JP2008542278A5 - - Google Patents
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- JP2008542278A5 JP2008542278A5 JP2008513580A JP2008513580A JP2008542278A5 JP 2008542278 A5 JP2008542278 A5 JP 2008542278A5 JP 2008513580 A JP2008513580 A JP 2008513580A JP 2008513580 A JP2008513580 A JP 2008513580A JP 2008542278 A5 JP2008542278 A5 JP 2008542278A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- sequence
- variable domain
- chain variable
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000623 proteins and genes Proteins 0.000 claims 39
- 102000004169 proteins and genes Human genes 0.000 claims 39
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 5
- 210000004602 germ cell Anatomy 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 101000830598 Homo sapiens Tumor necrosis factor ligand superfamily member 12 Proteins 0.000 claims 3
- 102000058177 human TNFSF12 Human genes 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 208000034189 Sclerosis Diseases 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68514905P | 2005-05-27 | 2005-05-27 | |
| US60/685,149 | 2005-05-27 | ||
| PCT/US2006/019706 WO2006130374A2 (en) | 2005-05-27 | 2006-05-25 | Tweak binding antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012256386A Division JP2013040210A (ja) | 2005-05-27 | 2012-11-22 | Ｔｗｅａｋ結合抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008542278A JP2008542278A (ja) | 2008-11-27 |
| JP2008542278A5 true JP2008542278A5 (enrdf_load_stackoverflow) | 2009-07-09 |
| JP5175181B2 JP5175181B2 (ja) | 2013-04-03 |
Family
ID=37482143
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008513580A Expired - Fee Related JP5175181B2 (ja) | 2005-05-27 | 2006-05-25 | Ｔｗｅａｋ結合抗体 |
| JP2012256386A Withdrawn JP2013040210A (ja) | 2005-05-27 | 2012-11-22 | Ｔｗｅａｋ結合抗体 |
| JP2014170135A Withdrawn JP2014221837A (ja) | 2005-05-27 | 2014-08-25 | Ｔｗｅａｋ結合抗体 |
| JP2016212746A Expired - Fee Related JP6234535B2 (ja) | 2005-05-27 | 2016-10-31 | Ｔｗｅａｋ結合抗体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012256386A Withdrawn JP2013040210A (ja) | 2005-05-27 | 2012-11-22 | Ｔｗｅａｋ結合抗体 |
| JP2014170135A Withdrawn JP2014221837A (ja) | 2005-05-27 | 2014-08-25 | Ｔｗｅａｋ結合抗体 |
| JP2016212746A Expired - Fee Related JP6234535B2 (ja) | 2005-05-27 | 2016-10-31 | Ｔｗｅａｋ結合抗体 |
Country Status (29)
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7129061B1 (en) * | 1996-08-07 | 2006-10-31 | Biogen Idec Ma Inc. | Tumor necrosis factor related ligand |
| TR200102021T2 (tr) | 1999-01-15 | 2001-12-21 | Biogen, Inc. | TWEAK ve TWEAK reseptörü antagonistleri ve bunların imünolojik bozuklukların iyileştirilmesi için kullanımları |
| CA2887716C (en) * | 2002-04-09 | 2017-01-24 | Biogen Idec Ma Inc. | Methods for treating tweak-related conditions |
| CA2587018A1 (en) * | 2004-11-08 | 2006-05-18 | University Of Maryland, Baltimore | Tweak as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death |
| US7939490B2 (en) | 2004-12-13 | 2011-05-10 | University Of Maryland, Baltimore | TWEAK as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death |
| US20090068102A1 (en) * | 2005-02-17 | 2009-03-12 | Biogen Idec Ma Inc. | Treating stroke |
| EP1859277A4 (en) | 2005-02-17 | 2010-03-17 | Biogen Idec Inc | TREATMENT OF NEUROLOGICAL DISORDERS |
| WO2006122187A2 (en) | 2005-05-10 | 2006-11-16 | Biogen Idec Ma Inc. | Treating and evaluating inflammatory disorders |
| WO2006130429A2 (en) * | 2005-05-27 | 2006-12-07 | Biogen Idec Ma Inc. | Treatment of cancer |
| WO2006138219A2 (en) | 2005-06-13 | 2006-12-28 | Biogen Idec Ma Inc. | Methods of diagnosis / prognosis of inflammatory conditions |
| EP2069521A4 (en) * | 2006-10-16 | 2009-12-16 | Biogen Idec Inc | BIOMARKERS OF SCLEROSIS IN PLATE |
| US8685741B1 (en) * | 2007-03-07 | 2014-04-01 | Nestec S.A. | Methods for diagnosing irritable bowel syndrome |
| WO2009134776A2 (en) | 2008-04-29 | 2009-11-05 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
| CN102112495A (zh) | 2008-06-03 | 2011-06-29 | 雅培制药有限公司 | 双重可变结构域免疫球蛋白及其用途 |
| BRPI0913366A8 (pt) | 2008-06-03 | 2017-07-11 | Abbott Lab | Imunoglobulinas de domínio variável duplo e seus usos |
| CA2729949A1 (en) | 2008-07-08 | 2010-01-14 | Abbott Laboratories | Prostaglandin e2 dual variable domain immunoglobulins and uses thereof |
| US8093006B2 (en) | 2009-04-02 | 2012-01-10 | Hoffmann-La Roche Inc. | Antibodies against human tweak and uses thereof |
| NZ621170A (en) | 2009-05-13 | 2015-08-28 | Genzyme Corp | Anti-human cd52 immunoglobulins |
| UY32870A (es) * | 2009-09-01 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| TW201119676A (en) * | 2009-10-15 | 2011-06-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| WO2011065940A1 (en) | 2009-11-24 | 2011-06-03 | Biogen Idec Ma Inc. | Method of supplementing culture media to prevent undesirable amino acid substitutions |
| WO2011097500A2 (en) | 2010-02-04 | 2011-08-11 | University Of Louisville Research Foundation, Inc. | The tweak/fn14 system regulates skeletal muscle atrophy and regeneration |
| PE20130614A1 (es) * | 2010-06-24 | 2013-07-01 | Abbvie Inc | Inmunoglobulinas con dominio variable dual y su uso |
| NZ607480A (en) | 2010-08-03 | 2014-10-31 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| MX2013002270A (es) | 2010-08-26 | 2013-05-14 | Abbvie Inc | Inmonoglubinas de dominio variable doble y usos de las mismas. |
| JP5941049B2 (ja) * | 2010-10-05 | 2016-06-29 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | ヒトｔｗｅａｋに対する抗体およびその使用 |
| TW201333035A (zh) | 2011-12-30 | 2013-08-16 | Abbvie Inc | 針對ｉｌ－１３及／或ｉｌ－１７之雙特異性結合蛋白 |
| CA2868404A1 (en) | 2012-04-05 | 2013-10-10 | F. Hoffmann-La Roche Ag | Bispecific antibodies against human tweak and human il17 and uses thereof |
| TW202014439A (zh) | 2012-11-01 | 2020-04-16 | 美商艾伯維有限公司 | 抗-vegf/dll4雙重可變區域免疫球蛋白及其用途 |
| AR095199A1 (es) * | 2013-03-15 | 2015-09-30 | Genzyme Corp | Anticuerpos anti-cd52 |
| EP2970459A2 (en) | 2013-03-15 | 2016-01-20 | AbbVie Inc. | Dual specific binding proteins directed against il-1beta and il-17 |
| JP2016000003A (ja) * | 2013-04-19 | 2016-01-07 | アステラス製薬株式会社 | 新規抗ヒトｔｗｅａｋ抗体 |
| US20160243224A1 (en) | 2013-10-04 | 2016-08-25 | Biogen Ma Inc. | Tweak antagonists for treating lupus nephritis and muscle atrophy |
| WO2016094881A2 (en) | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Lrp-8 binding proteins |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白 |
| WO2018112362A1 (en) | 2016-12-16 | 2018-06-21 | Biogen Ma Inc. | Stabilized proteolytically activated growth differentiation factor 11 |
| EP3814379A4 (en) | 2018-05-07 | 2022-03-30 | Genmab A/S | METHOD OF TREATMENT OF CANCER WITH A COMBINATION OF AN ANTI-PD-1 ANTIBODY AND AN ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATE |
| US12220570B2 (en) | 2018-10-05 | 2025-02-11 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use |
| MX2021004772A (es) | 2018-10-29 | 2021-08-16 | Biogen Ma Inc | Variantes de fc5 humanizado y estabilizado para mejorar el transporte de la barrera hematoencefalica. |
| PH12021550945A1 (en) * | 2018-10-31 | 2022-03-28 | Astellas Pharma Inc | ANTI-HUMAN Fn14 ANTIBODY |
| CN112778372A (zh) * | 2019-11-11 | 2021-05-11 | 苏州泽璟生物制药股份有限公司 | 咪唑并喹啉取代磷酸酯类激动剂及其制备方法和应用 |
| TW202302648A (zh) * | 2021-03-12 | 2023-01-16 | 美商健生生物科技公司 | Cd79b抗體於自體免疫治療應用之用途 |
Family Cites Families (76)
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| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4475196A (en) | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
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| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
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| CA2587018A1 (en) | 2004-11-08 | 2006-05-18 | University Of Maryland, Baltimore | Tweak as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death |
| US7939490B2 (en) * | 2004-12-13 | 2011-05-10 | University Of Maryland, Baltimore | TWEAK as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death |
