BRPI0612138B8 - compostos éter aminocicloexílicos e método para fazer os mesmos - Google Patents
compostos éter aminocicloexílicos e método para fazer os mesmosInfo
- Publication number
- BRPI0612138B8 BRPI0612138B8 BRPI0612138A BRPI0612138A BRPI0612138B8 BR PI0612138 B8 BRPI0612138 B8 BR PI0612138B8 BR PI0612138 A BRPI0612138 A BR PI0612138A BR PI0612138 A BRPI0612138 A BR PI0612138A BR PI0612138 B8 BRPI0612138 B8 BR PI0612138B8
- Authority
- BR
- Brazil
- Prior art keywords
- formula
- ether compounds
- making
- aminocyclohexyl ether
- compounds
- Prior art date
Links
- MHWUUEBDNXLKJI-UHFFFAOYSA-N 1-(1-aminocyclohexyl)oxycyclohexan-1-amine Chemical class C1CCCCC1(N)OC1(N)CCCCC1 MHWUUEBDNXLKJI-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000013522 chelant Substances 0.000 abstract 1
- -1 clathrate Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/14—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69098905P | 2005-06-15 | 2005-06-15 | |
| US60/690,989 | 2005-06-15 | ||
| US74824805P | 2005-12-07 | 2005-12-07 | |
| US60/748,248 | 2005-12-07 | ||
| PCT/US2006/023668 WO2006138673A2 (en) | 2005-06-15 | 2006-06-15 | Synthetic processes for the preparation of aminocyclohexyl ether compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0612138A2 BRPI0612138A2 (pt) | 2010-10-19 |
| BRPI0612138B1 BRPI0612138B1 (pt) | 2021-03-16 |
| BRPI0612138B8 true BRPI0612138B8 (pt) | 2021-05-25 |
Family
ID=37395936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0612138A BRPI0612138B8 (pt) | 2005-06-15 | 2006-06-15 | compostos éter aminocicloexílicos e método para fazer os mesmos |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US7754897B2 (enExample) |
| EP (1) | EP1915340B1 (enExample) |
| JP (1) | JP5159616B2 (enExample) |
| BR (1) | BRPI0612138B8 (enExample) |
| CA (1) | CA2612375C (enExample) |
| MX (2) | MX2007016248A (enExample) |
| WO (1) | WO2006138673A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7705036B2 (en) * | 2004-04-01 | 2010-04-27 | Cardiome Pharma Corp. | Deuterated aminocyclohexyl ether compounds and processes for preparing same |
| CA2561733A1 (en) * | 2004-04-01 | 2005-10-13 | Cardiome Pharma Corp. | Pegylated ion channel modulating compounds |
| US8692002B2 (en) | 2004-11-18 | 2014-04-08 | Cardiome Pharma Corp. | Synthetic process for aminocyclohexyl ether compounds |
| JP5159616B2 (ja) | 2005-06-15 | 2013-03-06 | カーディオム ファーマ コーポレイション | アミノシクロヘキシルエーテル化合物の調製のための合成プロセス |
| US20080312309A1 (en) * | 2007-05-04 | 2008-12-18 | Cardiome Pharma Corp. | Controlled release oral formulations of ion channel modulating compounds and related methods for preventing arrhythmia |
| EP2445504A4 (en) | 2009-06-23 | 2012-11-14 | Medicinova Inc | 2-AMINO-1- (2-ISOPROPYLPYRAZOLO [1,5-A] PYRIDINE-3-YL) PROPAN-1-ONE ENANTIOMER COMPOSITIONS AND METHODS THEREOF |
| US8932836B2 (en) | 2010-08-16 | 2015-01-13 | Codexis, Inc. | Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine |
| WO2012024100A2 (en) | 2010-08-16 | 2012-02-23 | Merck Sharp & Dohme Corp. | Process for preparing aminocyclohexyl ether compounds |
| CN115778934A (zh) | 2012-01-20 | 2023-03-14 | 德玛公司 | 经取代的己糖醇类用于治疗恶性肿瘤的用途 |
| WO2013142817A2 (en) | 2012-03-23 | 2013-09-26 | Dennis Brown | Compositions and methods to improve the therapeutic benefit of indirubin and analogs thereof, including meisoindigo |
| US20150182490A1 (en) | 2012-06-26 | 2015-07-02 | Del Mar Pharmaceuticals | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
| CN105492011A (zh) | 2013-04-08 | 2016-04-13 | 丹尼斯·M·布朗 | 不理想给药化学化合物的治疗增效 |
| KR102359214B1 (ko) | 2014-04-04 | 2022-02-07 | 델 마 파마슈티컬스 | 폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체 |
