JP2008542249A - 抗細菌活性を持つアミノピペリジンキノリン及びそのアザ等立体類似体 - Google Patents

抗細菌活性を持つアミノピペリジンキノリン及びそのアザ等立体類似体 Download PDF

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Publication number
JP2008542249A
JP2008542249A JP2008512908A JP2008512908A JP2008542249A JP 2008542249 A JP2008542249 A JP 2008542249A JP 2008512908 A JP2008512908 A JP 2008512908A JP 2008512908 A JP2008512908 A JP 2008512908A JP 2008542249 A JP2008542249 A JP 2008542249A
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JP
Japan
Prior art keywords
alkyl
amino
dihydro
methoxy
naphthyridin
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Pending
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JP2008512908A
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English (en)
Japanese (ja)
Inventor
レック，フォルカート
モーニングスター，マーシャル
ハートル，ハイナルカ
Original Assignee
アストラゼネカ アクチボラグ
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Publication of JP2008542249A publication Critical patent/JP2008542249A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2008512908A 2005-05-24 2006-05-23 抗細菌活性を持つアミノピペリジンキノリン及びそのアザ等立体類似体 Pending JP2008542249A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68403005P 2005-05-24 2005-05-24
PCT/GB2006/001889 WO2006125974A1 (en) 2005-05-24 2006-05-23 Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity

Publications (1)

Publication Number Publication Date
JP2008542249A true JP2008542249A (ja) 2008-11-27

Family

ID=36685663

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008512908A Pending JP2008542249A (ja) 2005-05-24 2006-05-23 抗細菌活性を持つアミノピペリジンキノリン及びそのアザ等立体類似体

Country Status (14)

Country Link
US (1) US20090131444A1 (no)
EP (1) EP1891078A1 (no)
JP (1) JP2008542249A (no)
KR (1) KR20080016577A (no)
CN (1) CN101258157A (no)
AU (1) AU2006250987A1 (no)
BR (1) BRPI0609887A2 (no)
CA (1) CA2608072A1 (no)
IL (1) IL187134A0 (no)
MX (1) MX2007014507A (no)
NO (1) NO20076675L (no)
RU (1) RU2007147413A (no)
WO (1) WO2006125974A1 (no)
ZA (1) ZA200709870B (no)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009539806A (ja) * 2006-06-08 2009-11-19 シュペーデル・エクスペリメンタ・アーゲー ２，５−二置換ピペリジン
JP2012511566A (ja) * 2008-12-12 2012-05-24 アクテリオン ファーマシューティカルズ リミテッド ５−アミノ−２−（１−ヒドロキシ−エチル）−テトラヒドロピラン誘導体
JP2015518487A (ja) * 2012-04-27 2015-07-02 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ ナフチリジン誘導体の製造方法
JP2017036307A (ja) * 2011-06-17 2017-02-16 アストラゼネカ アクチボラグ ｔｒａｎｓ−７−オキソ−６−（スルホオキシ）−１，６−ジアザビシクロ［３，２，１］オクタン−２−カルボキサミドとその塩が含まれる複素環式化合物を製造するための方法
JP2019517546A (ja) * 2016-06-08 2019-06-24 アジェンデ・キミケ・リウニテ・アンジェリニ・フランチェスコ・ア・チ・エレ・ア・エフェ・ソシエタ・ペル・アチオニＡｚｉｅｎｄｅ Ｃｈｉｍｉｃｈｅ Ｒｉｕｎｉｔｅ Ａｎｇｅｌｉｎｉ Ｆｒａｎｃｅｓｃｏ Ａ．Ｃ．Ｒ．Ａ．Ｆ．Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ 新しい抗菌性化合物

Families Citing this family (26)

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MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
EP1996579A2 (en) * 2006-03-10 2008-12-03 Actelion Pharmaceuticals Ltd. Antibiotic compounds
EP2001887B1 (en) 2006-04-06 2010-09-15 Glaxo Group Limited Pyrrolo-quinoxalinone derivatives as antibacterials
SG164384A1 (en) 2006-05-26 2010-09-29 Toyama Chemical Co Ltd Novel heterocyclic compound or salt thereof and intermediate thereof
SI2137196T1 (sl) * 2007-04-20 2011-01-31 Glaxo Group Ltd Glaxo Welcome House Tricikliäśne spojine, ki vsebujejo duĺ ik, uporabne kot antibakterijska sredstva
BRPI0812942B1 (pt) 2007-06-15 2018-11-21 Actelion Pharmaceuticals Ltd composto derivado de 3-amino-6 - (1-amino-etil) - tetra-hidropirano, composição farmacêutica e uso de referido composto.
CA2713182C (en) 2008-02-20 2016-09-13 Actelion Pharmaceuticals Ltd Azatricyclic antibiotic compounds
ES2533217T3 (es) 2008-10-07 2015-04-08 Actelion Pharmaceuticals Ltd. Compuestos antibióticos de oxazolidinona tricíclicos
EP2352734A1 (en) 2008-10-17 2011-08-10 Glaxo Group Limited Tricyclic nitrogen compounds used as antibacterials
US20120053350A1 (en) * 2009-04-30 2012-03-01 Ian Mangion Preparation of alkyl esters of n-protected oxo-azacycloalkylcarboxylic acids
JP5988506B2 (ja) * 2010-04-02 2016-09-07 セノミックス インコーポレイテッド 甘味修飾物質
AU2012295255B2 (en) 2011-08-12 2016-04-21 Senomyx, Inc. Sweet flavor modifier
AU2013237939A1 (en) 2012-03-30 2014-10-30 Cubist Pharmaceuticals, Inc. 1,3,4-oxadiazole and 1,3,4-thiadiazole beta-lactamase inhibitors
WO2014152996A1 (en) 2013-03-14 2014-09-25 Cubist Pharmaceuticals, Inc. Crystalline form of a beta-lactamase inhibitor
US9120796B2 (en) 2013-10-02 2015-09-01 Cubist Pharmaceuticals, Inc. B-lactamase inhibitor picoline salt
CN103613530B (zh) * 2013-12-02 2015-08-19 江苏弘和药物研发有限公司 一种芴甲氧羰基-3-哌啶醇的合成方法
CN105899487B (zh) * 2013-12-27 2018-10-19 株式会社Api 5-羟基哌啶-2-甲酸的制造方法
AR101674A1 (es) 2014-08-22 2017-01-04 Glaxosmithkline Ip Dev Ltd Uso de un compuesto tricíclico que contiene nitrógeno
CA2963901A1 (en) 2014-11-07 2016-05-12 Senomyx, Inc. Substituted 4-amino-5-(cyclohexyloxy)quinoline-3-carboxylic acids as sweet flavor modifiers
TW201722965A (zh) 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物
BR112019000716A2 (pt) 2016-07-13 2019-05-07 Syros Pharmaceuticals Inc inibidores de quinase dependente de ciclina (cdk7)
KR20200020911A (ko) 2017-06-30 2020-02-26 바이엘 애니멀 헬스 게엠베하 새로운 아자퀴놀린 유도체
MX2020001352A (es) 2017-08-09 2020-03-20 Denali Therapeutics Inc Compuestos, composiciones y metodos.
PL3676297T3 (pl) * 2017-09-01 2023-12-11 Denali Therapeutics Inc. Związki, kompozycje i sposoby
US11512067B2 (en) 2017-09-14 2022-11-29 Daiichi Sankyo Company, Limited Compound having cyclic structure
CA3129609A1 (en) 2019-02-13 2020-08-20 Denali Therapeutics Inc. Eukaryotic initiation factor 2b modulators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9822450D0 (en) * 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
BR0112750A (pt) * 2000-07-26 2003-09-09 Smithkline Beecham Plc Aminopiperidina quinolinas e seus análogos azaisostéricos com atividade antibacteriana
DE60119939T2 (de) * 2000-09-21 2006-11-30 Smithkline Beecham P.L.C., Brentford Chinolinderivate als antibakterielle mittel
CA2580621A1 (en) * 2004-09-24 2006-03-30 Actelion Pharmaceuticals Ltd New bicyclic antibiotics

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009539806A (ja) * 2006-06-08 2009-11-19 シュペーデル・エクスペリメンタ・アーゲー ２，５−二置換ピペリジン
JP2012511566A (ja) * 2008-12-12 2012-05-24 アクテリオン ファーマシューティカルズ リミテッド ５−アミノ−２−（１−ヒドロキシ−エチル）−テトラヒドロピラン誘導体
JP2017036307A (ja) * 2011-06-17 2017-02-16 アストラゼネカ アクチボラグ ｔｒａｎｓ−７−オキソ−６−（スルホオキシ）−１，６−ジアザビシクロ［３，２，１］オクタン−２−カルボキサミドとその塩が含まれる複素環式化合物を製造するための方法
JP2015518487A (ja) * 2012-04-27 2015-07-02 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ ナフチリジン誘導体の製造方法
JP2019517546A (ja) * 2016-06-08 2019-06-24 アジェンデ・キミケ・リウニテ・アンジェリニ・フランチェスコ・ア・チ・エレ・ア・エフェ・ソシエタ・ペル・アチオニＡｚｉｅｎｄｅ Ｃｈｉｍｉｃｈｅ Ｒｉｕｎｉｔｅ Ａｎｇｅｌｉｎｉ Ｆｒａｎｃｅｓｃｏ Ａ．Ｃ．Ｒ．Ａ．Ｆ．Ｓｏｃｉｅｔａ Ｐｅｒ Ａｚｉｏｎｉ 新しい抗菌性化合物

Also Published As

Publication number Publication date
IL187134A0 (en) 2008-02-09
KR20080016577A (ko) 2008-02-21
BRPI0609887A2 (pt) 2011-10-11
MX2007014507A (es) 2008-02-07
CA2608072A1 (en) 2006-11-30
CN101258157A (zh) 2008-09-03
NO20076675L (no) 2007-12-27
RU2007147413A (ru) 2009-06-27
ZA200709870B (en) 2008-11-26
WO2006125974A1 (en) 2006-11-30
AU2006250987A1 (en) 2006-11-30
US20090131444A1 (en) 2009-05-21
EP1891078A1 (en) 2008-02-27

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