JP2007531766A5 - - Google Patents
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- Publication number
- JP2007531766A5 JP2007531766A5 JP2007506547A JP2007506547A JP2007531766A5 JP 2007531766 A5 JP2007531766 A5 JP 2007531766A5 JP 2007506547 A JP2007506547 A JP 2007506547A JP 2007506547 A JP2007506547 A JP 2007506547A JP 2007531766 A5 JP2007531766 A5 JP 2007531766A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- hydrogen
- formula
- cyclohexane
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000001257 hydrogen Substances 0.000 claims 61
- 229910052739 hydrogen Inorganic materials 0.000 claims 61
- -1 Nonan-3-yl Chemical group 0.000 claims 58
- 150000002431 hydrogen Chemical class 0.000 claims 52
- 239000000651 prodrug Substances 0.000 claims 39
- 229940002612 prodrug Drugs 0.000 claims 39
- 229910052760 oxygen Inorganic materials 0.000 claims 23
- 229910052717 sulfur Inorganic materials 0.000 claims 21
- 229910052757 nitrogen Inorganic materials 0.000 claims 20
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 16
- 125000004423 acyloxy group Chemical group 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 16
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 14
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 14
- 239000001301 oxygen Substances 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 13
- 125000006828 (C2-C7) alkoxycarbonyl group Chemical group 0.000 claims 12
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 12
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 12
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 12
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 12
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 12
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 12
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 12
- 229910052794 bromium Inorganic materials 0.000 claims 12
- 229910052799 carbon Inorganic materials 0.000 claims 12
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 12
- 239000000460 chlorine Substances 0.000 claims 12
- 229910052801 chlorine Inorganic materials 0.000 claims 12
- 239000011737 fluorine Substances 0.000 claims 12
- 229910052731 fluorine Inorganic materials 0.000 claims 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 12
- HNQIVZYLYMDVSB-UHFFFAOYSA-N methanesulfonimidic acid Chemical compound CS(N)(=O)=O HNQIVZYLYMDVSB-UHFFFAOYSA-N 0.000 claims 12
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 12
- 239000011593 sulfur Substances 0.000 claims 12
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 12
- 108090000862 Ion Channels Proteins 0.000 claims 11
- 102000004310 Ion Channels Human genes 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 8
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 8
- 125000005842 heteroatom Chemical group 0.000 claims 8
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 8
- 125000006413 ring segment Chemical group 0.000 claims 8
- 125000003003 spiro group Chemical group 0.000 claims 8
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 6
- 239000012453 solvate Substances 0.000 claims 6
- 125000006699 (C1-C3) hydroxyalkyl group Chemical group 0.000 claims 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 125000004122 cyclic group Chemical group 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 4
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 4
- 229940126062 Compound A Drugs 0.000 claims 3