| NZ792518A (en) | 2016-10-06 | 2023-04-28 | Orbus Therapeutics Inc | Formulations for administration of eflornithine |
| WO2018200381A1 (en) | 2017-04-25 | 2018-11-01 | Temple Otorongo Llc | Pharmaceutical composition comprising tryptophan and phyllokinin derivative for use in treating psychiatric and psychological conditions |
| US12605349B2 (en) | 2024-09-05 | 2026-04-21 | Orbus Therapeutics, Inc. | Methods of treating grade 3 astrocytoma |
Family Cites Families (37)
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|---|---|---|---|---|
| CA710830A (en) | 1965-06-01 | Moser Paul | Disodium and calcium salt of the calcium complex of 2-aminocyclohexyl 2'-aminoethyl ether-n,n,n',n'-tetraacetic acid | |
| DE2860703D1 (en) | 1977-12-01 | 1981-08-20 | Bayer Ag | Benzyl ethers of cyclic 1,2-diols, methods for their preparation and their use as herbicides |
| DE2753556A1 (de) | 1977-12-01 | 1979-06-07 | Bayer Ag | Benzylaether von cyclischen 1,2-diolen, verfahren zu ihrer herstellung sowie ihre verwendung als herbizide |
| US4684728A (en) | 1979-01-12 | 1987-08-04 | Bayer Aktiengesellschaft | Solubilizing biologically active compounds with reactive hydrogen atoms |
| DE3871343D1 (de) | 1987-11-25 | 1992-06-25 | American Cyanamid Co | System fuer die verzoegerte (kontrollierte) freisetzung von substituierten dihydropyridin-calciumantagonisten. |
| DE3836917A1 (de) * | 1988-10-29 | 1990-05-17 | Bayer Ag | Verfahren zur herstellung von cyclopropylamin |
| US5215919A (en) * | 1991-02-25 | 1993-06-01 | Takeda Chemical Industries, Ltd. | Process for producing optically active 2-hydroxycycloalkanecarboxylic acid esters using microbially derived reductase |
| KR100477070B1 (ko) * | 1994-03-25 | 2006-04-21 | 이소테크니카 인코포레이티드 | 중수소화작용에의한의약품의효능강화법 |
| JP3789938B2 (ja) | 1995-02-03 | 2006-06-28 | ビーエーエスエフ アクチェンゲゼルシャフト | 酵素触媒作用アシル化による１級及び２級のヘテロ原子置換アミンのラセミ体分割 |
| DE19523868A1 (de) * | 1995-06-30 | 1997-01-02 | Huels Chemische Werke Ag | Verfahren zur Herstellung von Cyclopropanamin |
| PL189698B1 (pl) | 1996-03-12 | 2005-09-30 | Pg Txl Co | Kompozycja farmaceutyczna zawierająca lek przeciwnowotworowy i jej zastosowania |
| US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
| US6342507B1 (en) * | 1997-09-05 | 2002-01-29 | Isotechnika, Inc. | Deuterated rapamycin compounds, method and uses thereof |
| DE69832984T2 (de) * | 1997-10-08 | 2006-09-21 | Isotechnika, Inc., Edmonton | DEUTERIERtE und undeuterierte CYCLOSPORIN-ANALOGA UND IHRE VERWENDUNG ALS IMMUNMODULIERENDE AGENtIEN |
| CN1217918C (zh) | 1998-04-01 | 2005-09-07 | 卡迪欧梅制药公司 | 氨基环己基醚化合物和其用途 |
| US6264975B1 (en) | 1998-10-20 | 2001-07-24 | The University Of North Carolina At Chapel Hill | Methods of hydrating mucosal surfaces |
| AU2899400A (en) * | 1999-03-04 | 2000-09-21 | Nortran Pharmaceuticals Inc. | Aminocycloalkyl cinnamide compounds for arrhythmia and as analgesics and anesthetics |
| CA2311483A1 (en) | 2000-06-12 | 2001-12-12 | Gregory N Beatch | IMIDAZO [1,2-A] PYRIDINIC ETHERS AND USES THEREOF |
| CA2413702A1 (en) * | 2000-06-28 | 2002-01-03 | Teva Pharmaceuticals Industries Ltd. | Carvedilol |
| US7524879B2 (en) | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7057053B2 (en) | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| EP1291336A3 (en) | 2001-09-05 | 2003-10-08 | Solvias AG | Preparation of optically active alpha-hydroxyethers |
| JP2003250577A (ja) * | 2001-12-27 | 2003-09-09 | Sumitomo Chem Co Ltd | ２‐ヒドロキシシクロアルカンカルボン酸エステルの製造方法 |
| WO2003105756A2 (en) | 2002-06-14 | 2003-12-24 | Johnson Matthey Pharmaceutical Materials, Inc. | Stereoselective synthesis of 1,2-disubstituted cycloalkyls |
