JP2008516902A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008516902A5 JP2008516902A5 JP2007536043A JP2007536043A JP2008516902A5 JP 2008516902 A5 JP2008516902 A5 JP 2008516902A5 JP 2007536043 A JP2007536043 A JP 2007536043A JP 2007536043 A JP2007536043 A JP 2007536043A JP 2008516902 A5 JP2008516902 A5 JP 2008516902A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- heteroaryl
- phenyl
- fluorine
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(C(*[Al]=C)=C(*)N1)=C(*)C1=O Chemical compound *C(C(*[Al]=C)=C(*)N1)=C(*)C1=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004050196.3 | 2004-10-15 | ||
| DE102004050196A DE102004050196A1 (de) | 2004-10-15 | 2004-10-15 | Substituierte 2-Pyridon-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| PCT/EP2005/010697 WO2006042638A1 (de) | 2004-10-15 | 2005-10-05 | 3,6-substituierte 5-arylamino-1h-pyidin-2-on derivative und verwandte verbindungen als poly(adp-ribose)polymerase (parp) inhibitoren zur behandlung von durch nekose oder apoptose verursachten gewebeschäden oder erkankungen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008516902A JP2008516902A (ja) | 2008-05-22 |
| JP2008516902A5 true JP2008516902A5 (enExample) | 2008-11-06 |
| JP4875623B2 JP4875623B2 (ja) | 2012-02-15 |
Family
ID=35414525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007536043A Expired - Fee Related JP4875623B2 (ja) | 2004-10-15 | 2005-10-05 | 壊死又はアポトーシスによって生じた組織損傷又は疾患の治療におけるポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）阻害剤としての３，６−置換された５−アリールアミノ−１ｈ−ピリジン−２−オン誘導体及び関連化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7863280B2 (enExample) |
| EP (1) | EP1802578B1 (enExample) |
| JP (1) | JP4875623B2 (enExample) |
| KR (1) | KR20070063005A (enExample) |
| CN (1) | CN101035761B (enExample) |
| AT (1) | ATE393146T1 (enExample) |
| AU (1) | AU2005297570C1 (enExample) |
| BR (1) | BRPI0516516A (enExample) |
| CA (1) | CA2583565A1 (enExample) |
| DE (2) | DE102004050196A1 (enExample) |
| DK (1) | DK1802578T3 (enExample) |
| ES (1) | ES2304721T3 (enExample) |
| IL (1) | IL182093A (enExample) |
| MX (1) | MX2007003360A (enExample) |
| PT (1) | PT1802578E (enExample) |
| WO (1) | WO2006042638A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003284237A1 (en) * | 2002-10-16 | 2004-05-04 | Transport Systems, Inc. | Monorail sortation system |
| US7961081B2 (en) * | 2003-05-22 | 2011-06-14 | John Tomlienovic | Anti-theft system and method |
| CN101242822B (zh) | 2005-07-18 | 2011-08-24 | 彼帕科学公司 | 治疗卵巢癌的药物 |
| AU2007292387A1 (en) | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Treatment of cancer |
| JP2010502731A (ja) | 2006-09-05 | 2010-01-28 | バイパー サイエンシズ，インコーポレイティド | Ｐａｒｐ阻害剤による脂肪酸合成の阻害、及びその治療方法 |
| WO2009012242A2 (en) * | 2007-07-13 | 2009-01-22 | Icagen, Inc. | Sodium channel inhibitors |
| KR20100102609A (ko) | 2007-11-12 | 2010-09-24 | 바이파 사이언스 인코포레이티드 | Ｐａｒｐ 억제제를 단독으로 사용하거나 항종양제와 병용하여 유방암을 치료하는 방법 |