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- BXQJYIXHTMSDRB-UHFFFAOYSA-N cyclohexane;hydrochloride Chemical compound Cl.C1CCCCC1 BXQJYIXHTMSDRB-UHFFFAOYSA-N 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 206010003119 arrhythmia Diseases 0.000 claims 2
- 230000006793 arrhythmia Effects 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 2
- 239000002207 metabolite Substances 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- DFVBVSNZKYWCMO-UKOKCHKQSA-N 1-[(1s,2s)-2-(2,2-diphenylethoxy)cyclohexyl]pyrrolidin-3-one;hydrochloride Chemical compound Cl.C1C(=O)CCN1[C@@H]1[C@@H](OCC(C=2C=CC=CC=2)C=2C=CC=CC=2)CCCC1 DFVBVSNZKYWCMO-UKOKCHKQSA-N 0.000 claims 1
- YAZBMYSXOHXTDS-HLRBRJAUSA-N 1-[(1s,2s)-2-(3-cyclohexylpropoxy)cyclohexyl]pyrrolidin-3-one;hydrochloride Chemical compound Cl.C1C(=O)CCN1[C@@H]1[C@@H](OCCCC2CCCCC2)CCCC1 YAZBMYSXOHXTDS-HLRBRJAUSA-N 0.000 claims 1
- XBZGZASGVCLUPR-QJHJCNPRSA-N 1-[(1s,2s)-2-[(2,6-dichlorophenyl)methoxy]cyclohexyl]pyrrolidin-3-one;hydrochloride Chemical compound Cl.ClC1=CC=CC(Cl)=C1CO[C@@H]1[C@@H](N2CC(=O)CC2)CCCC1 XBZGZASGVCLUPR-QJHJCNPRSA-N 0.000 claims 1
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 1
- NEOIOGUWEUTYIH-UHFFFAOYSA-N 3-azabicyclo[3.2.0]heptane Chemical compound C1NCC2CCC21 NEOIOGUWEUTYIH-UHFFFAOYSA-N 0.000 claims 1
- BNFSPYSVBPJHMM-QJHJCNPRSA-N 4-[(1s,2s)-2-[(2,6-dichlorophenyl)methoxy]cyclohexyl]morpholine;hydrochloride Chemical compound Cl.ClC1=CC=CC(Cl)=C1CO[C@@H]1[C@@H](N2CCOCC2)CCCC1 BNFSPYSVBPJHMM-QJHJCNPRSA-N 0.000 claims 1
- FLQPBRSXCOUBFF-YJBOKZPZSA-N C1CC[C@@H]([C@@H](C1)CCC2=CC(=C(C=C2)Cl)Cl)N3CCOCC3 Chemical compound C1CC[C@@H]([C@@H](C1)CCC2=CC(=C(C=C2)Cl)Cl)N3CCOCC3 FLQPBRSXCOUBFF-YJBOKZPZSA-N 0.000 claims 1
- NDXWYFRURWLGQQ-GJZGRUSLSA-N C1CC[C@@H]([C@H](C1)N2CCC(=O)C2)OC3=C(C=CC=C3Cl)Cl Chemical compound C1CC[C@@H]([C@H](C1)N2CCC(=O)C2)OC3=C(C=CC=C3Cl)Cl NDXWYFRURWLGQQ-GJZGRUSLSA-N 0.000 claims 1
- 101000701051 Legionella pneumophila Zinc metalloproteinase Proteins 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical group [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 239000013522 chelant Substances 0.000 claims 1
- DCKVRNILNZRZTH-UHFFFAOYSA-N cyclopentane;hydrochloride Chemical compound Cl.C1CCCC1 DCKVRNILNZRZTH-UHFFFAOYSA-N 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 1
- 0 C*c1cccc2ccccc12 Chemical compound C*c1cccc2ccccc12 0.000 description 3
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55940504P | 2004-04-01 | 2004-04-01 | |
| US60/559,405 | 2004-04-01 | ||
| US58699204P | 2004-07-08 | 2004-07-08 | |
| US60/586,992 | 2004-07-08 | ||
| PCT/US2005/010878 WO2005113011A2 (en) | 2004-04-01 | 2005-03-31 | Prodrugs of ion channel modulating compounds and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007531766A JP2007531766A (ja) | 2007-11-08 |
| JP2007531766A5 true JP2007531766A5 (enExample) | 2008-04-24 |
| JP4954864B2 JP4954864B2 (ja) | 2012-06-20 |
Family
ID=34972985
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007506547A Expired - Fee Related JP4954864B2 (ja) | 2004-04-01 | 2005-03-31 | イオンチャネル調節化合物のプロドラッグおよびその使用 |
| JP2007506319A Expired - Fee Related JP4991037B2 (ja) | 2004-04-01 | 2005-03-31 | イオンチャネル調節化合物を含む薬物結合体 |
| JP2008088708A Pending JP2008214353A (ja) | 2004-04-01 | 2008-03-28 | Ｐｅｇ化イオンチャネル調節化合物 |
| JP2008088707A Pending JP2008179653A (ja) | 2004-04-01 | 2008-03-28 | Ｐｅｇ化イオンチャネル調節化合物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007506319A Expired - Fee Related JP4991037B2 (ja) | 2004-04-01 | 2005-03-31 | イオンチャネル調節化合物を含む薬物結合体 |
| JP2008088708A Pending JP2008214353A (ja) | 2004-04-01 | 2008-03-28 | Ｐｅｇ化イオンチャネル調節化合物 |
| JP2008088707A Pending JP2008179653A (ja) | 2004-04-01 | 2008-03-28 | Ｐｅｇ化イオンチャネル調節化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7786119B2 (enExample) |
| EP (1) | EP1729814A2 (enExample) |
| JP (4) | JP4954864B2 (enExample) |
| CA (1) | CA2561733A1 (enExample) |
| MX (1) | MXPA06011420A (enExample) |
| WO (1) | WO2005094897A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090041841A1 (en) * | 2003-05-02 | 2009-02-12 | Cardiome Pharma Corp. | Controlled release tablet formulations for the prevention of arrhythmias |
| EP1729815A2 (en) | 2004-04-01 | 2006-12-13 | Cardiome Pharma Corp. | Pegylated ion channel modulating compounds |
| WO2005097087A2 (en) * | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
| US7705036B2 (en) | 2004-04-01 | 2010-04-27 | Cardiome Pharma Corp. | Deuterated aminocyclohexyl ether compounds and processes for preparing same |
| JP4954864B2 (ja) * | 2004-04-01 | 2012-06-20 | カーディオム ファーマ コーポレイション | イオンチャネル調節化合物のプロドラッグおよびその使用 |
| US8692002B2 (en) * | 2004-11-18 | 2014-04-08 | Cardiome Pharma Corp. | Synthetic process for aminocyclohexyl ether compounds |
| MX2007016248A (es) | 2005-06-15 | 2008-03-07 | Cardiome Pharma Corp | Procedimiento sintetico para la preparacion de compuestos de eter aminociclohexilico. |
| JP5004067B2 (ja) * | 2005-10-31 | 2012-08-22 | 東レ・ファインケミカル株式会社 | ベンジルオキシ含窒素環状化合物の製造法 |
| JP2007131597A (ja) * | 2005-11-11 | 2007-05-31 | Toray Fine Chemicals Co Ltd | ベンジルオキシピロリジン誘導体の製造方法 |
| JP5004073B2 (ja) * | 2006-06-13 | 2012-08-22 | 東レ・ファインケミカル株式会社 | 光学活性ベンジルオキシピロリジン誘導体塩酸塩粉体及びその製造法 |
| WO2007052578A1 (ja) * | 2005-10-31 | 2007-05-10 | Toray Fine Chemicals Co., Ltd. | ベンジルオキシピロリジン誘導体の製造方法および光学活性ベンジルオキシピロリジン誘導体塩酸塩粉体の製造法 |
| WO2008112287A1 (en) | 2007-03-12 | 2008-09-18 | Nektar Therapeutics | Oligomer-beta blocker conjugates |
| WO2009032286A2 (en) | 2007-09-06 | 2009-03-12 | Nektar Therapeutics Al, Corporation | Oligomer-calcium channel blocker conjugates |
| US20110009446A1 (en) * | 2008-01-11 | 2011-01-13 | Nektar Therapeutics | Oligomer-guanidine class conjugates |
| BRPI0919920A2 (pt) * | 2008-10-22 | 2016-02-16 | Acucela Inc | compostos para tratamento de doenças e desordens oftálmicas |
| EP2413694A4 (en) * | 2009-04-03 | 2014-02-26 | Univ Toledo | PEG-ALBUMIN COMPOSITION WITH AT LEAST ONE PROTECTED THIOL REGION AS MEDICAMENTAL PLATFORM |
| US8993614B2 (en) | 2012-03-15 | 2015-03-31 | F. Hoffmann-La Roche Ag | Substituted pyrrolidine-2-carboxamides |
| US9974759B2 (en) | 2013-05-31 | 2018-05-22 | Indiana University Research And Technology Corporation | Beta 2 adrenoceptor antagonists for treating orthostatic hypotension |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4684728A (en) * | 1979-01-12 | 1987-08-04 | Bayer Aktiengesellschaft | Solubilizing biologically active compounds with reactive hydrogen atoms |
| IT1145362B (it) | 1980-03-06 | 1986-11-05 | Sigma Tau Ind Farmaceuti | Classe di acil-derivati della carnitina procedimento per la loro preparazione e loro uso terapeutico |
| US5160734A (en) * | 1987-11-25 | 1992-11-03 | American Cyanamid Company | Sustained release delivery system for substituted dihydropyridine calcium channel blockers |
| EP0317780B1 (en) * | 1987-11-25 | 1992-05-20 | American Cyanamid Company | Sustained (controlled) release delivery system for substituted dihydropyridine calcium channel blockers |