| WO2004014973A2 (en) | 2002-08-13 | 2004-02-19 | Sirus Pharmaceuticals Ltd | Biodegradable polymer |
| US7056540B2 (en) * | 2002-10-29 | 2006-06-06 | Council Of Scientific And Industrial Research | Enzymatic process for the preparation of optically active alcohols from ketones using tuberous root Daucus carota |
| DE60305200T2 (de) | 2003-05-02 | 2007-05-10 | Cardiome Pharma Corp. | Aminocyclohexylether-verbindungen und deren verwendung |
| CA2524034A1 (en) | 2003-05-02 | 2004-11-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
| WO2005016242A2 (en) | 2003-06-04 | 2005-02-24 | Cardiome Pharma Corp. | Synthetic process for trans-aminocyclohexyl ether compounds |
| US7345087B2 (en) * | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| WO2005097087A2 (en) | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
| CA2561819A1 (en) * | 2004-04-01 | 2005-12-01 | Cardiome Pharma Corp. | Prodrugs of ion channel modulating compounds and uses thereof |
| US7705036B2 (en) * | 2004-04-01 | 2010-04-27 | Cardiome Pharma Corp. | Deuterated aminocyclohexyl ether compounds and processes for preparing same |
| CA2561733A1 (en) * | 2004-04-01 | 2005-10-13 | Cardiome Pharma Corp. | Pegylated ion channel modulating compounds |
| US8692002B2 (en) * | 2004-11-18 | 2014-04-08 | Cardiome Pharma Corp. | Synthetic process for aminocyclohexyl ether compounds |
| JP5159616B2 (ja) | 2005-06-15 | 2013-03-06 | カーディオム ファーマ コーポレイション | アミノシクロヘキシルエーテル化合物の調製のための合成プロセス |
| US20090069404A1 (en) | 2007-09-09 | 2009-03-12 | Protia, Llc | Deuterium-enriched vernakalant |
-
2006
- 2006-06-15 JP JP2008517192A patent/JP5159616B2/ja not_active Expired - Lifetime
- 2006-06-15 MX MX2007016248A patent/MX2007016248A/es active IP Right Grant
- 2006-06-15 EP EP06785062.8A patent/EP1915340B1/en not_active Expired - Lifetime
- 2006-06-15 CA CA2612375A patent/CA2612375C/en not_active Expired - Lifetime
- 2006-06-15 US US11/455,280 patent/US7754897B2/en active Active
- 2006-06-15 WO PCT/US2006/023668 patent/WO2006138673A2/en not_active Ceased
- 2006-06-15 MX MX2014009461A patent/MX346530B/es unknown
- 2006-06-15 BR BRPI0612138A patent/BRPI0612138B8/pt active IP Right Grant
-
2010
- 2010-02-19 US US12/709,355 patent/US8080673B2/en not_active Expired - Lifetime
-
2011
- 2011-11-16 US US13/297,846 patent/US8344162B2/en not_active Expired - Lifetime
-
2012
- 2012-09-12 US US13/612,539 patent/US8618311B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0612138B1 (pt) | 2021-03-16 |
| US8344162B2 (en) | 2013-01-01 |
| BRPI0612138A2 (pt) | 2010-10-19 |
| MX346530B (es) | 2017-03-22 |
| CA2612375C (en) | 2013-08-06 |
| JP5159616B2 (ja) | 2013-03-06 |
| JP2008543874A (ja) | 2008-12-04 |
| EP1915340B1 (en) | 2013-08-07 |
| US20070015924A1 (en) | 2007-01-18 |
| US8618311B2 (en) | 2013-12-31 |
| EP1915340A2 (en) | 2008-04-30 |
| WO2006138673A3 (en) | 2007-03-22 |
| US20120271057A9 (en) | 2012-10-25 |
| CA2612375A1 (en) | 2006-12-28 |
| MX2007016248A (es) | 2008-03-07 |
| US20130090483A1 (en) | 2013-04-11 |
| US20120065408A1 (en) | 2012-03-15 |
| WO2006138673A2 (en) | 2006-12-28 |
| US8080673B2 (en) | 2011-12-20 |
| US7754897B2 (en) | 2010-07-13 |
| US20100217014A1 (en) | 2010-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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| B25A | Requested transfer of rights approved |
Owner name: CORREVIO INTERNATIONAL SARL (CH) |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 16/03/2021, OBSERVADAS AS CONDICOES LEGAIS. |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/06/2006 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |