CN114364673A - 含三环结构的芳香杂环化合物，及其制备方法和应用 - Google Patents

含三环结构的芳香杂环化合物，及其制备方法和应用 Download PDF

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Publication number
CN114364673A
CN114364673A CN202080063270.0A CN202080063270A CN114364673A CN 114364673 A CN114364673 A CN 114364673A CN 202080063270 A CN202080063270 A CN 202080063270A CN 114364673 A CN114364673 A CN 114364673A
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membered
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王喆
白海云
李德亮
潜安然
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Shanghai Longwood Biopharmaceuticals Co Ltd
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Shanghai Longwood Biopharmaceuticals Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
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  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

一种含三环结构的芳香杂环化合物，及其制备方法和应用，具体地，一种如下式I所示的化合物，或其光学异构体、水合物、溶剂合物，或其药学上可接受的盐。式I化合物可以用于治疗与PD‑1/PD‑L1信号通路有关的疾病。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN202080063270.0A 2019-09-09 2020-09-09 含三环结构的芳香杂环化合物，及其制备方法和应用 Pending CN114364673A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2019108488957 2019-09-09
CN201910848895.7A CN112457305A (zh) 2019-09-09 2019-09-09 含三环结构的芳香杂环化合物，及其制备方法和应用
PCT/CN2020/114261 WO2021047553A1 (zh) 2019-09-09 2020-09-09 含三环结构的芳香杂环化合物，及其制备方法和应用

Publications (1)

Publication Number Publication Date
CN114364673A true CN114364673A (zh) 2022-04-15

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CN202080063270.0A Pending CN114364673A (zh) 2019-09-09 2020-09-09 含三环结构的芳香杂环化合物，及其制备方法和应用

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US (1) US20220370429A1 (zh)
EP (1) EP4043457A4 (zh)
JP (1) JP2022547200A (zh)
KR (1) KR20220062051A (zh)
CN (2) CN112457305A (zh)
AU (1) AU2020346172B2 (zh)
CA (1) CA3153764A1 (zh)
MX (1) MX2022002838A (zh)
WO (1) WO2021047553A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112457305A (zh) * 2019-09-09 2021-03-09 上海长森药业有限公司 含三环结构的芳香杂环化合物，及其制备方法和应用
WO2021233454A1 (zh) * 2020-05-22 2021-11-25 上海长森药业有限公司 新型三环芳香杂环化合物，及其制备方法、药物组合物和应用
WO2024125662A1 (zh) * 2022-12-16 2024-06-20 上海长森药业有限公司 新型联芳环化合物作为免疫调节剂的制备和应用

Citations (7)

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Publication number Priority date Publication date Assignee Title
WO2018195321A1 (en) * 2017-04-20 2018-10-25 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
WO2019023575A1 (en) * 2017-07-28 2019-01-31 Chemocentryx, Inc. IMMUNOMODULATORY COMPOUNDS
CN109665968A (zh) * 2017-10-16 2019-04-23 四川科伦博泰生物医药股份有限公司 并环化合物及其制备方法和用途
CN109803651A (zh) * 2016-06-27 2019-05-24 凯莫森特里克斯股份有限公司 免疫调节剂化合物
CN110092745A (zh) * 2018-01-29 2019-08-06 广州丹康医药生物有限公司 一种含芳环的化合物及其应用
WO2019169123A1 (en) * 2018-03-01 2019-09-06 Bristol-Myers Squibb Company Compounds useful as immunomodulators
CN112457305A (zh) * 2019-09-09 2021-03-09 上海长森药业有限公司 含三环结构的芳香杂环化合物，及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9481659B2 (en) 2011-05-13 2016-11-01 Celgene International Ii Sàrl Selective heterocyclic sphingosine 1 phosphate receptor modulators
US10336709B2 (en) 2015-10-02 2019-07-02 Abide Therapeutics, Inc Lp-PLA2 inhibitors

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109803651A (zh) * 2016-06-27 2019-05-24 凯莫森特里克斯股份有限公司 免疫调节剂化合物
WO2018195321A1 (en) * 2017-04-20 2018-10-25 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
WO2019023575A1 (en) * 2017-07-28 2019-01-31 Chemocentryx, Inc. IMMUNOMODULATORY COMPOUNDS
CN109665968A (zh) * 2017-10-16 2019-04-23 四川科伦博泰生物医药股份有限公司 并环化合物及其制备方法和用途
CN110092745A (zh) * 2018-01-29 2019-08-06 广州丹康医药生物有限公司 一种含芳环的化合物及其应用
WO2019169123A1 (en) * 2018-03-01 2019-09-06 Bristol-Myers Squibb Company Compounds useful as immunomodulators
CN112457305A (zh) * 2019-09-09 2021-03-09 上海长森药业有限公司 含三环结构的芳香杂环化合物，及其制备方法和应用

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JP2022547200A (ja) 2022-11-10
EP4043457A1 (en) 2022-08-17
CN112457305A (zh) 2021-03-09
EP4043457A4 (en) 2023-08-23
WO2021047553A1 (zh) 2021-03-18
AU2020346172B2 (en) 2024-04-18
MX2022002838A (es) 2022-04-26
CA3153764A1 (en) 2021-03-18
US20220370429A1 (en) 2022-11-24
KR20220062051A (ko) 2022-05-13
AU2020346172A1 (en) 2022-04-28

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