CN114364685A - 含氮杂环类化合物，及其制备方法、药物组合物和应用 - Google Patents

含氮杂环类化合物，及其制备方法、药物组合物和应用 Download PDF

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CN114364685A
CN114364685A CN202080063271.5A CN202080063271A CN114364685A CN 114364685 A CN114364685 A CN 114364685A CN 202080063271 A CN202080063271 A CN 202080063271A CN 114364685 A CN114364685 A CN 114364685A
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王喆
潜安然
李德亮
张基勇
曾志宏
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Shanghai Longwood Biopharmaceuticals Co Ltd
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Abstract

本发明提供了一种含氮杂环类化合物，及其制备方法、药物组合物和应用，具体地，本发明提供了一种如下式I所示的化合物，或其光学异构体、水合物、溶剂合物，或其药学上可接受的盐；其中，各基团的定义如说明书中所述。所述的式I化合物可以用于治疗与PD‑1/PD‑L1信号通路有关的疾病。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN202080063271.5A 2019-09-09 2020-09-09 含氮杂环类化合物，及其制备方法、药物组合物和应用 Pending CN114364685A (zh)

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PCT/CN2020/114264 WO2021047556A1 (zh) 2019-09-09 2020-09-09 含氮杂环类化合物，及其制备方法、药物组合物和应用

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112457331A (zh) * 2019-09-09 2021-03-09 上海长森药业有限公司 含氮杂环类化合物，及其制备方法、药物组合物和应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230111910A1 (en) * 2020-01-21 2023-04-13 Shanghai Synergy Pharmaceutical Sciences Co., Ltd. Pd-1/pd-l1 inhibitor, preparation method therefor, and use thereof
CN117871740B (zh) * 2024-03-11 2024-05-10 炉霍雪域俄色有限责任公司 俄色果原浆液相色谱品质检测方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018119266A1 (en) * 2016-12-22 2018-06-28 Incyte Corporation Benzooxazole derivatives as immunomodulators
WO2018119224A1 (en) * 2016-12-22 2018-06-28 Incyte Corporation Tetrahydro imidazo[4,5-c]pyridine derivatives as pd-l1 internalization inducers
WO2018195321A1 (en) * 2017-04-20 2018-10-25 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
CN111039942A (zh) * 2018-10-12 2020-04-21 上海长森药业有限公司 含氮杂环类化合物，及其制备方法、药物组合物和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109678796B (zh) * 2017-10-19 2023-01-10 上海长森药业有限公司 Pd-1/pd-l1小分子抑制剂及其制备方法和用途
CN112457331A (zh) * 2019-09-09 2021-03-09 上海长森药业有限公司 含氮杂环类化合物，及其制备方法、药物组合物和应用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018119266A1 (en) * 2016-12-22 2018-06-28 Incyte Corporation Benzooxazole derivatives as immunomodulators
WO2018119224A1 (en) * 2016-12-22 2018-06-28 Incyte Corporation Tetrahydro imidazo[4,5-c]pyridine derivatives as pd-l1 internalization inducers
WO2018195321A1 (en) * 2017-04-20 2018-10-25 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
CN111039942A (zh) * 2018-10-12 2020-04-21 上海长森药业有限公司 含氮杂环类化合物，及其制备方法、药物组合物和应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ACS，STN REGISTRY数据库: "RN：724720-45-0、724728-57-8 、724728-55-6、724727-90-6 、724727-89-3 、724727-88-2 、724727-60-0、724727-54-2 、724721-59-9", 《ACS，STN REGISTRY数据库》, 10 August 2004 (2004-08-10) *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112457331A (zh) * 2019-09-09 2021-03-09 上海长森药业有限公司 含氮杂环类化合物，及其制备方法、药物组合物和应用

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