JP2007531731A5 - - Google Patents
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- Publication number
- JP2007531731A5 JP2007531731A5 JP2007506319A JP2007506319A JP2007531731A5 JP 2007531731 A5 JP2007531731 A5 JP 2007531731A5 JP 2007506319 A JP2007506319 A JP 2007506319A JP 2007506319 A JP2007506319 A JP 2007506319A JP 2007531731 A5 JP2007531731 A5 JP 2007531731A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- formula
- independently
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*C1=CC=CC=I1 Chemical compound C*C1=CC=CC=I1 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55940504P | 2004-04-01 | 2004-04-01 | |
| US60/559,405 | 2004-04-01 | ||
| US58699204P | 2004-07-08 | 2004-07-08 | |
| US60/586,992 | 2004-07-08 | ||
| PCT/US2005/011124 WO2005094897A2 (en) | 2004-04-01 | 2005-03-31 | Pegylated ion channel modulating compounds |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008088707A Division JP2008179653A (ja) | 2004-04-01 | 2008-03-28 | Peg化イオンチャネル調節化合物 |
| JP2008088708A Division JP2008214353A (ja) | 2004-04-01 | 2008-03-28 | Peg化イオンチャネル調節化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007531731A JP2007531731A (ja) | 2007-11-08 |
| JP2007531731A5 true JP2007531731A5 (enExample) | 2008-05-15 |
| JP4991037B2 JP4991037B2 (ja) | 2012-08-01 |
Family
ID=34972985
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007506547A Expired - Fee Related JP4954864B2 (ja) | 2004-04-01 | 2005-03-31 | イオンチャネル調節化合物のプロドラッグおよびその使用 |
| JP2007506319A Expired - Fee Related JP4991037B2 (ja) | 2004-04-01 | 2005-03-31 | イオンチャネル調節化合物を含む薬物結合体 |
| JP2008088708A Pending JP2008214353A (ja) | 2004-04-01 | 2008-03-28 | Peg化イオンチャネル調節化合物 |
| JP2008088707A Pending JP2008179653A (ja) | 2004-04-01 | 2008-03-28 | Peg化イオンチャネル調節化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007506547A Expired - Fee Related JP4954864B2 (ja) | 2004-04-01 | 2005-03-31 | イオンチャネル調節化合物のプロドラッグおよびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008088708A Pending JP2008214353A (ja) | 2004-04-01 | 2008-03-28 | Peg化イオンチャネル調節化合物 |
| JP2008088707A Pending JP2008179653A (ja) | 2004-04-01 | 2008-03-28 | Peg化イオンチャネル調節化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7786119B2 (enExample) |
| EP (1) | EP1729814A2 (enExample) |
| JP (4) | JP4954864B2 (enExample) |
| CA (1) | CA2561733A1 (enExample) |
| MX (1) | MXPA06011420A (enExample) |
| WO (1) | WO2005094897A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090041841A1 (en) * | 2003-05-02 | 2009-02-12 | Cardiome Pharma Corp. | Controlled release tablet formulations for the prevention of arrhythmias |
| WO2005097087A2 (en) * | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
| US7705036B2 (en) | 2004-04-01 | 2010-04-27 | Cardiome Pharma Corp. | Deuterated aminocyclohexyl ether compounds and processes for preparing same |
| US7977373B2 (en) | 2004-04-01 | 2011-07-12 | Cardiome Pharma Corp. | Prodrugs of ion channel modulating compounds and uses thereof |
| US7754897B2 (en) * | 2005-06-15 | 2010-07-13 | Cardiome Pharma Corp. | Synthetic processes for the preparation of aminocyclohexyl ether compounds |
| MXPA06011420A (es) * | 2004-04-01 | 2007-04-20 | Cardiome Pharma Corp | Compuestos pegilados de modulacion de canal de iones. |