| WO2011058367A2 (en) | 2009-11-13 | 2011-05-19 | Astrazeneca Ab | Diagnostic test for predicting responsiveness to treatment with poly(adp-ribose) polymerase (parp) inhibitor |
| WO2011141909A2 (en) | 2010-05-10 | 2011-11-17 | Radikal Therapeutics Inc. | Lipoic acid and nitroxide derivatives and uses thereof |
| TW201512171A (zh) | 2013-04-19 | 2015-04-01 | Pfizer Ltd | 化學化合物 |
| AU2016296905B2 (en) | 2015-07-23 | 2018-07-05 | Centre National De La Recherche Scientifique | Use of a combination of Dbait molecule and parp inhibitors to treat cancer |
| GB201519573D0 (en) | 2015-11-05 | 2015-12-23 | King S College London | Combination |
| WO2018162439A1 (en) | 2017-03-08 | 2018-09-13 | Onxeo | New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule |
| EP3615026B1 (en) | 2017-04-28 | 2021-03-03 | Akribes Biomedical GmbH | A parp inhibitor in combination with a glucocorticoid and/or ascorbic acid and/or a protein growth factor for the treatment of impaired wound healing |
| ES3008911T3 (en) | 2017-07-11 | 2025-03-25 | Vertex Pharma | Carboxamides as modulators of sodium channels |
| JP7534218B2 (ja) | 2018-03-13 | 2024-08-14 | ヴァレリオ・セラピューティクス | がんの治療における獲得耐性に対抗するｄｂａｉｔ分子 |
| WO2020012357A1 (en) * | 2018-07-10 | 2020-01-16 | Integral Biosciences Pvt. Ltd. | Heterocyclic compounds and methods of use |
| WO2020146682A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| WO2020146612A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| JP7646643B2 (ja) * | 2019-10-04 | 2025-03-17 | アンスティトゥート・ナシオナル・ドゥ・ラ・サンテ・エ・ドゥ・ラ・ルシャルシュ・メディカル・（インセルム） | 新規なピリジン－２（１ｈ）オン誘導体、その調製、及び疼痛を処置するためのその使用 |
| CA3159461A1 (en) | 2019-11-25 | 2021-06-03 | Iwao Ojima | Combination therapy using fabp5 inhibitors with taxanes for treatment of cancer |
| US20230348401A1 (en) * | 2020-01-15 | 2023-11-02 | The Trustees Of Princeton University | Inhibitors of Glucose-6-phosphate Dehydrogenase and Uses Thereof |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| WO2024261243A1 (en) | 2023-06-21 | 2024-12-26 | Hemispherian As | Combination comprising a deoxycytidine derivative and a parp inhibitor for use in a method of treating hr proficient cancer |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL70169A0 (en) * | 1982-11-18 | 1984-02-29 | Sterling Drug Inc | 2(1h)-pyridinones,their preparation and pharmaceutical compositions containing them |
| GB9121651D0 (en) * | 1991-10-11 | 1991-11-27 | Smithkline Beecham Plc | Chemical compounds |
| CA2153498A1 (en) * | 1993-11-10 | 1995-05-18 | Hidetsura Cho | Chroman derivative and medicinal use thereof |
| AU770600B2 (en) * | 1999-10-07 | 2004-02-26 | Amgen, Inc. | Triazine kinase inhibitors |
| EP1423120A4 (en) * | 2001-08-15 | 2005-12-28 | Icos Corp | 2H-PHTALAZINE-1-ONES AND METHODS OF USE THEREOF |
| AUPS019702A0 (en) * | 2002-01-29 | 2002-02-21 | Fujisawa Pharmaceutical Co., Ltd. | Condensed heterocyclic compounds |
-
2004
- 2004-10-15 DE DE102004050196A patent/DE102004050196A1/de not_active Withdrawn
-
2005
- 2005-10-05 WO PCT/EP2005/010697 patent/WO2006042638A1/de not_active Ceased
- 2005-10-05 PT PT05788702T patent/PT1802578E/pt unknown
