JP2023509944A5 - - Google Patents
Info
- Publication number
- JP2023509944A5 JP2023509944A5 JP2022540980A JP2022540980A JP2023509944A5 JP 2023509944 A5 JP2023509944 A5 JP 2023509944A5 JP 2022540980 A JP2022540980 A JP 2022540980A JP 2022540980 A JP2022540980 A JP 2022540980A JP 2023509944 A5 JP2023509944 A5 JP 2023509944A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- groups
- cycloalkyl
- heterocyclyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010025118 | 2020-01-10 | ||
| CN202010025118.5 | 2020-01-10 | ||
| CN202010036802.3 | 2020-01-14 | ||
| CN202010036802 | 2020-01-14 | ||
| CN202010273891 | 2020-04-09 | ||
| CN202010273891.3 | 2020-04-09 | ||
| CN202010680491.4 | 2020-07-15 | ||
| CN202010680491 | 2020-07-15 | ||
| CN202010819555.4 | 2020-08-14 | ||
| CN202010819555 | 2020-08-14 | ||
| CN202010971693 | 2020-09-16 | ||
| CN202010971693.4 | 2020-09-16 | ||
| PCT/CN2021/070826 WO2021139756A1 (zh) | 2020-01-10 | 2021-01-08 | 三环四氢异喹啉类衍生物、其制备方法及其在医药上的应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023509944A JP2023509944A (ja) | 2023-03-10 |
| JP2023509944A5 true JP2023509944A5 (enExample) | 2024-01-17 |
| JP7657807B2 JP7657807B2 (ja) | 2025-04-07 |
Family
ID=76787742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022540980A Active JP7657807B2 (ja) | 2020-01-10 | 2021-01-08 | 三環式テトラヒドロイソキノリン誘導体、その調製方法及びその医薬的応用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US12428428B2 (enExample) |
| EP (1) | EP4089094A4 (enExample) |
| JP (1) | JP7657807B2 (enExample) |
| KR (1) | KR20220125272A (enExample) |
| CN (2) | CN114746424B (enExample) |
| AU (1) | AU2021205156B2 (enExample) |
| BR (1) | BR112022013322A2 (enExample) |
| CA (1) | CA3164166A1 (enExample) |
| MX (1) | MX2022008091A (enExample) |
| TW (1) | TWI882060B (enExample) |
| WO (1) | WO2021139756A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2021205156B2 (en) | 2020-01-10 | 2026-07-02 | Jiangsu Hengrui Medicine Co., Ltd. | Tricyclic tetrahydroisoquinoline derivative, preparation method therefor and application thereof in medicine |
| CN117642405B (zh) * | 2021-07-09 | 2026-05-12 | 江苏恒瑞医药股份有限公司 | 一种三环四氢异喹啉类衍生物的盐型 |
| CN117813288A (zh) | 2021-07-15 | 2024-04-02 | 西藏海思科制药有限公司 | 芳氨基衍生物雌激素受体调节剂及其用途 |
| JP2025529974A (ja) | 2022-09-09 | 2025-09-09 | サノフイ | 置換テトラヒドロシクロヘプタ［ｅ］インドール誘導体、それらの調製のプロセス及びその治療的使用 |
| WO2025209455A1 (zh) * | 2024-04-01 | 2025-10-09 | 山东盛迪医药有限公司 | 一种选择性雌激素受体降解剂的制备方法 |
| WO2026086864A1 (zh) * | 2024-10-24 | 2026-04-30 | 江苏恒瑞医药股份有限公司 | 一种kat6抑制剂的联合使用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1113007A1 (en) | 1999-12-24 | 2001-07-04 | Pfizer Inc. | Tetrahydroisoquinoline compounds as estrogen agonists/antagonists |
| RU2009122670A (ru) | 2006-12-21 | 2011-01-27 | Плекссикон, Инк. (Us) | Соединения и способы для модуляции киназ и показания к их применению |
| WO2013073875A1 (ko) | 2011-11-15 | 2013-05-23 | 한국화학연구원 | 신규한 항바이러스성 피롤로피리딘 유도체 및 이의 제조방법 |
| EP2941421A4 (en) | 2013-01-07 | 2016-09-21 | Bg Negev Technologies & Applic Ltd | COUMESTAN, COUMESTROL, COUMESTAN DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF |
| WO2014141292A2 (en) | 2013-03-04 | 2014-09-18 | Intas Pharmaceuticals Limited | Endoxifen citrate polymorph and process for preparing the same |
| IN2013MU00665A (enExample) | 2013-03-05 | 2015-07-03 | Cipla Ltd | |
| CN105121413B (zh) | 2013-03-14 | 2018-09-14 | 赛拉根医药股份有限公司 | 多环雌激素受体调节剂及其用途 |
| EP2981530B1 (en) | 2013-04-04 | 2020-02-12 | The Administrators of the Tulane Educational Fund | Enhanced osteogenic activity of daidzein analogs on human mesenchymal stem cells |
| AP2015008858A0 (en) | 2013-05-28 | 2015-11-30 | Astrazeneca Ab | Chemical compounds |
| WO2015092634A1 (en) * | 2013-12-16 | 2015-06-25 | Novartis Ag | 1,2,3,4-tetrahydroisoquinoline compounds and compositions as selective estrogen receptor antagonists and degraders |
| EP3312184A4 (en) * | 2015-06-16 | 2019-02-27 | Jiangsu Hengrui Medicine Co., Ltd. | PIPERIDINE DERIVATIVE AND ITS PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF |
| EP3328999B1 (en) | 2015-07-30 | 2020-03-25 | Arcis Biotechnology Holdings Limited | Method using a quaternary ammonium compound |
| EP3440067B1 (en) * | 2016-04-08 | 2021-05-26 | F. Hoffmann-La Roche AG | Tetrahydroisoquinoline estrogen receptor modulators and uses thereof |
| UA125824C2 (uk) | 2016-10-24 | 2022-06-15 | Астразенека Аб | 6,7,8,9-ТЕТРАГІДРО-3H-ПІРАЗОЛО[4,3-f]ІЗОХІНОЛІНОВІ ПОХІДНІ, ЗАСТОСОВНІ В ЛІКУВАННІ РАКУ |
| WO2018130124A1 (zh) * | 2017-01-11 | 2018-07-19 | 南京圣和药业股份有限公司 | 作为选择性雌激素受体下调剂的三环类化合物及其应用 |
| WO2019002442A1 (en) * | 2017-06-29 | 2019-01-03 | Astrazeneca Ab | CHEMICAL COMPOUNDS |
| CA3082276C (en) * | 2017-11-14 | 2022-08-16 | Anlin Pharmaceuticals, Llc | Heterocyclic compounds and their application in medicine |
| CN111770924B (zh) * | 2018-04-04 | 2023-05-09 | 深圳福沃药业有限公司 | 用于治疗乳腺癌的雌激素受体降解剂 |
| WO2019228443A1 (en) | 2018-05-30 | 2019-12-05 | Dizal (Jiangsu) Pharmaceutical Co., Ltd. | Selective estrogen receptor downregulators and uses thereof |
| AU2021205156B2 (en) | 2020-01-10 | 2026-07-02 | Jiangsu Hengrui Medicine Co., Ltd. | Tricyclic tetrahydroisoquinoline derivative, preparation method therefor and application thereof in medicine |
-
2021
- 2021-01-08 AU AU2021205156A patent/AU2021205156B2/en active Active
- 2021-01-08 TW TW110100844A patent/TWI882060B/zh active
- 2021-01-08 CA CA3164166A patent/CA3164166A1/en active Pending
- 2021-01-08 JP JP2022540980A patent/JP7657807B2/ja active Active
- 2021-01-08 CN CN202180006879.9A patent/CN114746424B/zh active Active
- 2021-01-08 BR BR112022013322A patent/BR112022013322A2/pt unknown
- 2021-01-08 WO PCT/CN2021/070826 patent/WO2021139756A1/zh not_active Ceased
- 2021-01-08 KR KR1020227026103A patent/KR20220125272A/ko active Pending
- 2021-01-08 US US17/790,110 patent/US12428428B2/en active Active
- 2021-01-08 EP EP21738824.8A patent/EP4089094A4/en active Pending
- 2021-01-08 CN CN202310574384.7A patent/CN116731064B/zh active Active
- 2021-01-08 MX MX2022008091A patent/MX2022008091A/es unknown
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