| US8692002B2 (en) | 2004-11-18 | 2014-04-08 | Cardiome Pharma Corp. | Synthetic process for aminocyclohexyl ether compounds |
| JP2007131597A (ja) * | 2005-11-11 | 2007-05-31 | Toray Fine Chemicals Co Ltd | ベンジルオキシピロリジン誘導体の製造方法 |
| JP5004067B2 (ja) * | 2005-10-31 | 2012-08-22 | 東レ・ファインケミカル株式会社 | ベンジルオキシ含窒素環状化合物の製造法 |
| CA2627502C (en) * | 2005-10-31 | 2014-04-01 | Toray Fine Chemicals Co., Ltd. | Process for production of benzyloxypyrrolidine derivative, and process for production of hydrochloride salt powder of optically active benzyloxypyrrolidine derivative |
| JP5004073B2 (ja) * | 2006-06-13 | 2012-08-22 | 東レ・ファインケミカル株式会社 | 光学活性ベンジルオキシピロリジン誘導体塩酸塩粉体及びその製造法 |
| US9782488B2 (en) | 2007-03-12 | 2017-10-10 | Nektar Therapeutics | Oligomer-beta blocker conjugates |
| WO2009032286A2 (en) * | 2007-09-06 | 2009-03-12 | Nektar Therapeutics Al, Corporation | Oligomer-calcium channel blocker conjugates |
| US20110009446A1 (en) * | 2008-01-11 | 2011-01-13 | Nektar Therapeutics | Oligomer-guanidine class conjugates |
| BRPI0919920A2 (pt) * | 2008-10-22 | 2016-02-16 | Acucela Inc | compostos para tratamento de doenças e desordens oftálmicas |
| CA2754395A1 (en) * | 2009-04-03 | 2010-10-07 | The University Of Toledo | A peg-albumin composition having at least one protected thiol region as a platform for medications |
| US8993614B2 (en) | 2012-03-15 | 2015-03-31 | F. Hoffmann-La Roche Ag | Substituted pyrrolidine-2-carboxamides |
| US9974759B2 (en) | 2013-05-31 | 2018-05-22 | Indiana University Research And Technology Corporation | Beta 2 adrenoceptor antagonists for treating orthostatic hypotension |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4684728A (en) * | 1979-01-12 | 1987-08-04 | Bayer Aktiengesellschaft | Solubilizing biologically active compounds with reactive hydrogen atoms |
| IT1145362B (it) * | 1980-03-06 | 1986-11-05 | Sigma Tau Ind Farmaceuti | Classe di acil-derivati della carnitina procedimento per la loro preparazione e loro uso terapeutico |
| EP0317780B1 (en) | 1987-11-25 | 1992-05-20 | American Cyanamid Company | Sustained (controlled) release delivery system for substituted dihydropyridine calcium channel blockers |
| US5160734A (en) * | 1987-11-25 | 1992-11-03 | American Cyanamid Company | Sustained release delivery system for substituted dihydropyridine calcium channel blockers |
| US6517824B1 (en) * | 1990-05-14 | 2003-02-11 | University Of Medicine & Denistry Of New Jersey | Polymer compositions comprising antifibrotic agents, and methods of treatment, pharmaceutical compositions, and methods of preparation therefor |
| US20030186869A1 (en) * | 1990-05-14 | 2003-10-02 | George Poiani | Polymer compositions comprising antifibrotic agents, and methods of treatment, pharmaceutical compositions, and methods of preparation therefor |
| US5219564A (en) * | 1990-07-06 | 1993-06-15 | Enzon, Inc. | Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon |
| US5244889A (en) | 1991-11-26 | 1993-09-14 | Ciba-Geigy Corporation | Certain macrocyclic lactam derivatives |
| US6217869B1 (en) * | 1992-06-09 | 2001-04-17 | Neorx Corporation | Pretargeting methods and compounds |
| US5298492A (en) | 1992-08-04 | 1994-03-29 | Schering Corporation | Diamino acid derivatives as antihypertensives |