- 2005-10-05 AU AU2005297570A patent/AU2005297570C1/en not_active Ceased
- 2005-10-05 CN CN2005800338248A patent/CN101035761B/zh not_active Expired - Fee Related
- 2005-10-05 EP EP05788702A patent/EP1802578B1/de not_active Expired - Lifetime
- 2005-10-05 AT AT05788702T patent/ATE393146T1/de active
- 2005-10-05 JP JP2007536043A patent/JP4875623B2/ja not_active Expired - Fee Related
- 2005-10-05 BR BRPI0516516-4A patent/BRPI0516516A/pt not_active IP Right Cessation
- 2005-10-05 MX MX2007003360A patent/MX2007003360A/es active IP Right Grant
- 2005-10-05 DE DE502005003866T patent/DE502005003866D1/de not_active Expired - Lifetime
- 2005-10-05 ES ES05788702T patent/ES2304721T3/es not_active Expired - Lifetime
- 2005-10-05 DK DK05788702T patent/DK1802578T3/da active
- 2005-10-05 CA CA002583565A patent/CA2583565A1/en not_active Abandoned
- 2005-10-05 KR KR1020077008550A patent/KR20070063005A/ko not_active Abandoned
-
2007
- 2007-03-21 IL IL182093A patent/IL182093A/en not_active IP Right Cessation
- 2007-04-11 US US11/733,833 patent/US7863280B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008516902A5 (enExample) | ||
| EP2296653B1 (en) | Compounds and methods for treating inflammatory and fibrotic disorders | |
| JP7429750B2 (ja) | ピリダジノン化合物およびその使用 | |
| EP1087963B1 (en) | Inhibitors of glycogen synthase kinase 3 | |
| DE60215814T2 (de) | Vinylphenyl-derivate als glk-aktivatoren | |
| UA77167C2 (uk) | Похідні заміщених алкіламінів та їх застосування | |
| JP2021530478A (ja) | ＮａＶ１．８を阻害するためのピリジンカルボキシアミド化合物 | |
| CN101035761B (zh) | 作为聚(adp-核糖)聚合酶(parp)抑制剂、治疗由坏死或细胞程序死亡导致的组织损伤或疾病的3,6-取代的5-芳基氨基-1h-吡啶-2-酮衍生物和相关化合物 | |
| EP4473968A2 (en) | Pyridazinone compounds and uses thereof | |
| WO2017079641A1 (en) | N-[2-(1 -benzylpiperidin-4-yl)ethyl]-4-(pyrazin-2-yl)-piperazine-1 -carboxamide derivatives and related compounds as muscarinic receptor 4 (m4) antagonists for treating neurological diseases | |
| CN112638877B (zh) | 用于治疗rna病毒感染的苯基/吡啶基-n-苯基/吡啶基衍生物 | |
| JP2013503833A (ja) | 新規なピリミジンおよびトリアジン系ヘプシジン拮抗薬 | |
| KR20040048920A (ko) | 글리코겐 신타아제 키나제 3-베타 저해제(ｇｓｋ저해제)로서의 헤테로아릴 아민 | |
| JPH0789958A (ja) | ４−アミノピリミジン誘導体、その製造方法およびそれを含有する医薬品 | |
| JP2009023986A (ja) | 抗癌剤としてのビアリール誘導体 | |
| JPS59501409A (ja) | ピリドン化合物 | |
| EA016352B1 (ru) | Производные 5,6-бис-арил-2-пиридинкарбоксамида, их получение и их применение в терапии в качестве антагонистов рецепторов уротензина ii | |
| JP2022528042A (ja) | アミド類化合物の調製方法及びその医薬分野の使用 | |
| TWI794844B (zh) | 包含經由鏈接子連接之2或更多芳基或雜芳基的新穎羰基亞肼基二氰化物化合物及其用途 | |
| JP4719744B2 (ja) | カリウムチャンネル阻害剤 | |
| IL296632A (en) | phd inhibitory compounds, compositions and use | |
| HK40091925A (en) | Pyridazinone compounds and uses thereof | |
| AU2002238023B2 (en) | Pyridine-substituted benzanilides as potassium ion channel openers | |
| HK40040882A (en) | Phenyl/pyridyl-n-phenyl/pyridyl derivatives for treating a rna virus infection | |
| HK1155374B (en) | Compounds and methods for treating inflammatory and fibrotic disorders |