JP2008543874A5 - - Google Patents

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Publication number
JP2008543874A5
JP2008543874A5 JP2008517192A JP2008517192A JP2008543874A5 JP 2008543874 A5 JP2008543874 A5 JP 2008543874A5 JP 2008517192 A JP2008517192 A JP 2008517192A JP 2008517192 A JP2008517192 A JP 2008517192A JP 2008543874 A5 JP2008543874 A5 JP 2008543874A5
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JP
Japan
Prior art keywords
compound
formula
acyl
protecting group
oxygen protecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2008517192A
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English (en)
Japanese (ja)
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JP5159616B2 (ja
JP2008543874A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/023668 external-priority patent/WO2006138673A2/en
Publication of JP2008543874A publication Critical patent/JP2008543874A/ja
Publication of JP2008543874A5 publication Critical patent/JP2008543874A5/ja
Application granted granted Critical
Publication of JP5159616B2 publication Critical patent/JP5159616B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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JP2008517192A 2005-06-15 2006-06-15 アミノシクロヘキシルエーテル化合物の調製のための合成プロセス Expired - Lifetime JP5159616B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US69098905P 2005-06-15 2005-06-15
US60/690,989 2005-06-15
US74824805P 2005-12-07 2005-12-07
US60/748,248 2005-12-07
PCT/US2006/023668 WO2006138673A2 (en) 2005-06-15 2006-06-15 Synthetic processes for the preparation of aminocyclohexyl ether compounds

Publications (3)

Publication Number Publication Date
JP2008543874A JP2008543874A (ja) 2008-12-04
JP2008543874A5 true JP2008543874A5 (enExample) 2012-02-23
JP5159616B2 JP5159616B2 (ja) 2013-03-06

Family

ID=37395936

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008517192A Expired - Lifetime JP5159616B2 (ja) 2005-06-15 2006-06-15 アミノシクロヘキシルエーテル化合物の調製のための合成プロセス

Country Status (7)

Country Link
US (4) US7754897B2 (enExample)
EP (1) EP1915340B1 (enExample)
JP (1) JP5159616B2 (enExample)
BR (1) BRPI0612138B8 (enExample)
CA (1) CA2612375C (enExample)
MX (2) MX2007016248A (enExample)
WO (1) WO2006138673A2 (enExample)

Families Citing this family (16)

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US7705036B2 (en) * 2004-04-01 2010-04-27 Cardiome Pharma Corp. Deuterated aminocyclohexyl ether compounds and processes for preparing same
CA2561733A1 (en) * 2004-04-01 2005-10-13 Cardiome Pharma Corp. Pegylated ion channel modulating compounds
US8692002B2 (en) 2004-11-18 2014-04-08 Cardiome Pharma Corp. Synthetic process for aminocyclohexyl ether compounds
JP5159616B2 (ja) 2005-06-15 2013-03-06 カーディオム ファーマ コーポレイション アミノシクロヘキシルエーテル化合物の調製のための合成プロセス
US20080312309A1 (en) * 2007-05-04 2008-12-18 Cardiome Pharma Corp. Controlled release oral formulations of ion channel modulating compounds and related methods for preventing arrhythmia
EP2445504A4 (en) 2009-06-23 2012-11-14 Medicinova Inc 2-AMINO-1- (2-ISOPROPYLPYRAZOLO [1,5-A] PYRIDINE-3-YL) PROPAN-1-ONE ENANTIOMER COMPOSITIONS AND METHODS THEREOF
US8932836B2 (en) 2010-08-16 2015-01-13 Codexis, Inc. Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
WO2012024100A2 (en) 2010-08-16 2012-02-23 Merck Sharp & Dohme Corp. Process for preparing aminocyclohexyl ether compounds
CN115778934A (zh) 2012-01-20 2023-03-14 德玛公司 经取代的己糖醇类用于治疗恶性肿瘤的用途
WO2013142817A2 (en) 2012-03-23 2013-09-26 Dennis Brown Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo
US20150182490A1 (en) 2012-06-26 2015-07-02 Del Mar Pharmaceuticals Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof
CN105492011A (zh) 2013-04-08 2016-04-13 丹尼斯·M·布朗 不理想给药化学化合物的治疗增效
KR102359214B1 (ko) 2014-04-04 2022-02-07 델 마 파마슈티컬스 폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체
NZ792518A (en) 2016-10-06 2023-04-28 Orbus Therapeutics Inc Formulations for administration of eflornithine
WO2018200381A1 (en) 2017-04-25 2018-11-01 Temple Otorongo Llc Pharmaceutical composition comprising tryptophan and phyllokinin derivative for use in treating psychiatric and psychological conditions
US12605349B2 (en) 2024-09-05 2026-04-21 Orbus Therapeutics, Inc. Methods of treating grade 3 astrocytoma

