JP2008516902A5 - - Google Patents
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- Publication number
- JP2008516902A5 JP2008516902A5 JP2007536043A JP2007536043A JP2008516902A5 JP 2008516902 A5 JP2008516902 A5 JP 2008516902A5 JP 2007536043 A JP2007536043 A JP 2007536043A JP 2007536043 A JP2007536043 A JP 2007536043A JP 2008516902 A5 JP2008516902 A5 JP 2008516902A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- heteroaryl
- phenyl
- fluorine
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(C(*[Al]=C)=C(*)N1)=C(*)C1=O Chemical compound *C(C(*[Al]=C)=C(*)N1)=C(*)C1=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004050196.3 | 2004-10-15 | ||
| DE102004050196A DE102004050196A1 (de) | 2004-10-15 | 2004-10-15 | Substituierte 2-Pyridon-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament |
| PCT/EP2005/010697 WO2006042638A1 (de) | 2004-10-15 | 2005-10-05 | 3,6-substituierte 5-arylamino-1h-pyidin-2-on derivative und verwandte verbindungen als poly(adp-ribose)polymerase (parp) inhibitoren zur behandlung von durch nekose oder apoptose verursachten gewebeschäden oder erkankungen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008516902A JP2008516902A (ja) | 2008-05-22 |
| JP2008516902A5 true JP2008516902A5 (enExample) | 2008-11-06 |
| JP4875623B2 JP4875623B2 (ja) | 2012-02-15 |
Family
ID=35414525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007536043A Expired - Fee Related JP4875623B2 (ja) | 2004-10-15 | 2005-10-05 | 壊死又はアポトーシスによって生じた組織損傷又は疾患の治療におけるポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）阻害剤としての３，６−置換された５−アリールアミノ−１ｈ−ピリジン−２−オン誘導体及び関連化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7863280B2 (enExample) |
| EP (1) | EP1802578B1 (enExample) |
| JP (1) | JP4875623B2 (enExample) |
| KR (1) | KR20070063005A (enExample) |
| CN (1) | CN101035761B (enExample) |
| AT (1) | ATE393146T1 (enExample) |
| AU (1) | AU2005297570C1 (enExample) |
| BR (1) | BRPI0516516A (enExample) |
| CA (1) | CA2583565A1 (enExample) |
| DE (2) | DE102004050196A1 (enExample) |
| DK (1) | DK1802578T3 (enExample) |
| ES (1) | ES2304721T3 (enExample) |
| IL (1) | IL182093A (enExample) |
| MX (1) | MX2007003360A (enExample) |
| PT (1) | PT1802578E (enExample) |
| WO (1) | WO2006042638A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004035365A2 (en) * | 2002-10-16 | 2004-04-29 | Transport Systems, Inc. | Monorail sortation system |
| US7961081B2 (en) * | 2003-05-22 | 2011-06-14 | John Tomlienovic | Anti-theft system and method |
| RU2447889C2 (ru) | 2005-07-18 | 2012-04-20 | Бипар Сайенсиз, Инк. | Способ лечения рака (варианты) |
| CA2662337A1 (en) | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof |
| CN101522609A (zh) | 2006-09-05 | 2009-09-02 | 彼帕科学公司 | 癌症的治疗 |
| EP2173743A2 (en) * | 2007-07-13 | 2010-04-14 | Icagen, Inc. | Sodium channel inhibitors |
| JP2011503111A (ja) | 2007-11-12 | 2011-01-27 | バイパー サイエンシズ，インコーポレイティド | Ｐａｒｐ阻害剤単独又は抗腫瘍剤との組み合わせによる乳がんの治療 |
| WO2011058367A2 (en) | 2009-11-13 | 2011-05-19 | Astrazeneca Ab | Diagnostic test for predicting responsiveness to treatment with poly(adp-ribose) polymerase (parp) inhibitor |
| EP2569307A2 (en) | 2010-05-10 | 2013-03-20 | Radikal Therapeutics Inc. | Lipoic acid and nitroxide derivatives and uses thereof |
| TW201512171A (zh) | 2013-04-19 | 2015-04-01 | Pfizer Ltd | 化學化合物 |
| ES2879434T3 (es) | 2015-07-23 | 2021-11-22 | Inst Curie | Uso de una combinación de molécula Dbait e inhibidores de PARP para tratamiento del cáncer |
| GB201519573D0 (en) | 2015-11-05 | 2015-12-23 | King S College London | Combination |