| US20090068102A1 (en) * | 2005-02-17 | 2009-03-12 | Biogen Idec Ma Inc. | Treating stroke |
| EP1859277A4 (en) | 2005-02-17 | 2010-03-17 | Biogen Idec Inc | TREATMENT OF NEUROLOGICAL DISORDERS |
| EP1853312B1 (en) * | 2005-03-07 | 2014-12-10 | Genentech, Inc. | Methods and compositions for modulating tweak and fn14 activity |
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| WO2006138219A2 (en) | 2005-06-13 | 2006-12-28 | Biogen Idec Ma Inc. | Methods of diagnosis / prognosis of inflammatory conditions |
| EP2069521A4 (en) | 2006-10-16 | 2009-12-16 | Biogen Idec Inc | BIOMARKERS OF SCLEROSIS IN PLATE |
-
2006
- 2006-05-25 NZ NZ564092A patent/NZ564092A/en not_active IP Right Cessation
- 2006-05-25 PL PL06760258T patent/PL1888113T3/pl unknown
- 2006-05-25 GE GEAP200610459A patent/GEP20115324B/en unknown
- 2006-05-25 UA UAA200714838A patent/UA96416C2/uk unknown
- 2006-05-25 PT PT111917712T patent/PT2460831T/pt unknown
- 2006-05-25 DK DK11191771.2T patent/DK2460831T3/en active
- 2006-05-25 PL PL11191771T patent/PL2460831T3/pl unknown
- 2006-05-25 MX MX2013013851A patent/MX339015B/es unknown
- 2006-05-25 BR BRPI0611414A patent/BRPI0611414B8/pt not_active IP Right Cessation
- 2006-05-25 ME MEP-354/08A patent/MEP35408A/xx unknown
- 2006-05-25 HU HUE11191771A patent/HUE030701T2/hu unknown
- 2006-05-25 ES ES06760258.1T patent/ES2507069T3/es active Active
- 2006-05-25 JP JP2008513580A patent/JP5175181B2/ja not_active Expired - Fee Related
- 2006-05-25 LT LTEP11191771.2T patent/LT2460831T/lt unknown
- 2006-05-25 AU AU2006252830A patent/AU2006252830B2/en not_active Ceased
- 2006-05-25 CN CN201310054744.7A patent/CN103242447B/zh not_active Expired - Fee Related
- 2006-05-25 PL PL384684A patent/PL218791B1/pl unknown
- 2006-05-25 EA EA200702643A patent/EA018255B1/ru not_active IP Right Cessation
- 2006-05-25 CA CA2609600A patent/CA2609600C/en not_active Expired - Fee Related
- 2006-05-25 CN CN2006800275811A patent/CN101247830B/zh not_active Expired - Fee Related
- 2006-05-25 RS RS20070462A patent/RS55888B1/sr unknown
- 2006-05-25 EP EP06760258.1A patent/EP1888113B1/en active Active
- 2006-05-25 EP EP11191771.2A patent/EP2460831B1/en active Active
- 2006-05-25 SG SG201003724-0A patent/SG162728A1/en unknown
- 2006-05-25 CN CN2011103581313A patent/CN102441163A/zh active Pending
- 2006-05-25 KR KR1020137032481A patent/KR101679468B1/ko not_active Expired - Fee Related
- 2006-05-25 DK DK06760258.1T patent/DK1888113T3/da active
- 2006-05-25 ES ES11191771.2T patent/ES2605945T3/es active Active
- 2006-05-25 NZ NZ583636A patent/NZ583636A/en not_active IP Right Cessation
- 2006-05-25 SI SI200632111A patent/SI2460831T1/sl unknown
- 2006-05-25 EP EP11191813A patent/EP2460832A3/en not_active Withdrawn
- 2006-05-25 KR KR1020077030638A patent/KR20080023317A/ko not_active Ceased
- 2006-05-25 WO PCT/US2006/019706 patent/WO2006130374A2/en active Application Filing
- 2006-05-25 ME MEP-2008-354A patent/ME00261B/me unknown
- 2006-05-25 PT PT67602581T patent/PT1888113E/pt unknown
- 2006-05-25 SI SI200631822T patent/SI1888113T1/sl unknown
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2007
- 2007-11-22 IL IL187585A patent/IL187585A/en active IP Right Grant
- 2007-11-26 US US11/944,709 patent/US8048422B2/en not_active Expired - Fee Related
- 2007-11-29 IS IS8693A patent/IS8693A/is unknown
- 2007-12-10 ZA ZA200710765A patent/ZA200710765B/xx unknown
- 2007-12-27 NO NO20076607A patent/NO20076607L/no not_active Application Discontinuation
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2011
- 2011-09-09 US US13/228,784 patent/US20120009178A1/en not_active Abandoned
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2012
- 2012-11-22 JP JP2012256386A patent/JP2013040210A/ja not_active Withdrawn
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2014
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2016
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- 2016-12-14 CY CY20161101291T patent/CY1118343T1/el unknown