JP2008540486A5 - - Google Patents
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- Publication number
- JP2008540486A5 JP2008540486A5 JP2008510556A JP2008510556A JP2008540486A5 JP 2008540486 A5 JP2008540486 A5 JP 2008540486A5 JP 2008510556 A JP2008510556 A JP 2008510556A JP 2008510556 A JP2008510556 A JP 2008510556A JP 2008540486 A5 JP2008540486 A5 JP 2008540486A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- roflumilast
- combination product
- therapeutic compound
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000013066 combination product Substances 0.000 claims 14
- 229940127555 combination product Drugs 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 14
- FNKQXYHWGSIFBK-RPDRRWSUSA-N sapropterin Chemical compound N1=C(N)NC(=O)C2=C1NC[C@H]([C@@H](O)[C@@H](O)C)N2 FNKQXYHWGSIFBK-RPDRRWSUSA-N 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 13
- 230000001225 therapeutic effect Effects 0.000 claims 12
- 230000002265 prevention Effects 0.000 claims 8
- 208000023504 respiratory system disease Diseases 0.000 claims 8
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 claims 7
- 229960002586 roflumilast Drugs 0.000 claims 7
- PCGSQNPMMSALEJ-UHFFFAOYSA-N roflumilast n-oxide Chemical compound ClC1=C[N+]([O-])=CC(Cl)=C1NC(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1 PCGSQNPMMSALEJ-UHFFFAOYSA-N 0.000 claims 7
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 6
- 208000029523 Interstitial Lung disease Diseases 0.000 claims 4
- 239000003085 diluting agent Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 239000000047 product Substances 0.000 claims 3
- 206010014561 Emphysema Diseases 0.000 claims 2
- VPVOXUSPXFPWBN-UHFFFAOYSA-N L-sepiapterin Natural products N1=C(N)NC(=O)C2=C1NCC(C(=O)C(O)C)=N2 VPVOXUSPXFPWBN-UHFFFAOYSA-N 0.000 claims 2
- 208000006673 asthma Diseases 0.000 claims 2
- 239000000969 carrier Substances 0.000 claims 2
- 208000030603 inherited susceptibility to asthma Diseases 0.000 claims 2
- 210000003205 muscle Anatomy 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 2
- 208000002815 pulmonary hypertension Diseases 0.000 claims 2
- VPVOXUSPXFPWBN-VKHMYHEASA-N sepiapterin Chemical compound N1C(N)=NC(=O)C2=C1NCC(C(=O)[C@@H](O)C)=N2 VPVOXUSPXFPWBN-VKHMYHEASA-N 0.000 claims 2
- 229940126478 sepiapterin Drugs 0.000 claims 2
- BOEUHAUGJSOEDZ-UHFFFAOYSA-N 2-amino-5,6,7,8-tetrahydro-1h-pteridin-4-one Chemical compound N1CCNC2=C1C(=O)N=C(N)N2 BOEUHAUGJSOEDZ-UHFFFAOYSA-N 0.000 claims 1
- BOTGCSIOTOLSMF-UHFFFAOYSA-N 2-amino-6-(hydroxymethyl)-5,6,7,8-tetrahydro-1h-pteridin-4-one Chemical compound N1C(CO)CNC2=C1C(=O)N=C(N)N2 BOTGCSIOTOLSMF-UHFFFAOYSA-N 0.000 claims 1
- HWOZEJJVUCALGB-UHFFFAOYSA-N 6-Methyltetrahydropterin Chemical compound N1C(N)=NC(=O)C2=C1NCC(C)N2 HWOZEJJVUCALGB-UHFFFAOYSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000012895 dilution Substances 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05103938 | 2005-05-11 | ||
| PCT/EP2006/062117 WO2006120176A2 (en) | 2005-05-11 | 2006-05-08 | Combination of the pde4 inhibitor roflumilast and a tetrahydrobiopterin derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008540486A JP2008540486A (ja) | 2008-11-20 |
| JP2008540486A5 true JP2008540486A5 (enExample) | 2009-07-02 |
Family
ID=35125407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008510556A Withdrawn JP2008540486A (ja) | 2005-05-11 | 2006-05-08 | Ｐｄｅ４インヒビター及びテトラヒドロビオプテリン誘導体との組合せ物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20080221111A1 (enExample) |
| EP (1) | EP1940392A2 (enExample) |
| JP (1) | JP2008540486A (enExample) |