| US5219564A (en) | 1990-07-06 | 1993-06-15 | Enzon, Inc. | Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon |
| US20030186869A1 (en) | 1990-05-14 | 2003-10-02 | George Poiani | Polymer compositions comprising antifibrotic agents, and methods of treatment, pharmaceutical compositions, and methods of preparation therefor |
| US6517824B1 (en) | 1990-05-14 | 2003-02-11 | University Of Medicine & Denistry Of New Jersey | Polymer compositions comprising antifibrotic agents, and methods of treatment, pharmaceutical compositions, and methods of preparation therefor |
| US5244889A (en) | 1991-11-26 | 1993-09-14 | Ciba-Geigy Corporation | Certain macrocyclic lactam derivatives |
| US6217869B1 (en) | 1992-06-09 | 2001-04-17 | Neorx Corporation | Pretargeting methods and compounds |
| US5298492A (en) | 1992-08-04 | 1994-03-29 | Schering Corporation | Diamino acid derivatives as antihypertensives |
| US6191105B1 (en) | 1993-05-10 | 2001-02-20 | Protein Delivery, Inc. | Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin |
| US5681811A (en) | 1993-05-10 | 1997-10-28 | Protein Delivery, Inc. | Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same |
| CA2140553A1 (en) | 1993-06-11 | 1994-12-22 | Hitoshi Oinuma | Amino acid derivative |
| EP0720605B1 (en) * | 1993-09-24 | 2001-12-19 | University Of British Columbia | Aminocyclohexylesters and uses thereof |
| KR20040068613A (ko) | 1994-03-25 | 2004-07-31 | 이소테크니카 인코포레이티드 | 중수소화된 화합물 이를 포함하는 고혈압 치료용 조성물 |
| US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
| SI0932399T1 (sl) * | 1996-03-12 | 2006-10-31 | Pg Txl Co Lp | Vodotopna paklitakselna predzdravila |
| US6214966B1 (en) | 1996-09-26 | 2001-04-10 | Shearwater Corporation | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution |
| AU5194998A (en) | 1996-11-01 | 1998-05-29 | Magainin Pharmaceuticals, Inc. | Certain aminosterol compounds and uses therefor |
| EP0884325A1 (en) | 1997-04-24 | 1998-12-16 | Akzo Nobel N.V. | Thrombin inhibitors containing a peptidyl heterocycle |
| US6342507B1 (en) | 1997-09-05 | 2002-01-29 | Isotechnika, Inc. | Deuterated rapamycin compounds, method and uses thereof |
| DE69840586D1 (de) | 1997-10-08 | 2009-04-02 | Isotechnika Inc | Deuterierte Cyclosporin-analoga und ihre Verwendung als immunmodulierende Agenzien |
| EE04548B1 (et) * | 1998-04-01 | 2005-10-17 | Nortran Pharmaceuticals Inc. | Aminotskloheksleeterhendid, nende kompositsioonid ja nende kasutamine |
| AU4551199A (en) | 1998-06-08 | 1999-12-30 | Advanced Medicine, Inc. | Novel therapeutic agents for membrane transporters |
| CA2346656A1 (en) * | 1998-10-20 | 2000-04-27 | The University Of North Carolina At Chapel Hill | Methods of hydrating mucosal surfaces |
| WO2000047547A2 (en) * | 1999-02-12 | 2000-08-17 | Nortran Pharmaceuticals Inc. | Cycloalkyl amine compounds and uses thereof |
| KR20020008167A (ko) | 1999-04-29 | 2002-01-29 | 플레믹 크리스티안 | 잠재적 항정신병제로서의 글리신 분해계 저해제 |
| CA2311483A1 (en) * | 2000-06-12 | 2001-12-12 | Gregory N Beatch | IMIDAZO [1,2-A] PYRIDINIC ETHERS AND USES THEREOF |
| WO2002028412A1 (en) | 2000-10-05 | 2002-04-11 | Zealand Pharmaceuticals A/S | Novel use of peptide |
| JP2004509949A (ja) * | 2000-09-26 | 2004-04-02 | ザ ユニバーシティ オブ アリゾナ ファウンデーション | 化合物および癌またはウイルス性感染症治療におけるその使用方法 |
| JP2002105067A (ja) | 2000-09-28 | 2002-04-10 | Teijin Ltd | ２−フェニルチアゾール誘導体、およびそれを有効成分とする医薬組成物 |
