CN114364683A - 芳香杂环衍生物作为免疫调节剂的制备及其应用 - Google Patents

芳香杂环衍生物作为免疫调节剂的制备及其应用 Download PDF

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CN114364683A
CN114364683A CN202080063272.XA CN202080063272A CN114364683A CN 114364683 A CN114364683 A CN 114364683A CN 202080063272 A CN202080063272 A CN 202080063272A CN 114364683 A CN114364683 A CN 114364683A
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王喆
潜安然
李德亮
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Shanghai Longwood Biopharmaceuticals Co Ltd
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Shanghai Longwood Biopharmaceuticals Co Ltd
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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Abstract

本发明提供了一种芳香杂环衍生物作为免疫调节剂的制备及其应用，具体地，本发明提供了一种如下式I所示的化合物，或其光学异构体、水合物、溶剂合物，或其药学上可接受的盐；其中，各基团的定义如说明书中所述。所述的式I化合物可以用于治疗与PD‑1/PD‑L1信号通路有关的疾病。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN202080063272.XA 2019-09-09 2020-09-09 芳香杂环衍生物作为免疫调节剂的制备及其应用 Pending CN114364683A (zh)

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CN2019108488285 2019-09-09
CN201910848828.5A CN112457329B (zh) 2019-09-09 2019-09-09 芳香杂环衍生物作为免疫调节剂的制备及其应用
PCT/CN2020/114263 WO2021047555A1 (zh) 2019-09-09 2020-09-09 芳香杂环衍生物作为免疫调节剂的制备及其应用

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CN202080063272.XA Pending CN114364683A (zh) 2019-09-09 2020-09-09 芳香杂环衍生物作为免疫调节剂的制备及其应用

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112457329B (zh) * 2019-09-09 2023-08-25 上海长森药业有限公司 芳香杂环衍生物作为免疫调节剂的制备及其应用

Citations (5)

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WO2018119221A1 (en) * 2016-12-22 2018-06-28 Incyte Corporation Pyridine derivatives as immunomodulators
WO2018119266A1 (en) * 2016-12-22 2018-06-28 Incyte Corporation Benzooxazole derivatives as immunomodulators
WO2018195321A1 (en) * 2017-04-20 2018-10-25 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
CN111039942A (zh) * 2018-10-12 2020-04-21 上海长森药业有限公司 含氮杂环类化合物，及其制备方法、药物组合物和应用
CN112457329A (zh) * 2019-09-09 2021-03-09 上海长森药业有限公司 芳香杂环衍生物作为免疫调节剂的制备及其应用

Family Cites Families (3)

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HUE060233T2 (hu) * 2016-12-22 2023-02-28 Incyte Corp Tetrahidro imidazo[4,5-c]piridin-származékok mint a PD-L1 internalizációját indukáló szerek
AU2019301811B2 (en) * 2018-07-13 2022-05-26 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
JP7158577B2 (ja) * 2018-10-24 2022-10-21 ギリアード サイエンシーズ， インコーポレイテッド Ｐｄ－１／ｐｄ－ｌ１阻害剤

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018119221A1 (en) * 2016-12-22 2018-06-28 Incyte Corporation Pyridine derivatives as immunomodulators
WO2018119266A1 (en) * 2016-12-22 2018-06-28 Incyte Corporation Benzooxazole derivatives as immunomodulators
WO2018195321A1 (en) * 2017-04-20 2018-10-25 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
CN111039942A (zh) * 2018-10-12 2020-04-21 上海长森药业有限公司 含氮杂环类化合物，及其制备方法、药物组合物和应用
CN112457329A (zh) * 2019-09-09 2021-03-09 上海长森药业有限公司 芳香杂环衍生物作为免疫调节剂的制备及其应用

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