| KR (1) | KR20080005601A (enExample) |
| CN (1) | CN101171005A (enExample) |
| AU (1) | AU2006245770A1 (enExample) |
| BR (1) | BRPI0612796A2 (enExample) |
| CA (1) | CA2607331A1 (enExample) |
| EA (1) | EA200702358A1 (enExample) |
| IL (1) | IL186804A0 (enExample) |
| MX (1) | MX2007013766A (enExample) |
| NO (1) | NO20076206L (enExample) |
| WO (1) | WO2006120176A2 (enExample) |
| ZA (1) | ZA200708776B (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006321942A1 (en) * | 2005-12-05 | 2007-06-14 | Biomarin Pharmaceutical Inc. | Methods and compositions for the treatment of disease |
| WO2008089148A1 (en) * | 2007-01-12 | 2008-07-24 | Biomarin Pharmaceutical Inc. | Method of treating a metabolic or neuropsychiatry disorder with a bh4 derivative prodrug |
| MY153979A (en) | 2007-10-19 | 2015-04-30 | Boehringer Ingelheim Int | Substituted piperidino-dihydrothienopyrimidine |
| JP2011530540A (ja) * | 2008-08-12 | 2011-12-22 | オルファ スイス ゲーエムベーハー | テトラヒドロビオプテリンを含有する医薬剤形 |
| CN102256963B (zh) | 2008-12-19 | 2014-06-11 | 贝林格尔.英格海姆国际有限公司 | 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺 |
| WO2010097374A1 (de) | 2009-02-26 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Verbindungen als bradykinin-b1-antagonisten |
| WO2010097373A1 (de) | 2009-02-26 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Verbindungen als bradykinin b1 antagonisten |
| CA2759126C (en) | 2009-02-26 | 2017-08-22 | Boehringer Ingelheim International Gmbh | Compounds as bradykinin b1 antagonists |
| CA2790952C (en) | 2010-02-23 | 2017-07-04 | Boehringer Ingelheim International Gmbh | Compounds as bradykinin b1 antagonists |
| WO2011132435A1 (ja) | 2010-04-22 | 2011-10-27 | 学校法人日本大学 | 脳機能障害予防・改善用の薬剤及び飲食物 |
| CN102274222B (zh) * | 2011-08-18 | 2013-04-10 | 天津市汉康医药生物技术有限公司 | 高生物利用度的罗氟司特药物组合物及其制备方法 |
| US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
| WO2014037832A2 (en) | 2012-09-06 | 2014-03-13 | Mahesh Kandula | Compositions and methods for the treatment of epilepsy and neurological diseases |
| EP2847158A4 (en) | 2012-05-07 | 2015-12-30 | Cellix Bio Private Ltd | COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS AND NEURODEGENERATIVE DISORDERS |
| SG11201407300VA (en) | 2012-05-07 | 2014-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of neurological disorders |
| WO2013167990A1 (en) | 2012-05-07 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of depression |
| WO2013167993A1 (en) | 2012-05-08 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of neurological degenerative disorders |
| US9309233B2 (en) | 2012-05-08 | 2016-04-12 | Cellix Bio Private Limited | Compositions and methods for the treatment of blood clotting disorders |
| US9522884B2 (en) | 2012-05-08 | 2016-12-20 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic disorders |
| WO2013168023A1 (en) | 2012-05-08 | 2013-11-14 | Mahesh Kandula | Compositions and methods for treatment of parkinson's disease |
| WO2013167992A1 (en) | 2012-05-08 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of inflammatory disorders |
| WO2013168011A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of chronic pain |
| WO2013168001A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of moderate to severe pain |
| US9315461B2 (en) | 2012-05-10 | 2016-04-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurologic diseases |
| US9233161B2 (en) | 2012-05-10 | 2016-01-12 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological conditions |
| WO2013168033A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for treatment of neurologic diseases |