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CA710830A (en) 1965-06-01 Moser Paul Disodium and calcium salt of the calcium complex of 2-aminocyclohexyl 2'-aminoethyl ether-n,n,n',n'-tetraacetic acid
DE2860703D1 (en) 1977-12-01 1981-08-20 Bayer Ag Benzyl ethers of cyclic 1,2-diols, methods for their preparation and their use as herbicides
DE2753556A1 (de) 1977-12-01 1979-06-07 Bayer Ag Benzylaether von cyclischen 1,2-diolen, verfahren zu ihrer herstellung sowie ihre verwendung als herbizide
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JP3789938B2 (ja) 1995-02-03 2006-06-28 ビーエーエスエフ アクチェンゲゼルシャフト 酵素触媒作用アシル化による１級及び２級のヘテロ原子置換アミンのラセミ体分割
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US7524879B2 (en) 2000-10-06 2009-04-28 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
US7057053B2 (en) 2000-10-06 2006-06-06 Cardiome Pharma Corp. Ion channel modulating compounds and uses thereof
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JP2003250577A (ja) * 2001-12-27 2003-09-09 Sumitomo Chem Co Ltd ２‐ヒドロキシシクロアルカンカルボン酸エステルの製造方法
WO2003105756A2 (en) 2002-06-14 2003-12-24 Johnson Matthey Pharmaceutical Materials, Inc. Stereoselective synthesis of 1,2-disubstituted cycloalkyls
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DE60305200T2 (de) 2003-05-02 2007-05-10 Cardiome Pharma Corp. Aminocyclohexylether-verbindungen und deren verwendung
CA2524034A1 (en) 2003-05-02 2004-11-18 Cardiome Pharma Corp. Uses of ion channel modulating compounds
WO2005016242A2 (en) 2003-06-04 2005-02-24 Cardiome Pharma Corp. Synthetic process for trans-aminocyclohexyl ether compounds
US7345087B2 (en) * 2003-10-31 2008-03-18 Cardiome Pharma Corp. Aminocyclohexyl ether compounds and uses thereof
WO2005097087A2 (en) 2004-04-01 2005-10-20 Cardiome Pharma Corp. Merged ion channel modulating compounds and uses thereof
CA2561819A1 (en) * 2004-04-01 2005-12-01 Cardiome Pharma Corp. Prodrugs of ion channel modulating compounds and uses thereof
US7705036B2 (en) * 2004-04-01 2010-04-27 Cardiome Pharma Corp. Deuterated aminocyclohexyl ether compounds and processes for preparing same
CA2561733A1 (en) * 2004-04-01 2005-10-13 Cardiome Pharma Corp. Pegylated ion channel modulating compounds
US8692002B2 (en) * 2004-11-18 2014-04-08 Cardiome Pharma Corp. Synthetic process for aminocyclohexyl ether compounds
JP5159616B2 (ja) 2005-06-15 2013-03-06 カーディオム ファーマ コーポレイション アミノシクロヘキシルエーテル化合物の調製のための合成プロセス
US20090069404A1 (en) 2007-09-09 2009-03-12 Protia, Llc Deuterium-enriched vernakalant

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