| US7057053B2 (en) * | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7524879B2 (en) * | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US6631745B2 (en) | 2001-07-02 | 2003-10-14 | Fmc Technologies, Inc. | Riser pull-in method and apparatus |
| US6623729B2 (en) | 2001-07-09 | 2003-09-23 | Korea Advanced Institute Of Science And Technology | Process for preparing sustained release micelle employing conjugate of anticancer drug and biodegradable polymer |
| US20030026764A1 (en) | 2001-07-31 | 2003-02-06 | Immunomedics, Inc. | Polymeric delivery systems |
| JP2003113084A (ja) | 2001-10-02 | 2003-04-18 | Mitsubishi Pharma Corp | 肺高血圧症の治療及び／または予防薬 |
| IL147953A (en) | 2002-02-01 | 2008-04-13 | Meir Bialer | Derivatives and pharmaceutical compositions of n-hydroxymethyl tetramethylcyclopropyl- |
| TW200407310A (en) | 2002-06-07 | 2004-05-16 | Glaxo Group Ltd | Compounds |
| NZ537770A (en) * | 2002-06-21 | 2007-03-30 | Suven Life Sciences Ltd | Tetracyclic arylsulfonyl indoles having serotonin receptor affinity |
| CN1678326A (zh) * | 2002-06-28 | 2005-10-05 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2'－c－甲基－3'－o－l－缬氨酸酯核糖呋喃基胞苷 |
| WO2004014973A2 (en) * | 2002-08-13 | 2004-02-19 | Sirus Pharmaceuticals Ltd | Biodegradable polymer |
| WO2004082585A2 (en) | 2003-03-20 | 2004-09-30 | Sirus Pharmaceuticals Ltd | Water-soluble conjugates of phenytoin |
| SI1560812T1 (sl) * | 2003-05-02 | 2006-10-31 | Cardiome Pharma Corp | Aminocikloheksil etrske spojine in njihove uporabe |
| CA2524034A1 (en) * | 2003-05-02 | 2004-11-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
| KR100495009B1 (ko) | 2003-07-02 | 2005-06-14 | 삼성전자주식회사 | 화상형성 장치의 전사벨트 텐션 자동 인가 장치 |
| WO2005018635A2 (en) | 2003-08-07 | 2005-03-03 | Cardiome Pharma Corp. | Ion channel modulating activity i |
| WO2005079861A2 (en) | 2004-02-13 | 2005-09-01 | Safeway Investments Ltd. | Polymeric water soluble prodrugs |
| JP4954864B2 (ja) * | 2004-04-01 | 2012-06-20 | カーディオム ファーマ コーポレイション | イオンチャネル調節化合物のプロドラッグおよびその使用 |
| EP1729815A2 (en) | 2004-04-01 | 2006-12-13 | Cardiome Pharma Corp. | Pegylated ion channel modulating compounds |
| US7705036B2 (en) | 2004-04-01 | 2010-04-27 | Cardiome Pharma Corp. | Deuterated aminocyclohexyl ether compounds and processes for preparing same |
| WO2005097203A2 (en) * | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Serum protein conjugates of ion channel modulating compounds and uses thereof |
| MX2007016248A (es) * | 2005-06-15 | 2008-03-07 | Cardiome Pharma Corp | Procedimiento sintetico para la preparacion de compuestos de eter aminociclohexilico. |
| US7845611B1 (en) * | 2007-11-16 | 2010-12-07 | Sholander Alfred M | Door operated page turner device, system and method for books |
-
2005
- 2005-03-31 JP JP2007506547A patent/JP4954864B2/ja not_active Expired - Fee Related
- 2005-03-31 US US11/547,419 patent/US7786119B2/en not_active Expired - Lifetime
- 2005-03-31 EP EP05763506A patent/EP1729814A2/en not_active Withdrawn
- 2005-03-31 WO PCT/US2005/011124 patent/WO2005094897A2/en not_active Ceased
- 2005-03-31 MX MXPA06011420A patent/MXPA06011420A/es unknown
- 2005-03-31 CA CA002561733A patent/CA2561733A1/en not_active Abandoned
- 2005-03-31 JP JP2007506319A patent/JP4991037B2/ja not_active Expired - Fee Related
-
2008
- 2008-03-28 JP JP2008088708A patent/JP2008214353A/ja active Pending
- 2008-03-28 JP JP2008088707A patent/JP2008179653A/ja active Pending
-
2010
- 2010-07-07 US US12/831,804 patent/US20100273724A1/en not_active Abandoned
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