| US9242939B2 (en) | 2012-05-10 | 2016-01-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of respiratory disorders |
| US9403857B2 (en) | 2012-05-10 | 2016-08-02 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic syndrome |
| WO2013168005A2 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of restless leg syndrome and fibromyalgia |
| US9394288B2 (en) | 2012-05-10 | 2016-07-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of asthma and allergy |
| WO2013168000A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of severe pain |
| US9499527B2 (en) | 2012-05-10 | 2016-11-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of familial amyloid polyneuropathy |
| WO2013167997A2 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of metabolic syndrome |
| WO2013168004A2 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of fibromyalgia pain |
| SG11201407319YA (en) | 2012-05-23 | 2014-12-30 | Cellix Bio Private Ltd | Compositions and methods for treatment of inflammatory bowel disease |
| CA2873098A1 (en) | 2012-05-23 | 2013-11-28 | Cellixbio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
| SG11201407326XA (en) | 2012-05-23 | 2014-12-30 | Cellix Bio Private Ltd | Compositions and methods for treatment of mucositis |
| WO2013175347A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of respiratory disorders |
| WO2013175344A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of periodontitis and rheumatoid arthritis |
| WO2013175376A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of local pain |
| US9108942B1 (en) | 2014-11-05 | 2015-08-18 | Mahesh Kandula | Compositions and methods for the treatment of moderate to severe pain |
| WO2014020480A2 (en) | 2012-08-03 | 2014-02-06 | Mahesh Kandula | Compositions and methods for the treatment migraine and neurologic diseases |
| WO2014037833A2 (en) | 2012-09-06 | 2014-03-13 | Mahesh Kandula | Compositions and methods for the treatment inflammation and lipid disorders |
| CA2873029A1 (en) | 2012-09-08 | 2014-03-13 | Cellixbio Private Limited | Compositions and methods for the treatment of inflammation and lipid disorders |
| WO2014041446A2 (en) * | 2012-09-17 | 2014-03-20 | Mahesh Kandula | Compositions and methods for the treatment of metabolic diseases |
| US9333187B1 (en) | 2013-05-15 | 2016-05-10 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammatory bowel disease |
| SG11201509782TA (en) | 2013-06-04 | 2015-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of diabetes and pre-diabetes |
| US9096537B1 (en) | 2014-12-31 | 2015-08-04 | Mahesh Kandula | Compositions and methods for the treatment of mucositis |
| CN105434328A (zh) * | 2014-09-01 | 2016-03-30 | 天津药物研究院有限公司 | 一种含罗氟司特固体分散体的固体制剂及其制备方法 |
| CA2976314C (en) | 2014-09-26 | 2021-02-23 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy and neurological disorders |
| CA2967908C (en) | 2014-09-29 | 2020-11-17 | Mahesh Kandula | Compositions and methods for the treatment of multiple sclerosis |
| JP6564868B2 (ja) | 2014-10-27 | 2019-08-21 | セリックス バイオ プライヴェート リミテッドＣｅｌｌｉｘ Ｂｉｏ Ｐｒｉｖａｔｅ Ｌｉｍｉｔｅｄ | 多発性硬化症の治療のための、フマル酸モノメチルエステルとピペラジン又はエチレンジアミンとの３つの成分の塩 |
| US9173877B1 (en) | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of local pain |
| US9284287B1 (en) | 2014-11-05 | 2016-03-15 | Cellix Bio Private Limited | Compositions and methods for the suppression of carbonic anhydrase activity |
| US9175008B1 (en) | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Prodrugs of anti-platelet agents |
| US9150557B1 (en) | 2014-11-05 | 2015-10-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of hyperglycemia |