| WO2018162439A1 (en) | 2017-03-08 | 2018-09-13 | Onxeo | New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule |
| CA3096127A1 (en) | 2017-04-28 | 2018-11-01 | Akribes Biomedical Gmbh | A parp inhibitor in combination with a glucocorticoid and/or ascorbic acid and/or a protein growth factor for the treatment of impaired wound healing |
| CA3069720A1 (en) | 2017-07-11 | 2019-01-17 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| KR20200130856A (ko) | 2018-03-13 | 2020-11-20 | 옹쎄오 | 암 치료에서 획득한 내성에 대한 디베이트 분자 |
| WO2020012357A1 (en) * | 2018-07-10 | 2020-01-16 | Integral Biosciences Pvt. Ltd. | Heterocyclic compounds and methods of use |
| WO2020146612A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| WO2020146682A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| EP4037770A1 (en) * | 2019-10-04 | 2022-08-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Novel pyridin-2(1h)one derivatives, their preparation and their use for the treatment of pain |
| JP7798358B2 (ja) | 2019-11-25 | 2026-01-14 | ザ・リサーチ・ファウンデーション・フォア・ザ・ステイト・ユニバーシティー・オブ・ニューヨーク | 癌の処置のためにタキサンと共にｆａｂｐ５阻害剤を使用する併用療法 |
| WO2021146543A1 (en) * | 2020-01-15 | 2021-07-22 | The Trustees Of Princeton University | Inhibitors of glucose-6-phosphate dehydrogenase and uses thereof |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CN121398822A (zh) | 2023-06-21 | 2026-01-23 | 四方生物科学有限公司 | 用于在治疗hr功能正常的癌症的方法中的用途的包含脱氧胞苷衍生物和parp抑制剂的组合 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL70169A0 (en) * | 1982-11-18 | 1984-02-29 | Sterling Drug Inc | 2(1h)-pyridinones,their preparation and pharmaceutical compositions containing them |
| GB9121651D0 (en) * | 1991-10-11 | 1991-11-27 | Smithkline Beecham Plc | Chemical compounds |
| US5719155A (en) * | 1993-11-10 | 1998-02-17 | Japan Tobacco Inc. | Chroman derivative and pharmaceutical use thereof |
| JP2003511378A (ja) * | 1999-10-07 | 2003-03-25 | アムジエン・インコーポレーテツド | トリアジン系キナーゼ阻害薬 |
| CA2456985A1 (en) * | 2001-08-15 | 2003-02-27 | Icos Corporation | 2h-phthalazin-1-ones and methods for use thereof |
| AUPS019702A0 (en) * | 2002-01-29 | 2002-02-21 | Fujisawa Pharmaceutical Co., Ltd. | Condensed heterocyclic compounds |
-
2004
- 2004-10-15 DE DE102004050196A patent/DE102004050196A1/de not_active Withdrawn
-
2005
- 2005-10-05 DE DE502005003866T patent/DE502005003866D1/de not_active Expired - Lifetime
- 2005-10-05 JP JP2007536043A patent/JP4875623B2/ja not_active Expired - Fee Related
- 2005-10-05 BR BRPI0516516-4A patent/BRPI0516516A/pt not_active IP Right Cessation
- 2005-10-05 CN CN2005800338248A patent/CN101035761B/zh not_active Expired - Fee Related
- 2005-10-05 CA CA002583565A patent/CA2583565A1/en not_active Abandoned
- 2005-10-05 WO PCT/EP2005/010697 patent/WO2006042638A1/de not_active Ceased
- 2005-10-05 MX MX2007003360A patent/MX2007003360A/es active IP Right Grant
- 2005-10-05 DK DK05788702T patent/DK1802578T3/da active
- 2005-10-05 EP EP05788702A patent/EP1802578B1/de not_active Expired - Lifetime
- 2005-10-05 PT PT05788702T patent/PT1802578E/pt unknown
- 2005-10-05 AU AU2005297570A patent/AU2005297570C1/en not_active Ceased
- 2005-10-05 AT AT05788702T patent/ATE393146T1/de active
- 2005-10-05 KR KR1020077008550A patent/KR20070063005A/ko not_active Abandoned
- 2005-10-05 ES ES05788702T patent/ES2304721T3/es not_active Expired - Lifetime
-
2007
- 2007-03-21 IL IL182093A patent/IL182093A/en not_active IP Right Cessation
- 2007-04-11 US US11/733,833 patent/US7863280B2/en not_active Expired - Fee Related
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