| US5681811A (en) * | 1993-05-10 | 1997-10-28 | Protein Delivery, Inc. | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
| US6191105B1 (en) * | 1993-05-10 | 2001-02-20 | Protein Delivery, Inc. | Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin |
| KR0156780B1 (ko) | 1993-06-11 | 1998-11-16 | 나이토 하루오 | 아미노산 유도체 |
| WO1995008544A1 (en) * | 1993-09-24 | 1995-03-30 | The University Of British Columbia | Aminocyclohexylesters and uses thereof |
| WO1995026325A2 (en) * | 1994-03-25 | 1995-10-05 | Isotechnika Inc. | Enhancement of the efficacy of drugs by deuteration |
| US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
| EP0932399B1 (en) | 1996-03-12 | 2006-01-04 | PG-TXL Company, L.P. | Water soluble paclitaxel prodrugs |
| US6214966B1 (en) * | 1996-09-26 | 2001-04-10 | Shearwater Corporation | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution |
| WO1998019682A1 (en) | 1996-11-01 | 1998-05-14 | Magainin Pharmaceuticals Inc. | Certain aminosterol compounds and uses therefor |
| EP0884325A1 (en) | 1997-04-24 | 1998-12-16 | Akzo Nobel N.V. | Thrombin inhibitors containing a peptidyl heterocycle |
| US6342507B1 (en) * | 1997-09-05 | 2002-01-29 | Isotechnika, Inc. | Deuterated rapamycin compounds, method and uses thereof |
| DK0991660T3 (da) * | 1997-10-08 | 2006-02-13 | Isotechnika Inc | Deuterede og udeuterede cyclosporinanaloger og deres anvendelse som immunmodulerende midler |
| PT1087934E (pt) * | 1998-04-01 | 2004-07-30 | Cardiome Pharma Corp | Compostos de eter de aminociclo-hexilo e as suas utilizacoes |
| WO1999064045A1 (en) * | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Novel therapeutic agents for membrane transporters |
| JP2002527459A (ja) * | 1998-10-20 | 2002-08-27 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 粘膜表面を水和する方法 |
| WO2000047547A2 (en) | 1999-02-12 | 2000-08-17 | Nortran Pharmaceuticals Inc. | Cycloalkyl amine compounds and uses thereof |
| BR0010151A (pt) | 1999-04-29 | 2002-06-11 | Merck Patent Gmbh | Inibidores do sistema de clivagem de glicina como antipsicóticos potenciais |
| CA2311483A1 (en) | 2000-06-12 | 2001-12-12 | Gregory N Beatch | IMIDAZO [1,2-A] PYRIDINIC ETHERS AND USES THEREOF |
| WO2002028412A1 (en) | 2000-10-05 | 2002-04-11 | Zealand Pharmaceuticals A/S | Novel use of peptide |
| JP2004509949A (ja) * | 2000-09-26 | 2004-04-02 | ザ ユニバーシティ オブ アリゾナ ファウンデーション | 化合物および癌またはウイルス性感染症治療におけるその使用方法 |
| JP2002105067A (ja) | 2000-09-28 | 2002-04-10 | Teijin Ltd | 2−フェニルチアゾール誘導体、およびそれを有効成分とする医薬組成物 |
| US7057053B2 (en) * | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7524879B2 (en) * | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| BR0211318B1 (pt) * | 2001-07-02 | 2010-12-14 | mÉtodo de interligaÇço de uma coluna de ascensço com uma tubulaÇço de fluxo e conjunto para conexço de uma coluna de ascensço. | |
| US6623729B2 (en) * | 2001-07-09 | 2003-09-23 | Korea Advanced Institute Of Science And Technology | Process for preparing sustained release micelle employing conjugate of anticancer drug and biodegradable polymer |
| JP2005501052A (ja) * | 2001-07-31 | 2005-01-13 | イムノメディクス, インコーポレイテッド | ポリマー送達系 |
| JP2003113084A (ja) | 2001-10-02 | 2003-04-18 | Mitsubishi Pharma Corp | 肺高血圧症の治療及び/または予防薬 |
| IL147953A (en) | 2002-02-01 | 2008-04-13 | Meir Bialer | Derivatives and pharmaceutical compositions of n-hydroxymethyl tetramethylcyclopropyl- |
| TW200407310A (en) | 2002-06-07 | 2004-05-16 | Glaxo Group Ltd | Compounds |
| BR0312176A (pt) * | 2002-06-21 | 2005-04-05 | Suven Life Sciences Ltd | Composto, composição farmaceutica, uso de um composto, método para o tratamento, método para reduzir a morbidez e a mortalidade associadas com o excesso de peso, processo para a preparação de um composto, novo intermediario e processo para a preparação de um novo intermediario |
| MXPA04012802A (es) * | 2002-06-28 | 2005-04-19 | Idenix Cayman Ltd | Ester 2'-c-metil-3'-o-l-valina de ribofuranosil-citidina para el tratamiento de infecciones por flaviviridae. |
| WO2004014973A2 (en) | 2002-08-13 | 2004-02-19 | Sirus Pharmaceuticals Ltd | Biodegradable polymer |
| WO2004082585A2 (en) | 2003-03-20 | 2004-09-30 | Sirus Pharmaceuticals Ltd | Water-soluble conjugates of phenytoin |
| WO2004098525A2 (en) | 2003-05-02 | 2004-11-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
| CA2524323C (en) * | 2003-05-02 | 2012-05-15 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| KR100495009B1 (ko) * | 2003-07-02 | 2005-06-14 | 삼성전자주식회사 | 화상형성 장치의 전사벨트 텐션 자동 인가 장치 |
| WO2005018635A2 (en) | 2003-08-07 | 2005-03-03 | Cardiome Pharma Corp. | Ion channel modulating activity i |
| WO2005079861A2 (en) * | 2004-02-13 | 2005-09-01 | Safeway Investments Ltd. | Polymeric water soluble prodrugs |
| US7754897B2 (en) * | 2005-06-15 | 2010-07-13 | Cardiome Pharma Corp. | Synthetic processes for the preparation of aminocyclohexyl ether compounds |
| US7977373B2 (en) * | 2004-04-01 | 2011-07-12 | Cardiome Pharma Corp. | Prodrugs of ion channel modulating compounds and uses thereof |
| US7705036B2 (en) * | 2004-04-01 | 2010-04-27 | Cardiome Pharma Corp. | Deuterated aminocyclohexyl ether compounds and processes for preparing same |
| MXPA06011420A (es) * | 2004-04-01 | 2007-04-20 | Cardiome Pharma Corp | Compuestos pegilados de modulacion de canal de iones. |
| WO2005097203A2 (en) | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Serum protein conjugates of ion channel modulating compounds and uses thereof |
| US7845611B1 (en) * | 2007-11-16 | 2010-12-07 | Sholander Alfred M | Door operated page turner device, system and method for books |
-
2005
- 2005-03-31 MX MXPA06011420A patent/MXPA06011420A/es unknown
- 2005-03-31 EP EP05763506A patent/EP1729814A2/en not_active Withdrawn
- 2005-03-31 US US11/547,419 patent/US7786119B2/en not_active Expired - Lifetime
- 2005-03-31 WO PCT/US2005/011124 patent/WO2005094897A2/en not_active Ceased
- 2005-03-31 CA CA002561733A patent/CA2561733A1/en not_active Abandoned
- 2005-03-31 JP JP2007506547A patent/JP4954864B2/ja not_active Expired - Fee Related
- 2005-03-31 JP JP2007506319A patent/JP4991037B2/ja not_active Expired - Fee Related
-
2008
- 2008-03-28 JP JP2008088708A patent/JP2008214353A/ja active Pending
- 2008-03-28 JP JP2008088707A patent/JP2008179653A/ja active Pending
-
2010
- 2010-07-07 US US12/831,804 patent/US20100273724A1/en not_active Abandoned
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