| US9321716B1 (en) | 2014-11-05 | 2016-04-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic syndrome |
| US9290486B1 (en) | 2014-11-05 | 2016-03-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy |
| US10208014B2 (en) | 2014-11-05 | 2019-02-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological disorders |
| US9932294B2 (en) | 2014-12-01 | 2018-04-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
| US9206111B1 (en) | 2014-12-17 | 2015-12-08 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological diseases |
| CN110845355A (zh) | 2015-01-06 | 2020-02-28 | 塞尔利克斯生物私人有限公司 | 用于治疗炎症和疼痛的组合物和方法 |
| CN106176639A (zh) * | 2015-04-30 | 2016-12-07 | 四川科伦药物研究院有限公司 | 一种制备罗氟司特片的方法 |
| CN106139161A (zh) * | 2016-08-12 | 2016-11-23 | 合肥久诺医药科技有限公司 | 一种罗氟司特包合物及其固体制剂 |
| WO2019147824A1 (en) | 2018-01-26 | 2019-08-01 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a pde4 inhibitor |
| CN116726361A (zh) | 2018-11-19 | 2023-09-12 | 比奥拉治疗股份有限公司 | 用生物治疗剂治疗疾病的方法和装置 |
| US11707610B2 (en) | 2019-12-13 | 2023-07-25 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
| WO2021213455A1 (zh) * | 2020-04-23 | 2021-10-28 | 浙江养生堂天然药物研究所有限公司 | 药物组合及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5877176A (en) * | 1991-12-26 | 1999-03-02 | Cornell Research Foundation, Inc. | Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis |
| US5830461A (en) * | 1992-11-25 | 1998-11-03 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Methods for promoting wound healing and treating transplant-associated vasculopathy |
| SI0706513T1 (en) * | 1993-07-02 | 2002-10-31 | Altana Pharma Ag | Fluoroalkoxy-substituted benzamides and their use as cyclic nucleotide phosphodiesterase inhibitors |
| DE4418097A1 (de) * | 1994-05-24 | 1995-11-30 | Cassella Ag | Verwendung von Tetrahydropteridin-Derivaten als Hemmstoffe der NO-Synthase |
| ATE252385T1 (de) * | 1996-08-30 | 2003-11-15 | Daiichi Suntory Pharma Co Ltd | Vorbeugende oder heilende mittel für krankheiten, die durch mangel an stickoxid-synthase (nos) ausgelöst sind |
| SE0000307D0 (sv) * | 2000-01-31 | 2000-01-31 | Univ Zuerich | Method and formulation för treatment of vasoconstriction |
| US6544994B2 (en) * | 2000-06-07 | 2003-04-08 | Eprov Ag | Pharmaceutical preparation for treating or preventing cardiovascular or neurological disorders by modulating of the activity of nitric oxide synthase |
| MXPA06004687A (es) * | 2003-10-31 | 2006-06-27 | Altana Pharma Ag | Uso de bh4 para el tratamiento de enfermedades respiratorias. |
-
2006
- 2006-05-08 WO PCT/EP2006/062117 patent/WO2006120176A2/en not_active Ceased
- 2006-05-08 KR KR1020077028279A patent/KR20080005601A/ko not_active Withdrawn
- 2006-05-08 CA CA002607331A patent/CA2607331A1/en not_active Abandoned
- 2006-05-08 CN CNA2006800148286A patent/CN101171005A/zh active Pending
- 2006-05-08 AU AU2006245770A patent/AU2006245770A1/en not_active Abandoned
- 2006-05-08 JP JP2008510556A patent/JP2008540486A/ja not_active Withdrawn
- 2006-05-08 US US11/919,742 patent/US20080221111A1/en not_active Abandoned
- 2006-05-08 EA EA200702358A patent/EA200702358A1/ru unknown
- 2006-05-08 MX MX2007013766A patent/MX2007013766A/es not_active Application Discontinuation
- 2006-05-08 BR BRPI0612796-7A patent/BRPI0612796A2/pt not_active IP Right Cessation
- 2006-05-08 EP EP06755065A patent/EP1940392A2/en not_active Withdrawn
-
2007
- 2007-10-15 ZA ZA200708776A patent/ZA200708776B/xx unknown
- 2007-10-21 IL IL186804A patent/IL186804A0/en unknown
- 2007-12-03 NO NO20076206A patent/NO20076206L/no not_active Application Discontinuation
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