdrawn
- 2006-06-27 PE PE2006000739A patent/PE20070016A1/es not_active Application Discontinuation
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2007
- 2007-12-14 NO NO20076424A patent/NO20076424L/no not_active Application Discontinuation
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2010
- 2010-04-16 US US12/761,447 patent/US8329718B2/en active Active